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cover of episode Episode 192: Debunking Myths- Sedation and Ventilator Asynchrony

Episode 192: Debunking Myths- Sedation and Ventilator Asynchrony

2025/3/17
logo of podcast Walking Home From The ICU

Walking Home From The ICU

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Kaylee Dayton
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Sylvia Stephanos
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Sylvia Stephanos: 我在医疗ICU工作,观察到我们深度镇静ARDS患者以优化患者-呼吸机互动,但这并不奏效。深入研究后,我发现深度镇静可能加剧而非改善呼吸机异步。呼吸机异步有多种类型,例如无效触发、双重触发和反向触发,需要分别处理。我们应该首先优化呼吸机设置,而非增加镇静剂。丙泊酚等镇静剂可能导致快速浅呼吸模式,加剧异步。与丙泊酚和咪达唑仑相比,右美托咪啶对呼吸机异步的影响较小。阿片类药物可能比镇静剂对呼吸时机的影响更大,延长呼气相可以帮助消除异步。反向触发是一种由于外部刺激(例如呼吸机)引起的非自主呼吸反射,在深度镇静患者中更常见。更清醒的患者能够更好地与呼吸机互动,减少呼吸机异步。深度镇静后出现谵妄会使减少镇静剂变得困难。深度镇静的风险包括延长ICU住院时间、机械通气时间、获得性肌无力、活动受限、谵妄、死亡率增加和ICU后综合征。深度镇静并未被证实能改善肺通气和氧合,反而可能增加死亡率。早期深度镇静是死亡率的独立预测因素。镇静和镇痛通常由护士根据既定目标和参数进行管理,这可能导致镇静剂量过高。药剂师应该参与呼吸机异步的管理,就像他们参与抗生素管理一样,关注镇静剂的适应症、剂量和不良事件。“呼吸机异步”不应该被用作增加镇静剂的理由。 Kaylee Dayton: 我在清醒和行走ICU工作多年,观察到患者清醒状态下呼吸机同步性良好。深度镇静的普遍使用与我多年的临床经验相悖。我与Sylvia的讨论让我对镇静剂如何影响呼吸机同步性有了更清晰的认识。药剂师应该对镇静剂的使用进行管理,确保其仅在必要时且以适当的方式使用。多学科查房有助于优化镇静策略。

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This chapter explores the common myth that sedation improves ventilator asynchrony in ICU patients. It highlights a contrasting experience in an awake and walking ICU, questioning the widespread practice of sedation for ventilator management. The discussion sets the stage for debunking this myth with evidence-based research.
  • Sedation is widely believed to improve ventilator asynchrony.
  • Awake and walking ICUs have achieved good outcomes without heavy sedation.
  • The prevailing practice is challenged by anecdotal evidence from an ICU with different approach.

Shownotes Transcript

For years we have been taught at the bedside that sedation “improves ventilator asynchrony”. We have believed that patients must be sedated to be compliant with the ventilator. Is that true? What does the research show? Sylvia Stefano, PharmD, BCCP joins us armed with the evidence and ready to debunk the myths.

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