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cover of episode Episode 59 - Red meat for the public health crowd

Episode 59 - Red meat for the public health crowd

2019/11/5
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Free Associations

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J
Jennifer Ryder
M
Matt Fox
Topics
Matt Fox: 本期节目讨论了一篇关于红肉健康影响的争议性研究,该研究建议成年人维持目前的红肉和加工肉类摄入量,这一结论与现有膳食指南相悖,引发了广泛的媒体关注和专业人士的质疑。研究结果基于多项系统综述,但其结论的可靠性受到质疑,部分原因在于其对单一随机对照试验的过度依赖以及对观察性研究结果的解读方式。此外,该研究中利益冲突的披露问题也引发了担忧。 Jennifer Ryder: 目前,不同机构对红肉和加工肉类的膳食指南存在差异,主要基于观察性研究,存在混杂因素和绝对风险评估不足等问题。Nutri-Rex联盟基于五篇系统综述,对红肉和加工肉类的健康影响进行了评估,并提出了新的膳食建议。对于未加工红肉,该研究建议成年人保持目前的消费水平;对于加工肉类,也建议成年人保持目前的消费水平。这些建议的强度较弱,基于证据确定性低。研究中考虑了个人健康相关价值观和偏好,但忽略了动物福利和环境问题。 Jennifer Ryder: 该研究的结论存在争议,部分原因在于既得利益者的存在,例如牛肉产业、营养指南制定者和从事饮食营养研究的学者。研究中使用的随机对照试验数量有限,且主要基于一项大型研究,这使得结论的普适性和可靠性受到质疑。此外,该研究未充分披露第一作者之前的研究与糖业的关系,这引发了人们对其客观性的担忧。

Deep Dive

Key Insights

Why did the authors of the red meat study suggest continuing current consumption levels?

The authors based their weak recommendation on low certainty evidence from randomized controlled trials showing little to no effect on major health outcomes. They found that reducing red meat intake may result in very small reductions in risk, but the benefits were not significant enough to warrant a strong recommendation.

What were the main criticisms of the red meat study?

Critics argued that the study was influenced by industry ties, particularly the lead author's previous work funded by the sugar industry. Additionally, the study's reliance on a single randomized trial for most of its evidence was seen as misleading and insufficient to overturn existing dietary guidelines.

How did the red meat study's methodology differ from previous dietary guidelines?

The study emphasized the use of randomized controlled trials over observational studies, which previous guidelines had relied on more heavily. It also introduced a focus on personal values and preferences regarding meat consumption, which was not a primary consideration in earlier guidelines.

What was the significance of the water rat's behavior in the cane toad study?

The water rat's precise removal of the cane toad's gallbladder, a highly poisonous organ, and consumption of the heart, which is not poisonous, suggests a learned behavior that could potentially help control the invasive cane toad population. This behavior highlights the intelligence and adaptability of the water rat.

Why did the red meat study face controversy despite its rigorous conflict of interest screening?

The controversy stemmed from the lead author's undisclosed ties to the sugar industry, which was revealed after the study's publication. This, combined with the study's reliance on a single randomized trial and its weak evidence basis, led to concerns about the study's trustworthiness and potential industry influence.

What were the key health outcomes considered in the red meat study?

The study focused on all-cause mortality, major cardiometabolic outcomes (CVD mortality, stroke, myocardial infarction, diabetes), and cancer incidence and mortality for GI cancers, prostate cancers, and gynecologic cancers. Quality of life and willingness to change meat consumption were also considered.

How did the red meat study's recommendations align with or differ from existing dietary guidelines?

The study's recommendations to continue current red meat consumption levels differed from existing guidelines, which suggest limiting red and processed meat intake. The study's focus on individual decision-making rather than public health perspectives also set it apart from traditional guidelines.

What was the rationale behind the water rat conservation efforts mentioned in the cane toad study?

The water rat's ability to safely consume cane toads by removing their poisonous organs offers a natural solution to controlling the invasive cane toad population. Conservation efforts aim to protect this native species from threats like pollution, fishing lines, and predation by non-native animals.

Chapters
Matt and Jen discuss a new set of surprising recommendations around eating red meat, focusing on the study's methodology and findings.
  • The study suggests continuing current levels of red meat consumption based on low certainty evidence.
  • The authors formed the Nutritional Recommendations International Consortium (Nutri-Rex) to address perceived shortcomings in prior studies.
  • The study's recommendations are based on five systematic reviews, focusing on health outcomes associated with red and processed meat consumption.

Shownotes Transcript

Matt and Jen discuss a new set of surprising recommendations around eating red meat, we skip the second segment entirely because we had so much to say on segment 1, and Jen reveals who has been killing all the cane toads.

Journal club article:

Red meat recommendation study)