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cover of episode Revolutionizing Healthcare: How Bioengineering & Stem Cells Are Transforming The Future Of Medicine

Revolutionizing Healthcare: How Bioengineering & Stem Cells Are Transforming The Future Of Medicine

2025/2/27
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Kevin Caldwell: 我职业生涯的转变是从追求最令人兴奋的工作转向追求最有意义的工作，这最终促成了Ossium Health的创立。我从小就看到祖父母在医疗系统中经历了反复的治疗，却无法恢复健康活力，这让我开始思考如何才能预防疾病，而不是仅仅治疗症状。传统的医疗系统在应对慢性病和衰老问题方面装备不足，而再生疗法是解决这些问题的关键。Ossium Health致力于通过生物工程改善人类健康，我们利用器官捐献者的骨髓开发了多种细胞疗法。骨髓移植是一种具有70年历史的强大细胞疗法，可以永久性地替代患者的血液和免疫系统，用于治疗多种血液和免疫疾病。骨髓移植有两个主要应用：重建血液和免疫系统，以及在器官移植中诱导免疫耐受，减少排异反应。我们从器官捐献者获得骨髓，并将其用于骨髓移植，这降低了移植排异反应的发生率。我们观察到，使用器官捐献者骨髓进行骨髓移植，患者的移植排异反应（移植物抗宿主病）发生率更低，这与骨髓中较少的幼稚T细胞有关。骨髓移植前，需要清除患者自身的骨髓，为新的骨髓细胞移植腾出空间，这个过程在全身进行。骨髓移植后，患者需要在医院环境中度过一段免疫功能受损的时期，需要密切监测以防止感染。虽然骨髓移植后患者通常会使用抗生素，这可能会对肠道菌群产生影响，但Ossium Health目前的研究并未关注这方面。我们还提供Ossagraft，这是一种骨骼修复产品，用于加速脊柱手术后的愈合。Ossagraft主要用于骨融合和重建，目前不适用于软骨修复。骨骼修复技术，例如Ossagraft，主要用于治疗与年龄相关的骨骼退化和损伤，以改善患者的活动能力和生活质量。Ossium Health正在研究一种方法，利用器官捐献者的骨髓进行器官移植，从而避免使用免疫抑制药物，这将彻底改变器官移植。通过结合器官捐献者的骨髓进行部分骨髓移植，可以诱导免疫耐受，从而实现无需免疫抑制剂的器官移植。Ossium Health正在进行一项关于无需免疫抑制剂进行器官移植的研究，未来将进行临床试验。患者可以通过Ossium Health的网站或clinicaltrials.gov网站了解其产品和临床试验信息。 Richard Jacobs: (访谈者，未表达核心观点)

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Chapters
Kevin Caldwell, CEO of Ossium Health, discusses the company's mission to improve human health through bioengineering, focusing on stem cell therapies and organ donor bone marrow banking. They aim to treat life-threatening hematologic conditions, organ transplant rejection, and musculoskeletal defects.
  • Ossium Health uses organ donor bone marrow to develop stem cell therapies.
  • Bone marrow transplants have a 70-year history in treating blood cancers.
  • The company's platform-based model enables treatment of various blood and immune diseases.

Shownotes Transcript

Can bioengineering improve the health, vitality, and longevity of human beings? What would the future look like if the medical system were about preserving health rather than just treating symptoms? In this episode, Kevin Caldwell, the CEO, Co-Founder, and President of Ossium Health, sits down to share his thoughts…

Ossium Health is a commercial-stage bioengineering company that uses its exclusive organ donor bone marrow banking platform to develop stem cell therapies for patients suffering from life-threatening hematologic conditions, organ transplant rejection, and musculoskeletal defects. Initially built from a small startup, it evolved into the clinical-stage bioengineering company it is today with one primary mission: To improve human health through bioengineering.

Join the conversation now to explore:

How Kevin’s mindset shift in business led to the creation of Ossium.  Why the healthcare system isn’t adequately equipped to deal with modern chronic diseases.  Types of cell therapies that provide relief for patients with blood and immune conditions. The role that cell composition plays in the reactivity between donors and recipients. 

Before founding Ossium, Kevin worked as an Engagement Manager at McKinsey’s San Francisco) office, where he advised clients in the biotechnology and healthcare industries. His projects spanned from conducting due diligence on biotech startup acquisitions to restructuring financially distressed biopharma companies. Over the course of his tenure, Kevin led more than 20 engagements for over a dozen clients, guiding teams in strategies for revenue growth, market-entry, and organizational restructuring.

To learn about Kevin’s cutting-edge work with Ossium Health, visit their website) now!

Episode also available on Apple Podcasts: https://apple.co/30PvU9C)

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