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cover of episode 277. Ecdysteroids 101
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Lucas Owen
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Lucas Owen: 本期节目深入探讨了蜕皮甾体，一种旨在促进肌肉生长而不抑制天然睾酮的化合物。节目首先介绍了蜕皮甾体的背景，指出其作为植物防御化学物质，模拟昆虫蜕皮激素的作用，并对人体具有生物学效应。随后，节目详细阐述了蜕皮甾体的主观效果，包括增强训练、勃起改善、肌肉硬化、营养分配和充血等。节目还引用多项研究结果，证明蜕皮甾体可以增加肌肉质量、提高卧推最大重量、延长免疫反应、降低皮质醇水平，并具有抗分解代谢作用。此外，节目还讨论了蜕皮甾体对激素参数的影响，以及其作用机制，包括影响血管紧张素1-7通路、增加一氧化氮合成、与雌激素受体相互作用、降低肌生长抑制素和增加蛋白质合成等。最后，节目特别强调了蜕皮甾体产品造假的普遍性，提醒消费者选择可靠的来源，并检查实验室检测报告，以确保产品成分的真实性。 Lucas Owen: 节目中提到的研究结果显示，20-羟基蜕皮甾酮补充剂可以显著增加肌肉质量和力量，同时降低皮质醇水平，减少肌肉分解。这些研究结果支持了蜕皮甾体作为一种潜在的运动表现增强剂和肌肉生长促进剂的观点。然而，节目也指出，许多蜕皮甾体产品存在造假问题，其成分可能与标签标示不符，甚至含有禁用的物质。因此，消费者在选择产品时务必谨慎，选择那些能够提供可靠实验室检测报告的品牌，以确保产品成分的真实性和安全性。

Deep Dive

Key Insights

What are ecdysteroids and how do they affect humans?

Ecdysteroids are plant defense chemicals that mimic the effects of insect molting hormones. In humans, they are believed to have anabolic effects, such as promoting muscle growth and enhancing workout performance, without affecting sex hormones.

What are some commonly reported effects of ecdysteroids?

Commonly reported effects include enhanced workout performance, better erections, muscle hardening, and anti-hyperglycemic effects that lead to fuller muscles and better pumps.

How effective is 20-hydroxy-ecdysone (20-HE) in muscle mass gain?

A study showed that 48 milligrams of 20-HE per day for 10 weeks led to a 2-kilogram increase in muscle mass, while the placebo group experienced a 0.35-kilogram reduction.

What are the anti-catabolic effects of ecdysteroids?

Ecdysteroids, particularly 20-hydroxy-ecdysone, were shown to preserve lean muscle mass and reduce creatine kinase, a marker of muscle breakdown, in a 12-week study.

How do ecdysteroids affect cortisol levels?

Supplementation with 20-hydroxy-ecdysone was associated with significantly lower cortisol levels post-workout compared to placebo, indicating a potent anti-cortisol effect.

What are the potential health benefits of ecdysteroids beyond muscle growth?

Ecdysteroids have been shown to reduce body weight, waist circumference, total body fat, and serum cholesterol and triglycerides. They also appear to support the immune system and extend the immune response.

Why are ecdysteroids controversial and what are the risks?

Ecdysteroids are controversial due to their potential anabolic effects and the fact that they are highly counterfeit. Many products do not contain the claimed amounts of ecdysteroids, and some may contain banned substances like androstenedione.

What is the importance of sourcing high-quality ecdysteroid products?

It is crucial to source high-quality ecdysteroid products because many on the market are counterfeit and may not contain the active ingredients. Reliable lab results that differentiate 20-HE from terkesterone content are essential to ensure the product's efficacy and safety.

Chapters
This chapter introduces ecdysteroids, plant chemicals mimicking insect hormones, and their controversial history, initially marketed for muscle growth with no perceived side effects, later becoming popular in Russia and Central Europe. The supplement's popularity is tied to its perceived lack of toxicity and absence of effects on sex hormones.
  • Ecdysteroids mimic insect molting hormones
  • Initially marketed as having no side effects
  • Popularity in Russia and Central Europe

Shownotes Transcript

In this episode, Lucas delves into everything you need to know about ecdysteroids.

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Disclaimer:

The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy) for more information.