279. TUDCA New Research: More Than Liver Health
Boost Your Biology with Lucas Aoun
Deep Dive
What is TUDCA and why is it becoming popular in the health optimization space?
TUDCA (Tauroursodeoxycholic acid) is a hydrophilic bile acid naturally produced in the liver. It is popular for its wide spectrum of health benefits, including liver protection, kidney protection, gut health, glucose metabolism, obesity, weight management, and neurological protection. It is particularly known for its ability to protect the liver from general stress and regenerate damaged liver cells.
What are the key health benefits of TUDCA beyond liver protection?
TUDCA offers benefits for kidney protection, gallbladder protection, gut health, glucose metabolism, obesity, weight management, and neurological protection. It has shown potential in treating neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's, and ALS. It also aids in detoxification and protects against damaging compounds such as alcohol and drugs.
What does the research say about TUDCA's effectiveness in liver health?
Research shows that TUDCA can reduce liver enzymes, improve overall liver function, and lower total cholesterol. It is effective in treating liver cirrhosis and chronic liver disease, with studies suggesting it stimulates hepatocyte proliferation and improves biochemical markers.
How does TUDCA benefit neurological health?
TUDCA has shown potential in treating neurodegenerative diseases such as Alzheimer's, Huntington's, Parkinson's, and ALS. It may improve insulin sensitivity in the liver and muscle, and it has been linked to better metabolic health and reduced adiposity.
What are the recommended dosages for TUDCA and how should it be taken?
Dosage recommendations vary. A high dosage of 1,750 milligrams per day for four weeks has been shown to improve insulin sensitivity and fatty liver disease. A lower dosage of 10 to 13 milligrams per day for three months can improve liver regeneration rates. The typical dosage is 500 milligrams daily, and it is often split into three to four doses throughout the day to maintain homeostatic levels.
What are the potential side effects of TUDCA?
Potential side effects of TUDCA include nausea, diarrhea, GI distress, and skin eruptions. These side effects are generally mild and resolve with cessation of the supplement.
Why should people with the APOE4 genetic variant consider using TUDCA?
People with the APOE4 genetic variant may benefit from using TUDCA, as it has shown potential in improving insulin sensitivity and reducing the risk of neurodegenerative diseases like Alzheimer's.
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