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cover of episode 287. TUDCA New Research: More Than Liver Health

287. TUDCA New Research: More Than Liver Health

2024/12/10
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Lucas Owen: TUDCA 是一种亲水性胆汁酸，由肝脏自然产生，作为补充剂，它已被证明对多种健康状况有益，包括神经退行性疾病、肝脏保护、肾脏保护、胆囊保护、肠道健康、葡萄糖代谢、肥胖和体重管理等。TUDCA 的益处远不止于肝脏保护，它还有助于解毒，保护身体免受酒精、药物、类固醇等有害物质的损害。其益处还扩展到许多器官系统，如大脑、肾脏、消化系统、眼睛，以及改善胰岛素敏感性、新陈代谢、疼痛、炎症、激素健康和体重管理。 大量的研究支持 TUDCA 的益处。研究表明，TUDCA 可以降低肝酶水平，改善肝功能，降低胆固醇，并可能刺激肝细胞增殖。此外，研究还表明 TUDCA 与阿尔茨海默病的胆汁酸代谢紊乱之间存在关联，并可能具有治疗潜力。最新研究表明，TUDCA 对神经系统和认知健康有益，并能改善葡萄糖耐量和减少脂肪组织。TUDCA 对多种神经炎症性代谢疾病（如阿尔茨海默病、亨廷顿病等）以及其他疾病（如视网膜疾病、中风等）具有保护作用。携带 APOE4 基因变异的人群可能从服用 TUDCA 中获益。 建议 TUDCA 与食物一起服用，以帮助消化和吸收脂溶性维生素，避免空腹服用可能导致的胃肠道不适。TUDCA 通过改善胆汁流动、调节肝细胞、抑制细胞凋亡等机制发挥作用。TUDCA 的副作用通常很轻微，包括恶心、腹泻、胃肠道不适和皮疹等，停药后通常会消失。TUDCA 的剂量范围很广，不同剂量对不同指标的影响有所不同，建议根据自身情况和医嘱调整剂量，并可能需要分次服用。总而言之，TUDCA 是一种多功能的补充剂，具有多种健康益处，值得考虑添加到日常保健中。

Deep Dive

Key Insights

What is TUDCA and what are its primary health benefits?

TUDCA, or tauroursodeoxycholic acid, is a hydrophilic bile acid naturally produced in the liver. It is known for its wide range of health benefits, including liver protection, kidney protection, gallbladder protection, gut health, glucose metabolism, obesity, and weight management. It is particularly popular for protecting the liver from general liver stress and improving liver function.

How does TUDCA help with liver health?

TUDCA helps with liver health by reducing liver enzymes, improving overall liver function, and lowering total cholesterol. It also aids in detoxification, protecting the liver from damaging compounds such as alcohol, drugs, and steroids. Studies have shown that TUDCA can stimulate hepatocyte proliferation, which is crucial for liver regeneration.

What are the neurological benefits of TUDCA?

TUDCA has shown robust benefits for neurological and cognitive health. It has therapeutic effects in Alzheimer's disease, providing neuroprotection and neuroregeneration. It also shows potential for treating other neurological conditions such as Huntington's disease, Parkinson's disease, and ALS.

How does TUDCA affect metabolic health?

TUDCA improves glucose tolerance and reduces adiposity in fatty tissue, making it beneficial for metabolic health. It has been shown to improve insulin sensitivity and reduce the risk of diabetes. Studies indicate that TUDCA can help with weight management and obesity.

What are the recommended dosages for TUDCA?

Recommended dosages for TUDCA vary. For liver health, 10 to 13 milligrams per day for three months can improve liver regeneration rates and decrease ALT. For insulin sensitivity and fatty liver disease, 1,750 milligrams per day for four weeks is effective. A typical dosage is 500 milligrams daily for two six-month periods. Dosages are often split into three to four doses throughout the day to maintain homeostatic levels.

What are the potential side effects of TUDCA?

Potential side effects of TUDCA include nausea, diarrhea, GI distress, and skin eruptions. These side effects are generally mild and resolve with cessation of the supplement. Taking TUDCA on an empty stomach may lead to GI distress, so it is recommended to take it with food.

Why is TUDCA becoming popular in the health optimization space?

TUDCA is becoming popular in the health optimization space due to its wide spectrum of health benefits. It is known for protecting the liver from stress and improving liver function, but it also offers benefits for the brain, kidneys, digestive system, eyes, insulin sensitivity, metabolism, pain and inflammation, hormonal health, and weight management.

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Shownotes Transcript

TUDCA is a bile salt which has rapidly gained popularity in the last few years but many people don't know what they're actually taking. In this solocast, Lucas explains exactly what TUDCA is and some of the unique findings.

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Disclaimer:

The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy) for more information.