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cover of episode 307. GLP-1 Agonists, Fat Loss Biohacks & Hormone Optimisation With Dr. Kyle Gillet

307. GLP-1 Agonists, Fat Loss Biohacks & Hormone Optimisation With Dr. Kyle Gillet

2025/3/24
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Boost Your Biology with Lucas Aoun
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Lucas Aoun: 我想了解更多关于GLP-1的研究，特别是高剂量GLP-1激动剂的临床应用和最新研究。 Kyle Gillett: 高剂量GLP-1激动剂虽然能增加体重减轻效果，但副作用也显著增加。低剂量GLP-1激动剂（如每周1毫克的Ozempic）耐受性较好，但仍存在胆囊问题和视网膜病变等副作用。在美国，大约三分之一到二分之一的超重美国人至少尝试过一次GLP-1激动剂。GLP-1激动剂是我治疗肥胖的第二常用药物（仅次于生物相同激素），但必须根据个人情况选择。GLP-1激动剂的副作用因人而异，剂量决定毒性。正确剂量的GLP-1激动剂可以帮助患者增加瘦体重，前提是摄入足够的蛋白质并避免过度热量限制。对于糖尿病患者，高剂量GLP-1激动剂的益处可能大于其风险；而对于非糖尿病患者，应使用最低有效剂量。二甲双胍和GLP-1激动剂都是胰岛素增敏剂，都会影响肠道菌群，其影响好坏取决于个体肠道菌群的初始状态。二甲双胍和GLP-1激动剂对生长激素的影响相反：二甲双胍抑制IGF-1信号传导，而GLP-1激动剂则增加生长激素和IGF-1。GLP-1激动剂的适用人群包括：有糖尿病前期、严重胰岛素抵抗、高体脂率（女性>40%，男性>30%）的人群。GLP-1激动剂除了改善血糖，还有其他益处，例如增加生长激素，改善内皮细胞健康等。我认为，阿米林激动剂和抑制肌肉生长抑制素的药物将是未来的重要治疗方法。阿米林是由胰腺β细胞产生的，与胰岛素一起作用，其缺乏会导致胰岛素作用受损。卡格列诺肽（Cagrelenotide）是一种新型阿米林激动剂，具有改善血糖、骨骼健康和血管舒张的作用。肌肉生长抑制素抑制剂是促进肌肉生长的另一种潜在方法。比马格鲁单抗（Bimagrimab）是一种新型肌肉生长抑制素抑制剂，其临床试验数据非常乐观。一项临床试验显示，司美格鲁肽与奥司他韦联用对老年患者的肌肉增长有益。对于已经优化了生活方式的人群，肌肉生长抑制素抑制剂和阿米林激动剂可以进一步促进肌肉和骨骼的生长。对于肾功能健康的人群，蛋白质摄入量没有上限，身体会自行调节。肌酸激酶（CK）水平可以反映训练强度和身体水分状况。规律运动可以提高胰岛素敏感性，降低对胰岛素的需求。空腹胰岛素水平与减脂能力相关，但低于一定水平后，减脂效果不会进一步提升，反而会促进肌肉增长。新型长效阿米林激动剂可能以每周一次的注射方式给药。我尝试过左旋肉碱，它可以促进脂肪酸进入线粒体。我认为，目前进行卵泡抑素基因疗法还为时尚早。亚甲蓝可以帮助人们戒除选择性5-羟色胺再摄取抑制剂（SSRI）和选择性去甲肾上腺素再摄取抑制剂（SNRI），并具有改善认知功能的作用。高剂量的亚甲蓝可能会减少肌肉充血，因为它具有清除一氧化氮的作用。虽然亚甲蓝会降低一氧化氮水平，但长期服用后，身体会适应并增加一氧化氮的生成。

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Shownotes Transcript

In this episode of the Boost Your Biology podcast, Lucas Aoun interviews Dr. Kyle Gillett, who shares insights on GLP-1 agonists, their clinical applications, and the latest research in hormone optimization. The conversation explores the mechanisms of action of GLP-1 compared to metformin, the target demographics for GLP-1 use, and the lesser-known benefits of these medications. Dr. Gillett also discusses emerging therapies such as amylin agonists and myostatin inhibitors, highlighting their potential in muscle growth and overall health. The episode concludes with a discussion on protein intake and its importance in muscle mass and bone health. In this conversation, Kyle Gillett discusses the implications of high protein diets on aging, the importance of various biomarkers in blood testing, and the role of creatine kinase in assessing training intensity. He delves into insulin sensitivity and its effects on muscle gain, emerging treatments like amylin agonists, and the benefits of methylene blue. The discussion also touches on nitric oxide levels and their impact on performance, providing a comprehensive overview of current trends in health and fitness.

Podcast Show Notes/Links:

Dr. Kyle Gillet’s IG: https://www.instagram.com/kylegillettmd/

Get Lucas’ New Supplement Here: https://www.inb4supps.com/

Disclaimer:

The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy) for more information.