31. Are You Ready To Unlearn? Debunking The Biggest Health Myths With Georgi Dinkov (Haidut)
01:32:41 Share

Ever feel like you're carrying something heavy and don't know where to put it down? Or wonder what on earth you're supposed to do when you just can't seem to cope? I'm Hesu Jo, a licensed therapist with years of experience providing individual and family therapy, and I've teamed up with BetterHelp to create Mind If We Talk, a podcast to demystify what therapy's really about. In each episode, you'll hear guests talk about struggles we all face, like living with grief or managing anger.

Then we break it all down with a fellow mental health professional to give you actionable tips you can apply to your own life. Follow and listen to Mind If We Talk on Apple Podcasts, Spotify, Amazon Music, or wherever you get your podcasts. And don't forget, your happiness matters.

Race the rudder. Race the sails. Race the sails. Captain, an unidentified ship is approaching. Over. Roger. Wait, is that an enterprise sales solution? Reach sales professionals, not professional sailors. With LinkedIn ads, you can target the right people by industry, job title, and more. We'll even give you a $100 credit on your next campaign. Get started today at linkedin.com slash results. Terms and conditions apply.

I can't tell you how often I hear, oh, I'm a little OCD. I like things neat. That's not OCD. I'm Howie Mandel, and I know this because I have OCD. Actual OCD causes relentless unwanted thoughts. What if I did something terrible and forgot? What if I'm a bad person? Why am I thinking this terrible thing? It makes you question absolutely everything, and you'll do anything to feel better. OCD is debilitating, but it's also highly treatable with the right kind of therapy.

Regular talk therapy doesn't cut it. OCD needs specialized therapy. That's why I want to tell you about NoCD. NoCD is the world's largest virtual therapy provider for OCD. Their licensed therapists provide specialized therapy virtually, and it's covered by insurance for over 155 million Americans.

If you think you might be struggling with OCD, visit nocd.com to schedule a free 15-minute call and learn more. That's nocd.com. The information depicted in this podcast is purely for informational purposes only. Please consult your healthcare professional before making any changes to your lifestyle or routine. ♪

Hey everyone and welcome to the Boost Your Biology podcast. My name is Lucas and I am the founder of Ergogenic Health. Together in this podcast series, we will go underground to explore cutting edge health and human performance insights that you simply cannot search on Google to help you upgrade your existence. So without any further ado, let's jump into today's episode.

Hello everyone and welcome to yet another episode of the Boost Your Biology podcast. I'm your host Lucas and today I have a special guest in with me. Somebody that I've looked up to for quite some time. I've been stalking a lot of his posts on Reddit for a number of years now and have actually learned

Hi everybody

It actually started for me started as a hobby about at this point about 18 years ago I was first out of college around 2002 and that was just after the dot-com crash And I my degree from college was in computer science So it really was not a good time to be looking for a job with this kind of degree and I tried really hard but basically there was nothing there and there's a full-time jobs and

And because when I came to the United States, I came in as a foreign student, in order to be allowed to stay in the country, you have to find a full-time job, otherwise they'll kick you out, you have to leave. So the only thing that I was able to find was basically a full-time internship at a biomedical research facility called the National Biomedical Research Foundation. And they were basically creating these websites where people, it was like a search engine for protein sequences.

so I was one of the people hired to do the actual coding. Um, and it was a lot of like algorithm implementation for search for string searching, string matching and things like that. Um, so while initially it was purely an it job for me, basically I was surrounded and worked for about three years, uh, with some of the brightest biochemists, doctors and biologists, uh, that were, uh,

really worldwide renowned and they were in the DC area. Some of them came from the National Institutes of Health. Others came from a institute in Switzerland as guest scientists. And basically very soon there was only three IT people and we kept going out to like happy hours and drinking and parties with all of these medical minded people. And if you want to fit in, you have to kind of speak the lingo.

So they would always talk about their biology stuff and I would sit there with my geek buddies and we'd talk about computers, but neither one is interested in what the group has to say and they're grossly outnumbering us. So I kind of took an interest and I said, okay, so it's fascinating. I want to learn more about the human body and how things work. Where do I start? And even back in 2002, the response was kind of, you don't really need to go to school for that anymore. Oh,

Almost everything is online at this point. So I recommend a couple of books. There was a book on endocrinology for medical students. There was an introductory book in biochemistry also for medical students.

And then there were a few other books that they recommended, one on neurology and one on physiology. So I kind of read these books and then they said, you know, these like I form closer relationships with maybe four or five of these medical professionals that are in that outfit. And they kept saying, look, we give seminars and talks all the time as part of, I mean, you know, we help out to build this website because we have this grant from the government, but really our job, our daily job is to teach.

So why don't you show up and start, you know, they call it auditing. You're sitting there with the other students, but you're not taking the exams and you're not getting a grade, but you're sitting there and basically learning, if you want, as much as the other students do.

So I did that between 2002 and 2005. So I guess I read the equivalent of a reading material for at least two years of medical school. And then I attended quite a few seminars that these people were giving on a variety of topics.

And after that, I found a job in the IT sector. But at this point, I had an interest. So I said, so what do I do? They said, look, without a degree, you're not going to be able to do anything more serious because nobody's going to give you money to do your own research if you have no credentials.

But in terms of knowledge, they're saying you already have the background, so all you really need at this point is start reading PubMed. And I said, that's it. They're like, yeah, but from this point on,

Whatever research it is that you want to do, you just have to keep learning whatever niche in the biochemistry world you decide to explore. And then all the experimental results are published on PubMed. Just keep reading. So I kept reading and reading and reading. And around 2008 or 2009, I decided to embark on the notorious low-carb diet.

Don't ask me why. I mean, I read some studies that said it was a cool thing to do. And keep in mind, that's probably about five to 10 years before the low-carb diet became really like the hot thing to do.

So I embarked on this almost next to zero-carb diet. I was an avid athlete in college. I was a rower in college, which is a type of an endurance sport. And after college, I kept running just to stay in shape. And a lot of the studies on low-carb basically said it really helps for endurance sports. So I said, oh, perfect. Seems like something healthy to do. It will help me stay in shape. It will give me more energy. What's not to like?

So for about three to six months, I felt really good. I actually lost weight. I was feeling great.

And then I started getting these really weird neurological symptoms that really freaked me out. I started getting tingling and even numbing in my extremities, but it was like come and go, come and go. So initially I felt like, oh my God, I'm having a stroke. So I went to the doctor. He's like, no, like if you had a stroke and there's an issue with a limb, it's not going to go away. You basically like, you'll be paralyzed for a while, sometimes permanently.

So the doctor is like, let's see how this goes, but I'm going to have to send you for some MRIs, see how things go. And I said, so what do I do with a low-carb diet? The doctor's like, stick with it. It's the best thing you can do for your health. So stupid enough, I stuck with it, right? And I kept running and I kept exhausting myself. Needless to say, work was extremely stressful. You know, for any new immigrant in the United States, you have to prove yourself. That's just how it is. So I was working probably the equivalent of at least two jobs,

And as you know, 2009 was the second recession that hit, so things got even uglier. So the combination of this extreme stress at work and what I later found out would be extreme self-imposed stress at home by running like a maniac, maybe six, seven miles a day, five days a week, and being on a low-carb diet. So these symptoms didn't go away. In fact, I started getting these chronic headaches.

I started getting like insomnia. I started getting anxiety. And once the doctor heard about the headaches, he's like, that's it, I'm sending you for an MRI. Sounds like, you know, something might be going on. So MRI thankfully came back clean. So I went back to the doctor. He's like, you know, the MRI is clean. So technically I cannot give you a diagnosis, but he's like, your symptoms are consistent.

with something called multiple sclerosis. So I'm like, so what's that? It's like, well, it is a chronic demyelinating disease. And basically the symptoms are numbness, weakness in the extremities, anxiety, basically sometimes cognitive difficulties, trouble sleeping,

you know, basically easily fatigued. I was starting to get fatigued at the time. So I'm like, oh my God, that sounds really bad. He's like, yeah, I mean, basically there are several kinds of these, several types of multiple sclerosis and

And, you know, if you're getting the one that's remittance or relapsance, that's the mildest version. But if you're getting the secondary progressive or primary progressive, most people are in a wheelchair within five years of diagnosis. So I said, to hell with that. You know, I really don't want, I'm not looking forward to this. So when I started searching online, what can alleviate? And then for whatever reason, I typed aspirin, multiple sclerosis, and one of Dr. Pete's articles popped up.

So I just clicked on it, I read it and something in me just like a light bulb went off. So it just went right. So I basically look at the website, I saw that it's one of many other articles, I went back to the previous page,

I read all 30 in one day and I said, "This guy is really on to something." It may not be because I already had the background in biochemistry and he had both the contrary view and also what really drew me to it was the energetic viewpoint, which seemed to have been neglected by almost every doctor that I talked to. Now, I go to a doctor and say, "Listen, I'm having an energy problem. I am fatigued all the time. I can't sleep.

When I sleep, I don't feel rested when I wake up. So something is going on with me that gives me this fatigue. They say, no, it's just a symptom of the disease. It's really not a problem in and of itself. So it's a result of the disease, but it's not a cause. And here is this guy, Dr. Pete, saying, no, actually, it's very much the cause of

of the structural changes that some people call multiple sclerosis. There are many diseases, right? So modern medicine says you can either have a structural disorder or a functional disorder. So they'll do everything in their power to find what your structural disorder may be. That includes imaging, biopsies, blood tests,

physical examinations, all of these things. And if nothing comes back as abnormal, but you're still feeling crappy, they'll say it's a functional disorder. It's not a structural one. Well, this functional disorder cannot be coming out of nowhere. Something must be behind it. So either you guys haven't found the structural disorder yet, but it is there, or it's actually the other way around. Maybe it's the functional disorder that precedes those structural abnormalities that are coming, that are

that are materializing later on. And Dr. P was saying it's the latter, right? It's basically, it's the functional deterioration which is driven by energetic deficiency, which ultimately starts changing the structure of the body. And there

And there's a very good analogy, which I think he gave in one of his interviews. I like to use it all the time. If you go to the doctor, regular doctor, the analogy that they have of the human body is like a car. So you have a car, and if it's a structurally sound car, then it doesn't really matter what kind of fuel you put in the engine. The car may go slower or faster, but even if you put crappy fuel, it's not going to damage the actual car, right? It's not going to make...

like a door fell off or it's not going to give it a flat tire, right? Well, as it turns out in biochemistry, biology, especially human physiology, it's actually that analogy no longer works.

the structure of your car, meaning the car being your body, your organism, inherently depends on the energy and the efficiency with which the energy is being produced. So like a better example would be, so the cell, in order for the cell to maintain itself, not only alive, but structurally sound, it needs to produce a sufficient amount of energy because the cell is a self-repairing mechanism. It doesn't have a mechanic which you can take the car to and say, oh, uh,

The cell is leaking, let's stitch it up and it will be fine. Sometimes you have a room you can do that, but at the cellular level, the cell has mechanisms for self-repair, but all of those mechanisms require energy. And if you don't have the energy, the cell starts to physically deteriorate, structurally deteriorate, with the ultimate result being sometimes the cell dies and leaks its contents into the bloodstream.

So very quickly, having now the background in biochemistry, I started researching these ideas and I found out that there is an ocean of contrarian science that for some reason is very rarely making the public mainstream, especially the medical publications, but it's there. It's not hidden. It's just not talked about, right? If you go to PubMed and search any of these topics that we're about to discuss, you will find tons and tons and tons of studies. Some of them are

older yes there's no there's no arguing about that but they have not been reclaimed they have not been retracted and they have not been falsified so until then i think it's i think modern medicine is really doing a disservice and at this point i would probably go as far as to call it fraud by discussing

all of our problems as if there's only one true pathway which has never been challenged. That's not how, and most people of your listeners who have done science, they know that typically in science, you always have a few major hypotheses that are always competing for dominance, right?

But for some reason in medicine, over the last 50 to actually 100 years, we have never heard the challenging hypothesis to the mainstream, which is the genes are the determinants of your destiny. If anything goes wrong with you, unless it's a trauma, which, you know, caused by some kind of a blunt force, everything else is driven by some kind of genetic mechanism.

dysfunction or disorder. So the key to health is to find which genes are responsible and then we maybe silence them. If they're the bad genes or if they're good ones, then we activate them, right? Or if there's some gene that has mutated, like in cancer cells, because they keep claiming cancer is a genetically driven disease, then we maybe use our latest and greatest genetically gene editing techniques like CRISPR and we

they remove that gene and replace it with something else. So still, the old mechanical car analogy, something's wrong structurally with the car and we're going to fix it, but that's not how the cell works. If the cell is not producing energy well, no matter how you repair it,

As soon as that repair process is done and you walk away, the cell will continue to deteriorate because it cannot maintain itself. Yes, you can help it externally by maybe doing something structural, some structural help, but unless you fix the energetic problem, the functional side of the story,

health will not be restored. So the ultimate message, I think, from Dr. Pete's writings is that structure and function cannot be separated and they intimately depend on each other. So bad function generates bad structure and then that bad structure propagates, it enables further deteriorating function, which then enables further deteriorating structure and on and on it goes into a vicious cycle until it is somehow interrupted.

It makes no sense to speak of these two aspects of health separately. They're the same, they're two sides of the same coin. And that was the first time I heard of people speak like that, at least in the medical field, because even the brightest, these bright people that I work with at the biomedical option facility, they were very hardcore medicalians.

as I like to call them, medical mechanics. Um, but that's what I learned in school. That's, that was the research. And, uh, you know, I'm grateful to at least they showed me, they said, you know, how and where I can learn more about it. But since then, since this was a circa 2009, 2010, when I discovered Dr. Pete, um, I've been reading all of, I've read all of his work, every interview, every publication, all of his books. And, uh,

thousands of other studies on top of that. And to me, the picture at this point is very clear. Not only is he right, but it's not him being right. He simply synthesized in a really good and accessible way, this tremendous amount of contrarian evidence that we have never been told about.

And I don't know if it's our fault for never asking the questions because I think we have, but we've always been reassured, like, don't worry about it. The experts are handling. Well, how many chronic diseases have we cured over the last hundred years? Zero.

How many cancer cases have you truly cured? Zero. When you go to a doctor and you have cancer and, you know, they start treating you, even if, like, let's say you have a mild, let's say stage one, right? So you basically go through these procedures, the tumor disappears, and then they tell you for the next five years you're in remission, you're not cured.

So after five years, they qualify you, they classify you as cured, but the doctor tells you it can always come back. The exact same tumor can always come back. Well, why doctor? You told me I'm cured. Well, we can never guarantee that some cancer cell has not remained somewhere dormant and then it will not restart the same process in the future.

And Dr. P is saying, the problem is that you guys, meaning the doctors, are treating cancer as an isolated tissue-specific disease.

Of course it can come back. You know why? Because the problem is systemic. The cancer is simply the symptom of the systemically deranged metabolism, which manifests itself in the organ that just happens to be the most energetically deranged. If you have a liver issue and then your metabolism chronically declines over time, chances are if you develop some kind of a cancer and the liver is the weakest part, you'll probably get liver cancer, right?

And the same thing goes with bone, skin, brain, lung, colon, you name it, cancers. It really depends on which organ has endured the most assault. It's not a coincidence that chronic alcoholics have a rate of liver cancer that is several hundred times higher than the general population. How's that for genetically determined disease?

I mean, what are the alcoholics and how genetically deranged mutants that is susceptible to liver cancer independently of their drinking? No, any same person will see the two and two and put them together and say, Oh, four, guess what? It's probably the,

the chronic alcoholism that is leading to this liver cancer. And now medicine is slowly starting to recognize that, but it's really, for them, it's always an uncomfortable discussion because to them, cancer is the result of a cell that has mutated. It has become cancerous. And then that's why it has a deranged metabolism. So the structure changed first, and then the functional disorder came later. And in Dr. Pete's, uh,

And really, the metabolic theory teachings is the exact opposite. It's the chronic assault on function, which is the production of energy, that ultimately has led to a derangement in structure. And basically, that's what we call cancer. So cancer is a symptom of bad metabolism, of assault from suboptimal environment, of chronic stress, of

of exposure to presenogens, you name it, it's the result of all of these things, one or more, right? Not the other way around. To this day, there is no proof

So science cannot create an animal model that is genetically somehow guaranteed to develop cancer. There are some models that are more likely to develop the cancer, but even then they cannot isolate a specific gene that is responsible for the development of cancer. They have these strains of rats, they call them spontaneously hypertensive rats, or like

which are rats that are type 2 diabetic. So basically they've modified their genome to make them more susceptible to develop these diseases, right?

but they don't talk about which genes specifically they have modified to be responsible for that. They talk about like a group of genes. And by the way, if you go and look, the genes that are usually modified to produce the diabetes are actually disease, the genes involved in fatty acid metabolism. So, you know, mainstream medicine will tell you a thousand times over that diabetes is a sugar disease. Limit your sugar and you'll be fine. Yet in animal research, the models show

the animal models that have been genetically modified to reliably produce diabetes, not always, not guaranteed, but increase the chance of it, the genes that have been modified are the ones that actually increase the synthesis of fats and the oxidation of fats. Nothing to do with sugar. So I've actually talked to several doctors about this, and the response is always, we're not rats.

Like, how can you use this as an example to justify the claim that, you know, diabetes is somehow a fat disease? I'm like, well, almost every type of diabetic that I know is severely obese. So let's start with that. That obesity on them is accumulated fat. Well, that's because they eat too much sugar. I don't think

I don't think so. I mean, I know plenty of people who eat high carb, low fat diets. They don't get fat. It's usually the combination of high fat and high carb diets that lead to this rapid obesity, and not just any type of fat, but the type of fat that produces a chronic inflammatory response, which the PUFA, the polyunsaturated fats, are known for.

are the main precursors of the inflammatory mediators of the body the pharmaceutical industry has spent billions of dollars developing drugs that inhibit the enzymes that synthesize inflammatory mediators from the polar unsaturated fats well let's take it a step further

why instead of developing these drugs that inhibit enzymes why not just limit the intake of approval which will also have the effect of decreasing information the response you get is you can't do that the proof are essential without them you die show me the evidence oh yeah here is the study from the 1930s one study by a guy called burr and his wife who

who did one study with rats to basically see what happens if you deprive these rats of the polyunsaturated fats in the diet and you gave them fully saturated fats.

So these rats became lean and their metabolic rate doubled. They couldn't get these rats to become obese, even though they fed them the calorie equivalent of four rats a day. So imagine instead of eating 2,000 calories, you eat 8,000 to 10,000 calories a day and you continue losing weight. That's how fast their metabolism became. But they also noticed some symptoms such as dry skin, cracking skin,

and basically really high body temperature, right? These are all, yes, undoubtedly signs of high metabolism, but it's because when you increase the metabolic rate, that also increases your need, your dietary need for all of the co-factors that go into maintaining the body.

If you now have the metabolism that can metabolize 8,000 calories a day, guess what? You will need to increase pro rata your intake of minerals and vitamins and other nutrients probably at least four times to what you were taking before. And if you don't, which is what they did with those poor rats, then of course these rats are going to develop nutritional deficiencies.

But those rats still were extremely resilient and they had very hard time killing them because almost every animal experiment that tries to assess toxicity and or changes in health eventually ends up with the animals being killed by either like a blunt force trauma or like bleeding them or giving them like some kind of a suffocating gas. Well, guess what? I think they try to kill them with some kind of a gas, like carbon dioxide. The rats would just not die. They were actually have this in the study, uh,

to the study saying that the rats were extremely resilient to sacrifice. So I thought, wow, well, shouldn't that be a major finding of the study? Guess what? We removed the poofy from the diet and these rats became impossible to kill. I think most humans would be interested in being like that, right? Especially given the current situation with the virus and everything else going around. But we don't hear that. And guess what? Since the 1930s, no other study has been done to replicate the findings of that study.

The study was taken completely as 100% true, and something so important was based on a single study. And to make matters worse, we're now finding that the same thing was done for cholesterol. The same thing was done for the studies linking sugar to cardiovascular disease, the famous key studies from the '70s. The same thing was done for the studies linking saturated fat to cardiovascular disease.

major public health decisions, policies really, because now the official dietary recommendations are avoid saturated fat, avoid cholesterol, increase unsaturated fats in the diet, all of these things, because you'll be healthier, you'll have less risk of cardiovascular disease. All of these turns out to have been based on nothing but a handful of studies. Most of them

done in the 1950s to the early 1970s and no replication since then and for some of them no no replication ever right the the birth study um uh from the 1930s uh claiming that proof is essential has never been replicated why would you base public health policy affecting billions

of people around the world on a single study without even bothering just to say, look, everybody makes mistakes. Maybe you guys picked a peculiar breed of rats. Maybe you had the bad lighting in the lab. Maybe they did not like you or your wife who were handling. Who knows what could have caused these side effects that they saw in the rats. Just so we know, you should always replicate results, studies that are used for such experiments

wide-reaching public health policies. It was never done. So here we are. Basically, at this point, the claim of the official mainstream medicine is do not eat saturated fat. Replace as much as possible the saturated fat with unsaturated fats.

and preferably the polyunsaturated fats. Not even the monounsaturated, which is found in things like olive oil and avocado. They say, no, that's not unsaturated enough. You need to do even more unsaturated, like the type of oils found in sunflower oil and all kinds of seed oils, because the more unsaturated the fat is, the

the greater its effects on lowering cholesterol. Ooh, the evil cholesterol, right? But now it turns out that FDA reversed its 50 year long standing on dietary cholesterol. Last year, the FDA, the American agency responsible for setting up public health policy, which becomes almost like a law said,

you no longer need to avoid dietary cholesterol. It has no link to heart disease. That's after 50 years fear mongering saying, take your statins. If you don't take your statins, if you don't bring your cholesterol under control, you're gonna develop heart disease. And guess what? Just like that,

with one decision not very widely publicized, but it's there, if you search for it, if you search in Google FDA reverses staining of cholesterol, you'll find it. So there we are. I mean, it turns out 50 years of public health policy was not only wrong, it likely led to the unnecessary and early death of tens of millions of people, if not more.

Yeah. Wow. There's a, there's a lot to, a lot to unpack there, but I really want to delve sort of back into a little bit onto, onto Dr. Ray Pete's work and his early work on understanding the energetic viewpoint and, and how really for my listeners, cause this will be all brand new to them. So they, they won't know much about, I guess, like, you know, the fact that

when we ramp up metabolism, we're going to be depleting nutrients. So do you want to sort of discuss, I know that Ray Pede's very big on optimizing thyroid function and I'm a huge believer in that's like the critical driver for improving metabolism. So do you want to talk about how the thyroid and how like, you know, the thyroid impacts general metabolism? So the thyroid is sort of like the conductor, the master conductor of metabolism. Um,

And very early in the 20th century, studies were shown, studies were starting to show that there is a really strong correlation, inverse correlation, between thyroid function and cardiovascular disease. The lower your thyroid function, the more susceptible you are to cardiovascular disease. And usually it coincided with the rise of cholesterol,

gaining weight, joint problems, skin problems, memory problems. So all of these things were clustering together and they were strongly associated with declining thyroid function. And I think really like the culmination of this research was in Broda Barnes' work,

which was done in the 50s, I think up to the 70s, who was a researcher who really put the focus on thyroid. He said, "Listen, there is no mystery to cardiovascular disease. Cardiovascular disease is nothing but basically the decline of structure of the heart and the blood vessels as the result of low metabolism

And basically, when metabolism is low, you tend to develop these low-grade inflammatory reactions everywhere in the body, but specifically in the blood vessels. And the way the body tries to imperfectly protect you from this chronic inflammation, because it can rupture a vessel. I mean, if the vessel is chronically inflamed, it can rupture, and then if it's a major vessel, you can die from bleeding. So,

The body knows that very well and tries to protect you as much as possible by plugging the really problematic areas with a combination of cholesterol and immune cells. So if you look at the plaques that are forming inside of the blood vessels, they're composed mostly of white blood cells and cholesterol. So that's actually one of the reasons why the cholesterol hypothesis formed. People thought, oh, it's the cholesterol that's creating the plaques. It's really the, you know, the

So cholesterol is kind of clogging your veins. No. But what about the second aspect? Why didn't you guys discuss what are white blood cells doing in these plaques? This is usually a sign that there is an inflammatory reaction going on. So this thing for over 50 years was never discussed. Cholesterol was, because they just didn't have a drug to attack the problem, but they did have the drugs to attack the cholesterol aspect. So they said, well, let's bank on cholesterol and let's,

leave the immune aspect, the inflammatory aspect. Let's leave that aside for a while. Let's take care of the cholesterol. If it doesn't work, we're going to figure it out later. Well, guess what? For 50 years, they've been battling high cholesterol and nothing has come out of it. So now they're finally starting to see that, yes, cardiovascular disease is a disease, a result of

of chronic inflammatory processes in the body, which brings us, brings immediately PUFA and the FORFRA, just as I mentioned earlier. The two enzymes, cyclooxygenase and lipoxygenase, are the enzymes responsible for creating most of the inflammatory mediators using PUFA as a raw material.

But guess what? Pro-Feed Essential makes billions of dollars in sales every year, whether it's fish oil or like, you know, specific foods that are being produced. I mean, America produces mostly corn and soy. These are heavily government subsidized crops. So, as a...

one result of all these crops are the seed oil, soybean oil, and corn oil. And guess what? The agricultural industry wants to sell it. How do you sell billions of tons of oil every year to an unsuspecting public? You convince it that it's good for it, right? So what does thyroid have to do with it? Well, when the cell has a sufficient amount of energy and the

And the amount of energy it produces basically correlates-- it's controlled by thyroid. Thyroid basically determines how efficiently you use oxygen and how completely

the fuel from food is turned into this internal energetic molecule called adenosine triphosphate. So without thyroid, basically the cell has three metabolic steps, and without thyroid, you're stuck in the first step, which is very inefficient and very ancient. Even amoebas and bacterias and very primitive slimes, like kind of organisms, multi-cell organisms have it. It's called glycolysis.

And basically the glycolysis is a very inefficient way of producing energy from food. And the resulting, so it produces very little ATP, but it consumes a lot of oxygen. And then one output of the glycolysis, excessive glycolysis, is lactic acid. So if you have the three steps, which are glycolysis, curbs cycle, and electron transfer chain, those are the three steps of the metabolism. If you have only the first one working, glycolysis, you're producing very low amount of energy.

and producing a lot of lactic acid, which lactic acid itself is a toxic molecule. The body doesn't like it, tries to get rid of it as soon as it's produced. But more importantly, if you're not producing sufficient amount of energy, just as I mentioned earlier, it leads to structural degradation over time, leads to inflammatory processes because one way

the body tries to repair damage is basically triggering a localized inflammatory reaction which awakens the immune system and basically the immune system starts sending all of these cells in that direction where the inflammation is coming from trying to repair. But in order to repair the damage,

a lot of these primitive growth processes are being triggered and to synthesize new tissues, new cells, new machinery for the cells, DNA, RNA, enzymes, everything that the cell needs. And unfortunately, if that growth process is not inhibited, which also requires energy, eventually you get uncontrolled growth, which is the hallmark of cancer.

And it just so happens that cancer cells can only produce energy through glycolysis. So a recent study came out, let's not go back to about four years ago, which one of the leading cancer biologists in the United States, actually the world really, it was a team of three of them, who wrote an editorial article in the journal Nature and said, "We've been looking at cancer the wrong way."

Cancer is not a mutated disease. Cancer is simply a reversal to a very primitive state of metabolism. When a sufficiently large group of cells becomes convinced that the sophisticated way of metabolizing, which maintains structure, which is the Krebs cycle and electron transport chain, are no longer working.

So if sufficient number of cells gets damaged or is under stress and is not allowed to metabolize food properly through the three steps fully, then eventually you get a sufficient group of cells that form a quorum and they're saying things are really bad, the environment is really suboptimal, we should

dispose of most of our higher functionality. And instead of let's say liver cells doing whatever liver cells do, the liver cells are now saying, no, we need to replicate and grow because we are going to ensure survival by increasing numbers.

And usually the body says, no, actually I can ensure survival by having these highly specialized cells doing whatever they're supposed to be doing in the organ and not being concerned too much with growth, right? But if you don't have the energy, if you have a suboptimal functioning organism, the way the organism thinks it will survive is by increasing its numbers. And actually it works at the society level too. Multiple studies have shown that people that live in really

stressful cultures, stressful environments tend to have a lot more children than people who live in much more benign, positive, beneficial cultures because I guess it's an instinct, right? If you think you're not going to live very long and life will be short and brutal, then if you want to procreate, if you want to maintain your bloodline, you're going to have a lot

Because you don't expect all of them to survive either. And that's how it has been for the world for the, you know, really all the way up until maybe 100 years ago, which with the advance of antibiotics, improved sanitation, improved food production, you know, finally, a good portion of the population of the world decided to have maybe two, three kids instead of 12 or more.

So the analogy here is the same way. Basically the thyroid is what controls, allows the cell to go beyond glycolysis, go beyond the primitivism, beyond the stage of growth and division, and then allow it to produce sufficient energy so it can differentiate. In other words, it can become the specialized energy

and benign acting type of cell that makes a lure, lung, spleen, intestine, brain, skin, whatever. So what really keeps us humans and in the shape of a human is thyroid hormone. Thyroid hormone is the great orchestrator of

inhibiting growth, of actually channeling growth in a creative way because the body is constantly renewing itself, is constantly producing cells and constantly shedding them. So if for whatever reason these new cells that are being produced, if they're not being channeled in the proper direction to become specific organs, right, and well-functioning, which requires a three-step metabolism, which requires thyroid, these cells have nothing else to do except grow and replicate. And that's how you get the cancer.

Fascinating. Fascinating stuff there. So maybe in terms of thyroid function, I know there'll be people that are listening in and they're probably wondering, I guess, maybe strategies to optimize thyroid function. And we know the obvious one is to reduce poofers and to replenish B vitamin status and all the nutrients and things like that. But what else either promotes thyroid function or hinders thyroid function?

So thyroid function has been known to be inversely correlated with adrenal function.

and positively correlated with gonadal function. And if it's inversely correlated with adrenal function, it automatically means stress inhibits thyroid, right? So anything that promotes adrenal function, no matter what it is, even if it's a positive type of stress, anything that raises cortisol or any of the other mediators on the cortisol pathway. So usually when you're under stress, the brain produces something called corticotropin-releasing hormone, CRH.

And then that is a signal for the pituitary to start producing another hormone called ACTH, adrenal corticotropin-releasing hormone. Now, that ACTH starts circulating in the bloodstream. The adrenals have these receptor soils. In other words, they pick up that signal from the blood and say, oh, you're under stress. I need to produce cortisol. Because the function of cortisol, it really has two major functions. One is to maintain the blood sugar levels at all costs.

because your brain consumes about 40% of your daily calories and really the calories of the energy that the body produces. This means that the brain, which prefers to burn sugar, this means the blood sugar needs to be maintained high. I'm not sure how many of your listeners know diabetic people, but diabetic people can almost...

they can go in a corner like a heartbeat if their blood sugar drops too quickly. So the usually diabetic people always care with themselves, both insulin and glucose tablets, because if they start feeling lightheaded and it's like they're about to pass out, they immediately put a glucose tablet under their tongue. Well, the great regulator of blood sugar, meaning keeping it relatively high, uh, is cortisol. Uh,

And cortisol and insulin have this like inverse relationship. Basically, the purpose of insulin is to lower blood glucose because it's allowing the tissues to basically extract it from the bloodstream and metabolize it, right? And the purpose of cortisol is actually to supply more glucose into the bloodstream when you're under stress because the cortisol is trying to protect

your vital organs, mostly the brain, because without brain you die, and your heart, and your lungs, by maintaining at least a baseline level of blood glucose. But how does he do that? Well, if you're not eating, or if you have exhausted the glycogen stores, which is the most stored in the liver and a little bit in the muscles, then the body needs glucose from somewhere, right? And that somewhere can only come from other tissues.

and most of the tissues are composed of protein, of amino acids. And the role of cortisol, second biggest role, is to basically, as you should say, but still related to blood glucose levels, is to shed or shred, really, these tissues and turn them into amino acids, which then travel to the liver, and they're converted to glucose through the process of gluconeogenesis.

Now, I think it's already, you know, the fact that I said that cortisol shreds your tissues, your soft tissues, is already an indication that's probably not something you want to be happening all the time. It can really, like, it can, like, truly melt you away in a matter of days if you're under extreme stress. Even bones.

Basically, cortisol is a very powerful osteolytic agent. It can give you really thin-looking limbs. People with Cushing syndrome, which is a disease of cortisol excess, they're very fat in the middle of the trunk, and they're extremely thin.

extremities. So it's called the lemon and sticks model. So they really look like a lemon with like, you know, four sticks sticking out. And that's what cortisol does. So I gave you this analogy because I wanted to point out another result of cortisol excess is the synthesis of fat.

So that's how you need to see the opposite activities and effects of cortisol and thyroid. So cortisol will destroy your lean tissue and bones, but it will make you accumulate fat. And at the same time, it will keep the levels of blood sugar high, which also means insulin will be high because if the blood sugar levels are starting to rise, the body is trying to protect against that as well. So it will jack up insulin as well. So every time you have high cortisol, you're likely to also have high insulin.

Many people are now starting to make the claim that maybe we're looking at diabetes the wrong way. It's not really type 2 diabetes. It's not really a disease of excess insulin, but something else is going on. Well, that something is excess cortisol. There are actually clinical trials with drugs that block the effects of cortisol and the receptor, and they can reverse type 2 diabetes in a matter of a week.

Have you heard of any other intervention that can reverse type 2 diabetes in a week? Apparently it's there and the studies are published. They're human studies. They're not even, they're out with rats, they're out with mice, they're out with dogs and cats and monkeys. And now we have a clinical trial with humans.

And the response of mainstream medicine still is, oh, it's a multifactorial problem. It's very difficult, very complex. We don't know what exactly is causing type 2 diabetes. We'll start with the obvious. If it doesn't work, then we're going to worry about if it's something more complicated or not. So really, basically, anything that raises cortisol or CRH or ACTH immediately has the effect of dampening the synthesis of thyroid hormone in your thyroid gland.

to make matters worse because the thyroid gland produces mostly T4, which is actually a precursor to the active thyroid hormone. The active one is T3. So that T4 that the thyroid gland produces, so it's released into the bloodstream and travels around and eventually makes its way to the liver. Now there are enzymes in the liver, uh,

ion-denase enzymes that convert T4 into T3. But guess what? Cornisol inhibits those enzymes too. So if your cortisol is elevated, actually the other stress hormones do it too. Estrogen does it as well. Serotonin does it as well. ACTH, CRH, prolactin, all of these, uh,

fresh mini-us is what I like to call them, have the nasty effect of inhibiting either the synthesis of pre-thyroid T4 in the thyroid gland or the conversion of T4 into T3 in the liver. So you're getting into this hyper-metabolic state and sometimes your doctor, sometimes at blood tests you may see the TSH being in range, but now they've actually modified the range. The normal range used to be up to six,

And after 70 years of claiming that this is a perfectly good range, it doesn't need to be modified, suddenly the American Association of Endocrinology lowered it to four. That's a 30% drop of the normal range.

And zero coverage of this in the mainstream press. So we went from basically one third of the people that we've told them they're normal, the metabolism is normal, suddenly become hypothyroid. But that to me is like a public health disaster. I never saw any mainstream publication, any mainstream press

like a mainstream media outlet to even discuss this. Even the specialized medical outfits that would cover what's happening in the medical world in a more popular fashion, like Scientific American, right? Science Alert.

Science News, there are a number of different, they're not blogs, but they're like newspapers for science. Not a single one of them had a coverage of this tremendous change of public health implication policy that basically said, oh my God, at least one third of the people that we've seen throughout all these years, they were told they're healthy, they were very serious in the chronological problem. So anyways.

But that's really the main takeaway from the story is stress directly lowers your metabolism.

and basically there are many mediators of stress. Not everybody will react in the exact same way. Some people will react to stress with elevated cortisol. Some people who have post-traumatic stress disorder and are at the stage of almost adrenal, pre-adrenal failure, they cannot muster up the cortisol response, but they have other stress mediators, serotonin, estrogen, prolactin, um,

growth hormone, those will be elevated and those can cause the declining thyroid function as well. So it's really, you have to look at the systemic picture, but there are many ways to assess if somebody is in a chronic stress state or not. And if any of these stress mediators is elevated, or at least in a range where it's known to be pathological, you can safely assume that metabolism is probably going to be negatively affected. And there are actually,

really cheap and reliable ways to assess metabolic function that don't require blood tests. The two simplest ones are you measure your core body temperature at waking, armpit or mouth or ear temperature will probably be fine, but armpit temperature is the most reliable. So waking temperature, if waking temperatures are not at least 97.5 to 98 degrees, chances are your metabolism is not where it should be. And more importantly,

If your temperatures do not rise to at least 98.5 after eating breakfast, after a long night of fasting basically, then that's also not a good sign. Heart rate is another great indicator of thyroid function because if your levels of T3 are low, something is blocking the effects of thyroid hormone at the cellular level, which is what fats do, specifically polyunsaturated fats.

your heart rate is going to be low. And what do I mean by low? Below 75 beats per minute at waking. Now, you know, because, you know, you're exhausted, you know, the glycogen is being depleted throughout the night. So it's okay to have a 75, 60 to 75 beats per minute at waking. But if you eat,

Then for a healthy person, temperature will rise to at least 98 degrees and a heart rate should rise to at least 80 beats per minute. If either one of these things is not happening, your metabolism is not where it should be. Something is blocking some kind of a stress response, whether because of the long period of darkness and not eating, which is what is happening throughout the night, or something else in your lifestyle is preventing metabolism from ramping up in response to eating, to food.

So what else? Things that are endocrine disruptors. There are many things in our environment, the most famous ones being BPA,

So, there are type of, if you look at the structure of the molecule, it is reminiscent to the synthetic estrogens that were developed in the '60s and '70s to treat female problems such as amenorrhea, menopause, you name it. But basically, it's two phenol molecules. That's why it's called bisphenol. And it's just several different functional groups attached to the molecule.

to the wings, but there are actually multiple publications that show that these endocrine disruptors are really nasty because they act as thyroid hormone receptor antagonists, while simultaneously they're also estrogen receptor agonists

cortisol receptor agonists, and androgen antagonists. So they're going to block your thyroid function. They're going to act like a stress mediator. They're going to emasculate you if you're a man, and they're going to masculinize you if you're a woman, which I don't think many people would want that, right? So they're going to tank your metabolism. And guess what? They're also carcinogenic and pro-inflammatory. It's really hard to get like more nasty than that, except possibly ionizing radiation.

Speaking of which, if you look at the rates of ionizing radiation exposure, it's really going through the roof for the majority of the western population. You go to a doctor for any kind of like a problem like a cough, they're gonna say, "Oh, let's get an x-ray just to make sure it's not pneumonia," right? Or, "Oh, my, I don't know, my kneecap hurts. Oh, let's take an x-ray. Let's make sure it's not something bad, that it doesn't require surgery." Every exposure to ionizing radiation counts because

It turns out that this is another thing we've been lied to for almost 50 years. It turned out that the initial theory that was developed in the 60s that said that ionizing radiation is subject to a so-called threshold principle. In other words, there's a unique threshold of danger that is different for every individual, right?

But they kind of, they've published some guidelines that are saying as long as you stay below this exposure level, most people are safe. Now they said, no, actually ionizing, the danger, the risk of ionizing radiation exposure is cumulative. So you can have an X-ray, you could have had an X-ray at the age of two,

and then you had another one at the age of 18. And if you just happen to be a susceptible individual, these two exposures to radiation combined were enough to set you over the critical threshold and give you cancer. And now they're saying, oh my God, yes, it is cumulative. We should limit radiation exposure, but...

The COVID-19 industry is a really big one here. I mean, there's so many CT scan machines, PET scan machines, all kinds of entire branches of medicine built around radiation. Even though an MRI and an ultrasound alone or in combination will give you just as good, if not even better imaging results without any of the risks.

So, ionizing reagent and the current disruptors stress poor diet. So, speaking of poor diet, the PUFAs, the polyunsaturated fats, really any type of fat tends to have a slight anti-thyroid effect, but most of the saturated fats are anti-thyroid.

they have a pro metabolic effect as well. Many of them are anti-estrogenic. They increase both the synthesis of cholesterol and the conversion of cholesterol into downstream steroids, which is what we want. And that process actually happens to be declining dramatically with aging because thyroid function declines. So in older people, you tend to see high cholesterol. One of the first things, one of the greatest distinctions between a young person and an old person is that the young person's cholesterol is really normal.

In an old person, you're almost guaranteed to see an elevated cholesterol. Some of this is adaptive, but the reason it's adaptive is the body is saying, oh my, oh, I'm not synthesizing the steroids that I need in a proper amount, so I better ramp up my cholesterol synthesis to compensate for that.

But some of the effects are also due to the diet. Basically the replacement of saturated fat with polyunsaturated fats have led to both a state of chronic inflammation, which hinders steroid function. Thyroid function is actually one of the first to decline when there is an excess of inflammatory mediators in the blood. When there is a sufficient amount of prostaglandins or local trianes, which are synthesized from PUFA,

thyroid function can be almost completely shut down. More, perhaps, just as importantly, but more importantly, the polyunsaturated fats have the ability to inhibit the transport of thyroid hormone to the cells, inhibit the uptake of thyroid hormone by the cells, and in some cases, depending on the type of polyunsaturated fat, the specific fatty acid, they may even be able to block the actual thyroid receptor in the cells,

So really PUFA is in its own right an endocrine disruptor, not very different from the bisphenols, mostly because the bisphenols happen to be very potent, but luckily they're still in a relatively minor amount. I mean, it's still enough to affect us, but it's nothing compared to PUFA. PUFA we eat voluntarily and in massive amounts. So in the large doses of PUFA exposure that we get every day,

Chances are that PUFA is actually a bigger, an endocrine disruptor with a bigger impact than the actual endocrine disruptors such as bisphenol A and many of the fluor containing ones from like Teflon and other plastic and petroleum derived products. So PUFA really is a very versatile product

or wide-acting endocrine disruptor, dietary endocrine disruptor, to which everybody has access on a daily basis throughout their entire lives and usually more than once a day. I mean, they're present in almost every food, every commercial food, in sufficient amounts to cause problems.

Georgie, let's circle back and discuss some of those stress mediators. Obviously, you've mentioned PUFA being one of the hallmark stress mediators that's influencing serotonin, prolactin, cortisol, and obviously the low-carbohydrate diet, which is also going to be detrimental to metabolism.

So I guess I want to delve into, you mentioned that there were specific medications to actually block cortisol. And I'm familiar with one of them. I've used one of them quite a lot, ciproheptadine. In fact, it was your thread that actually prompted me to ever try ciproheptadine. And it's a powerful tool, in my opinion. It's a very, very powerful medication that needs to be used very cautiously. Obviously, this is not...

not medical advice for those listening in, but in terms of ciproheptadine, do you want to sort of explain, and even the anti-serotonin effect and how that influences autism?

Sure. So another major theory which is now starting to crumble is that serotonin is the happy hormone, right? You hear this all the time on TV. Most of the drugs for depression are being marketed as drugs that boost the serotonin system. But guess what? If you look at, again, all of this is published, none of this is hidden, but it's just it's never promoted, so we don't know that it's actually a contrarian view.

In the 1940s, the name of serotonin wasn't serotonin, but was something called enteramin. So enteramin means an amine produced in the intestines. So they knew as early as the 1940s that many people with cancer had an elevated synthesis of serotonin. And one of the symptoms of that is easy flushing in the face,

Basically, thrombosis, you can see filovirus, which is inflammation of the superficial veins in the blood vessels.

mood disturbances, depression actually, and in extreme cases, psychosis. So serotonin was known as something potentially very dangerous as early as the 1940s. Even back then, they knew that serotonin was one of the primary factors, if not the primary factor, behind every fibrosis.

Yet none of this made into any kind of drugs, and it's the same authority that was promoted as a cure for this, mostly for political reasons, because they noticed that at the time, this was like the early 60s, the civil rights movement and the hippie movement, the social justice movement in the United States, all the hippies were basically heavily using drugs that were dopaminergic.

And the powers that be were concerned, the society is getting out of control and these people cannot really be reasoned with, they're not following orders. And really that's a nightmare for any politician in power. If the population is not following orders, then to them this is anarchy, right? How are we gonna control,

400 million people, 300 million people if they're not following our orders. So they, they, they sponsored research which demonstrated that serotonin acts opposite to dopamine. So they said, oh, if all of the, all of these dopaminergic drugs are driving people crazy, then maybe if we, if we give them serotonergic drugs, we're going to calm them down and we're going to make them, uh,

you know, malleable and obedient. And that was very, very true. But that is never publicized. The original impetus for the serotonin, the development of serotonergic drugs was never to cure depression. In fact, it was known that serotonin could cause depression, but it was considered acceptable because it will calm people down, it will make them easy to control, peaceful, loving, and whatnot. No.

None of this really materialized except the obedience. Yes, serotonin is a very good way to make an organism obedient. You know why? Because it inhibits the production of energy. Multiple studies have shown that animals that have poor metabolic function, poor mitochondrial function, are extremely submissive and obedient, even in societies that don't really have hierarchies. So there are some animals in societies that have extreme hierarchies, like ants or bees, right?

But you have others that are more egalitarian, such as like some types of apes, especially like chimpanzees, bonobos are notorious being the most egalitarian probably species, the closest to us. But even in those species, it's known that interfering with the synthesis, with the production of energy, makes your organisms very obedient animals.

and subservient and willing to do just about anything that they're being asked to do or like forced to do. And then that's what really the government sponsored in the 60s to come up with these drugs that will calm down the crazy hippies and the pharmaceutical system obliged and basically produced these certain drugs. And they said, well,

you know, we need to come up with, with a good sales pitch, right? And the sales pitch has to be convincing because sufficient portion of the medical professionals already knew the serotonin could be dangerous. So they said, well, guess what? Yeah, it may be dangerous, but it can cure depression. Uh,

So first of all, the studies that showed that serotonergic drugs can cure depression, they have never been replicated. And most of the drugs that are on the market right now that are really known to be effective as antidepressants, turns out that most of these drugs are actually partial serotonin antagonists.

and on top of everything, they increase the synthesis of protective neuro steroids in the brain, such as allopregnanolone or progesterone or pregnenolone. So now we know that yes, these drugs are serotonergic and they're really dangerous, but more importantly, it turns out that their antidepressant effect had nothing to do with them increasing serotonin. If anything, it's for the contrary.

Sometimes people see me challenging him as like, "Oh, show me the evidence that dopamine cures depression." I'll tell you, go to Google, type dopamine agonist, and look at the Wikipedia page that shows up. You'll give you about 20 of them. Click on every single link and you'll see that every single dopamine agonist, and keep in mind, dopamine and serotonin are inversely correlated. They're largely blocking each other's effects. The hippies back in the '60s were using dopaminergic drugs.

They didn't have any depression. They were pretty happy people by all accounts, right? So every single dopamine-abundance drug in clinical use known is a potent antidepressant.

then go and type serotonin antagonist and then they work similarly to dopamine, right? To dopamine agonist. So everything that acts as a dopamine agonist is going to block the effects of serotonin indirectly. And then you have these drugs that are directly blocking serotonin effects, they're called serotonin antagonists. Check out the Wikipedia page about them. Every single one of them synthesized so far is known to have a potent antidepressant effect

And then go and check some serotonin agonists, not the antidepressant drugs because they're known as SSRIs. They prevent the deactivation of serotonin, right? But find drugs that were developed specifically of serotonin agonists. In other words, drugs that can act like serotonin but cannot be deactivated, right? Every single one of them is known to have a side effect of psychosis, depression, and

sometimes terminal, cancer, emphysema, bone dissolution, osteopenia, osteoporosis, you name it, osteolytic really symptoms, um, uh,

atrophy of the skin, atrophy of muscles, and you're like, "Oh, so why atrophy of muscles?" As it turns out, serotonin and cortisol have a very intimate relationship. It looks like serotonin is the primary controller of the synthesis of cortisol in the body. So this means that serotonin has an intimate participation in the stress system.

Anything that promotes the synthesis of cortisol cannot be looked at as something benign and most certainly not something whose activity or synthesis should be promoted. And as early as the 1950s, they found out that you can use serotonin antagonists to treat the Cushing syndrome, which I mentioned earlier, which is a disease of cortisol excesses.

So that's lowering cortisol indirectly. If you block serotonin or lower the effects of serotonin, that is a powerful way of telling the organism you're no longer under threat. It looks like, based on animal research and publications from evolutionary biology, that serotonin is a very ancient hormone, actually it's a neurotransmitter, and its primary purpose in the body is to signal threat

So when an organism is under threat, one of the first things that it does, it limits the non-crucial aspects of metabolism and the maintenance of non-crucial organs. So in other words, serotonin reverts you really back to the primitive state where the only thing maintained functional will be brain and heart,

the lungs and really some things that keep you barely alive, like a hibernating animal. Speaking of hibernating animal, it's the rise of serotonin that causes hibernation in every known animal that hibernates. If you have squirrels that hibernate, they're very well known, you have bears. So they eventually do the trials. If you inject

deeply hibernating squirrels and bears with cyproheptadine or another serotonin antagonist, they immediately wake up. You know, the bear will try to eat you because it's hungry, right? The squirrel, like, you know, maybe acting disoriented a little bit, but it's waking up. It no longer wants to hibernate. Why? Because when you block serotonin, you're unleashing, you're removing the brakes on metabolism. So in other words, the body's like, oh, I'm

I'm good and ready to go again. Give me food because I need food to produce energy. So a great way to lose weight is to block serotonin or decrease its synthesis because not only does your body, you're no longer under stress, but it says, uh,

you know i'm ready to go give me the energy because i will utilize it why would i utilize it well if serotonin is low cortisol will be low and you will not look like the lemon with sticks i will not be using the food to store it as fat which is a result of the stress signal really when you're under stress you're under threat the body says anything you put into that mouth

I'm going to use very little of it to keep you alive. Everything else go back to storage, right? Which is the fatty tissue. So when you're blocking serotonin, you're really blocking a very primitive and ancient, perhaps the primary signal of threats, which is a type of stress, of course, as well. Uh,

And the other cortisol blocker that I actually had in mind when I mentioned the clinical trial for diabetes, it's a drug that was developed as an abortion pill in the 1950s by a French company that has since been bought, I think, by Sanofi, and now it's owned by Roche. It's a Swiss pharmaceutical giant. And the drug is known as RU486. It's also known as Mifepristone, which...

Most people these days know it as the abortion pill. Why? Well, guess what? Here's an interesting story. When Sanofi first developed the drug, they actually developed it as a glucocorticoid antagonist. In other words, a drug that blocks the effects of cortisol at the receptor. But at the time, there wasn't much of a market for cortisol antagonists. It's just not many people with Cushing syndrome. It was really a drug of largely academic interest.

But because the cortisol receptor and the progesterone receptor, their structure is very similar, drugs that usually block one block the other as well. So they quickly realized, the scientists, the marketing officers at Sanofi, realized that they have a tremendous opportunity to market this drug

as an abortion bill, especially with the rise of feminism and basically the movements for female equality and whatnot, they said, oh my God, we have a perfect opportunity to sell this as a birth control bill, essentially, instead of an anti-cortisol bill. Nobody was interested in anti-cortisol bills at the time. But never forget,

that RU486 was developed, designed as a cortisol receptor antagonist. It's only later when its progesterone antagonism became known, and because you need the progesterone to maintain pregnancy,

anything that blocks the progesterone receptor will usually induce immediate abortion so now they're using it as an abortion pill or emergency contraceptive pill in usually combination with uh with some with either an estrogen or some other synthetic uh steroid that prevents um

the implantation of the fetus. So, yeah, so blocking cortisol either by decreasing serotonin, right, because it lowers the synthesis of cortisol as well, or blocking cortisol directly has very widespread systemic, pro-metabolic, anti-stress, anti-aging effects. You can produce every symptom of aging

by simply providing the organism with an excessive amount of cortisol. You can create, there's a disease called progeria, which is a disease of accelerated aging in humans, but there are also several animal models developed that can mimic it because they want to study it, how it develops, right? And in order to do this in animals, you have to develop something that looks similar

to the equivalent disease in humans. Guess what? They discovered they produce it in animals reliably by simply injecting them massive amounts of cortisol. So it's cortisol really, the relative excess of cortisol with aging and the declining levels of the anti-stress hormones, such as prognenolone, progesterone, DHEA, testosterone, dihydrotestosterone, really those are the hormones that keep you young because why? Because they oppose the effects of cortisol

They oppose the effects of estrogen. They oppose the effects of prolactin. So they have a direct structurally protective effect because cortisol really dissolves you as an organism. All it can do is destroy all of your lean tissue and bones and promote the synthesis of fat. So clearly something that opposes that effect.

will make you look better. You'll be lean, you'll be muscular. Speaking of which, it turns out that the vast majority of anabolic androgenic steroids that the bodybuilders use turns out that about 80% of their so-called anabolic effect is actually anti-catabolic effect. It's blocking the effects of cortisol. And recently bodybuilders wisened up to the fact that this drug called IU486 exists

And they're starting using it because it still is not banned in most competitions. So now if you go to Google and type bodybuilding space RU486, you're going to find thousands of threads of bodybuilders all over the world, mostly from the last three to four years, discussing what a great drug RU486 is because it is actually a steroid.

But it's not known as anabolic steroid, but it's now an anti-catabolic one. But guess what? It turns out that most of the benefits, muscular benefits that these steroids bodybuilders were abusing were actually due to simply blocking the effects of cortisol.

So Georgie, I want to briefly touch on one of your key products that you sell, that you endorse or sell, and that is lapidin. So that's obviously the key ingredient in lapidin is imodine. So do you want to talk briefly about some of the benefits of imodine in the context of cortisol?

Yeah. So, a modulatory has multiple benefits, probably the primary one being that it's actually a quino. So, it serves as an electron acceptor and modulatory

And most diseases, according to the metabolic theory, happen to do with the fact that you basically, of the three steps of metabolism, you're only using one. So if metabolism, if life really in general is the process of flow of electrons from food to oxygen, and then something is blocking that flow, and that's why disease develops, logical

hypothesis would be that if you restore the flow somehow, then you will be eliminating many of the health problems. Quinones do that because they accept these excess electrons that are coming from food, right? So if the pathways are blocked, quinones can serve as an emergency electron acceptor and prevent the disease from happening and in many cases cure it.

A modin just so happens to be a very powerful inhibitor of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1, which is the enzyme responsible for synthesizing cortisol from the relatively inactive precursor known as Corizone.

So, cortisone has a ketone group on position 11, while cortisol has a hydroxyl group on position 11. And that tiny little change makes all the difference. It makes cortisone an extremely potent glucocorticoid, while cortisone actually is precursor, happens to be a relatively antagonistic. So, it's not as potent as RU486, but it still serves to balance the effects of cortisol in the body. And if that enzyme, 11-beta-HSD1,

is overexpressed or working in overdrive, you're gonna synthesize in a ton of cortisol with all of the negative effects that that entails. Immoline happens to be the most potent natural inhibitor of that enzyme. And actually not even natural, they've been trying to synthesize synthetic, in other words artificial,

the analogs of Imodine, they will inhibit that enzyme and to my knowledge, nothing is really synthesized that actually manages to beat how potent Imodine is. So just a few milligrams of Imodine are sufficient to inhibit the activity of that enzyme by more than 50%. And now, given that mainstream medicine has started to wisen up,

about the role of cortisol in almost any disease but especially type 2 diabetes remember cortisol makes you store fat in the middle it makes you lose muscle mass it makes you look like a lemon with sticks that's how people with type 2 diabetes look so

the thinking goes maybe if we block cortisol or inhibit its synthesis, we're going to be able to reverse this pathology. Voila! That's exactly what they did. So if you go to Google and type 11-beta HSD1 inhibitor diabetes, you will get a ton of studies, most of them with synthetic inhibitors because they're patented, they're expensive and whatnot. But guess what? There are also studies with amodin.

Yes, there are animal studies, but now there's actually a clinical trial going on. I'm not sure, maybe they're actually in Australia or Canada. I know it was like a Commonwealth member. And basically they're using a modem, isolated a modem, to actually see if it's going to,

either relieve the obesity or maybe potentially even improve the whole diabetic state of people with type 2 diabetes but the animal evidence from animal studies with a modern is overwhelming going back at least 30 years so if you can't find isolate in the morning you can do cascara unfortunately the cascara products on the market are is very difficult to ascertain the quality because the

really good quality cascara is very expensive because it's actually an extract from a bark. So many people, many vendors out there, especially importing it from China, will basically sell you this powder and

the amount of ammonia in the bark actually depends on the environment that the tree has been growing into. And it's known that if there's drought, if the tree doesn't get sufficient water, or if it's basically been sprayed with pesticides, etc., you actually, the amount of ammonia in the bark will drastically decrease.

So in many cases, if you're using Cascara Sagrada Bark products, you won't be getting much of an ammonia. That's one of the reasons why we developed Lopotin because you're actually getting the purified ammonia, which is the main active ingredient in Cascara.

And because Chiara has been studying for a very long time, nothing else has come out as a potentially active ingredient. It's really only the amomum that's giving it all of the benefits that there are not. Pro-digestive, pro-motility, anti-inflammatory, pro-metabolic, and of course, anti-cortisol.

Terrific. I'll be, for those listening in, I'll be linking Lapidin in the show notes for people to check out. That's at ideallabs.dc. The other thing I wanted to mention, Georgie, and this is probably the final, because we've got to wrap up soon, but the final thing I wanted to point out that you mentioned on your website, which is phenomenal, is the negative association of DHT with prostate cancer.

Yeah. So that's another theory that we've been sold onto. And it turns out it's mostly fraud, actually. It's not even negligence because they had a drug to sell and the estrogen industry wanted to expand its market by giving estrogen not only to women, but also to men. I don't think I need to advertise it to men and tell them that...

having high estrogen in the male is really not beneficial. I mean, you develop boobs. It's called, it's called gynecomastia. It's really basically a condition indistinguishable for having female breasts. And in fact, many transgender people that are, that are converting from males to females, they would actually go on a very high dose estrogen and progesterone therapy. But,

to give themselves breasts. But the factor most responsible for breast growth is the estrogen. So it doesn't seem like something that's good to give males, right? But the estrogen industry is relentless and it wanted to double its market. So it was not enough that they were selling estrogen pills to menopausal women or to women of childbearing age as a contraceptive. They wanted to now give it to males. So they used the well-known correlation method

No question, but the well-known effects that DHT has on the prostate, it makes it grow. Yes, it does. Because it's actually an organ with a very high expression of the androgen receptor, so it's very sensitive to potent androgens. DHT is the most potent androgen we produce. It's synthesized with testosterone, but testosterone is about five to eight times weaker as an androgen agonist than DHT. So DHT is really what's making us males, right?

So it has this effect of masculinizing the face, masculinizing the facial features, the body, basically giving you the V shape,

And then it's responsible for things like penis length, for bone strength, really truly like the male sexual phenotype. And they use this, the fact that in animal studies they've shown that, and also in humans later on they found out that elevated levels of DHT make the prostate grow. They said, oh, well,

One of the first things that we see before prostate cancer develops is that these people usually go through a stage called BPH, benign prostate hyperplasia. They said it's a risk for prostate cancer. It has never been proven, but actually it will progress to prostate cancer.

It's never been proven that it has any causal relationship whatsoever. But they said, no, DHT really enlarges your prostate. We actually need to develop a treatment for it. And what do they do? They develop something called chemical castration therapy. And it's really, that's how it's known to this day officially. It used to be a combination of physical and chemical castration, but many men started

They had broken the idea of having their balls cut off. So they said, "We're not gonna be able to sell many men on that surgery. Might as well develop something that's, you know, they can do it chemically." But make no mistake, you may be keeping your nuts down there, your nuggets, but they're not working anymore when they give you the chemical castration drugs. And those chemical castration drugs

are drugs that inhibit the synthesis of DHT. They're known as 5-alpha reductase inhibitors, the most notorious one being finasteride. And that's a whole separate story of just how many lives finasteride is ruined. Now there are actually massive class action lawsuits being prepared in America to sue the manufacturers of finasteride, which lie to people saying, oh, it's perfectly safe. You don't need DHT. Testosterone is perfectly sufficient to maintain you as a male.

As it turns out, not. Not only not, but hell not. It leads to depression, leads to suicide, it leads to feminization, leads to liver cancer, leads to prostate cancer, actually a very aggressive type of prostate cancer. Prostate cancer is perhaps the one cancer where even a mainstream doctor, if you're an older male, and you go to them, they'll give you a test. They even may do a biopsy. And usually if you have the so-called hormone-sensitive nephropathy,

non-aggressive type, they'll tell you the best course of action is doing nothing. Actually, the doctor for prostate cancer will tell you in the vast majority of cases, the prostate cancer develops so slowly, you're likely to die of natural causes earlier than the cancer will kill you.

But guess what? If you take finasteride, it has a very high chance of converting that mostly slow growing, really non-dangerous cancer into an extremely nasty type known as castration resistant prostate cancer, which is known to be resistant to any kind of really chemotherapy. So the only options are there

removing your entire prostate which renders you immediately both impotent and incontinent for life if you even survive it because it's not a simple surgery and then basically if that fails then radiation is your only chance but still prostate castration resistant prostate cancer is considered almost universally lethal and guess what the finasteride drug is known to cause it

So they said, "Oh, that's not enough. We need another type of therapy. What are we going to do to further decrease the amount of energies being produced because they're really causing prostate cancer?" We're going to give them an estrogen. So now, actually, the mainstream therapy for prostate cancer very often is a combination of a synthetic estrogen and

finasteride. So not only are they depriving you of almost everything that makes you a male, they're kind of standing you well on your way up to becoming a female. I've seen some men who have undergone castration therapy with estrogen,

or finasteride or both, the results are not pleasant, especially the combination therapy. They start looking like women. I don't know how many of your listeners are following American celebrity news, but there is this famous Kardashian family in California. And the father, actually, it's the second husband of the woman that's participating in the show, but he recently converted from a male to female.

And he published, he basically like in several interviews, they asked him, "So how did this happen?" Usually gender dysphoria, like wanting to be something other than your biological gender, if you're born a male with male genitals but you want to be a female, that usually starts to develop very early in puberty.

you are in your 60s. How did you suddenly become, how did you suddenly decide you wanted to become a woman? And he said, well, I don't know. It was just a very strong urge. And I actually started physically looking like a woman, which was true. So I talked to myself, just immediately,

immediately my sister's like, that guy has either been exposed to some really potent endocrine disruptors like Bisphenol A, which is heavily feminizing in males, or he's taken one of those drugs and lo and behold, he said that he's been on finasteride therapy for almost 10 years.

and he never put the two together in the interview. I mean, but he mentioned he was on this therapy and I said, what a great coincidence. You take finasteride for 10 years and suddenly in your 60s, you decided you want to be a woman, actually convert as a woman, right? After living your whole life as a heterosexual male,

and you know having sex with women by virtue of your own desire create beginning three children of your own physically right i mean this to me should be enough to trigger some deep retrospections and say hold on a second what happened to that guy to suddenly well start looking like a woman wanting to be a woman and then

undergoing all of these gender converting surgeries. And the only thing that I know, unless, I mean, he didn't mention anything else, right? The only thing is that he said he's been taking finasteride for a very long time. Well, knowing the anti-androgenic castration effects of finasteride, I probably don't need to tell you listeners that eunuchs, the castrated males, they look like females.

So that's what this drug does. It converts you into a eunuch without actually you losing your genitals physically. And there is the example, you know, at least one very high profile example. Bruce Jenner is his name. And now he's known as Caitlyn.

Yeah, just it's honestly shocking, shocking to hear. And every time I hear people discuss venesuride in different communities and like anti-aging forums and all that, I honestly just question like have they even seen the repercussions? And not only when they're on the drug, but even years after stopping, there's guys that are struggling to bounce back and five years later, they've still got venesuride.

you know, major side effects. So it's, again, another myth. If you don't believe, if they don't believe, simply go to the world type finasteride class action lawsuits and you'll see it. I mean, look, if thousands, tens of thousands of men are ganging up and getting ready to sue the hell out of the pharmaceutical industry. And, you know, this doesn't happen unless there is very serious evidence because the lawyers will not pick up the case. If the lawyers are going after it and agreeing to defend these men pro bono,

Lawyers are thinking there is some serious money to be made. There is a very, very strong evidence implicating finasteride in all of these problems that these men have been plagued with years, sometimes decades after using finasteride. Even a short course therapy, like a month or two months, people say something is wrong and they stopped it, but the drug already did its damage and now they're impotent.

They're infertile, they develop liver problems, they're suicidal, they're major depression. Anything you can come up with that plagues a male, it can be tied usually to some sort of androgen deficiency. It's not a coincidence that androgen therapy used to be one of the first things that a family doctor would try in the early 20th century. Basically, they're saying like, "Oh, if you're feeling sluggish, no interest in sex, quiet

quite obvious right that's a you know therapy will be useful for that but like mood disorders like bones are getting weak muscles are getting weak you're not you don't feel pleasure in life anymore your cholesterol is going up your heart you know your heart is not working properly the entry testosterone therapy was a very very common treatment you know for all of these these treatments of all these issues and we've been somehow

we became convinced because of pharmaceutical manipulation that the opposite is good for us. Let's, you know, let's lower androgens even more. Let's see how that goes. Were you seeing the results? So I'm glad that actually somebody is finally taking the fight to the pharmaceutical companies because

This has been going on for way too long, way too many lives have been growing. The only thing that needs to happen now to make this truly, truly like a worldwide beneficial event is for the prostate cancer patients to realize that finasteride has also ruined their lives as well, not simply the lives of the men who took the drug for baldness problems or, you know, or prostate enlargement problems, but now the problem is the prostate cancer patients

with all of the other users of the drug Finasteride and took it for other reasons, I think then you may have like a very, very, you know, worldwide impactful change of health policy because those will be tens of millions of patients around the world are saying, "Enough of this, you know, I want my life back. I don't want to be castrated. And I don't want my relatively benign prostate cancer to be turning into a killer cancer."

for which you guys have no treatment. And even if you did have a treatment, it renders me fully impotent and fully incontinent. What kind of life is this? I mean, I know I did a good portion of the males when they hear what awaits them with these treatments, they're probably going to say, you know what, how about you leave me alone and I'm going to die with dignity and not live like a castrated slime that has no joy whatsoever left in life. No dignity. Powerful stuff there, Georgie. Yeah.

We're actually running short on time, so we're going to have to probably, we'll definitely schedule another episode down the line, particularly around a lot of the interventions and things and some of the protocols that I see you recommend and some strategies to lower cortisol, boost androgen status, for example. I mean, I saw a huge benefit from, like I said, utilizing high-dose vitamin B1 at one stage. That was a game changer for mental clarity and

DHT for a fact. Niacin had some huge success with that. Like some of these compounds you've mentioned have derived a lot of benefit from. So just before we wrap up, Georgie, did you want to let my listeners know where they can find more of your content? Yes, I used to post and I still post a lot on the raypeatforum.com. So Ray Pete is the name of Raymond Pete. Raypeatforum, one word, dot com. But I also

But I also now have my own blog and I post what I was posting in the rape reform and I still do. My alias there was Haydut, H-A-D-U-T-U-T. And Hayduts were basically this group of rebels back in Bulgaria, which is where I'm originally from. And they were fighting the oppressive presence of the Ottoman Empire. So in a sense, it's a rebel without a cause. I think there is a song like that.

I would like to think myself as one, right? So HeyDoot is my online alias and I have a blog which is HeyDoot.me

So usually the blog is the blog that has the most recent content that I've posted and that blog is also linked to my Twitter account which is twitter.com/kejit and anything I post on the blog almost immediately gets reposted on Twitter and a little bit later, about a week later, I take everything from the blog and I also post on the AP forum.

But usually the blog and the Twitter are enough to be like, to keep abreast with like the latest that I've done and posted. And that's pretty much it. I mean, we have a company for several months, but I think we should probably discuss that like on the next podcast. For sure, man. Well, thanks everyone for joining in. And Georgie, I want to say massive thanks for coming on the show. It's been a pleasure having you here. And of course, like, I mean, you've influenced my journey hugely where I am today and even how I help

of people through my social media and things like that. So, you know, I've learned a lot from what you've taught, not only, you know, expressed on a way before, but then also delving into my own research and understanding human physiology. And yeah, I just want to say that I'm very grateful for the work that you do and just keep fighting a good fight.

- Yeah, man, thank you, appreciate it. I will, as long as I have people interested in my work, that's what keeps me going. You know, we, situation is pretty dire, but also we live in unprecedented times because now all of this information that used to be hidden and only accessible

By the powers that be, you have to be a licensed doctor. You used to have to be a licensed doctor to read a medical journal. Now almost everything is publicly, it's online. And with websites like Sci-Hub, now you have access to almost any publication over the last 100 years. And you don't need to be a doctor or you don't need a license to be able to search for and access the truth. It's only up to you.

And as we have learned the hard way, basically when you offload or outsource so much of your life changing decisions to third parties, very often these parties get into a position of power, absolute power, they'll say, "I don't wanna relinquish that power, I wanna control that individual."

and I'm going to tell them what's good for them, what's healthy and what's not, and I'm going to keep them in the dark. So that's the situation we're in right now, but we also have the unprecedented opportunity to find the truth because actually it is out there. It's simply not promoted, but it's up to us to go and find it because it has been published, and it has been published for more than 100 years. So that's the positive side of the story for me.

Fantastic. Thanks again, Georgie. And we'll wrap it up there. Thank you. Appreciate it. Thanks for letting me. Thank you everyone for joining in to today's episode. For in-depth show notes and lessons learned, visit nofilter.media forward slash boost your biology. This has been a No Filter Media production. Say what you want.

This is Paige DeSorbo from Giggly Squad. Boost Mobile is no longer that prepaid wireless company you remember. They've invested billions into building their own 5G towers across America. With Boost Mobile's networks, customers enjoy the speed and service they'd expect from the big three.

Plus groundbreaking benefits you'd only get from a true challenger of the industry. Boost Mobile will let you try the network risk-free for 30 days. So visit your nearest Boost Mobile store or find us online at BoostMobile.com today. What if I told you that right now millions of people are living with a debilitating condition that's so misunderstood many of them don't even know that they have it?

That condition is obsessive compulsive disorder, or OCD. I'm Dr. Patrick McGrath, the Chief Clinical Officer of NoCD. And in the 25 years I've been treating OCD, I've met so many people who are suffering from the condition in silence, unaware of just what it was. OCD can create overwhelming anxiety and fear around what you value most, make you question your identity.

beliefs, and morals, and drive you to perform mentally and physically draining compulsions or rituals. Over my career, I've seen just how devastating OCD can be when it's left untreated. But help is available. That's where NoCD comes in. NoCD is the world's largest virtual therapy provider for obsessive compulsive disorder.

Our licensed therapists are trained in exposure and response prevention therapy, a specialized treatment proven to be incredibly effective for OCD. So visit nocd.com to schedule a free 15-minute call with our team. That's nocd.com.

Okay, supply run, fix the faucet, get new tires. Here's the all-time best premium durable tire. You have enough to do without becoming a tire expert. GMC certified service technicians are factory trained to fit your vehicle with the tires specifically developed for it. And with our tire price match guarantee, you get the best fit for the best deal. Let us do the work. Available on select eligible tire brands at participating dealers only. Offer ends 12-31-25. Terms apply. See dealer for complete details. Visit gmc.com slash service to learn more.

you