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Thank you for listening to the Boost Your Biology podcast. My name is Lucas Owen. I uncover the most cutting edge health information on the planet, ranging from hormones, nutrition, supplementation, fat loss, biohacking, longevity, wellness, and a whole lot more.
Welcome to the Boost Your Biology podcast. And what is up, ladies and gentlemen, and welcome back to the Boost Your Biology podcast. Today, I'm here with the man who created biohacking and also the founder of Bulletproof. And for those wondering and interested, he is actually hosting a massively exciting conference in May 28th,
of this year in Austin, Texas. Joining me on the podcast, we have the man himself, Dave Asprey. Dave, welcome to the podcast. Thanks for having me on. I'm really excited to go deep with you. This is going to be fun. Awesome. Awesome. So Dave, I guess I really wanted to start out by asking you a pretty common question, which is, what would you say are the core drivers of accelerated aging? Governments.
Am I supposed to use my inside voice? No. Stress from society is a major, major cause. It's chronic elevation of stress hormones. And there's lots of research that backs this up. When people feel like they don't have freedom, when they feel like they don't have a choice, when they're
basically downtrodden and controlled. Stress hormones go up, violent behavior goes up, oxytocin goes down, testosterone usually goes down but could go up, cortisol goes up, adrenaline goes up, sleep goes down, and all those things make you old. So, you know, we got to point the finger at politicians first and foremost. And this is apolitical, but guys...
Like stop taking our ability to control our biology. And like, how about doing your job? So that's something. So I'm just going to say societal stressors and that includes social media and all that crap. That's actually it. And after that, it's toxins. It's not that you're not getting enough of something. And you found these 1970s whack jobs who were like, I'm going to run a marathon every two days and I'm going to eat a macrobiotic high toxin diet because I hate life itself. But I don't know. I hate life itself.
And what you end up with is a very high toxic burden and a high stress burden from excessive exercise and all the crap we put into the air and everything else. And what I've learned, if anything, in the biohacking and biohacking came out of longevity movement. It's that it's the negative things you're eating that make you old first. Your lack of NAD or B vitamins or whatever, you know, minerals, whatever,
That's important. You could probably deal with that if you weren't also punched in the face with oxalates and microplastics and endocrine disruptors and all those things. So that's really thing. Step one, stop doing the things that make you weak.
And that's, what's making us old is just, it's the negatives we're taking in. It's not the lack of positive. Yeah, I would agree. And you just mentioned, so microplastics is a massive topic at the moment. And I've sort of been, I personally have been investigating compounds to help strip the body of microplastics. And I'm,
I don't know, like it seems like there's only some preliminary sort of ingredients that can help to just generally detoxify, but nothing that's like specifically targeted for microplastics. Have you been keeping an eye out for this sort of space at all? Very much so. It's a hard problem to solve, but I think there are some things that will do it.
Um, what's on your list? I mean, I'll give you mine. Um, the initial ones that I've found. So we've just got the basic things like, um, chlorella, which can help to, um, you know, detoxify generally, but then there were also some probiotics that can help to degrade microplastics in the, in the gut. And I thought that was pretty, pretty interesting, but I'm also concerned about how can we specifically, um,
like chelate or bind or reduce microplastic buildup in the brain because i'm like yourself like i love like optimizing the brain so it's like how can we do that who cares if you live a long time and you have a great body if your brain is cooked yeah it's it i would rather be in a wheelchair with a working brain than look great and not know my name yeah you know i'd rather know my name and you know
and look good and feel good and all the things as I live to at least 180. So you got to not have the brain full of Tupperware. Yeah. What I've found aside from a chlorella, that's a pretty basic like anti, it binds a lot of bad stuff. I don't know about the electrical charge on it. I think it would work, but yeah,
calcium deglucarate have you played with that much i love that one yeah i've used it when i first tried that i had a really profound response like within the first couple of weeks um it just surged my libido went through the roof people don't respect calcium deglucarate enough and i wrote about it in my last book i'm like this is one of those weird calciums you want to take and i
It's the second most important detox process in the liver after glutathione and glucurate takes out estrogen. So there's a lot of guys like, okay, I'm having ED or whatever problems. And they think it's a lack of testosterone. Well, it's a testosterone is converting to estrogen and you're getting estrogen from lavender essential oil. And you know, your wife's perfume or all the crap that's out there, all the soy that they snuck into your food. So, um,
If you can make the liver better at pushing this out, of course everything is going to get better. And you can overdo it for sure, and that could affect probably DHT levels, which you want. So I recommend everyone take calcium deglucorate just to get rid of mold toxins and xenoestrogens and microplastics, as well as environmental estrogen. Some people get depressed, especially if they don't have enough estrogen, because as you know, we need some estrogen for longevity, just not too much.
For me, I first got into this maybe 10 years ago. I have struggled my whole life with man boobs. All the guys in my family have at least an A cup. And it's been something I've just never liked it. I've been really obese, 300 pounds. And I'm probably 6% now. I was 5% on my last scan. But I've been actually doing my best to put on a little bit of fat, which is challenging. For an obese guy with an obese family to be challenged to put on fat, something's working, right?
And calcium glucurate was the only thing that would get rid of my man boobs. And for a while I had to take an estrogen blocker, an herbal one, and I don't even take that anymore because I don't need to block it. And as long as my glucurates at the right level, I have a normal chest. And if you look at the cover of my new book,
This is an airbrush, no fasting, no diuretics. That's just whatever. Like I got off an airplane and went to a photo shoot in Miami for that. It's impressive. Holy crap. Like, and my favorite thing is all the trolls. You probably get them too. You're not 5% body fat. And I'm like, well, your mom says I'm 5% body fat. Like, what do you say to a troll like that? I don't know.
I know the feels. I know the feels. So of course, yeah. So calcium deglucorate. Yeah. Great, great compound to help with elevated beta-glucuronidase. So helping with that glucuronidation. The microplastics conversation is a big one. Mold is something that I want to talk about because I haven't had anyone. There's one more microplastic compound I wanted to share before we get into mold. And it actually overlaps so perfectly because most things that get rid of microplastics also help with mold. Cool. Yeah. Yeah. Yep.
So, and this one is, it's around bile flow. So the more you can get your bile to be excreted, the more microplastics will be excreted with it because the bile, as you know, it's like a fatty substance, right?
And it has a lot of cholesterol in it. And so if you want to lower the toxin burden in the body, don't recycle your bile. If your skin is white and you have Northern European genes, and sometimes if your skin isn't white and you just have the right genes, you have the HLA-DR thing that says you recycle bile. Your genetics handle famines better than average because you recycle bile. That means, unfortunately, you don't handle toxins as well as people who would not make it through a famine. So Mother Nature is creating diversity.
If you're one of those people increasing bioflow matters. So I read about this in the Bulletproof Diet, like my first major book, geez, 12, 14 years ago. And it's like, what would you, oh, a little bit of butter?
And then you can take things like anything bitter that increases bioflow and then you bind it. And to bind it, you would want to use activated charcoal. You could just fast out of choline. You could use one of my favorites is humic and fulvic. In fact, if you get danger coffee, which I know we're not shipping to Australia yet, apologies. Danger coffee is mold free, of course, because that's what I do. But it has a therapeutic dose of humic and fulvic in the beans themselves.
So that when you drink it, you're getting your binders. So I just like bile binders, glucurate would be my recipe for how to get rid of microplastics. Awesome. Love that. Love that. Yeah. Speaking of like the mold side of things, I mean, this is like, I haven't had anyone on the podcast talk about like the dangers of molds, like where it's possibly, I know, crazy, man.
where it's possibly hidden, what we can do about it. Let's go deep on that for a few minutes. Yeah, let's do it. Number one, totally free moldy movie.com. So this is a documentary I shot on toxic mold. I interviewed 10 of the top doctors in the world and 10 people like you and me who just got punched in the face by mold. One mold toxin is my favorite. It's called Zoralinone. You heard of this one?
No. Oh, it's the best mold toxin ever. It's 10,000 times more estrogenic than human estrogen. And in the US, there's a pharmaceutical feed company that concentrates it into little waxy pellets and you drop one into a cow's ear. And then just that little dose percolates through the capillaries into the cow's entire fatty system. And the cow gets fat on 30% less calories. No way. Yep.
I love Zoranone because it proves all the calories in calories out people are stupid just on its face. Like, oh, look, here's a drug that makes you fat and 30% less calories. Your dumb belief system has been disproven. And so you can go, you know, wash a Snickers bar down with a Diet Coke all you want. You'll just get sick because you don't know how bodies work. And if that doesn't work, I tell them to eat uranium because it has a million calories and they don't get fat and then they die too. I don't know what's up with those guys.
Like, it's just logic. I agree. Yeah. Anyway, Zeranon. How do you spell that? Z-E-R-A-L-E-N-O-N-E. And Zeranon.
There's about 200 species of mold that make really nasty mold toxins that cause systemic inflammation, direct mitochondrial harm, a link to cancer, diabetes, cardiovascular disease, all the diseases of aging. I wrote in Headstrong, my cognitive book, that this is a very likely cause of Alzheimer's. And then Dale Bredesen came out with actual proof that mold is a cause of Alzheimer's and Parkinson's for people.
some of the subtypes. So, okay, we've got a neurotoxin, but it's really a whole cluster of neurotoxins. And if you're breathing it or you're eating it, or you have an infection, it has different effects and they're all really bad for you. So I know a lot of high performers, they're out there like, I feel great. I'm doing all the things I want to do. And then all of a sudden,
you wake up and you feel hungover, dark circles, rashes, strange nightmares, nosebleeds, unexplained bruises, frequent respiratory infections, heart palpitations, chronic fatigue syndrome, POTS where your blood pressure just drops for no reason like you have long COVID. In fact,
chronic fatigue syndrome is almost always, but not always caused by toxic mold. And the symptoms are exactly the same as long COVID because they revolve around mast cells. So what's really going on here is we got to make sure that we don't have a funky smell, like an old mop in our bedroom, because it is reliably going to take you out. But, and this is why the movie moldy movie.com again, guys free. The reason it's so just important is,
Every person will have a different set of symptoms because mitochondria run everything. So you might have three things and your wife might have 10 things or one thing and they're not the same. So you think you're crazy. And the most just impactful quote in the whole movie was a husband and wife couple. They're both medical doctors.
And she's just wiped out with all these weird neurological symptoms and he's totally fine. And she thought she had like mental illness, but since her temperature was high, she biopsied every organ in her body to find what was wrong, really painful. And then a biopsy. Oh God. Yeah. I mean, these are hardcore doctors who don't believe anything about this. And at the end they finally figured out it was mold and we have them sitting there together and they're
He says, I never felt anything, but I know it's real. And she'd been in a wheelchair and all this crazy stuff, but they went and they did the science on it. So for people listening, if you have water damage in your house and you have all sorts of unexplained things, you can take all the peptides in the world, you'll still feel like shit. That said, there are some like MOTC and SS7,
and TB500 and BPC157 and what, LL37 that are going to be really good for you if you have mold. But until you get the mold out of the body and out of your environment, they're just going to be expensive band-aids. Yeah, yeah. The good way to look at it, and I really like that sort of addressing, like first and foremost, remove input.
Yes. Then optimize like functioning, or you could possibly do both at the same time. You could minimize input and optimize overall functioning using like PQQ, coenzyme Q10, you know, D ribose creatine. Yes. You've got to support mitochondrial function. Cause if you think about it 2 billion years ago, we were mitochondria floating in the ocean and some other cells. And they always tell us in seventh grade that,
Oh, you know, we were cells and we harnessed the mitochondria and mitochondria are pulling most of the shots. There's been an ancient war between bacteria and mold. That's where antibiotics come from. So it's no wonder that when you expose yourself to natural antibiotics called mold toxins, that the mitochondria that run your system feel like you're going to die. And they have all sorts of weird things because it's a very low level foundational disease.
incompatibility there. So I just say you got to address this because it'll affect everything you do. Going back to that, um, Zirillinone, that one you said that is a thousand times more potent than estrogen. Where is that commonly found? Um, it's commonly found in water damaged buildings. So it's actually not a, um, it's unlikely to be found in actual food products. Most mycotoxins can be found. Well, that let me, um, go back a bit.
In the world of food, there's two buckets of mycotoxins. Some of them are field toxins. They grow on the plant in the field. And some of them are storage toxins. And then you have environmental toxins, like in your home or your car, and those can come in through the skin. A lot of them, the worst ones come in through the skin and some come in through breathing.
And then you have the other nasty thing is if you get colonized, which happens to most people who live with mold for a long time, it grows in the interstitial tissues and it makes these mold toxins on board. So you can get ziralinone in corn and wheat and barley and oats and processed carbs and all sorts of those sorts of things.
It's possible to get a little bit in meat, but it's only if the animals are eating unhealthy grains. It'll be in their fat. But if it's an American cow that they treated this way, you eat lean conventional beef and you eat fatty grass-fed beef that won't have zirallinone. You're not going to get it in milk and eggs and muscle. So bottom line is organic, it might be worse.
Because they didn't even use a fungicide on it. So organic means nothing about toxic mold because toxic mold is entirely natural. The other thing that's really bad is there's a major toxin called fusarium that makes fusaricin and something called vomitoxin and some other nasty stuff. And that stuff used to grow on corn. So don't eat moldy ears of corn.
But once we started spraying glyphosate everywhere, glyphosate drove the mold to make 500 times more toxin. And now it goes down into the soil and it binds in the roots of the corn so that the toxin is inside the corn. You cannot see it and it will not be measured on a test because the toxin is bound to corn sugar.
As soon as you eat the corn, the amylase enzyme in your mouth digests the sugar and frees the toxin in your mouth. So we have huge problems with corn because of glyphosate making mold worse. Yeah, I'm not a fan of corn. I mean, the fact that it doesn't even digest, it comes out undigested is a clear sign that the body doesn't really want it in the first place, I guess.
There are ancient ways to prepare it, like nixilated and you soak it in lye and you beat the crap out of it. And it's a lot of work. I generally won't eat it if I'm in Central America and there's a traditionally processed corn thing made by a grandmother and cooked in tallow. Okay, fine. Other than that, I don't touch the stuff. It's just not worth it. Switching gears, Dave, just in terms of foods. I mean, I would love to hear about
three foods that you simply cannot live without oh kale and spinach and tofu clearly i mean that that's why i'm standing here okay three of my favorites as well yeah you you too oh and uh hot pockets i don't know you probably don't have those out there like some sort of pre-made gross thing um three foods i can't live without um is coffee a food
You could. I mean, I'd say it's sort of part of the Mediterranean diet. So yeah, you know what? There you go. If coffee is not a food, then we'll say I would want to have grass fed ribeye. If I can only have three, I'd probably add an avocado in there.
And then you really, if I was just going to eat three forever, you need some source of carb there. So it'd either be white rice or honey. But if I was looking, I mean, avocado and maybe, well, that's what I do. Probably some blueberries might be a good idea. Yeah. Yep. Yep. They're always, always stocked in my fridge year round because they're just, they're just staples, you know, maybe some eggs as well.
So, all right, with the carbohydrate front, I mean, you've worn a CGM probably many, many times over. There you go. You got one on right now, which is awesome. What have you learned through some of your own experiments? Like, I'm really curious to hear about just some crazy things you've identified through your own experiments. You know, I got my first CGM maybe 10 years ago because...
A type one diabetic wrote me this letter and sent me her Dexcom. And she said, Dave, like your coffee saved my life. Now when my blood sugar crashes, I have ketones as a backup fuel because of the MCTs. And it's really been life changing. There's lots of type ones who are like, thank God for understanding ketosis.
because I was, that was like the first big modern keto book, the first one, full recognition, you know, the Atkins diet in the 90s. I did that too. So I didn't invent keto by a long shot. I just popularized it at that point. And she sent it to me and just said, I got a new one. I think you'll like this. So I got early access because someone sent me a prescription device. And it's remarkable what carbs in the morning do. And it's,
Anyone who's still eating oatmeal, it's like you have to be willfully blind. Like, oh, it has a fiber. And you could have ice cream or donuts and have less effect on your blood sugar. This stuff makes you hungry. It is peasant food. And the way it's prepared these days, let's see.
We'll do cold oatmeal, like overnight oats to make sure there's no heat to destroy any of the phytic acid, which it doesn't get destroyed much anyway. So like you hate your skeleton if you do it that way. Right. Or you do the instant oatmeal, which is you might as well just like shoot glucose into your veins at that point. It's just it's ridiculous. So you learn that very quickly.
And you also learn sometimes like some foods will just spike your blood sugar, but they don't spike other people's nearly as much. So it's individual variability. And strangely, my friends at Viome are pretty good at predicting that now. They can look at your gut bacteria and tell you this food is going to spike your blood sugar ahead of time. So that's cool. And also just how important is it to have a big hunk of butter or a big bunch of steak if you're going to have carbs?
Eating that first and then the carbs is a totally different response than eating the carbs. So why do they give you bread before a meal? Well, because they want you to buy dessert. That's why. But if you ate the bread with the meal, you wouldn't want dessert. It's that big of a difference. That's actually a really good point. They do that a lot in Europe, like particularly in Italy and like Spain. They'll give you like a little dish of, you know, bread with the olive oil. But going back to some of the foods, I mean, like when I wore one as well, the sushi for me was like,
unbelievable how pronounced that spike was. But in terms of carbohydrates that you prefer or lean towards, I'm assuming they're carbohydrates that are easy for your gut to digest and minimally like they're not problematic in terms of their anti-nutrients, right? So that's why you said like honey, you said white rice,
Yeah. And for honey, it depends on the match. A lot of honey is high histamine if it's not handled well. So if you eat some honey and then your nose runs, you're not allergic to honey. You just got histamine in the honey because it was mistreated. And histamine is a foodborne toxin. So...
Yes, the vast majority of carbs need to be detoxed before you can touch them. And if you fell for that 1970s weird thing, no, the bran and the brown part of it, that is not good for you. This is the kind of clown thinking where you could say, well, here's a bowl of cyanide, but I put a multivitamin on top. And they look at it and go, oh, it has vitamins. And then they would drink it. It's like the movie Idiocracy. Like, oh, it has electrolytes. It must be good.
You have to look at the sum total of what's in there. So whole wheat, for instance, it is full of oxalate in the outer part of the grain, as well as lectins, as well as some other plant toxins. You take off the outer part of the wheat, you get rid of most of the toxins and white flour that hasn't been sprayed with glyphosate, especially European white flour, which is a different species of wheat than American flour,
If you ferment that for a day or two, you'll get rid of any phytic acid that's left and you can eat sourdough unless you have celiac. I actually make sourdough bread. And if I do it that way and I'm very careful about the flour, I have zero issues of any kind. And is that with like three ingredients, four ingredients? There's salt, water, and heavily fermented flour. And that's it actually. That is it. Wow. Yeah. Yeah.
And your gut can die. You can digest that. I take gluten enzymes just in case. But yeah, I had some of that last night. And it has about the same effect on my blood sugar as white rice and none of the things. But you give me a teaspoon of American wheat and my gut lining sheds at pimples and farting like it's bad. So glyphosate and the species of wheat are very important variables. Plus, you have to ferment it for 24 hours.
If you do what most people do, which is they put some baking powder in or you go to the pizza place that made the crust that day, it wasn't fermented. So if you do it the old school way and it's white flour, not whole wheat, you're going to feel great. And if you're saying, but whole wheat has whatever vitamin or it doesn't matter.
You don't get your nutrients from that kind of carb. You're just getting energy and starch. You get your nutrients from the animal products or maybe from some herbs and spices, which is where they really live. Like the outside of the wheat husk won't help you. So for carbs, that's what I do. For fruit, it's really important. Raspberries,
which I previously recommended, they're higher than spinach in oxalate. And if you switch from raspberries and blackberries to blueberries and you stop having to pee all the time and you have less joint pain, your skin clears up, well, you're welcome. That's oxalate you're dealing with. In terms of, because at one point, I'm actually curious to know, because you've been in this industry for many years, you understand some of the things that are sort of trended and leaky gut. At what point did that start to become like,
everyone was hyper focused on it or was it like it's always been around we just haven't really sort of leaky gut has been around for a very long time the person who first talked about it wrote the body ecology diet you ever read that book who's the author um the body ecology diet
Let's see. Donna Gates. Oh, yeah. Yeah. So I actually had the honor of hanging out, having dinner at her house and hanging out actually for many times. And if you've heard of the GAPS diet, the GAPS diet is a direct knockoff of the body ecology diet, like line by line almost. And
What was interesting is when I was with Donna, she'd say, well, eat some of this fermented kefir or whatever. And the stuff would just knock me on my butt because histamine is an issue, even if you have leaky gut. So because I was 300 pounds, I was on antibiotics every month for 15 years because I just kept getting chronic sinus infections. Toxic mold does that. I ended up saying, well,
I have leaky gut. So I got into this in the 90s. But just eating fermented things because you have leaky gut is a bad idea. And when you really start learning about this, you realize, oh, what was fermented? Because that really matters. If it's high in lectins or high in certain other things like oxalates, it's still going to probably cause issues for you. And if it was fermented with the wrong species or the wrong temperature or the wrong time, it can have a ton of histamine. And histamine usually is high in people's leaky gut.
And so leaky gut's a thing. And probably the most powerful way to fix it is stop eating things that slice the lining of your gut, which is high oxalate foods. Anything else that irritates you, probably nightshades. And then there's a supplement made out of papaya called caracol that Omnibiotic makes that has really good evidence for fixing it. You could also take acacia gum, which can help quite a lot.
But those are some of the main things. You got to restore the barrier one way or the other. And do you think most people, when they're looking at these autoimmune diseases, they're finally starting to pay attention to the fact that their gut is a hallmark contributor for that? Everybody's heard that. All disease starts in the gut from Hippocrates and all that kind of stuff.
But no one knows what to do about it. I knew that. So what did I do? Heck, I became a vegan and then a raw vegan and did everything possible to try and figure it out. I've taken a quarter million dollars worth of probiotics, right? And the reality is you probably need some prebiotics, some probiotics, some postbiotics, and you might need a parasite cleanse. And
Something like 90% of people in the U S have parasites and don't know it. I imagine Australia is about the same. Cause you guys travel a lot more to places that have parasites. Plus everything on Australia wants to kill you anyway. So yeah,
Like, what's going on with that? These are things like Giardia, protozoas, amoebas, and worms. So you could say, I want to get a stool test for that, but they don't work. And a guy named Dr. Cahill in New York in his 80s taught me about this. He said, oh, he said all the doctors before 1960 knew you have to look at the poop under a microscope. You cannot see it on a lab test. And I'd had a parasite problem. I didn't know what it was, but I thought it was a parasite.
For six months, like diarrhea 20 times a day. And having had lots- After traveling or? After eating salad in Phoenix.
And I sat down with him and he goes, oh, Dave, he goes, the people who are most recent immigrants get the 3 a.m. job chopping salad. And oftentimes they have a parasite from their country. And he goes, I've written six textbooks on tropical medicine and said, all right, bend over. And he puts a camera in and guys, cameras are very small these days, thankfully. And then I go, yep, there it is. You have a irritated patch 10 inches in. Call me in two hours. I'll tell you what you got.
And he called me, said, I looked at the slide and you have Giardia that's been there for a long time. And this other parasite that'll drill holes in your gut and move into your brain if you don't kill it. Good thing you came here. And he gave me a couple of drugs. I don't remember which ones. And I was fine in three days. This is after six months of hell. So maybe I thought I had leaky gut. Maybe I went through all this stuff. I could take pounds of charcoal, nothing worked. So what I'm saying is if you've done all the stuff that's supposed to work,
You could find a guy with a camera, or maybe we should do what they do in Central and South America. You just deworm yourself every year. So I think that there's a case for people who have chronic issues like I did to just say, I'm going to take some metronidazole, which is a pharmaceutical. It's considered antibiotic, but it kills almost all amoebas and protozoa and some worms.
And if you take it and everything gets much better than take it again, 10 days later to get the eggs that hatched and then rebuild your gut bacteria. That's the biohackers way to say it's cheaper and easier to use the drug with known side effects than it is to take a test that isn't going to really give me much info anyway. Now that, that deworming, um, that deworming sort of protocol, like, was that just like an oral antibiotic that you do sort of like once a year? Like what,
Yeah, if you go down to Mexico or similar places, probably out there, if you go to Thailand, they sell it in the pharmacy. And it's usually you just take it for one or two days for more. If you've had longstanding gut issues and you believe it's a parasite, the protocol is seven to 10 days.
Wow. Right. And I'm not saying we're going to take antibiotics just in case, but if you're dealing with something and all the normal stuff didn't work, maybe you need to do it. And this flies in the face of people like, well, there's side effects. Do you know what the side effects of having Giardia for 20 years are? They're not good. Exactly. Sometimes comparing risk is important. And whoever I'm going to really piss people off, whoever had that stupid Hippocratic oath first, do no harm.
Was this like profit management or something? Because here's the deal. It's okay to take a small risk for a big benefit. The real Hippocratic Oath, it should be treat me the way you treat your dad, assuming you liked your dad.
And like, that's how it's supposed to be. And sometimes like, you know what, that's a risk we're taking. And you do that with peptides. I do that with peptides. And it's just a way of thinking. So like, if your gut won't heal the way mine wouldn't heal for many, many years, toxic mold causes the lining of the gut to shed, look at mast cells and look at parasites. And at what point do, for example, like coffee enemas, do they have any merit for...
like, um, parasites and or worms at all. I learned a really important lesson about coffee enemas. You have to cool the coffee off first. Yeah. So I've done a few of them and not a ton and allegedly they work cause they hold the bile ducts open and they cause the liver to make more glutathione. I just get high from this. It's like, it's the worst overdose of caffeine. Although many people don't get that.
If you have parasites around the bile duct, they're not going to let go. So the old, old school parasite cleanses would tell you take something like black walnut hole or some of these marginally effective herbs and then do the enema or do whatever other bile treatments you want to do. I'm just I'm not a fan.
I would say if you're going to do it, make sure there's no mold in your coffee. But I think there's many other ways to heal the liver that are probably less messy. Yeah, yeah. It's actually one of the interventions that I've never really explored myself. And I've been so focused on like, I'd rather supplement with like liposomal glutathione, take my Tudka, take my artichoke extract. Like I love supporting my liver with these compounds. And I've had such a
Like for me, at the very least, the bile acid, Tudka, like it causes, have you heard of the effect, a ghost wipe? A ghost wipe? Oh yeah, I have. That's funny. That just came up in French, right? It's like, yeah, when you don't actually, there's no, it's such a perfect stool that you don't even really, the toilet paper, there's no... I don't wipe anyway because toilet paper is full of toxins. So I'm just kidding. I do it. Yeah.
You see that video online, but there's this one I go, I don't wipe because of toxins. And everyone's like, Oh my God, that's gross. But I have heard of the ghost swipe. Cause there's a word in French for it. Right. I don't even know there was a word in French for it. Maybe there is. Yeah, there is. And it's funny. Cause there isn't one in English exactly for that. Uh,
So yeah, if your gut's working right, you have enough soluble fiber, right? And your liver is working, you should have clean poops. Yeah, no, definitely. That's a good sign. I've been on Tudco for about six years now because I really got focused on my liver and I had a liver fibrosis scan from the deliverance guys who make the supplement called deliverance.
And I had the youngest liver they've ever seen. It said there was no fibrosis and they say young, but basically the level of softness, like how much can you like poke at it without there being hardening? And they were just like, what are you doing? This is years of high bile flow and Tudka. So you definitely should keep taking that forever if you're into that. Yeah, you've got three years on me there. I've been taking it for three years straight. I think it's a long time though. It's still pretty good. And I think...
Like the reason why I started taking it, and I always sort of mentioned the importance of liver health because after university, I would go back to the traditional Chinese medicine bookstore. And every time I'd read these textbooks, they always emphasize something called liver chi stagnation. And just like, it's so important. Yeah.
Are you into the Chinese medicine kind of thing? Well, I studied naturopathy, but I was also amongst other TCM students. So I was trying to understand how they view the body. And I was fascinated with the pulse, the tongue, the iris, that sort of stuff. There's so much value in it. And they always tell me, it's your liver or it's your spleen. And what do I do about that?
And then the recommendations are all over the place. But I've had really powerful benefits from more of like the energetic side of those practices. I write a lot about that, the book that's just coming out now called Heavily Meditated. I talk about like one monastery in a remote part of China where they protect the emperors of China.
like the people who come out of the monastery and one of the nine living grandmasters taught me some stuff about people and all. And he'll look at you and poke you and stick needles in you and put a cup over there and weird stuff happens, but it's always hard to know, like, is that my liver? And the way they describe how it's linked to like three to 5am wake ups or things like that, or like linked to emotions that always, that always fascinated me in that regard.
Yeah, there's a lot that Western medicine doesn't understand. And it's because as a biohacker, and before that, a computer hacker, like systems are what I work with. And if you were to take a pharmaceutical company, and just let them think the way they do, they say, well, I want you to discover bread. And they say, here, we got this. We tested the yeast, we baked it, we baked the flour, we baked the water, there was no such thing as bread.
Because the core belief that is unproven in big pharma is there must be one cause for a disease and only one medication can cure it. So every now and then they come out with medications that have two in them. But the general way of thinking is it's so reductionist that they'd be like, well, what's the one cause of hurting a thousand sheep? Right. And there isn't one cause. It's a whole bunch of things coming together together.
And it's a new way of thinking. And biohackers are running rampant over some of like the old school longevity things like the
like the A4M, the group that's been kind of doing the stodgy side of longevity medicine. And I see all these biohacking physicians, functional medicine doctors who are the next generation where they're seamlessly integrating lifestyle and peptides and pharmaceuticals, but they're so flexible about it because they're systems people instead of just, you know, oh, we just want to look at anti-aging.
So I'm encouraged by all the shifts that I see in the people who come to the biohacking conference.
Now, Dave, in terms of, I mean, speaking of systems, I mean, in what ways would you say AI is going to assist us in the healthcare space? AI is the coolest thing ever. It's going to let you have more knowledge and ask more questions than you ever could ask, even if you spent two and a half million dollars hacking yourself the way I have. And, yeah,
It's because you can upload all of your labs and say, what do I miss? What do I need to know? And you can actually, if you've downloaded your data from 23andMe and deleted it from the service, you can just take the file and dump it into whatever AI you like and say, tell me about my genetics. And then I'll just tell you what's going on. Like it'll answer almost any question. And I have been able to unpack some things in the last six months that would have taken me
like weeks of deep research and I could do it in 20 minutes. One good friend who's actually speaking at the biohacking conference, she's had cyclical vomiting for 20 years. This means about every six weeks for three days, she throws up every 20 minutes. And it's a little bit rough, right? I mean, that's a traumatic experience.
And it would have taken me a week to figure it out for her in the normal biohacking course of things. As it was, it was 20 minutes because I was, okay, got it. I know what you're deficient in. We know how to do that. We know the other steps of this. And so put together a protocol and literally within two days,
She's like, I got my brain back. Like, why? And she's actually mad. Why has no doctor ever done this? You know, it's been all this time. It's because they weren't biohackers, right? Because they were looking at this as a disease versus a systemic problem. Reductionist.
And the view that I've come to after all this time in longevity is that if you start biohacking to solve a problem, you will always become interested in longevity because I have my energy back. I'm going to live a long time and you're going to want to learn how to be happy. And that's a consciousness thing. So in that book I was showing you earlier, it's just coming out like, like May 20th in heavily meditated. It's a mitochondrial consciousness book. There you can see it. And, um,
What I'm proposing in the book is that the mitochondria are the foundational elements of your ego and that they are the first line interface to reality. And so the way your mitochondria sense reality is the way you sense reality. And it's a fundamental reason we meditate or we do breath work or we do psychedelics and all these other things that are techniques for basically accessing the control panel for mitochondria. So yeah.
And if you look at this, it's incredibly cool because you can use peptides the way that you're such an expert in to manipulate the mitochondria, which then manipulates your reality. And here's how it works. A signal happens, like I clap my hands, right? And you know, it had to go through the internet and it got to your ears and then you heard it. But the reality is after it hit your ears,
your auditory processing system didn't get a signal for a third of a second because the mitochondrial networks in your body held onto the signal to decide whether they were going to tell you about it. So they're running a filter on reality and they're,
I say a third of a second because we can measure it in neuroscience. And heavily meditated is based on 10 years of running a neuroscience clinic that does brain upgrades for billionaires and CEOs. So a thousand people's data, like, well, what works for meditation? What works for resolving these mitochondrial network detections of threat things? So here's how mitochondria make decisions about the world. And then I want you to tell me what you would do to shift this. So the first thing is,
is fear. If something is scary, run away from kill or hide. That's going to get nine times more focus and energy than anything else. Or if you meditate six times more. So fear first.
Okay. Once you go, it's not scary. The next one is food because bacteria want to eat everything just like all life on earth. And my evidence for that, a third of the average person's thoughts every day are about tacos or whatever you like, like literally a third what's for lunch. So fear of food. The next F word is one involved with PT 141. Do you know that one?
like it's related to reproduction i don't know you almost dropped an f-bomb on your own show fertility is what i was i thought you'd say like the f-word the f-word i was trying to check the adjective version of the f-word you know so fear food and uh the other f-word in order so all life on earth i don't care if you're a slime mold or a politician or a tree or whatever it's that same thing so is there anything you've ever done you're ashamed of that wasn't one of those three
Fear, food, or fertility. It's always coming back to at least one of those. It always does. No one I've ever met has named something that wasn't. So good news. They're a separate consciousness. That's not your brain. It's a distributed network inside your body filtering reality based on those rules. And the good news is if you don't waste all of your mitochondrial energy on those first three, the next one is friend because we're wired to be kind to each other, take care of the environment around us to form an ecosystem.
And the final F word is for personal development is forgiveness. It's like, that's how you go back and you reduce the amount of fear. So my whole mission with heavily meditated is guys get as much mitochondria energy as you can. And that's something we know we can talk about peptides and all the things around biohacking that we both practice more energy that lets you overcome fear, or you can have less fear.
And a reflection of fear is inflammation, right? And they could have hunger. You can, you can reduce hunger and turn it into nourishment. So like, what are the peptides that would reduce hunger? The GLP one. Oh yeah. I've noticed you had something on Instagram. I saw about a rather route ride. Oh yeah. Yeah. Yep. So that would be an example. Take some of that. Like you mean I hacked my consciousness because no, I'm no longer using a third of my thoughts on food. Yeah. So now it's like an energy, it's like an energy sparing effect.
Yeah. A consciousness sparing effect. It's consciousness sparing. So like now I have more energy to deal with fear. If I need to, I overcome that. And now I have more libido. And if there's not, if that's not happening, get yourself some PT 141 or Milano 10 to solve that problem right away. And it turns out libido is what you could call chi or life force energy. So you can channel it into porn or you can channel it into anything.
altered state experience. And I write about that and heavily meditated too. So if your libido is low, your life energy is low. If your libido is high, you can change things in the world. Testosterone is a reflection of that. So it's really weird how we have this connection of peptides and nutritional substances and our actual interface to the world. And your job is less fear. So number one, more energy, number two, less fear, more nourishment and less hunger. And then you're
What's going to happen after that appropriate and nourishing interactions because humans who are lonely and we'll just say unsatisfied were miserable. Right. And it doesn't do good things for us. But you have enough energy. You actually have conscious altered states like spiritual experiences in the bedroom.
And from there, it goes down to you have so much left for your community. And that's how we make the world a better place. But it starts with mitochondrial energy at the beginning. And each of the big F words I just talked about, like you know how to hack those with peptides.
And there's also breathwork and psychedelics and all the stuff that I talk about with BDNF and whatever else. But the framework is interesting. At least I think it is. I like that. I really do. I think it's a nice symbiotic relationship between those sort of different areas. You've got the fear, the food, the fertility. I'm curious to know about how legacy might fall into that. Like,
Because some, I mean, I have a huge goal, like, and I'm sure you have many, many, you know, big, long lasting legacy type missions and goals like that. I wonder where that would fit into that sort of picture. Yeah.
So I have, in addition to the normal longevity stuff I talk about, I've been traveling around the world and studying with gurus and in weird monasteries and doing all the strange stuff. And I share a lot of that in this book because I couldn't bring too much of that in at the start of the biohacking movement because it was already weird enough to put butter in coffee and put on the true dark glasses and all the weird stuff that biohackers now are known for. Yeah.
So you're asking, actually, you're asking about like a legacy, like, you know, once you, so, so there's, there's five things people do to deal with the first F word, which is fear of death.
And one of them is to try and create legacy. And Achilles is the most famous for that in the Greek myths. He had a choice of going home and being a farmer or going off and basically dying in battle and becoming immortal through his name.
So this is one of the ways we subconsciously protect ourselves from death is through that. And we do it through also reproduction. So you can fend off death by living forever through your genetics, like the Elon Musk strategy of as many kids as you can have. And he's right, by the way, the world is very, very low on babies. And hey, why not if you're Elon? So
Those are a couple of the strategies. The other one is to do the kind of processes that aren't heavily meditated to the point where you realize that everyone who's born dies and that there's nothing to be afraid of there. So for me, surprisingly, legacy is not at all a part of my strategy. I have no expectation anyone will know my name 100 years after I'm dead. In fact, can you name the fourth president of Australia? No. Or the US? Nope. Me either, because it doesn't matter. They're dead.
Right. So when I'm dead, I'm dead. Right. Like maybe some of the changes I've worked in society will continue on and evolve and grow. That's the reason I didn't trademark the word biohacking. That's why it's in the new the dictionary is a new word in 2018 because I didn't keep it for myself. I do not have a goal of feeding a billion people. I do not have a goal. Like, look, I want to help the people want help.
And I want to do a very good job of teaching them. And I'd like to make enough money along the way to be comfortable and happy and make enough money to actually do the change in the world I want. That's it. Like, I like my, you know, my loved ones to love me. But it's not about numbers. It's about seeing the change that I want to see in the world because humanity needs an upgrade or we're probably going to die. Like the species will die. So it's not like we can't do something about it. We just might as well do something now. Yeah.
I mean, fertility, like across the board, it's scary how like rapidly that's. Did you know that was my first book ever? It was called The Better Baby Book. No. My mother of my children was infertile. She's a medical doctor and they said, you'll never have kids. And I'm like, fuck that. So it took five years to write the book, but we created a nutritional protocol and supplements and restored her fertility, had two kids at 39 and 42 years.
with no IVF. And after I wrote that book, I never again had any worry about the population problem. There is no population problem. The fertility rate is plummeting. And that was, I think, 14 years ago. And people still read that book and have babies with it. And the problem is,
When I was 30, actually, how old are you? I'm young, man. I'm 20, 28. Oh, nice. Dude, you're killing it. I love this. So you're 28. So when I was 28. I look about 40. So let's just say when I was 28 or 30, it doesn't really matter. Our conversations were, man, I hope she doesn't get pregnant.
Like literally that was the fear. Yeah. Right. And now it's, I hope I can get pregnant. Yeah. And I have lots of, lots of 30 year old friends. They're like, I'm going to freeze my eggs. Or my doctor just told me I might not be able to have babies. And you go back to Zoranone and microplastics and,
And circadian stress from light bulbs is a major issue. You know, TrueDark makes these glasses that block some blue but not all the sleep glasses we make. People have been knocking them off for a while, but what we do is different because we know exactly which narrow bandwidths of light are screwing with our central timing system, which is what controls light.
fertility to a large extent. So it's amazing what a dark bedroom will do. And maybe you need some DSIP, right? One of the peptides that doesn't do anything for me, but for some people, it seems to help their sleep. So all of these are modulatable with signaling molecules, with nutrients, with lifestyle practices, and just with understanding what are the inputs that are messing with you. And it's the crappy carbs, it's the plant toxins, it's the manmade toxins, and it's the junk light.
Right. And then it's the social stress. And then, oh, and also we, it's the politicians. You should always put them in as causes of aging, but yeah. Going back to the kids at, you said 39, 42. Yeah. That was her age. Yeah. Yeah. So that was like, what were doctors saying back then? Were they like very pessimistic about it? Like they were just putting juts. I remember she, she was a doctor. So yeah.
I didn't care what the doctor said. I wasn't interested. We just drew our own labs. In fact, we started a lab testing company that could look at white blood cell proliferation in response to environmental toxins. So we could look at, do you actually have Lyme disease or something else? Or are you having an allergic reaction to an implant? It was, I think, the second direct-to-consumer lab testing company in the US. And
I learned a lot about what was really going on in the medical world back then. And so, yeah, the doctor said, you can't. And it's like, well, let's fix your thyroid. Let's fix your hormones. Let's get you off the soy milk and the flax seed that everyone says is healthy. Let's remove all the mold toxins and all the heavy metal toxins. And when all of that stuff lined up, magically fertility goes up.
It's just simple. Like just get, get healthy and then fertility follows. It's like it. The thing is get healthy works for most people. For me, when I weighed 300 pounds, dude, I went to the gym 90 minutes a day, six days a week for 18 months straight. And I never lost a pound. I mean, I had like, I, it didn't matter. It was my top priority and I just hammered it out and I finished it. Same size belt.
And, yes, I was stronger, but I was way over trained. I'd been on a low fat, like semi vegetarian diet. I had zirillinone in me. You can't lose weight on that stuff. My thyroid was almost undetectable. And I found out my testosterone levels were lower than my mom's.
Thank you, mold toxins and obesity. So with that, you can't just get healthy because you got to figure out why those are happening. And for me, it was mold toxins and heavy metals, as well as I think some genetic stuff that I dealt with, like methylation issues. So unpacking it can be hard. But guess what?
If I would have just sat down for four hours with any of the modern AI tools and described all my symptoms and said, act like a functional medicine doctor and tell me in stack ranked order what you think is most likely wrong and what to do about it, I would have got a list. Instead, what I did, I went to the doctor when I was maybe 25 and he said vitamin C would kill me, literally. And I said, what about Linus Pauling? And if you're listening, you might not know, but you should know if you're a doctor.
The only guy to get two Nobel prizes, he took 90 grams of vitamin C a day. By the way, I don't recommend that. It's going to raise your oxalate, but still.
Vitamin C isn't going to likely kill you. So I fired the doctor and I read every book. I studied every night for four hours until I fell asleep at my desk learning mitochondrial biology. And I called a doctor and I said, I have one of these seven conditions in this order. And I want this lab from this company and I want this treatment plan if I have it. And she just looked at me because I was angry and arrogant. And she looked at me and she said, would you at least allow me
To help you order the list. And I said, okay. And so she thought he had Lyme disease, which I have since learned is a symptom of toxic mold exposure. No one gets Lyme. Actually, I can't say no one. Less than 10% of people. And that's genetic. Like that's proven that number out of UCLA. Less than 10% of people who think they have Lyme actually have just Lyme. The rest of them, they have toxic mold that took out their immune system. You heal the mold, the Lyme goes away and it's out.
So I had Lyme maybe, but when I got rid of the mold, the Lyme cured itself.
And that whole process was so nasty and so expensive and just so much suffering that you realize, just get healthy. If you're dealing with, I don't know that it's metals or mold. The cool thing is AI knows. And you just say, ask me all the questions you need to know. And if it says, hey, did you have like weird, like sudden nightmares or weight gain after you moved to a new environment? It's like, ding, ding, ding, you have mold.
And you can say, no, I didn't really have that. But I live next door to a smelter. Well, ding, ding, ding, you have metals. And then you know where to spend your lab dollars. Because otherwise, yes, I made $6 million when I was 26. Thankfully, I did also lose it when I was 28. Not so thankfully. But I spent as much as it took to fear it was wrong and reverse that.
All of those problems that took about a half a million dollars and the rest of it. I'm like, why would I stop? I'm just going to upgrade. I'm going to increase my IQ and fix my brain and do all these other crazy things. Those were not necessary. That was longevity and fun and biohacking, but it cost me a half a million and it should have cost me $500. I just didn't know where to go and neither did my doctors. It's incredible.
Dave, if you had to leave my audience with like one final message or something that you really want to like put out to the world. This is straight out of heavily meditated and it's like the hardest thing to learn. And it's been my greatest struggle. And I think I'm there. If anything triggers you.
It means you're carrying a loaded gun. Now, you're in Australia, so that's illegal. Just kidding. But it does mean you're carrying a loaded gun. And it also means if I can trigger you because I made a joke about vegans or whatever, it means that I'm in charge of your nervous system.
So your number one goal as a biohacker is to learn how to go in to your control panel and turn off the alerts that keep coming up. Because if a troll online says bad things about you and it actually affects you in any way, you have an unresolved problem.
threat detection system inside your mitochondria that says criticism equals death and it changes your physiology and it wastes your peptides and wastes your hormones and it wastes your electrons and it's not okay so step one you get all your energy back do all the cool biohacks step two reprogram your mind and your body to not give you stress signals from things that aren't stressful
And that's been God, six months of my life with electrodes on my head. That's why like guys read heavily meditated. It's not a meditation book. It's every technology, every technique that we know of that lets you enter specific altered states.
In order to achieve certain goals. And the number one thing is stop wasting mitochondrial reserve on being mad at your mother-in-law or the person who cut you off in traffic or whatever the thing is, that's your button, right? Get rid of it all. And man, your business explodes, your relationships improve, and it's so much easier. And it's like a mix of biology and psychology.
I'm not even going to call it psychology. We'll call it spirituality. And ancient lineage stuff is just throughout the book. But biohacking uses data to prove that ancient knowledge is real or sometimes not.
Love that. Really, really love that. Well, Dave, thank you so much for featuring on the podcast. If my audience wants to check out the conference, I mean, your upcoming events, things like that, you're always traveling the world. You're doing so many exciting things and projects. What's the latest things? I mean, the up and coming events you've got, you got the conference in Texas. That one's biohackingconference.com. That's a big one.
We do 40 Years of Zen, the brain upgrade thing for CEOs every week in Seattle.
And we're coming up in October, we're doing something called the Business of Biohacking Conference. And this year, we should have about 200 entrepreneurs in the space where I teach you how to do what I did to grow Bulletproof to 140 million a year in revenues. So I bring in top names in business who've advised me, and then we sit there and we help you shape your business and learn all the things you need to know.
it's my belief that biohackers and longevity people we actually can save the world and to do it we have to be better at business than Pfizer yep that's a valid valid and fair statement thank you so much that's worth a trip out you should come out for that one I'd love to I'd love to we'll have to um we'll connect connect um further but
Anyway, thanks for listening in, guys. If you did enjoy today's podcast, please do leave it a five-star review. That always does help with the algorithm. And that's it for me today. I look forward to seeing you in the next episode. Hi, I'm Adam Grant, host of the podcast Work Life. For over 20 years, Paylocity has been simplifying work with innovative solutions that teams love, like On Demand Payment, which offers employees access to wages prior to payday,
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