We're sunsetting PodQuest on 2025-07-28. Thank you for your support!
Export Podcast Subscriptions
cover of episode Dr. Chris Palmer: Diet & Nutrition for Mental Health

Dr. Chris Palmer: Diet & Nutrition for Mental Health

2022/11/21
logo of podcast Huberman Lab

Huberman Lab

AI Deep Dive AI Chapters Transcript
People
A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
C
Chris Palmer
Topics
Chris Palmer: 本人从自身经历出发,讲述了饮食对精神健康的影响。起初,作者饱受精神疾病和代谢综合征的困扰,尝试各种治疗方法无效。后来,作者尝试了阿特金斯饮食,代谢综合征症状完全消失,并且情绪、精力、注意力和睡眠质量都得到了显著改善。随后,作者将生酮饮食应用于临床实践,治疗多种耐药性精神疾病,取得了显著疗效。其中,一位患有精神分裂症的患者在采用生酮饮食后,其精神分裂症症状自发缓解,体重减轻,生活质量显著提高。 作者认为,生酮饮食之所以有效,是因为它能够刺激线粒体自噬和线粒体生物合成,改善线粒体功能,从而改善大脑健康。生酮饮食可以改善神经递质水平、葡萄糖代谢、基因表达、肠道微生物群等,从而对精神健康产生积极影响。 作者还强调,生酮饮食并非一成不变,需要根据患者的具体情况进行调整,例如体重、症状、依从性等。对于肥胖患者,主要目标是限制碳水化合物摄入;对于体重正常或偏瘦的患者,则需要增加脂肪摄入。 作者还讨论了生酮饮食与间歇性禁食的结合,以及生酮饮食对酒精依赖症患者的影响。研究表明,生酮饮食可以减少酒精戒断症状和对酒精的渴望。但是,生酮饮食会增加血液中的酒精含量,因此生酮饮食的酒精使用者应减少饮酒量。 最后,作者还讨论了生酮饮食对女性激素水平和生育能力的影响,以及对阿尔茨海默病患者的潜在疗效。虽然目前缺乏大型临床试验数据,但一些小型研究表明,生酮饮食可以改善阿尔茨海默病患者的认知功能和生活质量。 Andrew Huberman: 作为访谈者,Andrew Huberman 博士对 Chris Palmer 博士的研究工作进行了深入的探讨和评价。他强调了饮食对精神健康的重要影响,以及生酮饮食在治疗精神疾病方面的潜在价值。Huberman 博士还对生酮饮食的机制、适用人群、潜在风险以及与其他治疗方法的结合进行了深入的探讨。他特别关注了生酮饮食对线粒体功能、葡萄糖代谢、神经递质水平以及肠道微生物群的影响。Huberman 博士还与 Chris Palmer 博士讨论了生酮饮食在治疗阿尔茨海默病和酒精依赖症方面的应用,以及生酮饮食与间歇性禁食的结合。此外,Huberman 博士还对生酮饮食的依从性问题、以及生酮饮食对男性和女性激素水平和生育能力的影响进行了探讨。

Deep Dive

Chapters
Dr. Chris Palmer discusses his personal journey and the history of his work in exploring the relationship between nutrition and mental health. He shares his experiences using diet to treat various psychiatric disorders and mentions his book, "Brain Energy."
  • Dr. Palmer's personal experience with mental illness and metabolic syndrome led him to explore nutrition's role in mental health.
  • His clinical experience using diet to treat treatment-resistant mental disorders showed remarkable results.
  • Dr. Palmer emphasizes the importance of metabolic disorders in mental health and improving treatment for various conditions.

Shownotes Transcript

My guest this episode is Chris Palmer, M.D.), a board-certified psychiatrist and assistant professor of psychiatry at Harvard Medical School). He explains the important connection between nutrition, metabolism and mental health and his pioneering work using the ketogenic diet to successfully treat patients with various mental illnesses, including depression and schizophrenia. Dr. Palmer explains how the ketogenic diet is an evidenced-based treatment for epilepsy, mimics the fasted state and can offset the cognitive decline in Alzheimer’s. He describes the key roles of mitochondria in mental health, how certain conditions likely arise from mitochondrial dysfunction, and how low-carbohydrate diets increase mitochondrial turnover to improve mental health. He also explains how low-carbohydrate diets positively impact the gut microbiome and weight loss, important risk factors for mitochondrial health such as marijuana and alcohol, and the best way to increase circulating ketones depending on individual needs. We also cover how a ketogenic diet impacts mood, sleep, and fertility. Dr. Palmer’s work stands as a revolutionary approach to mental health and disease that, given the prevalence of mental health challenges, should be of interest to people of all backgrounds and ages.

For the full show notes, visit hubermanlab.com).

Thank you to our sponsors

Athletic Greens: https://athleticgreens.com/huberman)

LMNT: https://drinklmnt.com/huberman)

Supplements from Momentous

https://www.livemomentous.com/huberman)

Timestamps

(00:00:00) Dr. Chris Palmer, Mental Health & Metabolic Disorders

(00:03:42) Sponsor: LMNT

(00:07:18) Nutrition & Mental Health

(00:20:43) Low-Carb Diets & Anti-Depression, Fasting, Ketosis

(00:27:52) Schizophrenia, Depression & Ketogenic Diet

(00:33:58) Sponsor: AG1

(00:35:38) Psychiatric Mediations, Diet Adherence

(00:42:35) Highly Processed Foods, Ketones & Mental Health Benefits

(00:46:51) Ketogenic Diet & Epilepsy Treatment

(00:56:10) Ketogenic Diet & Mitochondria Health

(00:57:05) Nutrition & Benefits for Neurologic/Psychiatric Disorders

(01:05:44) Mitochondrial Function & Mental Health

(01:15:12) InsideTracker

(01:16:23) Mitophagy, Mitochondrial Dysfunction, Aging & Diet

(01:25:09) Neurons, Mitochondria & Blood Glucose

(01:31:54) Obesity, Ketogenic Diet & Mitochondria

(01:40:00) Mitochondrial Function: Inheritance, Risk Factors, Marijuana 

(01:46:34) Alcohol & Ketogenic Diet

(01:55:21) Brain Imaging, Alzheimer’s Disease & Ketones

(02:01:05) Exogenous (Liquid) Ketones vs. Ketogenic Diet

(02:06:27) Neuronal Damage, Ketones & Glucose 

(02:10:16) Alzheimer’s Disease, Age-Related Cognitive Decline & Ketogenic Diet

(02:23:45) Ketogenic Diet & Weight Loss

(02:35:47) Ketogenic Diet & Fasting, Hypomania, Sleep

(02:46:37) Low Carbohydrate Diets, Menstrual Cycles, Fertility

(02:52:23) Obesity Epidemic, Semaglutide & GLP-1 Medications 

(03:01:01) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Social Media

Title Card Photo Credit: Mike Blabac)

Disclaimer)