We're sunsetting PodQuest on 2025-07-28. Thank you for your support!
Export Podcast Subscriptions
cover of episode Dr. David Anderson: The Biology of Aggression, Mating, & Arousal

Dr. David Anderson: The Biology of Aggression, Mating, & Arousal

2022/9/12
logo of podcast Huberman Lab

Huberman Lab

AI Deep Dive AI Chapters Transcript
People
A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
D
David Anderson
Topics
Andrew Huberman: 本期节目探讨了情绪与状态的差异,以及侵略性、交配和唤醒等行为的神经生物学机制。重点关注了不同类型侵略性的神经环路基础,以及激素在侵略性行为中的作用。 David Anderson: 情绪应被视为一种内部状态,它改变大脑的输入-输出转换。情绪状态具有持久性、强度和泛化性等特征。唤醒状态并非单一,而是存在多种行为特异性的唤醒状态,例如性唤醒和攻击性唤醒。侵略性行为可以分为进攻性攻击、防御性攻击和捕食性攻击,它们涉及不同的神经环路。下丘脑腹内侧核(VMH)参与进攻性攻击行为的产生,而恐惧行为则由VMH上部的区域控制。侵略性行为受多种激素的影响,包括雌激素、孕激素和睾酮。雌性小鼠的侵略性行为主要发生在哺乳期。交配行为和侵略性行为之间存在重叠,下丘脑腹内侧核(VMH)和前视丘内侧区(MPOA)都参与这两种行为的调控。对MPOA中控制交配行为的神经元的刺激可以引发雄性小鼠的交配行为,即使在攻击行为发生时也是如此。疼痛调制在攻击行为和交配行为中发挥作用,下丘脑腹内侧核(VMH)和导水管周围灰质(PAG)参与其中。社会隔离会增加侵略性、恐惧和焦虑,这与促痛激肽(tachykinin)的释放有关。 Andrew Huberman: 本期节目还探讨了情绪与身体之间的联系,以及自主神经系统在其中的作用。迷走神经在情绪状态的表达中起着关键作用。

Deep Dive

Chapters
The podcast explores the distinction between emotions and states, viewing emotions as a type of internal state that changes the brain's input-output transformation. It emphasizes the neurobiological processes underlying states, focusing on their facets like persistence, intensity, and generalization.
  • Emotions are seen as internal states controlling behavior.
  • States have dimensions like persistence, intensity, and generalization.
  • Different types of arousal exist, specific to behaviors, not just a generalized arousal.

Shownotes Transcript

My guest is David Anderson, PhD, a world expert in the science of sexual behavior, violent aggression, fear and other motivated states. Dr. Anderson is a Professor of Biology at the California Institute of Technology (Caltech), a member of the National Academy of Sciences and an investigator with the Howard Hughes Medical Institute (HHMI). We discuss how states of mind (and body) arise and persist and how they probably better explain human behavior than emotions per se. We also discuss the many kinds of arousal that create varying levels of pressure for certain behaviors to emerge. We discuss different types of violent aggression and how they are impacted by biological sex, gender, context, prior experience, and hormones, and the neural interconnectedness of fear, aggression and sexual behavior. We also discuss peptides and their role in social isolation-induced anxiety and aggression. Dr. Anderson also describes novel, potentially powerful therapeutics for mental health. This episode should interest anyone wanting to learn more about mental health, human emotions, sexual and/or violent behavior.  

For the full show notes, visit hubermanlab.com).

Thank you to our sponsors

AG1 (Athletic Greens): https://athleticgreens.com/huberman)

LMNT: https://drinklmnt.com/huberman)

Supplements from Momentous

https://www.livemomentous.com/huberman)

Timestamps

(00:00:00) Dr. David Anderson, Emotions & Aggression 

(00:03:49) Sponsors: LMNT

(00:08:10) Emotions vs. States

(00:10:36) Dimensions of States: Persistence, Intensity & Generalization

(00:14:38) Arousal & Valence 

(00:18:11) Aggression, Optogenetics & Stimulating Aggression in Mice, VMH

(00:24:42) Aggression Types: Offensive, Defensive & Predatory 

(00:29:20) Evolution & Development of Defensive vs. Offensive Behaviors, Fear

(00:35:38) Hydraulic Pressures for States & Homeostasis

(00:37:24) Sponsor: AG1

(00:39:46) Hydraulic Pressure & Aggression

(00:44:50) Balancing Fear & Aggression

(00:48:31) Aggression & Hormones: Estrogen, Progesterone & Testosterone

(00:52:33) Female Aggression, Motherhood

(00:59:48) Mating & Aggressive Behaviors 

(01:05:10) Neurobiology of Sexual Fetishes 

(01:10:06) Temperature, Mating Behavior & Aggression

(01:15:25) Mounting: Sexual Behavior or Dominance?

(01:20:59) Females & Male-Type Mounting Behavior

(01:24:40) PAG (Periaqueductal Gray) Brain Region: Pain Modulation & Fear 

(01:30:38) Tachykinins & Social Isolation: Anxiety, Fear & Aggression 

(01:43:49) Brain, Body & Emotions; Somatic Marker Hypothesis & Vagus Nerve 

(01:52:52) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips

Title Card Photo Credit: Mike Blabac)

Disclaimer)