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cover of episode Dr. Kyle Gillett: Tools for Hormone Optimization in Males

Dr. Kyle Gillett: Tools for Hormone Optimization in Males

2022/12/12
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Huberman Lab

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Kyle Gillett: 青春期会影响成年后的身高、体型和身体组成。儿童肥胖可能会在青春期通过改变生活习惯来重置。青春期发育速度差异很大,过早进入青春期可能会降低成年后的身高。在青春期举重不会阻碍生长,但"脏增肌"会。"脏增肌"是指为了增加肌肉和脂肪而过量摄入卡路里。儿童肥胖会导致青春期提前到来,因为过多的脂肪会分泌瘦素,激活下丘脑,从而释放促性腺激素。由于儿童肥胖率的增加,男性和女性的青春期开始时间都在提前。青春期故意增重可能会限制身高,并阻碍长骨生长。长骨的生长主要与雌激素α受体有关。应该终生避免故意增重或快速增重。在医生的监督下,改变身体成分是安全的。人一生中存在两个青春期:第一个发生在生命最初三个月,第二个是通常所说的青春期。应该定期进行血液检查来监测激素水平,就像对新车进行全面诊断一样。如果血液检查免费且随时可得,建议人们在18岁时进行第一次激素水平检测。在青春期后期,当出现一些第二性征时,是进行激素水平检测的好时机。建议18岁的人每六个月进行一次血液检查,以监测激素水平。维持健康的激素水平需要关注饮食、运动和睡眠。维生素D有助于睾酮的产生,IGF-1有助于骨骼密度和生长。在青春期和二十几岁时,纯素食或纯肉食饮食对激素水平有害。膳食纤维对肠道菌群至关重要,必需脂肪酸对大脑发育至关重要。并非每个人都需要服用多种维生素,但它通常是安全的。对于超重的人来说,卡路里限制是有益的;但对于体重正常的人来说,卡路里限制会降低睾酮水平。卡路里限制会减少激素的构成成分,并导致分解代谢状态。除了饮食和运动外,压力管理、社交联系和人生目标对激素优化也很重要。为了优化激素水平,人们应该多进行户外活动、找到终身运动爱好,并找到人生目标。在优化行为和营养后,再考虑补充剂,最后是处方药。补充剂和药物是达到目标的工具,食物也是药物。 Ander Huberman: 很难客观地评估性欲、精力和恢复能力是否处于健康范围内。可以使用开放式问题和动机性访谈来评估男性的激素健康状况,并可以使用ADAM问卷进行筛查。患者在就诊结束时才透露重要的健康信息是很常见的。勃起功能障碍可能是心血管疾病的早期征兆。过度手淫和观看色情作品可能会降低性欲。频繁手淫和观看色情作品会抑制LH和FSH的释放,从而降低睾酮水平。多巴胺波浪池比喻说明了多巴胺水平的自然波动,频繁的刺激会降低多巴胺敏感性。每周3-4次剧烈运动,外加3-4次轻度运动,对激素健康有益。剧烈运动不应持续超过一小时。过度训练会导致睾酮水平降低,并可能导致卡路里赤字。睾酮替代疗法(TRT)并非总是必要的,尤其是在睾酮水平正常的情况下。对于睾酮和雌激素水平正常的年轻男性来说,服用外源性睾酮通常没有必要。服用外源性睾酮的理由因人而异,但对于年轻男性来说,好处通常不超过坏处。

Deep Dive

Chapters
This chapter explores the two puberty stages: the first three months of life and adolescence. It discusses how puberty timing and duration affect adult height, body composition, and the impact of childhood obesity and resistance training on growth.
  • Early puberty can decrease adult height.
  • Resistance training does not stunt growth, but dirty bulking can.
  • Childhood obesity causes early puberty.
  • It's safe to change body composition under a physician's supervision.

Shownotes Transcript

My guest is Kyle Gillett, MD), a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We discuss how to optimize male hormones using a range of nutritional and behavioral tools, exercise, and supplementation (including discussions on tongkat ali, fadogia agrestis, creatine, peptides and more). We explain how puberty and aging affect hormone levels, how to use bloodwork to monitor hormone levels, how hormone health impacts fertility, libido, hair loss, and prostate health, and describe behaviors that negatively impact testosterone levels. We also discuss how to approach prescription hormone therapies, including which biomarkers to monitor when using these approaches and how to optimize synergistic hormones (e.g., growth hormone and thyroid hormone) to support complete hormone health safely and rationally. Dr. Gillett offers numerous actionable tools that can be tailored to specific goals and age ranges to attain and maintain optimal levels of male hormones for overall health, well-being and longevity. 

For the full show notes, visit hubermanlab.com).

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Timestamps

(00:00:00) Dr. Kyle Gillett & Male Hormone Optimization

(00:03:56) Sponsor: LMNT

(00:07:43) Puberty: Height, Resistance Training, Childhood Obesity

(00:15:14) “First” vs. “Second” Puberty

(00:17:17) Hormone Optimization & Blood Work

(00:22:14) Diet, Exercise, Sleep & Hormones

(00:28:23) Hormones, Stress, Social Connection & Purpose

(00:32:19) Hormones, Supplementation & Medication

(00:34:08) Determining Individual Hormone Levels, ADAM Questionnaire

(00:40:35) Libido, Masturbation, Pornography & the Dopamine “Wave Pool”

(00:47:56) Sponsor: AG1

(00:49:46) Sustainable Exercise Regimen for Hormone Health

(00:58:12) Testosterone Replacement Therapy (TRT)

(01:01:02) Supplementation: Creatine & Hair Loss, Betaine, L-Carnitine & Allicin (Garlic)

(01:11:45) Vitamin D, Boron; SHBG & Free Testosterone

(01:15:34) Sponsor: InsideTracker

(01:16:39) Tongkat Ali (Eurycoma longifolia; Longjack) & Steroid Pathways

(01:22:09) Fadogia Agrestis & Testosterone 

(01:26:32) Optimize Growth Hormone & IGF-1: Diet, Fasting, Supplements & Exercise 

(01:31:52) Optimize Thyroid Hormone: Iodine & Goitrogens

(01:33:56) Peptides: Growth Hormone, Tesamorelin, Ibutamoren & Gut Microbiome

(01:42:06) Testosterone Therapy

(01:47:03) Prescriptions & Hormones: Human Choriogonadotropin (HCG), Clomiphene

(01:52:56) Testosterone Therapy + HCG, Fertility & Temperature

(01:55:30) Hormone Health Q&A: Marijuana, Nicotine, Cycling, Pelvic Floor, Alcohol, Fat

(02:06:08) Prostate Health & Tadalafil, Prostate Specific Antigen (PSA)

(02:09:56) Hair Loss & DHT; Turmeric & Curcuminoids

(02:18:13) BPAs, Phthalates & Hormone Health

(02:21:55) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac)

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