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cover of episode Essentials: How to Control Your Sense of Pain & Pleasure

Essentials: How to Control Your Sense of Pain & Pleasure

2025/6/19
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Huberman Lab

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A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
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Andrew Huberman: 大家好,在本期节目中,我将探讨痛感和快感这两种感觉。我认为,理解这两种感觉背后的神经机制以及我们如何主观地体验它们至关重要。我的皮肤是人体最大的感觉器官,它包含着大量的神经元,这些神经元能够检测各种刺激,如光触、温度和压力。这些神经元通过电信号将信息传递到大脑,大脑则根据我们的经验和一些先天的机制来解释这些信号,从而产生痛感或快感。我认为,我们的期望、焦虑程度、睡眠质量以及昼夜节律都会影响我们对痛感和快感的体验。例如,如果我们知道一个痛苦的刺激即将到来,我们的大脑会更好地准备,从而减轻疼痛感。此外,多巴胺和血清素等神经递质在调节快感方面也起着关键作用。总的来说,我认为理解痛感和快感背后的神经机制可以帮助我们更好地控制和管理这些感觉,从而改善我们的生活质量。

Deep Dive

Chapters
This chapter introduces the concepts of pain and pleasure, explaining that they exist on a continuum and are detected by our skin, the largest sensory organ. It discusses how our skin's neurons transmit information to the brain, which interprets these signals based on experience and hardwired mechanisms. Pain and pleasure are subjective experiences that are influenced by multiple factors.
  • Pain and pleasure are opposite ends of a sensory continuum.
  • Skin is the largest sensory organ, containing neurons that detect touch, temperature, and pressure.
  • The brain interprets sensory signals to create the experience of pain and pleasure, influenced by both experience and innate mechanisms.

Shownotes Transcript

In this Huberman Lab Essentials) episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity.

I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure.

Read the episode show notes at hubermanlab.com).

Thank you to our sponsors

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Timestamps

00:00:00 Pain & Pleasure

00:00:39 Skin, Appetitive vs Aversive Behaviors

00:02:10 Skin, Neurons & Brain

00:04:46 Brain Interpretation, Homunculus, Two-Point Discrimination Test

00:07:43 Pain & Pleasure, Subjective Interpretation

00:09:53 Sponsor: AG1

00:11:30 Tool: Pain & Expectation

00:13:08 Pain Threshold

00:14:46 Heat & Cold, Tool: Moving into Cold or Hot Environments

00:16:37 Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine

00:20:54 Acupuncture, Electroacupuncture, Pain Management

00:23:44 Sponsors: LMNT & Eight Sleep

00:26:36 Red Heads & Pain Threshold, Endorphins

00:28:32 Improving Pain Threshold, Dopamine

00:30:00 Pleasure, Dopamine, Serotonin; Depression, Anti-depressants

00:34:12 Pleasure & Pain Balance, Dopamine, Addiction

00:36:08 Recap & Key Takeaways

Disclaimer & Disclosures)

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