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cover of episode Essentials: Lose Fat With Science-Based Tools

Essentials: Lose Fat With Science-Based Tools

2025/4/3
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Huberman Lab

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A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
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Andrew Huberman: 我是神经生物学和眼科学教授,长期以来,人们在讨论减肥时严重低估了神经系统的作用。神经系统,包括大脑和脊髓以及它们与身体器官的所有连接,控制着一切。神经元与脂肪细胞相连,可以通过释放肾上腺素来调节脂肪的燃烧。 我们身体中不同类型的脂肪实际上都受到神经元的支配,这些神经元可以改变这些脂肪燃烧的可能性。因此,神经系统是这一过程的主要控制者,它在卡路里消耗方面起着重要作用。 肾上腺素(也称为肾上腺素)是神经元促进脂肪燃烧的关键物质。长期以来,人们认为当我们空腹、进行剧烈运动或处于压力状态时,体内游离的肾上腺素会促进脂肪氧化。但事实并非如此。刺激脂肪氧化的肾上腺素主要来自与脂肪细胞相连的神经元,这是一个局部过程。这意味着我们可以通过特定的运动模式和环境来刺激这些神经元,从而释放脂肪,促进脂肪燃烧,达到减肥的目的。 轻微的运动,例如活动身体,可以刺激神经元释放肾上腺素,从而促进脂肪燃烧。经常活动身体,即使是轻微的活动,也能显著增加脂肪代谢和脂肪减少。发抖本身会促进棕色脂肪的产热作用,从而加速脂肪燃烧。发抖会释放琥珀酸,琥珀酸作用于棕色脂肪,增加产热和脂肪燃烧。 间歇性冷暴露可以有效刺激颤抖,从而促进脂肪燃烧,但需注意安全,避免过冷。短时间运动时,空腹或非空腹运动对脂肪氧化影响不大;长时间中等强度运动时,空腹运动更利于脂肪燃烧。高强度运动时,空腹运动更早地达到脂肪燃烧的转换点。高强度运动后进行低强度运动,空腹状态下进行,可以最大限度地燃烧脂肪。 肾上腺素是各种运动形式促进脂肪燃烧的最终通路。运动前摄入100-400毫克咖啡因可以促进脂肪燃烧,但需注意咖啡因的耐受性。饮用马黛茶可以增加GLP-1,从而促进脂肪燃烧,尤其是在运动前饮用效果更佳。白藜芦醇和二甲双胍可以降低胰岛素水平,从而促进脂肪燃烧。坚持任何一种饮食计划都能导致体重下降,关键在于坚持。保持较低的胰岛素水平有助于促进脂肪燃烧。

Deep Dive

Chapters
This chapter explores the crucial role of the nervous system in fat loss, a factor often overlooked. It explains the processes of fat mobilization and oxidation, highlighting the importance of adrenaline (epinephrine) released from neurons directly connected to fat cells. This local adrenaline release is key to accelerating fat burning.
  • Nervous system governs fat loss, often overlooked.
  • Adrenaline (epinephrine) crucial for fat oxidation, released locally from neurons.
  • Fat mobilization and oxidation are two distinct processes.

Shownotes Transcript

In this Huberman Lab Essentials) episode, I explore how the nervous system impacts fat loss and how certain behaviors and supplements can accelerate fat burning.

I explain how non-exercise movements like fidgeting and shivering trigger adrenaline to boost fat metabolism. I also examine the impact of exercise intensity and fasted workouts on fat burning, and how supplements such as caffeine, GLP-1 and berberine can further support fat loss. These science-based tools go beyond traditional calorie counting to enhance metabolism and improve body composition.

Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday.

Read the episode show notes at hubermanlab.com).

Thank you to our sponsors

AG1: https://drinkag1.com/huberman)

David: https://davidprotein.com/huberman)

LMNT: https://drinklmnt.com/huberman)

Timestamps

00:00:00 Huberman Lab Essentials; Fat Loss

00:01:00 Calories In, Calories Out; Nervous System

00:02:57 Fat Burning, Nervous System & Adrenaline

00:06:31 Sponsor: David

00:07:45 Increase Adrenaline, Shivering, Tool: Fidgeting

00:11:25 Shivering & Fat Loss, White & Brown Fat

00:14:42 Tool: Deliberate Cold Exposure Protocol

00:16:43 Sponsor: AG1

00:18:38 High, Medium vs Low-Intensity Exercise, Exercise Fasted?

00:24:30 Tool: Exercise for Fat Loss; Adrenaline

00:27:18 Sponsor: LMNT

00:28:34 Caffeine, Dose, Exercise & Fat Loss

00:30:17 GLP-1, Yerba Mate, Exercise; Semaglutide

00:33:16 Berberine, Metformin, Insulin

00:34:12 Diet, Adherence, Carbohydrates & Insulin

00:35:52 Recap & Key Takeaways

Disclaimer & Disclosures)