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cover of episode The Shark Inside You

The Shark Inside You

2025/6/18
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Radiolab
AI Deep Dive AI Chapters Transcript
People
A
Aaron Matthew LeBeau
B
Becca Bressler
C
Caroline Burrell
H
Helen Dooley
L
Lula Miller
L
Lulu Miller
M
Martin Flanick
Topics
Becca Bressler: 我发现鲨鱼的免疫系统非常独特，特别是它们产生的抗体，可能为我们对抗癌症和其他疾病提供新的途径。我参观了Aaron Matthew LeBeau的实验室，亲眼目睹了他们如何利用鲨鱼的免疫系统来开发新型抗体，这些抗体具有高度的灵活性和靶向性，能够进入人类抗体无法触及的癌细胞角落。我对鲨鱼抗体在医学上的应用前景感到非常兴奋。 Lula Miller: 我对鲨鱼抗体能够对抗甚至自然界中不存在的物质感到震惊。这展示了免疫系统的强大能力和适应性。我意识到我们对鲨鱼的恐惧可能源于我们对它们的不了解，而实际上，这些生物可能拥有拯救我们的力量。 Aaron Matthew LeBeau: 我致力于利用鲨鱼的免疫系统开发新型抗体，用于治疗癌症和其他疾病。我通过给鲨鱼注射癌细胞或其他病原体，刺激它们产生特定的抗体。这些抗体具有高度的靶向性，能够精确地锁定癌细胞，并将其摧毁。我在小鼠实验中取得了显著的成果，并计划在灵长类动物身上进行进一步的研究。我相信鲨鱼抗体在未来医学中具有巨大的潜力。 Caroline Burrell: 我对抗体在免疫系统中的作用进行了深入的研究。抗体是免疫系统的重要组成部分，能够识别和中和各种病原体。人类的免疫细胞可以产生数十亿种不同的抗体，每种抗体都具有独特的靶向性。我相信鲨鱼抗体具有独特的优势，可能为我们提供新的治疗策略。 Helen Dooley: 我研究免疫系统的进化，试图了解免疫系统是如何发展到今天的。我们发现鲨鱼是地球上最古老的拥有像我们一样的免疫系统的生物。鲨鱼的免疫系统虽然在某些方面不如人类的复杂，但它也具有独特的优势，例如鲨鱼抗体的高度灵活性和靶向性。 Martin Flanick: 我在鲨鱼的免疫细胞中发现了一种新型抗体，这种抗体具有高度的灵活性，能够进入人类抗体无法触及的癌细胞角落。我相信这种新型抗体可能为我们提供新的治疗癌症的策略。我提出了“大白鲨假说”，认为鲨鱼免疫系统的进化与它们捕食带骨骼的动物有关。

Deep Dive

Chapters
The episode starts with the introduction of Aaron Matthew LeBeau, a scientist with a background in football who's now working with sharks. His lab, located in an unexpected place, houses a large saltwater tank with nurse sharks, which play a significant role in his research on ancient keys that could help fight diseases.
  • Aaron LeBeau's unique background combining football and science
  • Location of the lab: an unmarked bunker with a saltwater tank
  • Nurse sharks as a source of ancient keys for fighting diseases

Shownotes Transcript

This is episode three of Swimming with Shadows: A Radiolab Week of Sharks.

Today, we take a trip across the world, from the south coast of Australia to … Wisconsin. Here, scientists are scouring shark blood to find one of nature’s hidden keys, a molecular superhero that might unlock our ability to cure cancer: shark antibodies. They’re small. They’re flexible. And they can fit into nooks and crannies on tumors that our antibodies can’t.

We journey back 500 million years to the moment sharks got these special powers and head to the underground labs transforming these monsters into healers. Can these animals we fear so much actually save us? 

*Special thanks to Mike Criscitiello, David Schatz, Mary Rose Madden, Ryan Ogilvie, Margot Wohl, Sofi LaLonde, and Isabelle Bérubé.***EPISODE CREDITS: **Reported by - Becca BresslerProduced by - Becca Bressler and Matt KieltyOriginal music from - Matt Kielty and Jeremy BloomSound design contributed by - Matt Kielty, Jeremy Bloom, and Becca Bresslerwith mixing help from - Jeremy BloomFact-checking by - Diane Kellyand Edited by  - Pat Walters

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