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cover of episode Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575

Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575

2025/2/20
logo of podcast Passion Struck with John R. Miles

Passion Struck with John R. Miles

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John R. Miles: 我很好奇,自从我们上次谈话以来,在益智药的使用方面出现了哪些进展或见解? Dr. Scott Sherr: 益智药是一个很大的类别,人们对益智药的定义有很多不同之处。我一直对将益智药与对身心健康的全面理解相结合很感兴趣,这包括宏观层面(例如与人交谈或个人感受)和微观层面(例如负责优化细胞生物学的维生素、矿物质、营养素和辅助因子)。改善线粒体健康可以提高认知和身体能力,从而减少对益智药的依赖。 John R. Miles: 我知道你作品中人们最感兴趣的关键成分之一是亚甲蓝。 Dr. Scott Sherr: 亚甲蓝的剂量非常重要。低剂量亚甲蓝可以改善线粒体功能,而高剂量则具有抗感染作用,并能应对严重的急性线粒体压力。亚甲蓝可以帮助线粒体产生更多能量,并帮助身体排出能量产生的废物。胰岛素抵抗是线粒体功能障碍的主要原因。亚甲蓝在治疗神经退行性疾病和慢性疲劳方面显示出前景。对于神经退行性疾病,低剂量亚甲蓝的长期使用比高剂量短期使用更有效。慢性疲劳和脑雾等症状都与线粒体功能障碍有关,亚甲蓝可以改善这些症状。低剂量亚甲蓝可以长期安全地用于支持线粒体功能。与其他类型的益智药相比,亚甲蓝在长期使用方面更安全,因为它不仅能增强能量产生,还能辅助排毒。茶和咖啡等饮料含有抗氧化剂,可以长期安全地使用。规律使用低剂量亚甲蓝可以提高专注力、耐力和持久力。 John R. Miles: 你今天提到了 GABA,这将是我们今天的主要关注点。亚甲蓝、益智药和 GABA 之间有什么联系? Dr. Scott Sherr: GABA 是大脑中最丰富的抑制性神经递质,对于放松和休息至关重要。亚甲蓝可以预防去甲肾上腺素、多巴胺和血清素的分解,从而提升情绪和专注力。维持 GABA 系统平衡对于休息、恢复和消化至关重要,这在快节奏的现代生活中常常被忽视。焦虑、抑郁、睡眠问题等症状可能表明 GABA 缺乏。抑郁症并非血清素缺乏,GABA 缺乏可能是一个重要因素。GABA 缺乏可能与自杀风险相关,因为它会影响情绪调节和认知稳定性。GABA 在调节神经元活动方面起着关键作用,其失衡与癫痫等神经退行性疾病有关。镁和维生素 B6 是将谷氨酸转化为 GABA 的必需辅因子。癫痫发作的一个主要原因是谷氨酸毒性和谷氨酸过载,而增加 GABA 可以有效缓解。 John R. Miles: 你能更深入地解释一下 GABA 受体的结构和功能,特别是 GABA-A 和 GABA-B 受体,以及它们如何影响大脑活动吗? Dr. Scott Sherr: GABA-A 受体和 GABA-B 受体是两种主要的 GABA 受体,它们在调节大脑活动中发挥着不同的作用。酒精通过与 GABA-A 受体结合来增强 GABA 的活性,但这种作用是人工的,会导致耐受性和戒断症状。酒精会快速结合并解离 GABA 受体,导致 GABA 耗竭,并可能导致睡眠障碍。谷氨酰胺是谷氨酸的前体,谷氨酸是 GABA 的前体,补充谷氨酰胺可以帮助增加 GABA 的产生。压力会迅速消耗 GABA,因此管理压力对于维持 GABA 水平至关重要。培养有助于放松和休息的习惯对于优化 GABA 水平至关重要。长期处于交感神经兴奋状态会损害健康,培养副交感神经活动对于长寿至关重要。肠道健康和 GABA 水平失衡会影响情绪、压力管理和人生目标感。学习呼吸练习是优化 GABA 水平最简单有效的方法。直接补充 GABA 无效,应通过增强 GABA 受体活性来提高 GABA 水平。

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Shownotes Transcript

What if the key to unlocking peak performance and long-term well-being isn’t just about diet and exercise, but also about harnessing the power of oxygen, neurotransmitters, and cutting-edge health optimization tools? In this episode of Passion Struck, I welcome back Dr. Scott Sherr, a leading voice in hyperbaric medicine and health optimization. We break down the latest research and real-world applications of brain-boosting tools like methylene blue, nootropics, and GABA, the brain’s most abundant yet overlooked neurotransmitter.

Dr. Sherr takes us deep into the role of GABA in reducing stress, improving sleep, and boosting cognitive resilience. We also discuss how AI is revolutionizing personalized medicine and why biohacking could hold the key to unlocking human potential. If you’re looking for science-backed strategies to optimize mental clarity, brain function, and resilience, this episode is packed with insights you don’t want to miss!

***********For 10% off Just Blue, Blue Canatine, or TroCalm, go to https://troscriptions.com/) and use code passionstruck. **In the UK: https://www.xbrain.co.uk/product/troscriptions-blue-cannatine.)

Link to the full show notes:  https://passionstruck.com/dr-scott-sherr-on-gaba-the-hero-of-brain-health/)

Key takeaways:

  • Understanding GABA: The Brain's Unsung Hero
  • The role of Methylene Blue in Brain Health
  • The impact of Nootropics on Cognitive Performance
  • How GABA counteracts stress hormones like cortisol.
  • The impact of GABA on anxiety, depression, and epilepsy.
  • Enhancing mental clarity, memory, and focus for optimal brain function.

Connect with Scott Sherr: https://www.hyperbaricmedicalsolutions.com/integrative-hbot/scott-sherr)

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**Next on Passion Struck:**In the next episode of Passion Struck, John sits down with Katherine Morgan Schaffler, a renowned psychotherapist and author of The Perfectionist Guide to Losing Control, a Path to Peace and Power. Katherine challenges the conventional view of perfectionism, suggesting that it can be harnessed as a personal superpower rather than a flaw. Don't miss this enlightening conversation that could transform your relationship with perfectionism.

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