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cover of episode Assembloids: Recreating the Brain with Sergiu Paşca

Assembloids: Recreating the Brain with Sergiu Paşca

2025/5/2
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Sergiu Pașca
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Neil deGrasse Tyson: 我对这项研究感到兴奋,因为它代表着科学工具与目标的完美结合。我们终于拥有了与大脑复杂性相匹配的工具。 Chuck Nice: 类器官和组装体技术为研究大脑疾病提供了前所未有的机会,特别是那些难以在活体中研究的疾病。 Gary O'Reilly: 这项研究的伦理问题需要仔细考虑,特别是随着模型越来越接近真实大脑时。 Sergiu Pașca: 我的研究团队利用诱导多能干细胞技术(iPSC)创建了类器官和组装体模型,用于研究神经发育疾病,例如自闭症和癫痫。我们发现,这些细胞具有惊人的自组织能力,能够在培养皿中模拟大脑发育过程,甚至重现疼痛通路。通过这些模型,我们发现了Timothy综合征的潜在治疗方法,并正在开发更复杂的组装体模型,以研究更复杂的大脑疾病。我们也正在探索将这些模型移植到动物体内,以更真实地测试治疗药物的效果。伦理问题是我们工作的核心,我们始终确保获得患者的知情同意,并关注动物福利。

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How do you recreate a brain circuit in a dish, and what can it unlock about our minds? Neil deGrasse Tyson, Chuck Nice, and Gary O’Reilly explore the frontier of neuroscience with Stanford neuroscientist Sergiu Pașca, to break down stem cells, how the brain forms itself, and assembloids: self-organizing brain circuits.

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