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cover of episode The surprising truth about lectins

The surprising truth about lectins

2023/11/2
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ZOE Science & Nutrition

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J
Jonathan Wolf
W
Will Bulsiewicz
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Jonathan Wolf:许多人认为植物凝集素是有毒的、促炎的,会导致体重增加和肠漏综合征,这引发了人们的担忧。 Will Bulsiewicz:植物凝集素是一种抗营养物质,但一些抗营养物质实际上有益于健康。烹饪会破坏大部分抗营养物质,而且它们通常以少量存在,有助于维持营养平衡;因此,抗营养物质不太可能损害健康。植物凝集素是一种与碳水化合物结合的蛋白质,广泛存在于自然界中,包括细菌、真菌、单细胞生物和人体内,以及全谷物、豆类、许多水果、某些坚果和种子、一些乳制品和茄科蔬菜等食物中。 过量摄入植物凝集素会导致食物中毒,但前提是这些食物未经充分烹饪。1988年英国医院和2006年日本电视台的案例表明,未煮熟的豆类会导致食物中毒,但所有患者都在第二天康复。烹饪可以显著降低豆类中的植物凝集素含量,使豆类安全可食用。罐装豆类已经煮熟,因此无需担心植物凝集素问题。 关于植物凝集素的研究大多是在试管和老鼠身上进行的,而不是在人身上进行的,其结果不能很好地转化为人类。试管和动物研究的结果相互矛盾,既有研究表明其有害,也有研究表明其有益。 一项随机对照试验表明,高豆类饮食可以降低炎症、血压和胆固醇,并有助于减肥。大量研究表明,豆类摄入量与体重减轻、血糖控制改善、心血管疾病风险降低和结直肠癌风险降低有关。增加全谷物摄入量与冠心病风险降低、心血管疾病死亡率降低、癌症发病率降低、死亡率降低以及2型糖尿病发病率降低有关。 大多数美国人全谷物摄入不足,平均每周只食用少量豆类。目前没有研究支持低植物凝集素饮食对健康有益。声称通过减少植物凝集素摄入量而获得显著改善可能是安慰剂效应或排除了其他物质(例如FODMAPs)的结果。一项研究表明,对麸质敏感的人实际上是对果聚糖敏感,而不是对麸质敏感。 总的来说,只要不食用未煮熟的豆类,植物凝集素是安全的,并且对健康有益。许多关于植物凝集素有害的说法是基于选择性研究和逻辑谬误。一些人食用含植物凝集素的食物后出现症状,这可能是由于其他原因,例如FODMAPs。

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Lectins are a type of anti-nutrient that can interfere with the body's ability to use nutrients, but they are generally harmless and even beneficial in small quantities.

Shownotes Transcript

What are lectins, and are they dangerous? These “antinutrients” have come under attack and were recently the subject of a dietary fad fueled by a popular book. As always, there’s more to the story.

In today’s episode, Jonathan is joined by Dr. Will Bulsiewicz to dive deep into the world of lectins. They dissect questionable studies, debunk myths, and offer expert advice about how to approach foods containing these misunderstood compounds.

Will is a board-certified gastroenterologist with 14 years of experience. He’s also the New York Times best-selling author of Fiber Fueled and ZOE’s U.S. medical director. 

If you want to uncover the right foods for *your *body, head to joinzoe.com/podcast and get 10% off your personalized nutrition program.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide)

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Mentioned in today’s episode:

Lectins as bioactive plant proteins: A potential in cancer treatment) from* Critical Reviews in Food Science and Nutrition*

Plant-derived lectins as potential cancer therapeutics and diagnostic tools )from BioMed Research International

A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects )from the European Journal of Nutrition

Dietary legume consumption reduces risk of colorectal cancer: Evidence from a meta-analysis of cohort studies) from Scientific Reports

Intake of legumes and cardiovascular disease: A systematic review and dose-response meta-analysis) from Nutrition, Metabolism and Cardiovascular Diseases

Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study) from Clinical Nutrition

The effects of legume consumption on markers of glycaemic control in individuals with and without diabetes mellitus: A systematic literature review of randomised controlled trials) from Nutrients

Effects of dietary pulse consumption on body weight: a systematic review and meta-analysis of randomized controlled trials) from *The American Journal of Clinical Nutrition *

The "white kidney bean incident" in Japan) from Methods in Molecular Biology

Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity) from* Gastroenterology*

Is there a nutrition topic you’d like us to explore? Email us at [email protected]), and we’ll do our best to cover it. 

Episode transcripts are available here).