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cover of episode E57: Understanding Omicron, tech stocks plummet, VC's great resignation, Jack Dorsey's departure

E57: Understanding Omicron, tech stocks plummet, VC's great resignation, Jack Dorsey's departure

2021/12/4
logo of podcast All-In with Chamath, Jason, Sacks & Friedberg

All-In with Chamath, Jason, Sacks & Friedberg

AI Deep Dive AI Chapters Transcript
People
C
Chamath Palihapitiya
以深刻的投资见解和社会资本主义理念而闻名的风险投资家和企业家。
D
David Friedberg
美国企业家、商人和天使投资者,创立并领导了The Climate Corporation和The Production Board。
D
David Sacks
一位在房地产法和技术政策领域都有影响力的律师和学者。
J
Jason Calacanis
一位多才多艺的美国互联网企业家、天使投资人和播客主持人,投资过多家知名初创公司,并主持多个影响广泛的播客节目。
Topics
Chamath Palihapitiya:奥密克戎变体的出现及其对经济的影响值得关注;市场正在重新评估科技公司未来的增长潜力;通货膨胀已经成为一种持续的现象,难以逆转;一些风险投资家正在考虑退休,这与当前的宏观经济环境有关;当前的创业环境中,功利主义盛行,缺乏对客户、产品和团队的关注;许多在上一轮经济周期中赚取巨额财富的人,正在寻求更有意义的投资机会;美国需要改革移民政策,吸引更多高技能人才。 David Friedberg:奥密克戎变种的三个值得关注的方面:传播能力、免疫逃逸能力和严重程度;奥密克戎变种的突变数量之多使其与其他变种截然不同,甚至可能像一种全新的病毒;奥密克戎变种的出现可能与免疫功能低下的人体内病毒长期循环和突变有关,也可能与非洲其他地区缺乏病毒监测有关;奥密克戎变种传播速度极快,并且能够有效绕过疫苗或既往感染产生的免疫力。 David Sacks:早期对疫情的应对措施,包括封锁政策,在一定程度上避免了医院系统不堪重负;封锁政策的有效性存在争议,其效果可能被夸大;科技股下跌的主要原因是市场预期利率上升,这与通货膨胀预期有关;私募市场上的公司将面临融资挑战,因为公开市场的估值已经下降;当前的市场调整并非系统性风险导致,而是对高估值公司的重新定价;一些风险投资家在获得高额回报后选择退休,这可以理解;许多成功的风险投资家正在转向更有意义的领域,例如气候变化技术。 Jason Calacanis:通货膨胀已经成为现实,未来几年经济将面临阵痛;一些市场已经显示出通货膨胀压力减轻的迹象;供应链扭曲正在逐渐缓解,这可能导致通货膨胀压力在2022年减轻;美国政府调整了抵押贷款标准,这可能会刺激消费者支出。

Deep Dive

Chapters
The hosts discuss the Omicron variant, its mutations, and how it compares to other COVID-19 variants. They explore the potential impact of these mutations on transmissibility and vaccine efficacy.
  • Omicron has 30 mutations on its spike protein, making it significantly different from other variants.
  • The variant is seen as highly transmissible, with estimates of R0 ranging from 7 to 20.
  • Initial data from South Africa indicates high positivity rates but mild symptoms in most cases.
  • Policy responses to Omicron may affect economies more than the variant itself.
  • Vaccines and booster shots remain the most effective defenses against severe cases.

Shownotes Transcript

(0:00) Bestie Intro: Miami talk, gambling stories, Nancy Pelosi's retirement plans

(12:30) Understanding the Omicron variant

(24:49) Tech stocks plummet: why the selloff?

(33:44) Inflation: here to stay? What's the 10-year outlook?

(44:57) Anticipating a "Great Resignation" of successful VCs

(54:45) Tech people ruining Art Basel, comparing Bay Area / South Florida immigrant communities in terms of political activity, success of Indian-Americans in tech

(1:02:08) Mike Bloomberg donates $750M to charter schools

(1:07:52) Jack Dorsey's departure from Twitter, what it means for free speech

Follow the besties:

https://twitter.com/chamath)

https://linktr.ee/calacanis)

https://twitter.com/DavidSacks)

https://twitter.com/friedberg)

Follow the pod:

https://twitter.com/theallinpod)

https://linktr.ee/allinpodcast)

Intro Music Credit:

https://rb.gy/tppkzl)

https://twitter.com/yung_spielburg)

Intro Video Credit:

https://twitter.com/TheZachEffect)

Referenced in the show:

https://twitter.com/trvrb)

https://www.nejm.org/doi/full/10.1056/NEJMoa2115463)

https://twitter.com/erictopol/status/1466799350990839810)

https://twitter.com/Jason/status/1465037481187987457)

https://www.wsj.com/articles/china-set-to-create-new-stateowned-rare-earths-giant-11638545586

https://www.shippingandfreightresource.com/china-us-freight-rates-plunge-but-china-manufacturing-woes-create-new-headaches-for-shippers)

https://fortune.com/2021/08/09/lumber-prices-down-2018-levels)

https://twitter.com/rabois/status/1466816803418615812)

https://twitter.com/michelletandler/status/1465393612577853440)

https://www.wsj.com/articles/michael-bloomberg-why-im-backing-charter-schools-covid-19-learning-loss-teachers-union-11638371324)

https://www.technologyreview.com/2020/11/18/1012066/emtech-stage-twitters-cto-on-misinformation)

https://bariweiss.substack.com/p/twitter-is-about-to-get-way-worse)