We're sunsetting PodQuest on 2025-07-28. Thank you for your support!
Export Podcast Subscriptions
cover of episode Ozempic 101: Microdosing, PCOS, Fertility & Building Metabolic Health w/ Dr. Tyna Moore

Ozempic 101: Microdosing, PCOS, Fertility & Building Metabolic Health w/ Dr. Tyna Moore

2024/12/9
logo of podcast Pursuit of Wellness

Pursuit of Wellness
AI Deep Dive AI Insights AI Chapters Transcript
People
D
Dr. Tyna Moore
M
Mari Llewellyn
Topics
Mari Llewellyn: 本期节目讨论了GLP-1药物（如Ozempic）的益处、风险及个性化用药。GLP-1药物的益处不局限于减肥和糖尿病，它对身体多个器官系统都有影响，可以帮助减肥、改善多囊卵巢综合征（PCOS）和胰岛素抵抗。但GLP-1药物也存在风险，尤其对于代谢功能紊乱的人群，并会影响生育能力、慢性疼痛甚至成瘾性。许多人服用GLP-1药物的剂量过高，微剂量或周期性服用可能更有益。GLP-1药物可能对成瘾有积极作用，例如帮助解决无家可归人群的药物成瘾问题。对GLP-1药物的观点存在差异，需要保持开放心态，并参考相关研究。 Dr. Tyna Moore: GLP-1药物的益处不局限于减肥和糖尿病，它对身体多个器官系统都有影响。许多医生倾向于使用高剂量的GLP-1药物，而微剂量可能更有效。GLP-1药物在改善多囊卵巢综合征（PCOS）症状和青春期女性的囊性痤疮方面取得了初步成功。多囊卵巢综合征（PCOS）无法通过饮食在短期内完全逆转，需要多方面干预，母亲和祖母的健康状况会影响后代患多囊卵巢综合征（PCOS）的风险。GLP-1药物可以帮助改善代谢健康，从而减少对其他药物和严格饮食的依赖。低剂量GLP-1药物可以改善胰岛素信号传导、胰岛素受体敏感性以及线粒体功能，从而改善代谢健康。“瘦而胖”的人群也存在代谢健康问题，腿部和臀部肌肉发达有助于维持代谢健康。GLP-1药物可以调节肠道菌群平衡，改善肠道健康。人们使用Ozempic的错误方式包括剂量过高，导致肌肉和软组织流失，以及对纤瘦身材的过度追求。快速减肥可能导致肌肉和软组织流失，以及代谢功能紊乱。逐渐减量GLP-1药物，并关注其他健康指标，如肌肉质量和整体代谢健康。医生通常更倾向于使用低剂量的药物，患者可以与医生讨论剂量调整。GLP-1药物的剂量应根据个体情况进行调整，健康状况越好，所需剂量可能越低。周期性服用GLP-1药物可以保持受体敏感性。Ozempic、Wegovi、Mounjaro和Rybelsus都是GLP-1受体激动剂，但其作用机制和适应症略有不同。GLP-1药物通过影响多巴胺通路来帮助戒除药物、酒精和暴饮暴食等成瘾行为。但剂量过高可能导致快感缺失。

Deep Dive

Key Insights

Why did Dr. Tyna Moore start using GLP-1 medications outside of weight loss and diabetes?

Dr. Tyna Moore started using GLP-1 medications outside of weight loss and diabetes because of the extensive data showing their positive impacts on different organ systems of the body. She believed that these medications could benefit a broader range of health issues.

What are the benefits of low-dose GLP-1 medications for women with PCOS?

Low-dose GLP-1 medications can improve hormonal balance, reduce severe cystic acne, and help manage insulin resistance, which is a key driver of PCOS. They can also help normalize menstrual cycles and reduce overall inflammation.

Why are metabolic health concerns relevant to everyone, not just obese individuals?

Metabolic health concerns apply to everyone because 2018 data showed that 94% of US adults have compromised cardio-metabolic health, even before the lockdowns. Metabolic health isn't just about weight; it's about managing insulin resistance, inflammation, and other markers that can lead to chronic diseases regardless of body size.

How do GLP-1 medications impact the gut microbiome?

GLP-1 medications can shift the gut microbiome, favoring beneficial organisms and reducing pathologic ones. This can lead to improvements in bowel movements and overall gut health. However, rapid shifts can cause discomfort, nausea, and other side effects, which is why slow and low dosing is recommended.

What are the risks of using high doses of Ozempic for rapid weight loss?

High doses of Ozempic for rapid weight loss can lead to muscle loss, soft tissue loss, and long-term metabolic dysfunction. It can also bottom out blood sugar, induce anhedonia (loss of interest in activities), and lead to an unhealthy relationship with food and lifestyle.

Why is it important to individualize GLP-1 dosing?

Individualizing GLP-1 dosing is important because it allows for the optimal dosage based on each person's unique metabolic health, lifestyle, and goals. This approach can minimize side effects and ensure that the medication is effective without being overly suppressive.

How does GLP-1 help with drug and alcohol addiction?

GLP-1 medications impact the dopamine pathways, giving individuals more control over their addictions. They can help reduce cravings and improve mood, providing a leg up for those trying to overcome addictive behaviors. However, the dose and individual response are critical factors.

What are the key components of a comprehensive approach to using GLP-1 medications?

A comprehensive approach to using GLP-1 medications includes sleep optimization, strength training, stress management, and a healthy lifestyle. It's important to work with a doctor who understands the benefits and risks of individualized dosing and can provide ongoing support and adjustments.

What does wellness mean to Dr. Tyna Moore?

To Dr. Tyna Moore, wellness means freedom. She believes that without good health, one is limited by chronic pain and other health issues. Wellness is about having the autonomy to live a full, active life.

Chapters
Dr. Tyna Moore discusses the use of GLP-1 medications beyond weight loss and diabetes, highlighting their impact on various organ systems. She emphasizes the importance of microdosing and shares her personal journey and early successes with GLP-1s.
  • GLP-1s impact different organ systems.
  • Microdosing is crucial.
  • Early success stories focused on individuals and family members.

Shownotes Transcript

Ep. 157 On today’s episode of Pursuit of Wellness, Dr. Tyna Moore, a naturopathic and chiropractic physician with expertise in regenerative medicine, joins us to provide clarity on GLP-1 medications. With a background in metabolic health and chronic pain management, Dr. Tyna explains how GLP-1s can benefit individuals with weight loss goals, PCOS, and insulin resistance. She shares valuable advice on individualizing doses, understanding how these medications interact with insulin and muscle mass, and how to approach conversations with doctors about your dosage. We also cover the risks associated with Ozempic, especially in those dealing with metabolic dysfunction, and discuss how these drugs impact areas like fertility and chronic pain.

Leave Me a Message - click here!)

For Mari’s Instagram click here!)

For Pursuit of Wellness Podcast’s Instagram click here!)

For Mari’s Newsletter click here!)

For Dr. Tyna’s Instagram click here!)

For Dr. Tyna’s Website click here!)

**Sponsored By: **

  • The holidays are closer than ever, so make sure you order by December 16th to get their gift (or yours) underneath the tree in time! Visit Carawayhome.com/POW )to take advantage of this limited-time offer for up to 20% off your next purchase. Again that’s Carawayhome.com/POW) to get new kitchenware before the holidays. Caraway. Non-Toxic cookware made modern.

  • Visit BetterHelp.com/POW) today to get 10% off your first month. That’s betterhelp.com/POW).

  • Head to Manukora.com/POW) to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook!

  • Visit clearstemskincare.com) and use code POW at checkout for 20% off your first purchase. Again, that’s code POW for 20% off your first purchase on clearstemskincare.com).

  • The Fits Everybody collection is available in sizes XXS to 4X. You can shop now at SKIMS.com). After you place your order, be sure to let them know I sent you! Select "podcast" in the survey and be sure to select my show in the dropdown menu that follows. And if you’re looking for the perfect gifts for the whole family - SKIMS just launched their biggest Holiday Shop ever - also available at SKIMS.com)**. **

Show Links:

Episode Keywords + Tags (YouTube)

Health, Wellness, Fitness, Nutrition, Pursuit of Wellness, Dr. Tyna, Semaglutide, Microdosing, Weight Loss, GLP-1, Regenerative Medicine, Metabolic Health, Podcast Host, Peptide, PCOS, Obesity, Fertility, Social Media Influencers, Mucus, Mucinex, TikTok, Cystic Acne, Epigenetic, Infertility, Spironolactone, Androgen, Orthorexia, Peptide, Menstrual Cycle, Anti Inflammatory, Pharmaceuticals, Hormones, Insulin Signaling, Insulin Reception, Insulin Resistant, Metabolic Pathways, Waist Circumference, Skinny Fat, Muscle Mass, Toned, Lean, Arm Sculpting, Crohn's, Microbiome, Ozempic, Muscle Loss, Heroin Chic, Chain Smoking, Metabolic Dysfunction, Dosage, Individualized Dosing, Freedom, Chronic Pain

Topics Discussed

  • 00:00:00 - Introduction 

  • 00:03:54 - Dr. Tyna’s journey

  • 00:06:44 - Initial success stories

  • 00:07:54 - Fertility 

  • 00:09:20 - GLP-1’s and cystic acne

  • 00:16:22 - PCOS diagnosis

  • 00:21:09 - Low dose GLP-1 benefits

  • 00:29:18 - Who metabolic health applies to

  • 00:31:53 - Pick up the weights!

  • 00:34:41 - GLP-1’s and the microbiome

  • 00:37:20 - Ozempic mistakes

  • 00:41:49 - How Ozempic affects the body

  • 00:45:24 - Individualized dosing

  • 00:48:01 - How to talk to your doctor about low dosing

  • 00:52:56 - Cycling do’s and don’ts

  • 00:54:05 - Clarity around the different drugs

  • 01:00:01 - GLP-1’s and addiction

  • 01:02:46 - Dr. Tyna’s Ozempic Done Right University

  • 01:05:45 - Wellness to Dr. Tyna