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Fred Kaufman
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Mary Roach
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Tim Howard
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Wim de Vole
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Mary Roach: 我亲身参与了将手伸进活牛胃部的实验,这让我深刻地体会到胃部肌肉的强力收缩和内部环境的特殊性。胃部内部环境的温度、湿度以及食物的物理状态都给我留下了深刻的印象。这个体验与我在太平间或其他地方的经历完全不同,它让我对胃部的运作有了更直观的感受。 此外,通过对William Beaumont和Alexis St. Martin的故事的了解,我更加认识到早期对消化机制研究的艰难和突破。Beaumont的实验虽然在当时看来有些残忍,但却为我们打开了一扇了解消化系统运作机制的大门。 Tim Howard: 我将手伸进活牛胃部时,感受到了胃部肌肉强大的收缩力量,这让我对胃部作为消化器官的强大功能有了更深刻的认识。胃部内部环境的温度和湿度也给我留下了深刻的印象。 Jad Abumrad & Robert Krowich: 通过对William Beaumont和Alexis St. Martin故事的讲述,我们了解到在19世纪初期,人们对胃部消化过程知之甚少。Alexis St. Martin意外受伤后留下的胃部瘘孔,为Beaumont提供了前所未有的研究机会。Beaumont通过对St. Martin进行长达数年的实验,最终发现了胃液和酶在消化过程中的关键作用,并推翻了当时关于‘生命力’的理论。这不仅是医学史上的一个重大突破,也体现了科学探索的勇气和毅力。 此外,我们还探讨了人体消化系统的整体运作,以及肠道细菌在消化过程中的重要作用。 Fred Kaufman: 我认为胃是人体内神奇的转化中心,它将食物转化为我们自身的一部分。同时,人体是一个环面结构,因此胃部看似在我们体内,实际上却始终处于我们体外。这个独特的视角让我们对自身有了更深刻的理解。 Wim de Vole: 我设计的这个巨大的机械装置模拟了人体消化系统的运作过程,从食物进入到排出。这个装置清晰地展示了食物在各个消化器官中的变化过程,以及肠道细菌在消化过程中的重要作用。通过这个装置,我们可以更直观地了解人体消化系统的复杂性和神奇之处。

Deep Dive

Key Insights

What is a fistulated cow and why is it significant?

A fistulated cow has a hole in its side, called a fistula, which allows direct access to its stomach. This is significant because it enables researchers to study digestion in real-time by inserting their hands or instruments into the stomach. The practice began in agricultural schools and has provided valuable insights into how cows digest food, which is crucial for improving livestock health and nutrition.

What did Dr. William Beaumont discover through his experiments on Alexis St. Martin?

Dr. William Beaumont discovered that digestion is a chemical process driven by enzymes, not a mysterious 'vital force.' Through experiments on Alexis St. Martin, who had a permanent hole in his stomach, Beaumont observed the secretion of gastric juice containing enzymes that break down food. This was a groundbreaking revelation in the early 19th century, as it provided the first direct evidence of how the stomach digests food.

How did Alexis St. Martin end up with a hole in his stomach?

Alexis St. Martin was accidentally shot in the stomach in 1822, leaving a hole that never fully healed. The wound formed a fistula, a permanent opening that allowed Dr. William Beaumont to observe and experiment on his digestive process. This rare condition provided a unique opportunity to study human digestion in ways that were previously impossible.

What were some of the foods Dr. Beaumont tested in St. Martin's stomach?

Dr. Beaumont tested a wide variety of foods in St. Martin's stomach, including raw salted fat pork, corned beef, stale bread, cabbage, pigs' feet, animal brains, eggs (hard-boiled, soft-boiled, and fried), whipped eggs, baked custard, and carrot. He meticulously recorded how long each food took to digest, providing some of the first detailed data on human digestion.

What was the significance of the 'gastric juice' Beaumont observed in St. Martin's stomach?

The 'gastric juice' Beaumont observed was a clear, acidic fluid containing enzymes that break down food. This discovery proved that digestion is a chemical process, not reliant on a mysterious 'vital force.' Beaumont's experiments demonstrated that enzymes, which he called gastric juice, are the key to transforming food into nutrients the body can absorb.

How did Beaumont's experiments impact the understanding of digestion?

Beaumont's experiments revolutionized the understanding of digestion by proving it is a chemical process driven by enzymes. His work debunked the idea that digestion required a 'vital force' and laid the foundation for modern gastroenterology. His findings were published in a book in 1833, making him a pioneer in the field and earning him widespread recognition.

What was the relationship between Dr. Beaumont and Alexis St. Martin like?

The relationship between Dr. Beaumont and Alexis St. Martin was complex. Beaumont initially saved St. Martin's life after he was shot, but later exploited his condition for scientific experiments. St. Martin, who became increasingly irritable and resistant, eventually left but returned due to financial need. Beaumont saw St. Martin as both a patient and a scientific opportunity, while St. Martin was treated more as a medical curiosity than a person.

What is the significance of the mechanical gut at the Museum of Old and New Art?

The mechanical gut, created by Belgian artist Wim Delvoye, is a 40-foot-long reproduction of the human digestive system. It simulates the process of digestion, from ingestion to excretion, using a series of jars, tubes, and chemicals. The machine highlights the complexity of digestion and serves as both an artistic and scientific exploration of the human body.

Chapters
The episode starts with a playful introduction, then delves into the history of stomach research, highlighting the unusual methods employed by Mary Roach and early scientists to investigate the workings of the stomach. The human stomach is compared to a mysterious black box in the body.
  • Mary Roach's experience reaching into a fistulated cow's stomach.
  • The stomach as a site of magical transformation.
  • The human body as a torus.

Shownotes Transcript

For centuries, the stomach was a black box to humans. We didn’t understand the mystery of what happened to food after it went inside us. That is, until the early 1800s, when Dr. William Beaumont found a boy, Alexis St. Martin, with a hole in his stomach. 

Writer Mary Roach) brings us that story. She first sticks her hand inside the stomach of a live cow and then tells us how Beaumont conducted experiments on St. Martin to understand how the stomach breaks down food. This strange relationship between doctor and patient changed the way we understand digestion. 

Also, we have a brand new Terrestrials coming up just in advance of the Lunar New Year. We will be diving into the history and science of one of the animals associated with the festival. Check back in two weeks to hear that story. 

For more on guts, read:

Mary Roach, “Gulp: Adventures on the Alimentary Canal)”

Fred Kaufman, “A Short History of the American Stomach)”

Radiolab was created by Jad Abumrad and is edited by Soren Wheeler. Lulu Miller and Latif Nasser are our co-hosts. Dylan Keefe is our director of sound design. Our staff includes: Simon Adler, Jeremy Bloom, Becca Bressler, W. Harry Fortuna, David Gebel, Maria Paz Gutiérrez, Sindhu Gnanasambandan, Matt Kielty, Annie McEwen, Alex Neason, Valentina Powers, Sarah Qari, Sarah Sandbach, Arianne Wack, Pat Walters and Molly Webster. Our fact-checkers are Diane Kelly, Emily Krieger and Natalie Middleton. Production help from Tanya Chawla. Sound mixing by Joe Plourde.

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