A fistulated cow has a hole in its side, called a fistula, which allows direct access to its stomach. This is significant because it enables researchers to study digestion in real-time by inserting their hands or instruments into the stomach. The practice began in agricultural schools and has provided valuable insights into how cows digest food, which is crucial for improving livestock health and nutrition.
Dr. William Beaumont discovered that digestion is a chemical process driven by enzymes, not a mysterious 'vital force.' Through experiments on Alexis St. Martin, who had a permanent hole in his stomach, Beaumont observed the secretion of gastric juice containing enzymes that break down food. This was a groundbreaking revelation in the early 19th century, as it provided the first direct evidence of how the stomach digests food.
Alexis St. Martin was accidentally shot in the stomach in 1822, leaving a hole that never fully healed. The wound formed a fistula, a permanent opening that allowed Dr. William Beaumont to observe and experiment on his digestive process. This rare condition provided a unique opportunity to study human digestion in ways that were previously impossible.
Dr. Beaumont tested a wide variety of foods in St. Martin's stomach, including raw salted fat pork, corned beef, stale bread, cabbage, pigs' feet, animal brains, eggs (hard-boiled, soft-boiled, and fried), whipped eggs, baked custard, and carrot. He meticulously recorded how long each food took to digest, providing some of the first detailed data on human digestion.
The 'gastric juice' Beaumont observed was a clear, acidic fluid containing enzymes that break down food. This discovery proved that digestion is a chemical process, not reliant on a mysterious 'vital force.' Beaumont's experiments demonstrated that enzymes, which he called gastric juice, are the key to transforming food into nutrients the body can absorb.
Beaumont's experiments revolutionized the understanding of digestion by proving it is a chemical process driven by enzymes. His work debunked the idea that digestion required a 'vital force' and laid the foundation for modern gastroenterology. His findings were published in a book in 1833, making him a pioneer in the field and earning him widespread recognition.
The relationship between Dr. Beaumont and Alexis St. Martin was complex. Beaumont initially saved St. Martin's life after he was shot, but later exploited his condition for scientific experiments. St. Martin, who became increasingly irritable and resistant, eventually left but returned due to financial need. Beaumont saw St. Martin as both a patient and a scientific opportunity, while St. Martin was treated more as a medical curiosity than a person.
The mechanical gut, created by Belgian artist Wim Delvoye, is a 40-foot-long reproduction of the human digestive system. It simulates the process of digestion, from ingestion to excretion, using a series of jars, tubes, and chemicals. The machine highlights the complexity of digestion and serves as both an artistic and scientific exploration of the human body.
For centuries, the stomach was a black box to humans. We didn’t understand the mystery of what happened to food after it went inside us. That is, until the early 1800s, when Dr. William Beaumont found a boy, Alexis St. Martin, with a hole in his stomach.
Writer Mary Roach) brings us that story. She first sticks her hand inside the stomach of a live cow and then tells us how Beaumont conducted experiments on St. Martin to understand how the stomach breaks down food. This strange relationship between doctor and patient changed the way we understand digestion.
Also, we have a brand new Terrestrials coming up just in advance of the Lunar New Year. We will be diving into the history and science of one of the animals associated with the festival. Check back in two weeks to hear that story.
For more on guts, read:
Mary Roach, “Gulp: Adventures on the Alimentary Canal)”
Fred Kaufman, “A Short History of the American Stomach)”
Radiolab was created by Jad Abumrad and is edited by Soren Wheeler. Lulu Miller and Latif Nasser are our co-hosts. Dylan Keefe is our director of sound design. Our staff includes: Simon Adler, Jeremy Bloom, Becca Bressler, W. Harry Fortuna, David Gebel, Maria Paz Gutiérrez, Sindhu Gnanasambandan, Matt Kielty, Annie McEwen, Alex Neason, Valentina Powers, Sarah Qari, Sarah Sandbach, Arianne Wack, Pat Walters and Molly Webster. Our fact-checkers are Diane Kelly, Emily Krieger and Natalie Middleton. Production help from Tanya Chawla. Sound mixing by Joe Plourde.
Sign up for Radiolab for Kids’s newsletter! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up here.)
Radiolab for Kids and Terrestrials are supported by listeners like you. Support Radiolab by becoming a member of The Lab) today.
Follow Radiolab on Instagram), X) Facebook), Threads) and TikTok) @radiolab.
Support for Terrestrials is provided by the Simons Foundation, the Arthur Vining Davis Foundations, the Kalliopeia Foundation and the John Templeton Foundation.