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Why U.S. overdose deaths are dropping

2024/12/6
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Brad Feingood
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Keith Humphreys
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Shrita Walden
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Brad Feingood:美国阿片类药物过量死亡人数下降可能归因于更好的治疗途径和成瘾药物的可及性,例如美沙酮和长效布洛芬,以及纳洛酮的广泛使用。他所在的部门在今年前九个月分发了9万个纳洛酮试剂盒。此外,美沙酮和布洛芬的可及性也得到了扩展,长效布洛芬注射剂的推出也方便了人们的治疗。西雅图-金县公共卫生部门还设立了可随时接受服务的社区行为健康危机中心。 Keith Humphreys:美国阿片类药物过量死亡人数下降是一个令人欢迎的消息,但这并不意味着问题已经解决。各州之间以及不同社会群体之间存在巨大差异。例如,阿拉斯加州的过量死亡率反而上升了近40%。他认为,药物供应的变化(旧市场与新市场)和新冠疫情后的影响是导致这一现象的两个最主要原因。在芬太尼药物供应市场较新的地区,由于人们对芬太尼的效力不熟悉,其致死率可能高于在芬太尼药物供应市场较老的地区。此外,扩大纳洛酮的获取途径是挽救生命的最大措施,但它并不能解释最近12个月阿片类药物过量死亡率的急剧下降。自20世纪70年代以来,美国的药物过量死亡人数一直在增长,新冠疫情期间这一趋势加剧,而目前的下降只是相对于疫情期间的激增而言,并非相对于疫情前的增长趋势。 Shrita Walden:肯塔基州阿片类药物过量死亡率下降,部分原因是伤害减少策略的实施,但种族群体之间仍然存在差异。伤害减少是康复生态系统的一部分,如果没有伤害减少,就不会出现这种下降。然而,下降只体现在肯塔基州的白人社区,有色人种社区的数字仍在上升。她认为,医疗保健系统参与不足以及未能充分了解如何满足不同群体的需求是造成这种差异的原因之一。此外,她还强调了与社区有效沟通的重要性,以及在与有色人种社区成员沟通时,需要同时解决社会正义问题。她认为,纳洛酮的普及不仅仅是降低死亡率的原因,更重要的是与社区的有效沟通和参与。 Keith Humphreys: 他认为,解决阿片类药物危机需要关注需求端,即预防更多人开始吸毒,这需要长期规划和预防措施。他担心,新的政府可能会削减医疗补助计划,这将影响到帮助吸毒者的能力。他认为,执法部门应该被明智地使用,例如处理暴力事件,而不是将大量的人关进监狱。 Shrita Walden: 她认为,同时进行治疗和刑事处罚是不可行的,对药物滥用采取更加严厉的执法措施可能会适得其反。肯塔基州可能增加对执法部门在应对药物滥用和成瘾问题上的依赖。她支持安全吸毒场所,认为这些场所可以预防致命性过量吸毒,并改善与执法部门的关系。

Deep Dive

Key Insights

Why are U.S. overdose deaths decreasing?

The decline in overdose deaths is attributed to better access to addiction medications like methadone and buprenorphine, expanded naloxone distribution, and increased harm reduction efforts such as walk-in crisis centers and fentanyl test strips. Additionally, the waning effects of COVID-19 may have contributed, as the pandemic had previously accelerated overdose rates.

What role does naloxone play in reducing overdose deaths?

Naloxone, an opioid antagonist, reverses overdoses by restoring breathing. While it has been widely distributed for years, its consistent use has significantly reduced overdose fatalities. However, it doesn't explain the recent dramatic drop in deaths, as its impact has been gradual over time.

Why are some states seeing increases in overdose deaths while others are seeing decreases?

States with older fentanyl markets, where users are more familiar with the drug, are seeing larger declines in overdose deaths. In contrast, newer markets, particularly in the western U.S., are experiencing smaller drops or even increases, likely due to users being less aware of fentanyl's potency and its presence in their drug supply.

How has COVID-19 impacted overdose rates?

During the pandemic, overdose rates surged by up to 30% in some cities due to increased isolation, stress, and disrupted access to treatment. As the pandemic waned, these factors diminished, potentially contributing to the recent decline in overdose deaths.

What are the disparities in overdose death rates among different communities?

While overdose deaths have decreased in some communities, particularly among white populations, they continue to rise in communities of color. This disparity is linked to systemic issues such as lack of access to treatment, higher poverty rates, and historical trauma from the war on drugs.

What is the significance of fentanyl test strips in harm reduction?

Fentanyl test strips allow users to detect the presence of fentanyl in their drugs, helping them adjust their use to reduce the risk of overdose. This harm reduction tool is particularly important in newer fentanyl markets where users may not be aware of its presence.

Why is heroin becoming less common in the drug supply?

Heroin is being outcompeted by fentanyl due to its lower production cost and harder-to-seize supply chain. Fentanyl has become the dominant drug in many markets, making heroin less prevalent, especially in newer markets like the western U.S.

What is the potential impact of xylosine in the drug supply?

Xylosine, a sedative, may reduce the need for fentanyl, potentially lowering overdose deaths. However, it can also cause health damage and is not affected by naloxone, making its overall impact on mortality uncertain.

What is the future of harm reduction efforts under a potential Trump administration?

There is concern that harm reduction efforts, such as syringe service programs and safe consumption sites, may face backlash or funding cuts. However, programs that integrate harm reduction with recovery pathways may continue to gain support.

What are safe consumption sites, and how effective are they?

Safe consumption sites allow people to use drugs under medical supervision, reducing the risk of fatal overdoses. While they have been effective in preventing deaths, their adoption is limited by community opposition and their narrow geographic impact.

Chapters
The US has seen a significant drop in drug overdose deaths for the first time in decades. Experts attribute this decline to increased access to treatment and addiction medications, such as methadone and buprenorphine, as well as wider distribution of naloxone. However, there are still significant disparities across states and demographics, with some areas seeing increases instead of decreases.
  • Drug overdose deaths in the US dropped by roughly 15% from 2023 to 2024
  • Increased access to treatment and medications like methadone and buprenorphine contributed to the decline
  • Disparities exist across states and demographics, with some areas experiencing increases in overdose deaths

Shownotes Transcript

Translations:
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This is On Point. I'm Debra Becker. The staggering drug overdose death rate in the U.S. has dramatically dropped, according to the latest federal statistics. Some say it's the most significant decline in overdose deaths recorded this century.

But what seems like good news is also ambiguous. According to some drug experts, the decrease could be attributed to better access to treatment and addiction medications such as methadone and long-lasting buprenorphine. That's according to Brad Feingood, who works on overdose prevention for Seattle-King County Public Health.

Access to methadone has expanded. Access to buprenorphine has expanded. We are starting to deploy long-acting buprenorphine shots so people can get a shot of buprenorphine and it lasts for a month. And people really seem willing to do it. In King County, we also are standing up walk-in behavioral health crisis centers where people can just walk right in for a long time.

Detox was the front door. But if people can walk into a place, get care and get access to medication on demand without barriers, then that gives me a lot of hope. Feingold also says the overdose reversal drug naloxone has helped reduce deaths. His department distributed 90,000 naloxone kits in the first nine months of this year.

While it's likely that myriad reasons are behind the decline in the overdose death rate, most public health experts say it's not yet time to think that we're making our way out of the ravages of a more than decade-long opioid epidemic that's killed more than a million Americans. Joining us first to talk about this is Keith Humphreys. He's a professor of psychiatry at Stanford University where he studies addiction. Welcome to On Point, Keith.

Very happy to be here. So these numbers from the Centers for Disease Control and Prevention suggest that between June of 2023 and June of 2024, overdose deaths fell by about 14.5%. And these are provisional numbers, but a significant drop. What's your take here? First, I have to say I'm delighted to finally have something good to talk about after this.

After working on this problem for more than 10 years and the despair that it causes, I have to say personally for me, but for communities, it has felt like we were never going to turn the corner. So this is welcome news and congratulations to everybody who's on the front line trying to produce it. The question now is, will this last? Will this be sustained? Or is this like a cash bonus one year that we shouldn't

you know, assume is going to be our standing income. And we don't know the answer to that part yet. And let's talk about also there are huge differences here, right? Some states saw drops. If we look overall, it's a 14.5% decline. But some states saw increases. Alaska, perhaps, most notably. I think the overdose death rate there was up almost 40%. So what do you make of these huge disparities among the states?

That is a very important point to raise. We have geographical differences in that the older fentanyl markets and fentanyl spread in the United States from the east to the west are doing better now. They're showing larger drops. Whereas you go out west, the drops are smaller and sometimes, as you noted, there are increases. The second is that these drops are not being experienced comparably throughout all economic classes and all racial and ethnic groups.

You know, indigenous communities who have suffered really more than I think any other group in the United States throughout the entire epidemic are still suffering. Just one example, I mean, you know, access to treatment is not comparable. You know, life is not comparable. There's more poverty. There's more stress in some communities than others.

That's a very good reason not to say, you know, we're done now because we definitely have a lot of work to do. So when we say, let's just clarify this, older fentanyl market, that means when the synthetic opioid fentanyl first came on the scene or was detected in the drug supply. That's an older market where it's been around longer. A newer market where it was more recently introduced or found in the drug supply in those newer markets.

Are you theorizing here that perhaps people aren't used to fentanyl and therefore it could be more deadly in those newer markets than it is in markets that may have adapted to the potent nature of fentanyl?

That's exactly right. We have only one country to judge these sorts of dynamics on, which is a small country in northern Europe, Estonia, which has had a fentanyl-dominated market for 20 years. And when fentanyl first appeared, many, many people would go to their dealer and think they were buying heroin, but they instead were buying something far more potent, and there was an enormous spike in death rates. But it moderated over time for two reasons. One, the people who couldn't handle fentanyl—

you know, passed away. And the second reason was eventually every dealer and every user knew fentanyl was there. That's what they were selling and that's what they were buying. And so you didn't have surprise deaths anymore.

That's the situation we have out east where it's been there for a decade. It is not the situation we have in places like Nevada or actually some parts of California where the drug has been around for a couple of years, but there's still going to be a lot of people who aren't aware of it and aren't expecting it to be in their drug supply. So it's moved from east. The east is the older fentanyl market moving from east to west. So we see steeper declines in the overdose death rate in the east coast as opposed to the west. Correct. Okay.

So what about reasons also? So these are the numbers. A lot of disparities here, a lot of discrepancies. We're not quite sure why. It could be because of the familiarity with the potency of fentanyl, but it could also be a lot of other things going on, which is likely, right? So we also know that there's more so-called harm reduction, where folks are given supplies to help reduce the

the dangerousness of drug use and also the fatality rate of drug use. There's also medications. And there are fentanyl test strips to test for the presence of fentanyl in drugs so people can use accordingly. Are all of these factors in the drop, or how would you describe those? It's very important in trying to explain the drop to differentiate things that are good and things that could explain a dramatic change in the last 12 months.

And let's start with naloxone. Now, you mentioned that that's the drug. It's called an opioid antagonist. If someone's overdosing, it will usually restore their breathing fairly rapidly and stop them from dying. Stanford University had a partnership with The Lancet, a medical journal, and we had a commission that I led. And the modeling done by that study showed that expanding access to naloxone was the biggest life-saving policy that we had.

So if not for that, the opioid crisis would have been much, much worse. We wouldn't have been having 100,000 people. We've had 120,000, 130,000 people dying a year. That is very good. However, wouldn't it count for a dramatic change in the last 12 months because we've been putting naloxone out there pretty aggressively for many years?

So, while it is good, it wouldn't explain why this sudden drop. For that, you have to look at something that is qualitatively new in the last 12 months. And that's probably not going to be on the, you know, naloxone side, harm reduction side, or the treatment side, even though those all save lives. We've got to look outside that window of what is new in the last 12 months. And that's why people are looking as more plausible explanations.

at one, the changes in supply, old markets versus new markets, perhaps a change in the strength of the drug. And then the second thing we shouldn't forget, and I assume we can't forget, we just went through a COVID pandemic. And during that pandemic, overdose rates were jumping up by 30% in some cities in just 12 months.

Now, as COVID wanes, all the bad things that COVID did, which greatly accelerated the advance of overdoses, are now gone.

gone, or at least mostly gone. So there should be a dividend from that. And that is something plausible to talk about over that 12 months period because COVID, you know, disappeared about, you know, 12, 18 months ago. So where were we pre-pandemic? And then sort of in general terms, could you explain to folks? So where were we pre-pandemic? What happened during the pandemic? And where are we now? Is this drop really all that significant then?

We've been on a growth curve for drug deaths in the United States, sadly, since the 1970s at least, which is as far back as we have data, on an exponential growth curve. And some years that's been a little higher than that, some years a little lower, but it's been pretty steady, just mostly year after year after year. And that's what we were on up to 2020.

Then we saw this huge departure from history by COVID, where it just soared up to levels I'd never seen in my career growth that fast. Now what we're back to is the curve we were on in 2020. So if you looked, if you sort of disappeared the years of COVID and you just charted the death rate of this epidemic from, say, 2015, 16, 17, 18, 19, 20, and then 2024, it would actually be right on this line.

The drop is just relative to COVID. The drop is not relative to how the epidemic was progressing to that point. That's why, although I celebrate this, obviously, fewer deaths is always good. I am not going to relax because I know this could be a one-time change and not something enduring that I can just assume will continue into the future. Right. And also because we do have more awareness, more treatment, more naloxone. We have all of those things, too.

help reduce these numbers, maybe we should, you know, should we be saying this isn't really all that significant at all? It should be much more dramatic than this if you take all of those things into account. Without all those things, it is the absolute numbers would have been much, much worse. So if you look at, you know, these years where we broke over 100,000 deaths, which is horrific.

You know, if we, let's say we didn't have any overdose rescue protocols and we didn't have any FDA approved treatments, that number might've been 150,000 people. So they're making a big difference year after year after year. And, and we need to, to have them. Um, and at the same time, they, they didn't, their availability didn't change that much in the last 12 months to explain this drop. So we want to keep them and we, we want to, you know, the, ideally, I mean, I, I think the, in the best society, uh,

the availability of overdose rescue and of treatment would be greater than the availability of fentanyl, you know, if we could get to that point. Because people face that choice, people who use face that choice every single day, and we want to make it as easy as possible to make the healthiest choice. And, you know, so it's worth trying to push towards that as a way to help resolve this epidemic. Although, again, that would not explain this recent drop. Hmm.

And again, just so we can summarize here, you think the main things are changes in the drug supply and really coming off a pandemic where we saw a huge increase in overdose deaths. Those two things.

Yeah, those are the two most plausible things. And they're non-competing. I mean, both those things could be true. We always have to say about the drug supply, this is an illegal business. So all of us are in the dark. You know, we're inferring things of, you know, talking to people who use on the street, talking to people involved in interdiction. There's been some very good journalism about this.

the business itself down in Mexico, for example, which should point that way. But there is a lot of guesswork in figuring out what are drug cartels doing and how is that affecting the streets of our cities? Okay. We'll talk some more about this after a break. We're talking about the recent drop in drug overdose deaths in the U.S. I'm Debra Becker. This is On Point. Support for the On Point podcast comes from Indeed.

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You're back with On Point. I'm Deborah Becker. Today, we're talking about where and why overdose deaths are declining in the U.S. We're joined by Keith Humphreys. He's a professor of psychiatry at Stanford University, where he studies addiction. I'd like to bring someone else into the conversation now, Shrita Walden. She's executive director of the Kentucky

Harm Reduction Coalition in Louisville. Her group works to treat addiction and cut the number of overdoses and deaths through education and by providing materials such as syringes and naloxone. According to the latest CDC data, Kentucky had a 20% decline in overdose deaths between June of 2023 and June of 2024. Shreda, welcome to On Point. Hello. Tell us about your work in Louisville.

Well, harm reduction is definitely making a way here on the ground in Louisville, but throughout the state of Kentucky for the last 10 years as we have. We're right here at the head of our decade of doing services here on the ground and engaging, educating and empowering the community with overdose prevention, with with.

access to harm reduction resources, with access to treatment and recovery resources for a decade since 2014. And today, this weekend, starts our celebration. So I'm pretty excited about that. Your celebration of 10 years is this weekend?

It actually starts today. We're doing a three-day weekend journey through harm reduction, an unbound journey. Yes, yes, we are. So why do you think that the overdose death rate has gone down so dramatically in Kentucky? Is it in large part because of harm reduction or are there a lot of other things going on?

Well, yes, yes, absolutely. Harm reduction is, I call it, it's a part of the ecosystem of recovery. Without harm reduction, we would not have seen this decrease. However, I pause when I say we have a decrease because what our governor did share back in June of this year was that although we can celebrate a decrease that we've had, which is an amazing feat,

The decrease really only captured our white community here in Kentucky. Our communities of color continue to see a disparity as far as our numbers continue to rise. And that's what's disheartening. Why do you think there are disparities like that?

Well, that's really complicated and complex to unpack. One of the biggest things that I've shared with people is we have to think about the connection and lack of engagement in our healthcare systems, right? When we look at treatment and recovery with beds, which that's the world I come from, I'm a licensed clinical alcohol and drug counselor. And my first part of my career was spent 15 years in drug and alcohol treatment, and

And we always recognize that the beds that were made available were not filled with communities of color. So it's the lack of engagement and truly understanding how to meet people where they're at. That is the heartbeat and the foundation of harm reduction. How do we do that? And I think that we struggle as a country, but more so as a community on how to do that in a way that

centers people first and not punitive actions, which is the failed war on drugs. We know that the failed war on drugs targeted communities of color, especially in a crack epidemic back in the 80s. And it was not treatment first. It was criminalized. So trying to take that mindset and that traumatizing effect it had on an entire community of folks that are left in the shadows is very

Mm-hmm. All right.

You know, I want to talk about the effect of naloxone because it's sort of logical, right? If you give out a medication that reverses the deadly consequences of an overdose, then fewer people die. And, you know, we spoke with Kevin Donaldson, who uses drugs on the streets in Burlington, Vermont. And he told NPR's Brian Mann this year that he thinks that really more people are surviving because they have naloxone and naloxone.

They know now to use with others and to not use drugs alone. Here's a bit of what he said.

I feel like some of us have learned how to deal with the overdoses a lot better. For a while there, we're hearing about it every other day. But when was the last overdose we heard about? A couple weeks ago, maybe? That's pretty far and few between. That's Kevin Donaldson, who uses drugs on the streets in Burlington. What do you think, Shreda? I mean, is it just a logical assumption to say, well, we have a proliferation of naloxone, so fewer people are dying, you know? Or not quite that simple.

It isn't. And, you know, I appreciate you having his voice to this conversation because that's a part of harm reduction, making sure the people who are most impacted are involved. It's more than naloxone.

When you're engaging all the communities, I will say this. Our communities, our brothers and sisters here in Kentucky who are from our white community have a more open and relaxed conversation around drug use and drug culture. When we're trying to connect with Black community members, we have to not negate

some of the other issues that are happening in the social justice world, right? We can't leave out what's happening that's harmful when we're talking about law enforcement. Everybody across the world, right, saw what took place here in Kentucky with law enforcement and Breonna Taylor. And so imagine me walking into a space saying, I want to talk to you about naloxone and I don't want to talk about, you know, the, the,

crime rate and the disproportionality of gun violence and children being lost and all of the things. I have to be able to pivot and address both and. And that's where we are making traction. So this is not a downer conversation. We are seeing more and more

Black communities, Somalian communities, Latino communities getting more involved because we're opening the conversation to talk about both and all things. My conversation is probably going to be 45 minutes longer when I'm going into the West End of Louisville.

Because I'm going to talk about what's happening in the West End of Louisville. We're going to talk about the increased rate of police surveillance in the West End of Louisville. And I'm going to talk about overdose prevention versus going into the East End of Louisville, where I can go right in and talk about drug use and Ibogaine and all the access out there. Right. So just being able to pivot.

And I think our, you know, agencies that are more diverse with communities of color leading this effort are more realistically connecting with communities because we're not going to leave people out. I want to just ask Keith Humphrey something, because what certainly a lot of us have been seeing and reading, particularly in the past year, might be construed as a bit of a backlash issue.

to harm reduction efforts. Folks who are asking for different types of things regarding drug use and saying that, you know, giving people supplies or helping people is really condoning drug use and a tougher approach

is needed because this may not be working. Sridhar, I'm going to ask you about that, but I want Keith Humphries to weigh in on this first. And Keith, for you to tell me whether, is that an accurate assumption of what's going on right now? Is there a bit of a backlash to harm reduction efforts?

Certainly out where I am, that is the case. Which is near Stanford? Yeah. So San Francisco, further north, Oregon, Washington, up into British Columbia. But I think what I would characterize is it's a reaction to a certain understanding of harm reduction rather than harm reduction tools.

I haven't really heard people say anything negative about naloxone anywhere. And I travel a lot around the country. Or syringe exchange. We have syringe exchange places like Indiana now, like evidence-based tools that save lives. When people think that's harm reduction, most people think it's a good idea.

What has happened was it's sort of acquired some, I would say, some baggage that when people think, oh, when you mean harm reduction, you mean tent encampments are OK. You mean that crime and shoplifting and violence should not be stopped. You mean that someone can use drugs on my front porch and I can't do anything about it.

When people think it's that, of course, they have a more negative reaction to it than when they think of it as a set of public health tools that is there to save lives, including someday maybe the life of somebody that you love. Right. And, Shreeda, do you suspect that there is a bit of a backlash to some harm reduction efforts?

Absolutely. Here, there's a lot of education efforts that we're trying to do to explain what harm reduction really means here in Kentucky. The truth of the matter is our syringe service programs, we see here at Kentucky Harm Reduction Coalition programs,

We're close to 90% are white individuals that come and access our syringe service programs. Well, what we're talking about is route of use. And if you look at communities of color, we're not going to see a large amount as high as we do in our white communities of black individuals who are openly using syringes.

The other side is there is smoking, there's inhaling. And what our government and what our legislators are trying to learn and are a little bit more receptive now is there are health implications when people are not using sterile supplies. So that conversation is very sticky. I get it. I'm a life is going to go on in drug counselors. So I think that.

People have just a misunderstanding around substance use, around addiction itself, still continuing to believe that it's a choice, that people are choosing to end up in these situations. So there's a lot of unpacking, which is why it's a part of our pillar to educate our community on what's happening with substance use and the drug supply on the street.

You know, Keith mentioned that this, of course, is not an exact science by any means, and it's hard to really gauge what's happening here in sort of an underground illegal world. But I do wonder, you know, do we think that the fentanyl that is in the drug supply at the moment is less potent? There's been some suggestion that

It's been adulterated in such a way that makes it not as immediately deadly as it used to be. Shreeda, I want to go to you first. Do you think that that may be a factor here? No, I think that people don't understand drug culture, right? On the streets, because we have our staff, our outreach specialists are made up of teams of people with lived experience. What we have recognized is there are people who are actually victims.

using and have been using substances where they built up, you know, this and forgive me with my words. I'm trying to wrap everything around. But they build up enough to be able to continue to use. They have learned the tools of not using alone. They have learned how to use naloxone. These are active drug users. So in this culture, they are taking care of themselves. What we see is people who have in

you know, been, there's a fatality. What we are learning is that these individuals are part of the, we went to parties, we went to do something different. We went with our friends and I didn't know what was going to be in there. These, that's a separate group. So when people are seeing people continue to live, you're talking about people who are at

using drugs, which is a part of our community. We have taught very well, which is why you see the decline. But that rise that you see is we're talking about, I mean, when I was a youth, when you guys were youth, everyone has a story about when they tried something for the first time. Unfortunately, when individuals now try something for the first time,

it can become a fatal situation. That's what we're learning on the ground. And that's the difference between folks who are sitting in offices and just collecting data, but not getting the context behind the data, which is being out there in the streets, doing outreach, connecting with the community. That is not a sit behind your desk job. I'm an ED, I go out with my teams. I put on my gym shoes and do it. - This is On Point, I'm Debra Becker.

Also, though, let's talk about, if we go back to drug supply, Keith, we've heard a lot about the tranquilizer xylosine, and we're seeing reports that that is increasingly found in the drug supply. This is a sedative that can slow breathing, but apparently it can sedate someone so much that they don't need esophagitis.

as much fentanyl to stay high, so that could actually be reducing the overdose death rate? I mean, what are your thoughts about xylosine in the drug supply? Yeah. So it's an interesting speculation. I have to say that that's all I can say about it. I mean, so you could imagine that maybe then because the high lasts longer, I use fewer times today, and therefore my risk goes down. But on the other hand, naloxone doesn't affect xylosine.

And xylosine deoxygenates the skin and does damage to the body, which you would think over time might increase mortality. So I just leave it as an interesting idea. But on net, at the moment, I can't really be confident that xylosine is a net product.

benefit for health. It could just as easily be a net loss for health. You know, we also, when we were talking with Brad Feingood about his overdose prevention efforts with Public Health Seattle-King County in the state of Washington, he mentioned something else in the drug supply, something known as B-TEMPS, which apparently is an industrial chemical

So let's listen to what he says about this substance B-TEMPS in the drug supply. That's an industrial cleaner that's started to show up in our drug supply that we've been able to detect. We don't know what the impact of B-TEMPS is. People have reported a different smell from the drug.

and a little bit of different impact, but it's hard to quantify that on a mass scale. So whether or not that's impacted overdose death rates or not, it's hard to tell, but it is something that we've seen that's correlated around the same time.

So it used to be heroin and then it was fentanyl and then it was xylosine and now it's this B-temp. I mean, it's hard to feel like you can keep up with all the substances out there and their risk, right? But Keith Humphreys, I mean, is heroin even on the streets anymore? And what do policymakers do when things like industrial cleaners are coming into the drug supply?

Yeah, a really good question about heroin. I mean, if you just thought of this as a market, you would say fentanyl is the ultimate disruptive innovation. It beats out heroin because the production price is about 1% as high. It's much harder to seize because there's no farm anywhere like there is for heroin. There's no 7,000-mile supply line where you can grab the supplies. So fentanyl is just beating it out as a business. It's very hard to find

heroin out here in the San Francisco Bay Area. We still see some, you know, fair amount of heroin deaths in very old established markets like New York City. But I could easily imagine that in 10 years there won't be heroin any more than you find morphine addicted people like you used to before heroin outcompeted that.

The other point you're raising, and I would point people to the New York Times had a nice coverage of just chemists in Mexico. People who make illicit drugs are trying new things all the time. They're putting in all sorts of different drugs, different combinations of drugs, different potencies. Remember, they're unregulated. They can do whatever they want. And we see all the time a new drug emerges. It's there for two, three, four, five months, and then it disappears, and then some other combination comes back. So it's very tough to stay on top of all that.

Okay, we're talking about the drug overdose death rate in the U.S. and why it's plummeting. We'll have more after a break. I'm Deborah Becker. This is On Point.

This is On Point. I'm Deborah Becker. We're back with Keith Humphreys, who's a professor of psychiatry at Stanford University, and he studies addiction. Also with us, Shreda Walden, executive director of the Kentucky Harm Reduction Coalition. And we're talking about the steep drop in the U.S. overdose death rate. And Keith, before the

break, you mentioned a recent New York Times piece that talked about the Mexican drug cartels actually recruiting chemistry students to make new chemicals that could be infiltrated into the drug supply that keeps everybody guessing about exactly what is going on with the drug supply and how to control it. But right now, there's a bit of celebrating going on for this drop in the overdose death rate. And we're talking about

the myriad reasons behind that. But I'm wondering, you know, what about demand? What are we doing about demand and about the fact that the U.S. just seems to have an endless appetite for these types of drugs? Keith?

Yeah, that's a great question. I mean, if you look at the history of epidemics, no epidemic has ended by waiting for people to become ill and then throwing a lot of resources at them. Epidemics end through prevention when fewer people start getting sick. That's how COVID waned. That's how HIV spread.

You know, and AIDS waned. And that's why we need to do work on the prevention side. I mean, you know, Shrita, like me, has spent, you know, her efforts working with people who are addicted. That's super, super important, working with people who already use drugs.

But in the long term, the way we get out of this is if people just don't start down that path in the first place. And it's been hard to persuade people of that, partly because they have memories of lousy DARE programs when they were in junior high, which were ridiculous, and partly because our political system doesn't think ahead very well. So it's tough to persuade people. Why don't you allocate things for kids, especially kids growing up in tough neighborhoods, to

And the benefits will be five or 10 years down the road. That takes some leadership, and it's not always there. A lot of people are thinking, but I'm up for election in 18 months. I can't do that. Shreda, I did see some research suggesting that fewer young people are becoming addicted to opioids. Does your on-the-street view confirm that or not?

I was I was first. I want to say I really want to meet Keith because I like why it's come visit. Like you said, some wonderful things. And so let me pivot back. Addicted, meaning dependence. It's hard to say. I don't I don't particularly like given a diagnosis of dependence to youth because they're still developing. So that I cannot.

I cannot firmly say, make a comment about. What I can say is we are seeing an increase of substance use. I mean, we're seeing an increase with overdose. I mean, here in Kentucky, in Louisville, Kentucky, one of our largest school systems, the first day of school at 8 o'clock in the morning, a youth was rushed to the hospital because they were in an active overdose. They did survive, but this is what we're talking about, right? Is that...

The youth are the next, as we look at the next wave of who's being, who's actually in this epidemic and whose numbers are rising is our youth because they are the ones who are being missed

As Keith said so eloquently, the war on drugs did not help. And we're still trying here in Kentucky to use these prevention efforts that are led in the law enforcement or justice, Department of Justice mentality. So, no, I'm not seeing a decrease in use of our youth. I'm seeing an increase in

of youth using substances. We were supposed to be using, communities across the country, we're supposed to be using monies from opioid lawsuit settlements to do prevention and to help with treatment and to help address this. And we're talking multi, multi-million dollar settlements. But both of you weigh in on there. Shreeda, are you seeing some of that money and couldn't that be used for prevention and to help young people?

Well, absolutely. And I will say kudos to our government. Our

Our organization, Kentucky Harm Reduction Coalition, received in the first round, in the first round, $500,000 for our efforts for over 18 months. And we were part of about 22 organizations. It was very diverse, small grassroots organizations all the way up to hospitals. And they require collaboration with other community partners as

What we're seeing with the new attorney general, though, is that they want to pivot and involve more law enforcement. And I'm a little disappointed with that. They are also it's a semantics thing, right? Harm reduction is a part of prevention. But we're hearing that.

They want to move away from harm reduction. They want to move away from syringe service programs and look at a primary prevention. So I am vocalizing very loud that we are primary. We're primary, we're secondary, and we're tertiary sources of

prevention because we can meet people at each level. So this next legislative session that'll be starting soon in January, it's going to be a lot of conversation and a lot of push to ensure that we can keep monies rolling into community-based organizations and grassroots organizations that can do the work that the larger organizations are not equipped to do. Mm-hmm.

You know, I just want to—you brought up turning toward a more law enforcement-focused approach to all of this. And this seems to be happening around the country. The pendulum may be coming back. And we do know that President-elect Trump—

has said that drug dealers should face the death penalty. We actually have a clip of him saying that. It's from a November of 2022 speech that he gave when he was officially announcing his candidacy in Palm Beach, Florida. And he said there absolutely should be the death penalty for drug dealers. Let's listen.

I will ask Congress for legislation ensuring that drug dealers and human traffickers, these are terrible, terrible, horrible people who are responsible for death, carnage and crime all over our country. Every drug dealer during his or her life on average will kill 500 people with the drugs they sell, not to mention the destruction of families.

But we're going to be asking everyone who sells drugs, gets caught selling drugs, to receive the death penalty for their heinous acts because it's the only way. Now, the numbers that President-elect Trump mentioned there about drug dealers killing 500 people apiece, really those numbers are hard to fact check. We don't know for sure how many drug dealers are in the United States. What we do know is that the federal government prosecutes about 2%.

20,000 drug traffickers a year, and many of the folks who are arrested for drug dealing are people who are using and are dealing small amounts to fund their addiction. So I wonder, Keith Humphreys, are we, is the pendulum swinging back and we are going to see very tough measures against people who deal drugs and perhaps more of a law enforcement approach to trying to deal with addiction?

I think we're at a pivot point and we could go more than one way. I mean, so I...

In a positive sense, I believe most people recognize that a carcerally led racist suppression of poor communities such as we saw in the 80s and 90s is not destructive. And at least where I am, where we went absolutely the other way, kind of a laissez-faire, do whatever you want, drugs are everywhere and they're fine, that also is unpopular.

And so that's creating, there's a backlash to that, but I'm hoping people realize, you know, there's a lot of choices between those two extremes. We can use law enforcement intelligently, for example, to deal with things like violence, where you really have to have, you know, police involved. But for the rest of it,

to try to use them in a therapeutic way to nudge people onto a healthier pathway. So rather than lock a lot of people up, you know, I would much prefer things where the option is given. You don't have to do that. You know, you don't have to go to jail if you will please, you know, get involved in the health sector, do something for your health, take care of the addiction that is driving your offending. That's a productive way to use law enforcement. And this is a...

somewhat dangerous moment. I think we could really go, you know, in destructive directions as a country. We often kind of jerk this way and that way. And

I'm doing the best with the politicians I talk to to just try to find some sensible path between those extremes. During his first term, though, President-elect Trump did provide funding and help for addiction prevention programs and other things. So if you take that record and then you take this speech where he says that drug dealers should face the death penalty, do you think we'll get some kind of middle ground or do you expect that things will be very different under the new administration?

The First Step Act, which the president signed, you know, got the care of addiction into all the federal prisons. You know, that's great. And we know from around the state says there's a Medicaid reentry movement going on, that people are getting treatment paid for by Medicaid as they're leaving corrections. That dramatically lowers overdoses. It also lowers crime. I would think that would be continue to be popular.

Where I have some worries is that the backbone of the financing of the public substance use care system is the Medicaid program.

And I don't know what the new president and new Congress will do with that. And, you know, there's some concern that it will be dramatically cut. And if that happens, that would have quite an effect on our ability to help people who have problems with drugs. And, Shreida, you mentioned that in Kentucky, there does appear to be more interest in utilizing law enforcement to deal with drug use and addiction in your state. Why do you think

that that's happening right now? And do you think it will continue and perhaps even increase under a Trump administration?

Unfortunately, I do. It's quite scary because I always ask the question or tell people we can't treat and criminalize something at the same time. We have in our last legislative session passed a bill for a charge of murder for murder.

If you're found to be linked, I don't know the language. You have to look up that policy linked to someone who has had a fatality due to. And we've had a dad, one of the first of this year, a stepfather in rural Kentucky was charged for his stepchild's death.

Um, this doesn't help fear leads people. I do think it's unintentional. I think that fear is we have, um,

Excellent programs. It's shared. There's this program. I come from a law enforcement family. Just to give you a little context. Both of my parents are retired Chicago police officer detectives and uncles who are detect were are retired detectives from Chicago. So I understand the need for law enforcement, especially in a society we live in. And in Georgetown, Georgia.

here in Kentucky have an excellent program where these officers are integrating more of these approaches, these social service approaches, as well as right here in Louisville, the Newburgh police have case managers and social workers embedded into their police department. It's possible to do both. And I also believe that

We need to allow law enforcement to do what they need to do when crime is taking place. Is it criminal for someone to...

hustle on the street. No, people are not walking up, taking a syringe and stabbing someone in the arm and saying, you're going to die. That is a criminal act. Someone who goes out and gets something because they're trying to feed a need because they have a substance use disorder. They're down on their luck.

that's a different spectrum. And I just, I wish we could connect it more. I wish they would listen to more people like these programs, um,

to understand what we're dealing with. We're not saying let people do what they want and cause chaos. We're saying, are we addressing the issue or are we just repeating a failed systemic era of decades ago? Do you think there should be what are called safe consumption sites where people can use drugs under medical supervision to try to prevent a fatal overdose?

Absolutely. And it's not just a thought. I did a cross-country trip in 2023 in January and drove from Louisville, Kentucky. My final destination was on point in New York. And it was absolutely amazing to see the levels of care, to see people be able to walk through a door, bathe.

basic access to harm reduction materials and weave through this program. It was my dream of seeing the ecosystem of recovery. You start at one point, you meet people where they're at and you walk with them, walk alongside them. They had LPNs, they have a meditation space, they have case managers, they have therapists in a safe consumption space.

People are not dying there. To see their relationship with law enforcement improve over time, where law enforcement don't take people and lock them up, like here with our House Bill 5, where people who are houseless can be charged or sent to jail because they're houseless and be fined. Up there, they have police officers dropping people off at on point, right?

To receive services, to see the stories, to see the growth, to see people living and thriving is absolutely necessary. We live in a society where drug and substance use, mood and mind altering substances is embedded in the fabric of our society. We're bourbon country down here. So why are we acting as though we're not?

I do want to say that On Point is a safe consumption space in New York, not affiliated with our program, obviously, by the same name. But, Keith, what do we know about safe consumption sites in terms of data? And in about the last two minutes that we have left here of our program, you know, do you think that the movement to increase the number of these sites around the country is pretty much going to go on the back burner for now?

One of the most important things to know that these have been around in different countries for over 40 years and only a handful of people have died in them in all that time, you know, over, you know, probably millions of drug use episodes. So it's probably not a safer place in the world to use a drug than in one of those sites. That is certainly a good thing. They do treat people, as Sridhar just said, as human beings. They give dignity to people who often don't get dignity. That is another really good thing.

The challenge is they're very hard to cite. Most people don't like having them in the neighborhood.

Not many people access them. Usually they only affect a very narrow area. So they've never really fully taken off. I think to the extent they continue to exist in a new environment will depend on the thing Shreda said, is are they a pathway to recovery? Because recovery is something that everybody who loves somebody who has a drug problem is happy to see. So if they can be part of that, they're more likely to survive.

Keith Humphreys, professor of psychiatry at Stanford, thanks for being with us. Thank you. Shreda Walden, executive director of the Kentucky Harm Reduction Coalition, happy 10th anniversary. Thanks to you as well. Thank you. I'm Debra Becker. This is On Point.