We're sunsetting PodQuest on 2025-07-28. Thank you for your support!
Export Podcast Subscriptions
cover of episode Long-awaited ape genomes give new insights into their evolution — and ours

Long-awaited ape genomes give new insights into their evolution — and ours

2025/4/9
logo of podcast Nature Podcast

Nature Podcast

AI Deep Dive Transcript
People
A
Andy Meyer
K
Katerina Malkova
L
Lucas Kudana
Topics
Katerina Malkova: 我是生物学家Katerina Malkova。为了理解包括人类在内的猿类的进化,我们需要了解不同物种的基因组,即完整的遗传密码。研究非人类猿类的基因组可以提供关于是什么让我们成为人类的信息,并提供关于我们基因组中对疾病至关重要的部分的额外信息。这项研究是一个巨大的进步,它将非人类灵长类动物的基因组质量提升到了与人类基因组相同的水平,这使得对基因组所有部分进行全面比较成为可能。由于我们拥有这些个体的最终数据,我们最终可以得出关于这些基因组进化的结论。 Lucas Kudana: 此前,我们对猿类的基因组测序存在大量缺失部分,这阻碍了我们对这些部分如何进化的理解。这项新的研究弥补了这一缺陷,通过完整的基因组测序,让我们能够更全面地了解猿类的进化。这项研究的目标是完整地组装猿类基因组,没有任何缺失部分。这项研究是一个里程碑式的成果,它并非提供了所有的答案,而是为研究人员提供了提出关于猿类进化史的一系列新问题的机会。这项研究成果为研究人员提供了一个宝贵的资源,开启了无数新的研究途径,这些途径可以基于这些组装体进行。未来的工作包括对每个物种的多个个体进行完整基因组测序,以了解物种之间和物种内部的变异。未来的工作还包括将完整的基因组测序扩展到其他猿类和灵长类动物,以便在DNA水平上理解是什么让猿类成为猿类。这项研究利用长读长测序技术,成功组装了六种非人类猿类的完整基因组,包括之前难以测序的重复区域,这让我们对猿类基因组的组成有了更全面的了解。

Deep Dive

Shownotes Transcript

00:46 Complete sequencing of ape genomes

Researchers have sequenced the complete genomes of six ape species, helping uncover the evolutionary history of our closest relatives and offering insights into what makes humans human. The genomes of chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang have been sequenced end-to-end, filling in gaps that have long eluded researchers.

Research Article: Yoo et al.)

News: What makes us human? Milestone ape genomes promise clues)

08:47 Research Highlights

How sunflower stars are evading a mysterious epidemic, and how solar panels made of moon dust could power lunar bases.

Research Highlight: Revealed: where rare and giant starfish hide from an enigmatic killer)

Research Highlight: Solar cells made of Moon dust could power up a lunar base)

11:36 How to make a competitive laser-plasma accelerator

After decades of research, physicists have demonstrated that, in principle, an alternative kind of particle accelerator can work just as well as more conventional designs. Many particle accelerators that power huge experiments like the Large Hadron Collider at CERN are radio-frequency accelerators, but they are large and limited in how strong their magnetic fields can be. The new work shows that accelerators that instead use plasma to accelerate particles could be a viable alternative and could be built at much smaller scales.

Research article: Winkler et al.)

19:55 Briefing Chat

A drug that makes blood poisonous to mosquitoes, and how an AI worked out how to solve key challenges in *Minecraft *by ‘imagining’ solutions.

Science Alert: Drug For Rare Disease Turns Human Blood Into Mosquito Poison)

Nature: AI masters Minecraft: DeepMind program finds diamonds without being taught)

Vote for us in this year's Webby Awards

Vote for How whales sing without drowning, an anatomical mystery solved)

Vote for What's in a name: Should offensive species names be changed? The organisms that honour dictators, racists and criminals)

Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.) Hosted on Acast. See acast.com/privacy) for more information.