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cover of episode These malaria drugs treat the mosquitos — not the people

These malaria drugs treat the mosquitos — not the people

2025/5/21
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Nature Podcast

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People
B
Benjamin Thompson
E
Eva
F
Flaminia Kataruccia
F
Fredros Okumu
H
Henrietta Svare-Nielsen
H
Håkon Jönsson
N
Nick
通过创意和专业服务,在节日季节赚取额外收入的专家。
研究人员
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Flaminia Kataruccia: 我认为,目前控制疟疾传播的主要挑战在于蚊子对杀虫剂的抗药性日益增强。传统的杀虫剂蚊帐虽然在初期有效,但随着蚊子产生抗药性,其效果逐渐减弱。因此,我们需要新的策略来应对这一挑战。我们团队的研究重点是开发一种新的方法,即通过药物靶向蚊子体内的疟原虫,阻止其传播。我们筛选了多种化合物,发现其中一些可以有效杀死蚊子体内的疟原虫。更重要的是,我们成功地将这些化合物整合到蚊帐材料中,使其在实际应用中具有持久的保护效果。我相信,这种新策略可以成为控制疟疾传播的重要工具,尤其是在那些蚊子抗药性严重的地区。当然,这并非万能药,但它为我们提供了一种新的思路,即不必杀死蚊子,而是通过阻止其传播疟原虫来达到控制疾病的目的。 Fredros Okumu: 我对这个团队的研究印象深刻,他们的方法非常具有创新性。目前,杀虫剂蚊帐仍然是我们控制疟疾的主要手段,但我们必须承认,蚊子最终会产生抗药性。因此,我们需要寻找新的方法来延长蚊帐的使用寿命,并为其他预防手段(如疫苗)的开发争取时间。这个团队的研究提供了一种有希望的替代方案,即通过药物靶向蚊子体内的疟原虫。这种方法不仅可以保护蚊帐下的人,还可以保护更广泛的社区。当然,我们还需要在实际环境中进行更多的测试,以评估其效果。但我相信,这种新策略具有巨大的潜力,值得我们进一步研究和推广。我们应该尽快将这种蚊帐推广到农村地区,因为那里的人们最需要它。

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00:45 Treating mosquitoes for malaria

Researchers have developed two compounds that can kill malaria-causing parasites within mosquitoes, an approach they hope could help reduce transmission of the disease. The team showed that these compounds can be embedded into the plastics used to make bed nets, providing an alternative to insecticide-based malaria-control measures, which are losing efficacy in the face of increased resistance.

Research article: Probst et al.)

10:42 Research Highlights

The sunlight-powered device that can harvest drinkable water from desert air, and evidence that the world’s richest people are disproportionately responsible for climate impacts.

Research Highlight: Atacama sunshine helps to pull water from thin air)

Research Highlight: The world’s richest people have an outsized role in climate extremes)

13:02 The genetics that can lead to pregnancy loss

Researchers have found specific genetic mutations that can lead to pregnancy loss. It’s known that errors, such as the duplication of chromosomes, can lead to nonviable pregnancies but less has been known about non-chromosomal genetic errors. The new work identifies DNA sequence changes that can lead to a non-viable pregnancy. This may offer clinicians the ability to screen embryos for these changes to help avoid pregnancy loss.

Research article: Arnadottir et al.)

22:24 Briefing Chat

Bespoke CRISPR-based therapy treats baby boy with devastating genetic disease, and the ‘anti-spice’ compounds that can lower chillies’ heat.

Nature: World’s first personalized CRISPR therapy given to baby with genetic disease)

New Scientist: Chemists discover 'anti-spice' that could make chilli peppers less hot)

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