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cover of episode World’s tiniest pacemaker could revolutionize heart surgery

World’s tiniest pacemaker could revolutionize heart surgery

2025/4/2
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Nature Podcast

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Dan Fox
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John Rogers
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Noah Baker
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Pascal Geldsetzer
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Sharmini Bandel
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Sharmini Bandel & Noah Baker: 新型起搏器体积仅为米粒大小,可植入体内,无需手术取出,这解决了传统起搏器笨重且需要手术取出等问题。 John Rogers: 我研发了一种微型可生物降解起搏器,它通过皮肤照射的光线控制,无需外部电源,可注射植入,这是一种完全不同的设计理念,克服了传统起搏器的许多缺点。该设备由两小块金属构成,接触心脏组织后会形成电池,无需额外电源。光控开关对穿透生物组织的波长敏感,通过皮肤上的LED灯控制起搏器的开关和频率,甚至可以根据患者需求自动调节心率。该设备使用生物可吸收聚合物和人体可吸收的材料制成,在植入后9到12个月内会完全溶解,不会对人体造成不良影响。由于体积微小,可以注射植入,也可以通过多个起搏器对心脏进行更精细的控制,未来有望应用于大脑等其他需要电刺激的领域。

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Researchers have developed a tiny, injectable, temporary pacemaker that dissolves after use, eliminating the need for invasive removal procedures. This device is controlled by light shone through the skin and shows promise for various applications beyond cardiac use.
  • Injectable, dissolvable pacemaker
  • Controlled by light shone through the skin
  • No external power source needed
  • Tested in animal models and human heart tissue
  • Potential applications beyond heart pacing

Shownotes Transcript

00:46 Millimetre-sized pacemaker fits inside syringe

Researchers have developed a tiny, temporary pacemaker that dissolves when no longer needed, helping to overcome some of the challenges associated with current devices. Temporary pacemakers are often required after heart surgery but implanting them can require invasive procedures. This new device is injectable, requires no external power and is controlled using light shone through the skin. The tiny pacemaker has shown promise in animal and heart models, and the team think it could also be used in other situations where electrical stimulation is needed, like the brain.

Research Article: Zhang et al.)

08:19 Research Highlights

Measurements show that global warming is causing lakes to lose their oxygen, and a massive, 30-year analysis showing that a diet of plant-rich foods is associated with healthy ageing

Research Highlight: Life-giving oxygen is wafting out of lakes worldwide)

Research Highlight: The best foods for healthy ageing ― and the worst)

10:21 Shingles vaccine linked to reduced dementia risk

A large-scale population study suggests that getting a shingles vaccine reduces the probability of someone getting dementia by around one-fifth. By taking advantage of the way a shingles vaccine was rolled out in Wales, a team were able to compare dementia outcomes in vaccine-eligible people to those born just a few weeks earlier who were ineligible. Although more tests will be needed to confirm this finding and to understand the mechanisms behind it, the team hope that vaccination against this viral infection could represent a cost-effective way to for preventing or delaying dementia.

Research article: Eyting et al.)

20:20 Briefing Chat

Data suggests that racial profiling plays a role in whether someone receives a traffic citation or fine, and studies suggest that paying researchers who review manuscripts could speed up the peer-review process, without affecting the quality of reviews.

Ars Technica: Study of Lyft rideshare data confirms minorities get more tickets)

Nature: Publishers trial paying peer reviewers — what did they find?)

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