Why Everyone’s Talking About GLP-1 Agonists | Dr. Tyna Moore | Align Podcast #521
Align Podcast
Deep Dive
What are GLP-1 agonists and how do they function in the body?
GLP-1 agonists are peptides that mimic the action of the glucagon-like peptide-1 (GLP-1) hormone, which is naturally produced in the gut and brain. They help regulate insulin signaling, slow gastric motility, and have neuroregenerative effects. GLP-1 agonists like Ozempic are used to manage type 2 diabetes and obesity by improving insulin sensitivity and reducing appetite.
Why is GLP-1 considered beneficial beyond weight loss?
GLP-1 agonists have shown benefits in reducing chronic pain, improving metabolic health, and potentially aiding in neurological conditions like Alzheimer's and Parkinson's. They also have anti-inflammatory effects in the brain and can help with smoking, alcohol, and opioid cessation by modulating dopaminergic pathways.
How does trauma manifest as chronic pain in the body?
Trauma can lead to chronic pain by activating microglial cells in the brain, which drive an over-exaggerated nervous system response. This can result in centrally sensitized pain, where pain receptors become hypersensitive, and even non-painful stimuli like touch can be perceived as painful. Trauma often gets stored in deep tissues, and unresolved emotional stress can manifest as physical pain.
What are some natural ways to increase GLP-1 production in the body?
Natural ways to boost GLP-1 include maintaining a healthy gut microbiome through diet, exercise, and stress reduction. Bitter herbs like berberine, short-chain fatty acids, and certain probiotic strains can also stimulate GLP-1 secretion. Additionally, sunlight, movement, and feeling safe in one's environment contribute to optimal GLP-1 production.
Why is movement considered a powerful tool for processing trauma?
Movement helps process trauma by activating the body's waste management systems, such as the lymphatic system, and allowing emotional energy to dissipate. Physical activity, including walking, yoga, or heavy lifting, can help metabolize stress hormones and prevent trauma from becoming deeply ingrained in the brain. Movement also shifts focus away from rumination and into physical action, aiding in emotional regulation.
What are the risks associated with using GLP-1 agonists like Ozempic?
Risks include potential muscle loss if calorie intake is insufficient, gallstone issues due to slowed gastric motility, and anxiety in some individuals. However, concerns about thyroid cancer and pancreatic cancer have been largely debunked, as studies showing these risks involved extremely high doses in rats, not humans. Proper dosing and medical supervision can mitigate many of these risks.
How does stress contribute to chronic pain and disease?
Chronic stress leads to elevated cortisol levels, which can cause inflammation, immune suppression, and tissue breakdown. Over time, this can result in chronic pain, autoimmune conditions, and metabolic dysfunction. Stress also exacerbates emotional pain and unhealthy behaviors, creating a cycle that perpetuates physical and mental health issues.
What role does community play in managing stress and loneliness?
Community helps mitigate stress and loneliness by providing a sense of belonging and reducing feelings of isolation. Being around others, even without deep interaction, can ground individuals and offer emotional support. Activities like concerts, church, or group fitness classes create opportunities for connection and shared experiences, which are essential for mental well-being.
- GLP-1 is a peptide hormone made in the gut and brain.
- It plays a crucial role in insulin signaling and reception.
- Improves metabolic health by optimizing insulin function.
- Potential benefits extend beyond weight loss, including neuroregeneration.
Shownotes Transcript