Cholinergic Crisis – Signs and Symptoms Nursing Mnemonic (SLUDGE)
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  Outline SLUDGE

• S-Salivation
• L-Lacrimation
• U-Urination
• D-Defecation
• G-Gastric upset
• E-Emesis

Description A cholinergic crisis can occur if the body stops properly breaking down Acetylcholine. This can cause overactivity of Acetylcholine at the neuromuscular junction. Acetylcholine is part of Rest & Digest (Parasympathetic) – so we see overactive digestion and secretion.