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cover of episode 801: Using Gene Editing to Create Enhanced Cell Therapies - Dr. Kyle Cromer

801: Using Gene Editing to Create Enhanced Cell Therapies - Dr. Kyle Cromer

2025/2/24
logo of podcast People Behind the Science Podcast Stories from Scientists about Science, Life, Research, and Science Careers

People Behind the Science Podcast Stories from Scientists about Science, Life, Research, and Science Careers

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Kyle Cromer: 我从事基因编辑研究,目标是超越简单的DNA错误修正,赋予细胞新的功能以实现治疗目的。我的研究涵盖多个方面,包括使用CRISPR技术纠正DNA中的‘错误’,以及利用基因编辑技术增强细胞的治疗效力,例如提高红细胞产量,使其更安全有效。我目前的研究重点是利用人类临床基因数据,创造增强型细胞疗法,使细胞产生比正常细胞更多健康的红细胞。此外,我还致力于探索利用生物反应器大规模生产红细胞,以解决血液供应不足的问题,并开发治疗各种血液疾病的工程化血液制品。这项研究面临诸多挑战,例如如何高效地将基因编辑工具递送到体内特定细胞,以及如何大规模生产工程化细胞。尽管如此,我相信这项研究具有巨大的潜力,可以为治疗各种血液疾病带来突破性的进展。 在科研过程中,我经历过许多失败和挫折,例如耗时数月的实验最终失败,以及在项目推进过程中遇到的各种技术难题。但是,这些失败也让我积累了宝贵的经验,并学会了如何更有效地进行科研工作。例如,我采用了‘快速失败’的策略,尽早识别并解决问题,从而提高效率。同时,我也注重与其他研究人员的合作,共同攻克科研难题。 在职业生涯中,我得到了许多导师和同事的帮助和指导,他们教会了我许多宝贵的科研技能和经验。我也从与其他研究人员的合作中受益匪浅,这不仅促进了我的科研工作,也拓宽了我的视野。 展望未来,我希望能够继续从事基因编辑技术的研究,并将其应用于更多疾病的治疗。我相信,随着技术的不断进步,基因编辑技术将在未来发挥更大的作用,为人类健康做出更大的贡献。 Marie McNeely: 作为主持人,我没有表达具体的科学观点,而是引导访谈,了解Kyle Cromer博士的科研工作和人生经历。

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Dr. Cromer discusses his passion for visual art and how he balances his scientific career with his artistic hobbies. He describes his meticulous approach to abstract painting, comparing it to his scientific methodology.
  • Dr. Cromer enjoys visual art and painting.
  • He uses a systematic approach to abstract painting, similar to his scientific work.
  • He is currently on paternity leave.

Shownotes Transcript

Dr. Kyle Cromer is an Assistant Professor in the Department of Surgery at the University of California, San Francisco School of Medicine. In his lab, Kyle takes gene editing a step further beyond just modifying “the typos” in DNA to correct them back to what the code should be. He uses genome-editing approaches to introduce new functions into cells for different therapeutic purposes. Kyle has always been interested in visual art, so he enjoys visiting art museums and has dabbled in creating his own art as well. He and his wife have been stretching their own canvases and creating their own abstract paintings, each meticulously planned and sketched out in advance. Most recently, the two of them have been immersed in preparations for the birth of their first child. He completed his BS in Animal & Poultry Sciences at Virginia Tech and his PhD in Genetics at Yale University. Afterwards, he conducted postdoctoral research in Genetics at Harvard Medical School. Next he worked as a postdoctoral fellow and subsequently an instructor in Pediatrics at Stanford University before joining the faculty at UCSF. He has received various awards and honors over the past several years, including the Stanford Bio-X Star Mentor Award, the American Society of Gene & Cell Therapy Career Development Award, the UCSF Program for Breakthrough Biomedical Research New Frontier Research Award, the American Society of Hematology Junior Faculty Scholar Award, the Mary Anne Koda-Kimble Seed Award for Innovation from the UCSF School of Pharmacy, and the Catalyst Award from UCSF Innovation Ventures. In this episode, Kyle shares more about his life and science.