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cover of episode 808: Unraveling How Mitochondria Can Be Used to Reverse Aging and Treat Age-Related Diseases - Dr. Keshav Singh

808: Unraveling How Mitochondria Can Be Used to Reverse Aging and Treat Age-Related Diseases - Dr. Keshav Singh

2025/4/14
logo of podcast People Behind the Science Podcast Stories from Scientists about Science, Life, Research, and Science Careers

People Behind the Science Podcast Stories from Scientists about Science, Life, Research, and Science Careers
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我致力于研究如何利用线粒体来逆转衰老和治疗与衰老相关的疾病，例如癌症。我的研究表明，线粒体与衰老的所有标志都有关联，包括表观遗传调控改变、基因组不稳定性和细胞间通讯问题。线粒体是细胞的能量来源，随着年龄的增长，线粒体的功能会下降，导致能量减少。我的研究目标是通过恢复线粒体的功能来恢复能量，从而逆转衰老。 我们正在研究线粒体移植技术，该技术涉及将年轻的线粒体移植到衰老的细胞中，以恢复线粒体的功能。我们已经取得了一些进展，例如在小鼠模型中成功逆转了皮肤衰老。我们还正在研究线粒体移植技术在治疗其他与衰老相关的疾病中的应用，例如卵巢衰老。 我相信线粒体移植技术具有巨大的潜力，可以帮助人们延长健康寿命。我们正在努力开发这项技术，并将其转化为临床应用。我们正在努力解决一些技术挑战，例如线粒体的生物分布和降解。我们还正在努力建立线粒体移植技术的标准和规范，以确保这项技术的安全性和有效性。

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Dr. Singh enjoys flying kites, traveling, and painting mitochondria, especially when experiments don't go as planned. His mitochondrial paintings are diverse and even sold on eBay.
  • Enjoys flying kites on the beach, traveling, and painting.
  • Paints various types of mitochondria.
  • Uses electron micrographs and imagination for paintings.
  • Creates mitochondria-themed items like ties and scarves.

Shownotes Transcript

Dr. Keshav K. Singh is the Joy and Bill Harbert Endowed Chair and Professor of Genetics, Dermatology and Pathology at the University of Alabama at Birmingham. He is also the founding Editor-in-Chief of the Mitochondrion Journal. In addition, Keshav is the founder and Chief Scientific Officer of the company Yuva Biosciences. Research in Keshav’s lab focuses on how to reverse aging and diseases like cancer that are associated with aging. Mitochondria are relevant for all of the hallmarks of aging, including things like changes in epigenetic regulation, genomic instability, and communication problems between cells. He is working to better understand the intricacies of how mitochondria work and how they can be targeted or leveraged to improve health. Outside of work, Keshav enjoys flying kites on the beach, traveling, and painting. In particular, he gets creative painting all different kinds of mitochondria, and this is a great outlet for him when experiments aren’t working in the lab. Keshav began his studies in India, earning his Bachelor of Science degree in microbiology from Rohilkhand University and his Master of Science from G.B. Pant University of Agriculture and Technology. Next, he moved to Australia and was awarded his Ph.D. in Marine Biology from the University of Wollongong. Keshav then conducted postdoctoral research at Harvard University before joining the faculty at Johns Hopkins University School of Medicine. He later moved to the Roswell Park Comprehensive Cancer Center and served as Distinguished Professor of Oncology. Next, he joined the faculty at the University of Alabama at Birmingham where he is today. He is a Fellow of the Royal Society of Medicine and a member of Sigma Xi (The Scientific Research Honor Society). He has been recognized as one of the Innovation Heroes by Newsweek, and Yuva Biosciences was the recipient of the "Company of the Year - Innovation and Excellence into Mitochondrial Science" award at the Indian Icon Awards. In our interview, Keshav shares more about his life and science.