Bone Marrow Cells: Key To Vaccine Longevity?
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Why do some vaccines provide lifelong immunity while others only last a few months?
Some vaccines, like those for measles and yellow fever, stimulate a strong and long-lasting immune response, partly due to the activation of megakaryocytes in the bone marrow. These cells create a hospitable environment for antibody-producing B cells to survive for years, leading to prolonged immunity.
What role do megakaryocytes play in vaccine longevity?
Megakaryocytes, large cells in the bone marrow, create a supportive environment for B cells to survive and produce antibodies for extended periods. This helps maintain a long-lasting immune response, which is crucial for vaccines that offer years-long or lifelong immunity.
How can understanding megakaryocytes help in developing better vaccines?
Understanding how megakaryocytes support long-lasting immunity can help scientists design vaccines that better activate these cells. This could lead to vaccines with longer-lasting effects, reducing the need for frequent boosters and improving overall vaccine efficacy.
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