Regina Barber: 我了解到一项新的研究表明,马拉松运动员的大脑会在跑步过程中消耗一种叫做髓鞘的脂肪物质作为能量来源。这听起来像是大脑在能量不足时会消耗自身组织。研究发现,马拉松后,大脑中负责运动协调和感觉处理的区域髓鞘会减少,但这只是暂时的,两个月后会恢复正常。这项研究的意义在于,它有助于我们更好地理解多发性硬化症等神经系统疾病,并为这些疾病的治疗提供新的思路。然而,这项研究也存在一些局限性,例如样本量较小,仅观察了10名运动员的大脑。
Rachel Carlson: 另一位神经科学家Yannick Poitelot也对这项研究发表了评论。他认为,虽然这项研究的样本量小,并且扫描技术存在局限性,难以确定髓鞘变化是否完全由跑步引起,但这项研究仍然非常令人兴奋。这是首次表明人体髓鞘可以作为能量来源,这将激发该领域更多的研究。
Carlos Matute: (推测) 我作为一名神经科学家和马拉松运动员,对人体在高强度运动下的能量代谢机制非常感兴趣。我的研究表明,大脑会利用髓鞘作为一种能量来源,以支持长时间的剧烈运动。虽然髓鞘的减少是暂时的,但这为研究神经系统疾病提供了新的视角。
Yannick Poitelot: (推测) 我认为这项研究虽然样本量有限,并且成像技术也存在一些局限性,但它首次揭示了人体髓鞘作为能量来源的可能性,这具有重要的开创性意义。这项研究为未来研究神经系统疾病以及运动与大脑功能之间的关系提供了新的方向。
supporting_evidences
Regina Barber: 'And after marathons, they saw that myelin decreased in the runners' brains, especially in the areas of the brain that are important for things like motor coordination, like how we move our bodies, and sensory processing. So after a marathon, there's less myelin. Is that a bad thing? No. Well, the changes were all temporary. The researchers followed up with the runners two months after the marathon and scanned their brains again. And they saw that the amount of myelin returned to normal.'
Regina Barber: 'But there are some neurological diseases where myelin decreases and doesn't return to normal. Carlos thinks studying runners could help us better understand these disorders, like multiple sclerosis. It may be useful to develop new lines of treatment for sclerosis. Like neurodegenerative diseases.'
Rachel Carlson: 'Another neuroscientist in the field, Yannick Poitelot, told us the kind of scans the researchers took makes it hard to say for sure that running caused the change in myelin. But he says that this study was really exciting. It's one of the first to show that human myelin could be used as an energy source. And he thinks it could inspire lots of new work in the field.'
Running an entire marathon takes a lot* *of energy. Neuroscientist Carlos Matute) knows this: he's run 18 of them. He wondered how runners' bodies get the energy they need to make it to the finish line. His new research in the journal Nature Metabolism) may be the first step in answering the question – and suggests their brains might be (temporarily) depleting a fatty substance that coats nerve cells called myelin. *Have other questions about the brain? Let us know by emailing [email protected])! Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave).*Learn more about sponsor message choices: podcastchoices.com/adchoices)NPR Privacy Policy)