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cover of episode How Two Veterans Developed The Same Rare Brain Condition

How Two Veterans Developed The Same Rare Brain Condition

2025/1/7
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Short Wave

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I
Ibolya Chernak
J
John Hamilton
M
Michael Lawton
M
Michael Lozano
V
Valerie Lozano
W
William Wilcox
Topics
John Hamilton: 本报告探讨了动脉静脉畸形(AVM)这一罕见脑部疾病。AVM是一种血管和动脉的畸形缠结,可能导致脑出血,危及生命。 通常情况下,血液从心脏流经动脉,再流经毛细血管,最后流回静脉,毛细血管起到缓冲作用。但在AVM患者中,血液直接从动脉流回静脉,导致高压血液冲击脆弱的静脉,引发脑出血。 本报告关注两位海军陆战队士兵William Wilcox和Michael Lozano,他们都患有AVM,并探讨了其与武器爆炸的潜在联系。 Michael Lozano: 我曾是海军陆战队牵引炮手,长期使用陶式导弹系统等武器。在发射过程中,头部距离爆炸点非常近,反复暴露在爆炸波中。 我于2004年退伍后,开始出现严重的头痛、记忆力减退等问题,后来被诊断为AVM。我经历了手术,但记忆力并未完全恢复。我认为我的AVM与长期暴露在武器爆炸波中有关。 William Wilcox: 我在海军陆战队服役期间,也长期使用反坦克武器等重型武器,进行过多次高强度射击训练。 在2014年,我突然出现脑出血,被诊断为AVM。手术后,我留下了疤痕、钛螺丝和记忆缺失等后遗症,并患有癫痫。我认为我的AVM与我长期在军中使用重型武器有关。 Michael Lawton: 大多数AVM是由影响血管生长的基因变化引起的。起初,我认为Lozano的AVM与他的服役经历无关,这可能只是巧合。 但最近的研究表明,爆炸波可能会改变大脑中的基因,爆炸损伤可能导致与AVM相同的基因异常。虽然证据对于比AVM轻微的血管变化更强,但我们还需要进一步研究来确定爆炸损伤与AVM之间的确切联系。 Ibolya Chernak: 越来越多的研究表明,爆炸波会引起大脑血管变化。即使是单次爆炸,也会使血管需要修复。 反复的爆炸和修复可能会导致修复机制出现故障,从而导致类似AVM的血管畸形。在老鼠身上进行的实验已经证实了这一点。 Valerie Lozano: 我注意到我的丈夫Michael Lozano在退伍后出现记忆力减退和其他异常情况。 我们带他去医院检查,最终确诊为AVM。手术后,他的记忆力仍然存在问题。我相信他的AVM与他在军队中经历的爆炸有关。

Deep Dive

Key Insights

What is an arteriovenous malformation (AVM) and how does it affect the brain?

An arteriovenous malformation (AVM) is a rare condition where blood flows directly from arteries into veins through a tangle of abnormal blood vessels, bypassing the capillaries that normally buffer the pressure. This high-pressure flow can cause veins to leak or burst, potentially leading to a brain hemorrhage or stroke.

What are the potential causes of AVMs in military veterans like William Wilcox and Michael Lozano?

While most AVMs are caused by genetic changes affecting blood vessel growth, recent research suggests that repeated exposure to blast waves from firing heavy weapons may alter genes in the brain, potentially contributing to AVMs. Both Wilcox and Lozano experienced repeated blast exposures during their military service, which may have damaged their blood vessels.

What symptoms did William Wilcox and Michael Lozano experience due to their AVMs?

Both veterans experienced severe headaches, memory problems, and cognitive difficulties. Wilcox suffered a brain hemorrhage in 2014, leading to emergency surgery, while Lozano's AVM caused forgetfulness and emotional struggles, including PTSD and anger issues. Both men also faced long-term challenges, such as epilepsy (Wilcox) and memory loss (Lozano).

What evidence links blast waves from military weapons to brain damage?

Research indicates that blast waves from powerful weapons can cause concussion-like symptoms, including headaches and memory problems. Studies also suggest that repeated blasts may damage blood vessels in the brain, potentially leading to conditions like AVMs. Animal studies have shown malformed blood vessels resembling AVMs after repeated blast exposure.

How have William Wilcox and Michael Lozano adapted to life after their AVM diagnoses?

Wilcox lives with epilepsy, memory lapses, and a reliance on medication, while Lozano focuses on equine therapy at his War Horse Ranch, helping other veterans recover from trauma. Both men have found ways to manage their disabilities, with Lozano using horses to provide emotional support and Wilcox adjusting to his cognitive and physical limitations.

What steps has the military taken to address blast exposure risks?

The military has implemented measures to minimize blast exposure, particularly during training. However, these changes do not help veterans like Wilcox and Lozano, who were exposed to repeated blasts before such precautions were in place.

Shownotes Transcript

Some weapons used by the U.S. military are so powerful they can pose a threat to the people who fire them. Today, we meet two Marines, William Wilcox and Michael Lozano, who spent years firing missiles and rockets, then developed the same rare brain condition: arteriovenous malformation, or AVM. The condition sends high pressure blood from a tangle of abnormal blood vessels directly into fragile veins, which can leak or burst. Most AVMs are caused by genetic changes that affect the growth of blood vessels, so the connection between weapon blasts and AVM isn't always immediately clear. But NPR's brain correspondent Jon Hamilton reports that recent research suggests that blast waves can alter genes in the brain — and that the evidence is even stronger for less extreme blood vessel changes.*Have questions or story ideas? Let us know by emailing [email protected])!Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave).*Learn more about sponsor message choices: podcastchoices.com/adchoices)NPR Privacy Policy)