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cover of episode Targeting Sickle Cell Disease (Sponsored Content)

Targeting Sickle Cell Disease (Sponsored Content)

2025/5/18
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Masters in Business
AI Deep Dive AI Chapters Transcript
People
D
David Altshuler
I
Isaac Odame
J
Jordan Gaspore
T
Terry Booker
W
William Hobbs
Topics
Terry Booker: 作为一名镰状细胞病患者，我亲身经历了那种身体被扭曲的剧烈疼痛，这种疼痛深入骨髓，让我痛苦不堪。更令人沮丧的是，作为一名寻求止痛药的非裔美国女性，我常常被误认为是瘾君子，我的医疗需求被忽视。急诊室本应是帮助病人的地方，却常常让我感到无助和愤怒。尽管如此，我依然保持着信念，努力过上正常的生活，希望有一天人们能够真正理解我们的痛苦。 Isaac Odame: 镰状细胞病不仅仅是一种疾病，它还与系统性种族主义和社会不公紧密相连。非裔美国人在获得医疗保健方面面临着诸多障碍，这直接影响了他们的治疗效果。我们必须解决这些根本问题，确保所有患者都能获得公平的医疗待遇。同时，我也看到了患者们的力量，他们正在勇敢地为自己的权益发声，推动系统做出改变。我希望未来的治疗方案不仅能解决疾病本身，还能消除医疗体系中的种族歧视。

Deep Dive

Chapters
This chapter explores the profound impact of sickle cell disease on patients' lives, highlighting the chronic pain, medical uncertainties, and societal challenges faced by individuals like Terry Booker. It details the disease's effects on red blood cells, causing pain and organ damage.
  • Chronic pain is a defining symptom, described as feeling pressure in bones and pain throughout the body.
  • Patients often face diagnostic delays and misdiagnosis.
  • Racial bias in healthcare leads to inadequate pain management for Black patients.
  • Sickle cell disease affects red blood cells' shape and function, impeding oxygen flow and causing pain.

Shownotes Transcript

Terri Booker’s body burns with pain. She’s one of the 100,000 Americans living with sickle cell disease – a blood disorder that can cause severe pain, organ failure, and even premature death. The genetic condition came about to protect against malaria. Dr. William Hobbs leads clinical development for sickle cell disease at Vertex, and they are investigating multiple approaches to address the unmet needs that patients face. 

This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

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