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cover of episode Brad Marshall Dances with Whirl Pigs Through the Cambrian Explosion

Brad Marshall Dances with Whirl Pigs Through the Cambrian Explosion

2025/6/13
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David Gornoski

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Brad Marshall: 我认为肥胖并非仅仅是个人贪婪或懒惰的结果,而是更多地受到细胞内部选择和状态的驱动。细胞的代谢状态会影响我们的食欲和燃料燃烧方式,甚至可能导致我们过度进食。即使我们摄入过多的卡路里,在不同的细胞状态下,这些燃料也可能被燃烧掉,因此卡路里消耗并不是决定肥胖的关键因素。脂肪细胞如果进入生长模式,会隔离身体其他部分的燃料,导致血糖降低,从而产生饥饿感。这种细胞层面的代谢选择,才是理解肥胖问题的核心。

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Brad Marshall joins David Gornoski to talk about how fattening is about oxygen, why Oxygen is "happier" in CO2, the cellular origin of obesity, subclinical Torpor, how we handle hypoxia, and more.

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