Ukraine's Delayed Offensive, IVG Reproduction, Preparing for Debt Default
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What happened to Ukraine's spring offensive? Ukrainian leaders have talked up the attack for months, though it hasn't come yet. It turns out part of the strategy is talking about it. They're trying to round up weapons. I'm Steve Inskeep with Michelle Martin, and this is Up First from NPR News. ♪

New technology could change the way babies are made. This could be life-altering for individuals to build that family that they dream of. Scientists are using stem cells to make embryos. So what are the ethical concerns? And if the government defaults on its debt, it could mean higher mortgages and car payments. We'll talk about what you can do about that. Prepare for a potential default as you would for an impending recession. Stay with us. We'll tell you what you need to know to start your day.

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Major military operations are normally shrouded in secrecy. Yet Ukraine's planned offensive against Russia has been a source of public debate for months, which has created all sorts of expectations, some of them realistic, some not. We're joined now by NPR's Greg Myrie to tell us more about this. Greg, good morning.

Good morning, Michelle. So let me just start with something that Steve just mentioned. It might seem strange to signal when an attack is coming during an ongoing declared war. Why do we even know so much about Ukraine's planned offensive? Yeah, really a couple reasons. I mean, this has really been the most documented war in history. So a lot of things have played out publicly that we wouldn't normally see.

And Ukraine is making this big push for Western support, and it says it needs more weapons and more powerful weapons to carry out a big offensive. You know, and just recently, Michelle, we heard Ukrainian President Volodymyr Zelensky say the offensive wasn't quite ready because his country still needed some additional weapons that were on the way. Again, all this is pretty unusual stuff, and I would just finally note that some analysts say we're actually seeing the initial stages of the offensive in reference to the support

prize in relatively small attacks that are taking place inside Russia. So when the offensive does start in earnest, what is the goal and what would we expect to see?

Well, the widespread thinking is that Ukraine will strike somewhere in the southeast part of the country. It will likely try to reverse what Russia did at the start of the war last year, which was create this land bridge connecting Russian troops in eastern Ukraine, which is the Donbass region, to Russian forces in the south, in Crimea.

The U.S. and NATO are sending Ukraine tanks, drones, and artillery. This has given Ukraine more firepower than it's had at any earlier stage in the war. But the lengthy buildup has given Russia time to reinforce positions that could be vulnerable. I spoke about Ukraine's offensive with Michael Kaufman, who's at the Center for Naval Analyses.

It may require multiple offensives on multiple fronts and will likely be conducted over the period of several months rather than days or weeks. And so he does think this offensive will be much more challenging than the very successful one that Ukraine carried out last fall. I do want to remind people of that, that Ukraine took back quite a bit of territory last fall. So what would success look like this time?

Well, they're certainly going to need to recapture territory again. The question is how much to justify this big operation, which will almost certainly be the biggest carried out by Ukraine in the war, and to justify all this Western help. And I put this to Stephen Piper, a former U.S. ambassador to Ukraine. In the best case, what the Ukrainians do is they really liberate a lot of territory, perhaps even pushing the Russians back

to the line on February 23 of last year before this massive Russian invasion began, that would be a huge blow to Moscow. And he's right, it would be. But Pfeiffer and others acknowledge that a more realistic scenario is that Ukraine makes some advances, but perhaps on a more limited scale. So it sounds like this offensive carries some real risks for Ukraine. Can you just tell us what might those be?

If this offensive fails or even if it's only partially successful, some Western countries may rethink the support they're giving Ukraine. And that could mean scaling back military aid and calling for Ukraine to start looking for a negotiated settlement, even if that's very unpopular in Ukraine. Now, analysts I spoke with say this war continues to go very badly for Russian leader Vladimir Putin.

but they believe he's playing the long game. He still thinks he can deplete Ukraine's military, that the West will tire of supporting Ukraine, and that could give Putin a face-saving way out. Thank you. That is NPR's Greg Meyer. Greg, thank you so much. My pleasure.

Scientists may be on the cusp of an advance that could revolutionize the way human beings reproduce. Researchers are working to create human eggs and sperm in the lab. They would carry anyone's genes. In other words, people would manufacture custom-designed people.

NPR health correspondent Rob Stein is with us now to tell us more. Rob, welcome. Thanks for joining us. Sure. Nice to be here, Michelle. You know, so this honestly, the ability to create custom-made human eggs and sperm in the lab, I mean, I'm sorry, it sounds like something out of science fiction. How would scientists do that?

So it's called in vitro gametogenesis, or IVG, and researchers in Japan have already figured out how to do IVG in mice. And here's how it works. They take cells from the tails of mice and coax them in their labs to become what's known as induced pluripotent stem cells, or IPS cells.

These iPS cells can theoretically become any cell in the body, and in this case, the researchers figured out how to turn the iPS cells into mouse sperm and egg cells. They then used that sperm and eggs to make embryos and even implanted them in the wombs of female mice, which gave birth to healthy mouse pups.

And now these scientists and many others around the world are trying to do the same thing in humans. In fact, scientists have gotten as far as making very primitive human eggs and sperm this way. They can't make embryos or babies yet this way, but they're intensively working on that. Tell us more about the range of reasons why people would want to do this.

You know, Michelle, there are lots of reasons. The first one is to find new ways to help men and women who are infertile. So instead of adopting kids or working with sperm or egg donors to have kids, scientists could make infertile people their own sperm and eggs from, say, a blood cell and use those laboratory-made sperm and eggs to make embryos and babies that are genetically related to them.

Here's how Andrea Braverman put it at a recent workshop about this research at the National Academy of Medicine. This could be life-altering for individuals to build that family that they dream of,

And same goes for women of any age, rendering the biological clock irrelevant. And they could also be used to help gay couples have babies that have genes of both partners instead of using someone else's sperm and eggs. And here's how Catherine Krashel from Yale put it at the same workshop. We too could point to our children and say, he has your eyes and my nose in a way that is something that I think many queer people covet. Yeah.

And since then, I've spoken to infertile couples and gay and lesbian couples around the U.S. who would jump at the chance to do IVG. Okay, but this, I think, also immediately raises some concerns. So let's talk about that.

Yes, absolutely. If IVG ever does become possible, it raises lots of ethical, social, and legal questions. You know, it could, for example, allow people of any age to have babies, raising questions about whether there should be age limits. It could allow people to steal the DNA of, say, celebrities from maybe a clipping of hair to make babies without their consent.

And, you know, combined with new gene editing techniques, IVG could move so-called designer babies even closer to reality. Here's Emerita Pande. She's a professor of sociology at the University of Cape Town in South Africa. The desire to genetically modify the future generation in a hunt for an assumed perfect race is

Perfect baby, perfect future generation is not science fiction. IVG when used with gene editing tools like CRISPR should make us all worried. Now, I should say IVG is probably years away and may never happen. There are big technical hurdles, not the least of which is whether it would be safe. That said, many scientists say it could become a reality within five years or so, maybe even sooner.

That is NPR health correspondent Rob Stein. Rob, you've given us a lot to think about. Thank you so much. You bet. Thank you.

The Treasury Department says Congress has until about next week to raise the federal debt limit or else put the United States at risk of defaulting on its existing debts. If Congress fails to raise the debt ceiling, the fallout could be huge for many Americans. So what do we do? NPR's Arzu Razvani has been looking into the preparations. Hi there. Hi, Steve. How widespread would the impact be of a default?

A very broad swath of Americans would feel the effects. If you're already retired, a debt default would take a big bite out of your Social Security checks. Borrowing money to buy a car or a home will suddenly cost you a lot more. I was at an open house recently, and real estate agents there were pretty nervous about how a debt default could send interest rates soaring at a time when the housing market is already struggling.

Wait, wait, wait a minute. I understand the Social Security part because the government is paying these checks. And one of the first things that might happen if they run out of money is they might fail to pay the checks or delay paying the checks. But why the borrowing? If the federal government fails to pay its debts, why would that affect my home mortgage or somebody else's home mortgage?

Well, I mean, everything is connected. If the government defaults, it will grow harder to borrow money. The U.S. will have to pay higher interest rates on bonds, and then that tends to push up interest rates on all other kinds of borrowing, including yours and mine, for things like home mortgages. Which would explain why experts are warning of a widespread economic disaster if this came to pass. So how should people prepare? Yeah.

The personal finance experts and economists I've talked to all echoed one another on this topic. Anna Helhosky at NerdWallet sums it up best. We're advising people to prepare for a potential default as you would for an impending recession. So Helhosky says this because a default could really tip the U.S. into a recession. If the U.S. defaults, it would set off a domino effect.

Millions of Americans would suddenly lose their benefits. Interest rates would shoot up. These are all circumstances that make people way more cautious. They pull back on spending, so do businesses. People are laid off. These are all typically hallmarks of a recession. So what do you do?

Well, you want to return to the tried and true basics. Make sure you have at least three months' worth of your living expenses saved up and easily accessible, not tied up in some investment. Then you want to take a look at your debts. With high inflation, a lot of Americans have been leaning on their credit cards lately. So prioritize paying off those with the highest interest.

And generally remember that interest rates will be going up on everything. The last time the U.S. came close to a default, the stock market went all over the place and mostly down. What should people do if they have investments? So there's a great deal of consensus among financial experts and economists on this one. I put this to Teresa Ghilarducci, labor economist and expert in retirement security. Here's her advice. Right.

really fight your worst instinct to act on the news. All the academic research shows that if you buy and hold, you will do so much better than if you try to follow market trends, whether that be responding to an economic crisis or a recession. So the thing to remember here is that these investments, whether they're stocks or 401k accounts, they're all about the long game, even in this moment of economic uncertainty.

Arazu, thanks so much. You're welcome. And Piers Arazu-Rizvani. Another story we're following today, Florida Governor Ron DeSantis announced a presidential campaign. He was supposed to announce on Twitter spaces where you can have conversations heard by other people, and he was going to tell the owner, Elon Musk. Instead, people heard 20 minutes of technical problems. So, let's see. It's like we just keep crashing, huh? Yeah, I think we've got just a massive number of people online, so it's...

So it was restraining somewhat. More than half a million people tried to hear what DeSantis had to say, and the Florida governor finally did get to speak. He framed his campaign in terms that would appeal to hard right voters. Biden's allowed woke ideology to drive his agenda. We will never surrender to the woke mob

And we will leave woke ideology in the dustbin of history. Many Republicans have seen DeSantis as an alternative to Donald Trump, but several candidates are now contending against each other as well as Trump.

And that's Up First for Thursday, May 25th. I'm Michelle Martin. And I'm Steve Inskeep. Today's episode was edited by Andrew Sussman, Scott Hensley, Emily Kopp, and Mohamed El-Bardisi. It was produced by Claire Murashima, Shelby Hawkins, and Katie Klein. We get engineering support from Trey Watson, and our technical director is Hannah Glovna. Join us here tomorrow. Ready for more NPR news? There's a radio show for that. Find NPR's morning edition on your NPR station at stations.npr.org.

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