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cover of episode 302. Transdermal Testosterone Is NOT Suppressive!?

302. Transdermal Testosterone Is NOT Suppressive!?

2025/3/6
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Boost Your Biology with Lucas Aoun
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David
波士顿大学电气和计算机工程系教授，专注于澄清5G技术与COVID-19之间的误信息。
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David: 我过去十年痴迷于男性激素优化，特别是DHT。起初关注睾酮，但后来发现DHT才是睾酮的主要作用形式。通过自身实验和药学背景，我发现DHT对男性健康至关重要，它比睾酮更具雄激素活性，负责许多男性第二性征的发育，如性功能、认知能力、力量、勃起功能、性欲等。市面上有Andractum这种处方药，但浓度低，吸收率差。我们开发了更高浓度的DHT凝胶(10%和20%)，具有局部和全身作用。许多男性服用非那雄胺后出现低DHT症状，如情绪障碍、低欲望等，外用DHT可以有效改善这些症状。建议每日或每日两次外用，并可与低剂量HCG联合使用，以促进神经类固醇转化，避免剂量过高导致雌激素转化增加。经皮睾酮比注射睾酮能更好地转化为DHT，改善性功能和认知功能。睾酮与DHT的理想比例为5:1。DHT可以抑制雌激素与雌激素受体的结合，有助于治疗男性乳房发育症。外用DHT对内源性睾酮的抑制作用较小，恢复内源性睾酮生成也更快。LH水平会受到抑制，但不会完全关闭。外用DHT可以降低催乳素，降低雌激素，升高T3水平，对甲状腺功能有益。低游离T3会影响DHT的转化，而T3与5α还原酶之间存在比例关系。甲状腺功能与雄激素受体敏感性之间存在联系，甲状腺功能越好，雄激素受体的密度和敏感性越高。低碳饮食会影响T4向T3的转化，并影响DHT的转化。任何外源性雄激素，包括DHT，都会降低性激素结合球蛋白（SHBG）。生长激素（GH）与雄激素联合使用可以促进肌肉生长，但可能导致催乳素升高。 Lucas Aoun: 我与David讨论了经皮睾酮和DHT的应用，以及它们对男性健康的影响，包括治疗男性乳房发育症、改善性功能和认知功能、以及对内源性睾酮生成的影响。我们还探讨了HCG与DHT联合使用的益处，以及低碳饮食对甲状腺功能和激素水平的影响。此外，我们还讨论了其他激素（如皮质醇）与睾酮和DHT之间的相互作用，以及一些补充剂（如镁、牛磺酸、肌酸）在优化激素水平中的作用。

Deep Dive

Chapters
This chapter delves into the crucial role of DHT in male health, discussing its functions, benefits, and the controversies surrounding it, with a focus on transdermal application and its impact on various aspects of men's health. It also explores the importance of maintaining a proper testosterone to DHT ratio and the potential of DHT in treating gynecomastia.
  • DHT is a primary male androgen derived from testosterone.
  • DHT is 5-10 times more potent than testosterone in binding to androgen receptors.
  • Transdermal DHT application offers localized and systemic effects.
  • DHT plays a key role in masculinizing effects during puberty.

Shownotes Transcript

In this episode of the Boost Your Biology podcast, Lucas Aoun and David from AlphaGels delve into the intricacies of hormone optimization, focusing on testosterone and DHT. David shares his extensive knowledge on the significance of DHT, its functions, and the benefits of transdermal application. They discuss the importance of maintaining a proper testosterone to DHT ratio, the potential of DHT in treating gynecomastia, and the relationship between thyroid function and androgen receptor sensitivity. The conversation also covers practical advice for those considering hormone supplementation, including the use of HCG alongside DHT and the implications of transdermal testosterone use. In this conversation, Lucas Aoun and David delve into the complexities of hormonal health, focusing on thyroid function, the role of DHT, and the implications of SSRIs on mental health. They discuss the importance of understanding hormonal interactions, the misconceptions surrounding DHT and prostate health, and the significance of quality supplements. The dialogue emphasizes the need for a holistic approach to men's health, addressing both physical and mental well-being.

Relevant links:

David’s Twitter / X: https://x.com/AlphaGels

Buy Lucas’ NEW Herbal Supplement Here: https://www.inb4supps.com/

Disclaimer:

The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program.

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