Welcome to the huberman la podcast, where we discussed science and science space tools for everyday life. I'm Andrew huberman and i'm a professor of neutral logy and alpino logy at stanford school of medicine today. My guest is doctor kyle galette.
Doctor gillette is dolbear certified in family medicine and obesity medicine and practices out of a clinic in kansas and via telemedicine. He provides full spectrum medicine, including formal health preventive medicine, obstetrics, which is the branch of medicine and surgery concerned with childbirth and the care of women giving birth, and pediatrics. I first learned about doctors to let from a podcast of all things, and was immediately struck by the bread and depth of his knowledge on all things, hormones and hormones optimization.
As you'll see very soon today, doctor galet can teach you how to optimize your hormones using behavioral tools, nutrition, exercise based tools, supplementation and hormonal therapies, if those are appropriate for you. There are many professionals out there, including many medical doctors, of course, talking about hormone health. What really sets doctor i'll let apart from the pack is his ability to understand how the different factors that I described before, nutrition supplementation, exercise and hormonal and therapies, how those interact with one another and the safest and most rational ways to approach horton optimization.
During today's episode, you will learn how to optimize your hormones, not just testosterone on an extradition, but also prolactin in other hormonal pathways that impact your mood, mental health and physical health. Doctor jEllied is also an avid educator about hormones and other aspects of health. He does this on zero cost to consumer platforms such as instagram and social media.
On instagram, he is a KO galette. Md, that's K Y L E G I L L E T T no, eat the end. Md, so calculate md on instagram, and he is just let health on all other platforms, including linton, twitter, youtube, tiktok and facebook.
If you go to his or his other social media, you will learn a lot about hormonal health, about the latest science impacting obesity and metaphor health. He has a wealth of knowledge, and again, he's providing all that information at zero cost to you, the consumer. What you are soon to hear is a conversation between me and doctor cheeta about all things, hormones and hormones, health and hormones optimization.
We dive deep into mechanisms, but we are clear to establish what each word or set of concepts mean. So if you have no background in biology, or even if you do, i'm sure that you'll come away with a wealth of valuable knowledge. We also talk about specific protocols related, again, to list all factors, nutrition, supplementation and, where appropriate, hormone replacement therapy.
I know there's a lot of interest about these topics. Doctors should let is very thrown about addressing both male and female issues and addressing hormonal health for people at all stages of life. I'm sure that you will come away from this episode with the same impression that I did, which is the doctor jett is extraordinary, ily clear communicator, and that he has tremendous compassion for his patients, and that he has a deep love of understanding biology and medicine in ways that can benefit you.
Before we begin with today's episode, I want to emphasize that this podcast is separate from my teaching and research roles at stanford. IT is, however, part of my desire and effort to bring zero cost to consumer information about science and science related tools to the general public. In keeping with that theme, i'd like to thank the sponsors of today's podcast.
Our first sponsor is athletic Greens. Athletic Greens is in all in one of vitamin, mineral, probiotic drink. I've been taking athletic Greens since two thousand and twelve. So i'm delighted that their sponsor in the podcast, the reason I started taking athletic Greens on the reason I still take athletics Greens once or twice a day, is that IT helps me cover all of my basic nutritional need to make up for any deficiencies that I might have. In addition, IT has probiotics, which are vital for microbial on health.
I've done a couple of episodes now on the so called gut microbiome, and the ways in which the microbiome interacts with your immune system, with your brain to regulate mood, and essentially with every biological system relevant to health throughout your brain and body. With deleted Greens, I get the vitals I need, the minerals I need and the probiotic to support my microbes. If you'd like to try athletic Greens, you can go to athletic Greens dotcom flash huberman and claim a special offer.
You'll give you five free travel packs plus a year supply of vitamin d 3k two ton of data now showing that vitamin three is essential for various aspects of our brain and body health。 Even if we're getting a lot of sunshine, many of us are still deficient in vitamin d three and k two is also important because IT regulates things like cardiovascular function cause um in the body and so on. Again, go to athletic Greens that comes so huberman to claim the special offer of the five free travel packs and the year supply of vitamin d 3k two。 Today's episode is also brought to us by element.
Element is an electronic light drink that has everything you need and nothing you don't. That means the exact ratios of electrolier ts are an element. And there was our sodium, magnesium and patasse um but IT has no sugar.
I've talked many times before in this podcast about the key role of hydration and electoral lights for nerve cell function, neuron function, as well as the function of all the cells and all the tissues in organ systems of the body. If we have sodium anisim in patagium and present in the proper ratio, all of those cells functioned properly in all our bodily systems can be optimized. If the electronics are not present in the hydration is low, we simply can't think as well as we would otherwise.
Our mood is off, hormonal systems go off. Our ability to get in the physical action, to engage in endurance and strength and all sorts of other things is diminished. So with element, you can make sure that you're staying on top of your hydration and that you're getting the proper ratios of electoral lights.
If you'd like to try element, you can go to drink element, that element t dot com slash huberman, and you'll get a free element sample pack with your purchase. They're all delicious. So again, if you want to try element, you can go to element element t dot com slash huberman. Today's episode is also brought to us by waking up, waking up as a meditation APP that includes hundreds of meditation programs, mindfulness trainings, yoga eda sessions and n sdr non sleep depressed protocols.
I started using the waking up up a few years ago because even though i've been doing regular meditation since my teens and I started doing yoga eja about a decade ago, my dad mentioned to me that he had found an APP turned out to be the waking up APP, which could teach you meditations of different durations, and that had allowed of different types of meditations to place the bringing body into different states. And that he liked IT very much. So I gave the waking up up a try, and I too found IT to be extremely useful, because sometimes I only have a few minutes to meditate.
Other times I have longer to meditate. And indeed, I love the fact that I can explore different types of meditation to bring about different levels of understanding about consciousness, but also to place my brain body into lots of different kinds of states, depending on which meditation I do. I also love that the waking up up has lots of different type of yoga ea sessions.
Those you don't know yogananda a is a process of line very still, but keeping an active mind is very different than most meditations. And there is excEllent scientific data to show that yoga ea and something similar to IT called non sleep deep breath or nsd r, can greatly restore levels of cognitive and physical energy even, which is to a short ten minute session. If you'd like to try the waking up, you can go to waking up dot com slash huberman and access a free thirty day trial.
Again, that's waking up dot com slash huberman to access a free thirty day trial. Today's episode is also brought us by inside tracker. Inside tracker, a personalized nutrition platform that analyzed data from your blood n DNA to help you Better understand your body and help you reach your health goals.
I ve long been a believer in getting regular blood work done for the simple reason that many of the factors that impact your immediate and long term health can only be analyzed from equality. Blood test. There are a lot of blood and DNA test out there, but a major issue with many of them is that you get numbers back about levels of hormones of olive c factors, lipids, zada.
But you don't know what to do with that information. Inside tracker has solved that problem by creating a personalized dashboard. So you take your blood and or your DNA test, you get the results back and where certain values might be too high or too low for your preference, you can click on that.
And I will direct you immediately to life style factors and nutrition supplementation. It's Better that can help you bring those numbers back into the ranges that are ideal for you. So IT not only gives you information about where your health stands, IT gives you directives as to how to improve your health.
If you like to try inside tracker, go to inside tracker or not calm slash huberman to get twenty percent off any of inside trickeries plans that inside track ker dot com slash huberman to get twenty percent off. And now for my discussion about hormone health and optimization with doctor kyle geeta. Doctor gett, welcome.
Thank you for having me.
Well, i'm super excited to talk to you because I found out about you on a podcast. And IT immediately became clear that you are an encyclical pedia of knowledge about hormone health for men and for women across the lifespan. So I have many, many questions.
But before we dive into those questions, i'd love to just get a little bit of your background in terms of your medical training and what your particular orientation is tod treating your patients? And how do you think about this whole landscape that we call hormones health? What is a hormones? How do you envision people managing their hormones? You could just kind of fill in a few of those blanks for us. I think a lot .
of people would appreciate IT. absolutely. So i'm dual board certified in family medicine and obesity medicine. I've kind of tailored my training in order to provide what I call a baLance ed approach to total health, which includes body, mind and soul. I recently saw a podcast with joe rogan and mister beast and joe asked um mr.
Beast, how do you become such an amazing youtube and have all these um you know great click bait videos and how did you become good at IT and IT? Turns out he just became obsessed when he was a teenager. And that's essentially how i've Taylor red my education as well.
I become obsessed with optimal human performance, their body, their mind and even they're spirit. So attended medical at the university of kansas, which is. One of the few made schools that still emphasizes false spectrum care.
They emphasize exercises, medicine, they emphasize food is medicine of which I was active in both of those interest groups in residency. I was active in a lot of uh mindful, less curricular and then also things like walk with the dark, where you emphasize preventative medicine. That's something that we've gonna got away from and that nach LED me to horon health. I didn't really start as form on health, but its a very important component of health in general that many people don't emphasize.
great. Well this idea of preventive medicine, I think is starting to really take hold in the general population, especially given the events of the last few years. People realized that they are showing up to health chAllenges at a bunch of different levels. And with some people feeling very robust, other people feeling back on their heels, when someone comes to you as a patient, what are some of the first things that you want to know about them? I mean, obviously, you want know their blood pressure.
You want to know something about their mental health and family history, but in terms of hormonal health, what are the sorts of probe questions that you ask him? And what are you looking for? And I ask this because i'd like people to be able to ask some of these very same questions for themselves.
So when you do a physical exam and a history, you have a lot of different parts. You have your history of prison illness. If they have a complaint, maybe the patient doesn't have a complaint.
In that case, things like their social history and their family history are extremely important because that gives you an insight into their genetics and an insight into their hormone health. So a patients will tell me i'm doing okay, but IT helps to ask them, well, how are you now? Let's say the patient is fifty.
How are you now versus when you were twenty and what has changed? So i've got the question a lot. How do you get your doctor to order a Better lab work up or to even include your basic commons? And there is no magic answer to that.
But what really helps you tell them, you know, my energy is not as good as I used to be, my focus is not as good as I used to be, my athletic performance is not as good as I used to be. So you don't have to have a pathology in order for a la B2Be ind icated. You just need to have that permanent symptom.
This can be really helpful because for many people, the the idea of getting a blood test to look at their home hormones just seems like such an enormous hurle to get over and many doctors won't prescribe them. And would you say that it's using the approach you just described but that it's um equally effective for men and women? Or do you find that um for one reason or another that men women have different chAllenges in an advantage in trying to access their deeper hormone .
data yet slightly different um with women there's a lot more objective data. So if they're having menstrual regularities or um you know if they're going in, if they are not having a period, if they're having too heavy of periods, and those are things that they talk about very frequent, frequently with their doctor. Men are more hesitant, so men really want to know what their test astre one is. But they, at the same time, they really don't anna, tell their doctor how their libido is or how the energy is, because it's almost like they feel less masculine or they feel less like a guy when they say that even if they're just talking to their doctor about IT.
Yeah I think that that raises a really important point, which is that the whole discussion around hormone health is a bit of a barbed wire topic because in many ways, when we hear the word hormone, we think testosterone and estrogen, we think notions of masculinity and femininity, and of course, teston and esterton re present in all sexes, right, all criminals of backgrounds and just a varying degrees in ratio.
But IT also raises all these issues about sexual health that it's kind of interesting because I surrounded by medical doctors in my lab at stanford and the more physicians that I surround myself with, the more open is the discussion around sexual health and reproductive health. But in the general population, I think some of these topics are a little bit um taboo or against kind of barbed wire. And so I think that people are seeking a lot of this information on youtube and through communities that may or may not be very educated about the actual biology.
So along those lines, you know we could probably assume that hormones are changing across the lifespan. Think right, certainly from from childhood, puberty and onward. If if you would, i'd love to just going to take a snapp shot of what you think everybody should be thinking about or doing to optimize their hormone health, male or female, in the, lets say, in their twenty years, and then maybe we can migrate that to their thirties and forties. But before that, could you just tell us what everyone should be doing for their hormone health from puberty onward?
Yeah, the love definition returns applies. So doing a little amount of what I call lifestyle interventions over a long period of time is going to be far more helpful, efficient, then doing a lot and then doing nothing, or doing a lot and then doing nothing. So I talk about the big six pillars.
The two strongest ones are likely diet and exercise for hormonal health. Specifically, resistance training is particularly helpful for diet chloric restriction can be particularly helpful, especially with the epidemic of metabolic drome that is continuing to and go in this country and in developed countries in general. So those are the two most powerful.
So number one and number two are diet and exercise. For the last four, I have a little bit alliteration. So there's stress and stress optimization that has to do with courts, all that has to do with your mental health, that has to do with societal health and collective health of your family as well.
When you're a member of a family or even a very close friend, um trying to achieve optimal health together is very important. It's the same thing with native insulation, the same thing with horn optimization. If you do IT as a household unit, it's far more helpful.
So after stress, you have sleep optimization. Sleep is extremely important, especially for maicon, real health as well. And then you have sunlight watching compasses, anything that's outdoors. So you move more. You have cold exposure. You have heat exposure um that sunlight and the last one of spirit IT so um that's kind of the body, mind and soul if you have all the other five in other dial and completely but you don't have your spiritual health whatever you believe and that's going to profoundly impact your body and your mind as well and we're definitely going .
to touching into this notion of a spiritual health because I think for some people that might um draw connotations of of um certain things that may or may not be accurate. But I know a number of academic laboratories that are focused on this and a number of not just functioning medical clinic but um research clinics and hospitals throughout the country that are achieving some really interesting data, not just in in people that are quite sick but in healthy people are trying to further up to my heart. So we will definitely touch back to that if you um would be so kindness to maybe give us a little bit more detail about some of these other areas.
So when people here diet, I immediately think, okay, now we get into the the combat around vegan plant based carnival that but I think that my general view of this is that most people should probably be eating as few highly processed food, highly palatable able foods as possible, which doesn't mean eating foods that don't takes good, of course but what other sorts of things do you recommend in the realm of diet? Um and then I also want to know about chloric restriction because my understanding is that a clerk surplus can actually support certain hormones like test stone. So how does one combine clerk restriction and still optimize a hormones? But what would you say is a really terrific way to think about an approach? Diet.
yeah, diet should be an individualized approach. So if you have A A car, each car is made different and requires a different sort of fuel. Whether it's a race car, whether it's a deetle truck, they have different feels for different performance outcomes.
So if you trying to toe something or you've trying to go fast, so it's the same way with athletes, it's pretty well studied. The more intra workout carbs, ultra long distance athletes takes generally do Better. I think they've studied this in cyclists quite often and also depends on your genetics. So you can have a genetic polymorphism, and you meta lize carbs and sugar butter, even when they are on opposed by fiber.
How does one determine whether that they have such a polymorphism? I'm an omaar, so I do eat some high quality meets, not in huge qualities, but I also eventual and starts as I feel fine. I've never done an elimination.
I think I did very low cb diet once, and all that gave me was a lot of soria is and poor sleep. So I backed off. I probably didn't do IT correctly, but I know a lot of people that do quite well on on a very low carbon .
ero carb diet yeah particularly those who are risk of cancer because you have less, uh, blue coast that can be easily up taken into cells and then also people with ottawa on diseases.
They tend to do .
well on on lower carb diets. Yeah but yeah, as far as the how do you know basically you can use your biofeedback how you're feeling to guess what you tolerate well or you can just get genetic testing, which can be fairly expensive. But most of all, IT requires a physician or someone who knows how to interpret the test accurate.
And if someone had the means, or would you say that getting regular blood testing is a good idea? If so, what is regular blood testing? Is that every three months is that every six months, of course, the backdrop of life is changing to stress levels .
at a yeah every three to six months. For preventive purposes, at times you need blood tests that a faster frequencies than that. And then you should also get a blood test when you're fasting and when you're not fasting. So if you're looking for a damage to the beach you want, you don't just look at low tide. You look at high tide and you see what's happening at high tide as well.
It's a great way to put IT. And in terms of a general recommendations around exercise, I mean, i'm of the mind, based on the data that i've seen, that almost everybody should or everybody should be getting hundred and fifty to one hundred and eighty minutes minimum of zone two cardio per week. That of could continue a while having a conversation.
But with. If one were to exert any more effort, IT would have a hard time getting the words out, at least that right for cardiovascular health and general brain health and musk skeletal health, plus resistance and exercise. Is that more or less the control of what you recommend?
Yeah that's more or less the content or the more you're doing your zone to cardio, ask the exercise. The slightly less important, a long duration of chloric restriction is interesting .
and that brings us the chloric restriction. So it's very clear that color c restriction can allow one to lose weight, right? This is the classic ego C I C O, calories, calories out.
We are not disputing calories in, calories out somehow. That always has to be stated fifty times in any forum because of whatever follows people I think will anchor to and assume that we don't mean that. But I know uni both agree on calories, calories out as a fundamental of thermal dynamics.
But it's clear to me that based on what i've read, that when one is in a slight color, c surplus that hormone's like testosterone can be optimized. But is that true for somebody who's showing up with excessive body fat? How does this all work? But as body fat is manufacturing enzymes that convert to SaaS ter into estrogen, so in other words, how does someone know if they should use color restriction or .
avoid color restriction? Yeah, he's had to pass that out. So before I do the details a bit more, I should say as a board certified obesity medicine, physical, obviously the laws of the modern amic supply. And then in addition to that, there is nothing special about interment and fasting or choric restriction or exercise when IT pertains to losing body weight.
In general, when you do lose weight, about thirty three percent of that is lean body mass, and about ten percent of fat cells, ado cells, are actually in body mass as well, because as proteins in the water and things like that, that too. So the reason for exercise and the reason for chloric restriction in general, including interrelated investing, is health reasons that how you increase your health span, it's not necessarily gna make the weight on the scale change. But that isn't matter as much.
It's been fairly well. Studying in both mice and human is much easier to study in mice. So that's a presser to our six types of people, the ones that care about my studies and the ones that care about human studies.
But if you clerically restrict mice by forty percent, then they can have improved test astrium parameters, but only if the obese to start. And IT appears to be that same way in humans as well. So the easy way to think about IT is, if you obese or you have met a bolos on drome cleric, restriction will improve your testosterone.
There has been a study and they talk about all these studies in a systematically review from the male clinic proceedings in march of last year. And um they note that there is a study in Young healthy men and they clear clearly strict them and their taste trum does decrease. So if you're Young and healthy and you don't have meta lox ndr, me think chloro c restriction will likely decrease .
your testosterone. That clarifies a lot for me and I believe IT will clarify a lot for other people as well. And i'm delighted that you pointed out this distinction about fasting not being the only way to achieve color restriction.
There are a number of Young, healthy or older healthy people I know who like using intermit and fasting, even if they're not trying to lose weight for a couple of reasons. Some believe that I might extend life span. I think they're still that's still a bit of an open question.
It's a bit of a hard experiment to do because the control group, no one wants to be in the control group. As I say, IT doesn't right exactly, exactly. And the other feature of the silo, bit tRicky, is that many people like to in fasting because of the mental effects, the clarity of mind that they feel during fasting, the increased pleasure in eating when they finally do eat.
Um and here i'm referring to intermet fasting of the sort where eating windows anywhere from eight to twelve hours today not extended fast of twenty four hours or more. So the question therefore is for the healthy um lean enough person right non obese person is in fasting. A bad idea in terms of hormonal health is associating between this period of confident famine within a twenty four hours a problem if one is getting sufficient calories to make in weight.
Yeah so if there are a clerc maintenance, then it's not going to be um it's not going to be deleted, it's not going to be bad. Further hormones alth, there's a couple different hormones that we can talk about. We can talk about testosterone.
We can talk about DHA, which you usually go hand in hand. And then we can also talk about growth hormone, which is not a steroid hormone, but it's a peptide hormones. So it's a chain of proteins, a mino assets that are put together instead of a sterol.
Think of steel hormones is coming from cholesterol. So intervention, fasten, you do good a little Spike in growth ormon after you eat, but you also get a huge Spike in growth hormone, a more significant, less negligible Spike overnight. And that is improved if you are internet and fasting. So it's probably going to help your growth hormone, and subsequently I G, F one levels, which will help more in older age groups and Younger age groups.
And I like to eat dinner. So for me, at that mean, sometime around six or seven o'clock, sometimes eight o clock, I confess, last night. So it's working late.
I I pretty big. I is IT basically my only meal the day ten o'clock. That's a rare thing for me.
Can I still achieve a high degree of growth home or output if I let I avoid food in the two to three hours before going to sleep? Or does one have to be very deep into a fast in order to achieve this? The increase in growth hormone on there .
is still a pretty good growth hormone output even if you eat two or three hours before you sleep. It's just the law diminished turns. The longer you go, you get slightly more and slightly more.
Um and I know a number of people think of growth horn in the context of the exogenous growth hormone um in the fact that that can in some cases be associated with cancers um i've been asked many times before can the increasing growth hormone from things like sona or intermitten sting cause levels of growth woman that are so high that they caused cancers I my impulses to say no, that does. That seems like it's not likely to happen, but I should probably verify that statement with you.
Yeah so quite unlikely. I think about growth for moon and especially I G F one and there's actually an I G F one and I G F two. But I think about IT in terms of inducing an I G F one, mostly I G F one that's h synthesized ed in the liver and released in the liver first is igf one that's released um classically.
An example of this would be your igf one levels increase after resistance training or exercise and that's more of like pyrran or auto chin and they have more local action so that I G F one, it's pretty well study that if you just give people I G F one, it's not going to at physiological levels, it's not going to improve their body composition. However, that I G F one that's autocrat and parachute. Just working in those local tissues and muscles is likely part of the reason why you get a improved body composition response after exercise.
I see. And just to clarify for me and for for others, what can we say are the major functions of I G F one in I G F two that are from just growth ormon? Are they just have the active formal growth hormone on the kind of the pick accent of the of the of the assembly line.
so they have a much longer duration of action. I believe the half life of I G F one is several days, almost a week, where as growth hormone has an extremely fast half life of only hours, so growth hormone acts uh significantly on the liver to produce I G F one. So it's a it's around in the serum, in the blood along enough to where it's producing an effect. A pretty much all the time, very interesting ted one.
Then the other pillars, stress. You know we've talked a lot about stress on this podcast before in tools for managing stress sleeve, obviously, is a big one. I think you know if if nothing else, I will either put people to sleep with my podcast, certainly not this one, but my my solo episodes, or hopefully convince people that sleep is the foundation and physical health and and performance.
Are there any aspects of ormon optimization that can improve sleep? I know sleep can improve hormonal optimization, but are there any aspects of formal optimization that can improve sleep? And for people that are suffering from this common syndrome are going to sleep and then waking up at three or four in the morning, we know that can be associated with depression. But are there any hormonal indications that might lead to that kind of situation?
Yeah, there are three big ones. The first one is not super common, but its a very direct correlation. If you have a growth hormone deficiency, a true deficiency, whether you're an adult or a child, then your sleep is likely going to be affected.
And let's say you're a child with growth or more efficiency. Once that is replaced with therapy, your sleep is gna get significantly Better. The second one that's a very common scenario is if you're having what's called vaio motor symptoms of menopause or facial motor symptoms of underpays, which are also applicable, and that's where you're project ic activity. So your main project giants are progesterone and then pregnant alone and then five alpha, 3 alpha.
which is manufactured in the body.
So there are manufactured in a few places. In men, their manufactured some in the testes in the latest cells. In women, they're manufactured in the overs until many of pause, and they're also manufactured in the address inal gLance.
So um if you're in if you're pre a dream, a puzzle where your general glands are still worked in fairly well, usually still have a decent amount of progesterone around and this can be measured to so after mini pause, women make protest room from their uh overs, sorry, from their original gLance. If that protesters on cross the blood brain barrier, especially if it's five elephant three alpha, do so it's modified little bit. Then IT is both a gaba agonist um which helps sleep just like gabba does give a meur acid the main hiba ory neuro transmit of which lots of things work on alcohol works on gabas well.
Gaba pinson also works on gaba migraine medicines. Many of them work on gaba benzo o dies a peans and also non benzo s so of an example i've been so i'd be zani s an example of. A um non vince o would be ambient.
So those all work on gaba. So gaba is also helped by the protestant ic activity as well. That's why a lot of women in mini POS feel like their sleep is much worse is because they have lower activity of those projections.
Ons is the end for men in so called Andrew PaaS latest astro. Is that also one of the causes of poor sleep?
Latest aston, one can lead to poor sleep. But my third and ario is actually, if a man begins to rt, then they develop a horsey because of sleep. Here IT drastically raises the risk that somebody is going to have sleep up.
And then a lot of people, especially when they first started in the first month, two IT puts them in to this hyper sympathetic state because they have overactive energon receptor ors, especially after a long time of being hypocritical than they have A A physiologic dose of T, R T. And that causes the sleep issue itself. interesting.
I have a lot of questions about T R T T S. Also, replacement therapy, as you just mention, that when you say IT increases a sympathetic activity, but you don't mean ah that taking testosterone increases sympathy for others. That may in fact to the opposite.
Although it's very clear for my discussions with my colleagues on the in the end chrono gy side and also with the great doctor Robert suppose key that that increasing testoon merely exacerbate tes existing features of people. So the church become big, your jerks kind of people become even more kind in general. Um but we I want to get into T R T in depth.
That's very interesting. Me to hear that to also a replacement therapy increases the risk of sleep apia. And I want to make sure that I ask that, is that also the case of people that are using prt who are not hypocrites ult. Because in the classic situation, as somebody isn't making enough to stand there below three hundred and ground for this leader on the chart, they going into rt. But many people now is that's be honest, star are taking doses of testosterone one, even though they are in the sort of standard range because the range is so large because of other system logy that right?
Yeah, I do love the analogy that doctor's suppose he had about monks taking to stores one and making them more and more generous. So that does appear to be what testosterone usually does. Is that exaggerates, if you will, what you're previously like.
So it's not going to change you as a person but um if you you can add before you start test stone, meaning you meaning meaning you have Normal test stone and then you start T R T or um self administer T R T steroid with everyone to look at IT, then your risk of sleep apnea still goes up in a dose dependent fashion. So the higher the dose, the more risky with the the sympathetic and the pair sympathetic nervous system. The sympathetic is the fighter flight nervous system.
The pair sympathetic is the rest and digest. So if you have too much fighter flight and stress can cause that too, then you're not going to arrest as well. At night.
I want to touch on testosterone and women, because there .
is testosterone .
and women. I'd like to know where that testosterone on comes from, which tissues. I'd like to know whether or not testosterone replacement therapy makes sense in women. I'm hearing more and more about women using testosterone. And I like to know whether or not knowing a woman's tests for her to know her testosterone one is of equal, less than or more value than knowing, for instance, protesters on an estrogen levels, because I think there are a lot of conceptions about the rules of testosterone.
And women for health optimization. Testosterone is just as important to know for pathology prevention. For example, breast cancer, osteoporosis, estrogen and protest on are more important to know. So when you're thinking about women, women think think that they have such a tiny amount of testosterone because you could you test IT most people tested free testosterone um so testosterone that's unbound, which is by far though the smallest proportion of the astro any Andrew gen is bound by lots of different steroid binding proteins, but the ones that our most permanent are called S H B G or sex hormone binding globulin.
And that bines the androgen ics steroid, for example, dht or die hydra r test astro is associated with prostate enlargement, associated with male powder baldness, IT beds that the most strongly, and then IT binds to start room next most strongly, and then IT buds, things like understand a dion or D H G A D hydro F P and dress drone. And then IT finds the estrogen the weakest, like extradition. So if you look at the total amount of test, astro women actually have almost all women, not all women, but almost all of them have significantly more testosterone then extradition, but it's because it's different measurements. So extradition lot of time, as you know, peak grammes premiere as opposed to anode ma produced leader. So women have more testa stern than estrogen and significantly more D H, A than either.
Interesting, do women make the hydro test astro?
yeah.
And where does where does this test astro on come from? Because they don't have tests.
yeah. So most test astern and women that are premium puzzle can come from fika cells, T H E C A, so thk cells or cells in the overs that can produce us tost drone. And a lot of people um i've actually heard about hyper thy cosas not determine itself, but a lot of olympians that are their crimes somes are xy their females and they're not taking any way.
Feel sorry the X X O K, thank you. So the X X they are not X Y and they have never transitioned there been on any sort of uh homework replacement or test stroom. But they naturally produce a huge amount of testosterone, one as much as many men. And some of these women, I believe, there from botswana, were banned from competing in the olympics in certain distances. I believe they are banned from the four hundred meter and eight hundred meter because their natural testosterone one was deemed ed to be too high.
So they mistakenly think that they were using steroid.
They actually knew they were not using steroids. They knew is their thick of cells were just genetically gifted, I suppose, and they still made them change distances. Well, so one or two these athletes change to, I believe that was the three k or the five k and they still did quite well, but I was not their best event.
interesting. Yeah, that's turning out to be a very interesting in controversial area of this notion of hormones, eries and natural variation and hormones on different chromosome mal backgrounds faster. We should I do a whole episode about that because it's very much of the times.
So men and women .
both make dht. I'd like to ask about dht in men.
So often we hear about testosterone and men and free test astro and being the unbound form, of course, but die hydro testosterone um where does IT come from a men? What is the cascade event takes the astro to die? Hydra sastras? And what are some of the quote, quote, positive and negative effects of here? I'm only referring indolent im to stop and in fact I i'll make IT very clear whether or not um i'm talking about taking something or one's own natural production here. We're just I think of until now we've just been talking about natural production so tells about the H T N men such a powerful hormone during development, obviously. Um but what what is IT doing?
D H T is a very androgens corso, whether you are talking about D H E A, which is a mile a week handrosan, or testosterone, which is a relatively strong androgen, or dht, which is a very strong androgen, they buy into the energy receptor in both men and and women. So the a effect of all three of those is mediated by the energy receptor.
There's a couple of different beta extradition septr and alpha astro dio recept tors, but there's only one end of the receptor intriguing IT is on the x crimes. So men get there, ander and reception gene from their mother. Women get one energy receptor gene from their father, one from their mother, often the one that is more sensitive to energies and people with P. C, S, that's the one is active. The other one is method, ted and inactive.
Can I just poise t you and say it's started to interact? But I have to ask this question before, I forget, and I know a number of people are probably wondering, i've heard that whether not one develops male pattern boldness, whether not a male developed male pattern boldness and just to be very precise ah you could get some information about that by looking at your mother's father and that would in keeping with what you just described, that the extremities one which of course is handed off through the mother, is Carrying the genes that encode for the number and distribution of these of these androgen receptors that dht will buy to cause.
Of course, I think, as you'll probably tell us, that dht is a responsible for male pattern boldness and beard growth. Is that right? Should I look at my grandfather and my mothers side to determine what i'm likely to look like in terms of my dht? This is that a word?
Yeah it's the best guest that you can make clearly from theano types. You can measure your genotype and um you know get a Better idea of that assuming that it's true male pattern baldness is related to the gene transcription of the energy in receptor.
So I like to think of IT as how much of this energy en recept gene is activated by any hand rogen, so if you have an extremely sensitive gene, which usually means you have very few C A G repeater s, which is basically just a certain C A G and codes for a certain a mino acid. And if you have very few of the repeats s, then your energy in receptor gene works Better. Think of IT as a correlation to hunting tense disease, where if you have very few called try nuclear tide repeats, then it's not as severe as a disease. But after you get more and more C A G repeats s which, by the way, in the population you're getting more and more C H repeats um so it's A A natural selection, the process that has been ongoing for a of idea number reasons. But anyway, if you have more repeats than that, gene activites in the cytoplasm and move to the nucleus and causes gene transcription more often and her loss more often.
does that mean that we're seeing more hair loss now due to elevated levels of dht than we were fifty years ago?
Probably not the hair loss fifty years ago, not fifty years ago, but five hundred years ago was probably more significant because on average, five hundred years ago, people were more sensitive to androgen. So there's a syn rome called androgen in insensitivity around a iis. And that syndrome was related to win men who have the copy from their mother, who is a career.
There A R gene or andero gen recept gene is completely insensitive. So think of IT. IT doesn't have IT.
It's not related to the C A G repeats. But think of that, uh, reception is just not working at all. So there's a continuum. So everybody's recept works a little bit Better, or a little bit worse. And the Better interceptor works, the more likely you are to have male .
pattern lace to zoom out from this. But still keeping a and I on. D. H, T.
What do you like to see all women and all men due to optimize D. H. T? And here i'm talking about regardless of age. So we're still in this from puberty onward d phase. We haven't yet micro dissected out decade by decade, which we will do.
But what do you like to see people do to keep dht and check? But before you tell us that, could you tell us what positive things dht does when it's in the proper range? yeah.
So dht helps a lot. For the same reason why testosterone helps IT activates the energy recept gene IT helps effort feel good so I can be motivating. So that's how it's active in the scenes. IT also is active in cardiovascular tissue.
So if you look at um someone has heart failure or someone has cardiac yp trophy, the level of dh g can matter because it's also binding to the energid receptor in the mile cardio in the heart itself. So you think of the classic body builder. Heart is an easy example to make.
They are very thick muscle. Their muscle is very strong because there pumping blood often with high blood pressure. And that D H T and the testa drone and any D H T derivatives like mastering h ox andon prime and also bind to the heart, and they cause even more hypertrophy or enlargement of that muscle tissue. So then let's say the person stops in their recovering and they're trying to have cardiac modeling, which is where you take a very thick heart. And cardiac model is important and a lot of different um cardiac pathologies but if you give them fanatic I or dutasteride which inhibit the enzyme converts testosterone dht so making less activity at the energy recept gene, they have cardiac modeling and their heart health .
improves I see so for the non body builder, the typical woman or man or Young, Younger, old, what sorts of things support dht and thereby heart health? Presently dht is involved in some of the other things that testosterone is famous for in both men and women, things like libido, as you mention, making effort, feel, goods, motivation, drive and vital ality. It's A, I guess, be the the general phrase what what sorts of things support dht? What sorts of things are create problems for dht?
There's lots of diet, ary changes and supplementation that you're probably doing right now that's affecting your dht. So everybody all of the listeners because let's say you have a diet high and plant profanes, many of those inhibit the ensign that converts to to to dh.
Could you give us an example of of one of those either in supplementation form or in food form?
在 humans, certain current man oids, depending on the structure, will inhibit the ensign called five alpha adopt ste. That converts to on the D H T. Tuk black pepper extract.
So a few it's used often to increase bio availability, is also called bio perin. It's also a five of a ducket inhibit. So uh and on top of that people have different genetics too. So some people there are five reductive insides are three of them um there are from us some two, three and four I believe but some of them are active in the prostate, some of them are active in the brain and some of so IT depends on which tissue, the tissue specific in sims that depend on how much D H T. You convert.
Do you recommend that people avoid curcumin intimate for that reason? And is there any specific recommendations for men versus women .
if a man or a woman by the way, in women a lot of times if you just ask your doctor for A D H T check, it's the same unit, doesn't men so it's essentially undetectable. So uh you have to um you know especially if they're on oral contraceptives, which is a different topic, their dht is very likely undetectable, especially if it's free dht. You can measure both the dht and free dht, but if someone's dht is very low or if they have somewhat insensitive androgen recept via genetics or via lifestyle, then I recommend they avoid by available humanoids, by available tumeric black pepper extract. And they might be a good candidate for creating creating a like, creating mono hydrate and significantly increased the conversion of testosterone d hd.
interesting. There's also a lot really interesting data coming out now about the um the role of creating as a brain fuel and maybe even as a enhancer over time, the data is still a ongoing. But some of the studies and humans are pretty impressive, at least to me. I am glad you mentioned the thing about curcumin black pepper.
I ish you would have this conversation six years ago because I the experience of um jumping on the bandwagon of the excitement around tumor and I took a tumor supplement that was a couple capture of what I thought to be and I think was high quality tumeric and i've never felt as poor as I did in the subsequent few days. Flat line of lets you say everything that one would want to have in life, energy, vitality, just IT was a Cliff and um a friend somehow new that kirk min could inhibit five out for doctah that convert to sm to dhc. As you pointed out, I stopped taking IT was the only new addition to my diet and supplementation and things bounce back within about three, four days.
But I was remarkable. I mean, I felt like garbage and he was actually kind of frightening to experience the the sharpness of that Cliff. But um I know that some people like to mick for its a in time flaming ory properties that said a sounds like people either need to experiment or um and if they do obviously to approach that with caution any time you had to remove something you need to talk your doctor you're a doctor and i'm guessing that um if one were to experiment um would you say that most of these effects of things like cursing in are reversible as they were in me or is any potential of permanent damage if people have been taking them for a long time?
The effects are nearly always reversible when you're talking about five alpha duck tail inhibition so what tumour does but stronger um the most common story that we hear is regarding a supplement note as saw paul metal which a lot of older men take for the prostate ate health or financial de which you can take for your prostate or your hard or your hair or do you taste de.
So if you're having side effects on these, then it's probably because of a couple different reasons. One can be your ratio of androgen to estrogen is off when that needs addressed. Another one can be its inhibiting the conversion of your protesters, one to the other type of protesters on the five alpha, 3 alpha that we talked about earlier, that's helping with your sleep and your brain and your calmness, and that's definitely in effect.
Another one is depending on the type of supplement or md, they inhibit different ISO insides of the five alpha ductus. So if it's if they're just inhibiting one and two, then that's going to be a different effect. Then if they're inhibiting two and three.
So fanatic I does two and three. Sol poetic does one and two. And then due tasty de does all three.
The third one is active in the brain and due astride inhibits the third one a little bit weaker in vivo but strongly in vidro. So it's really hard to pass out. You can use biofeedback and experimenting, I do think, with supplements is safe to MIT. The time that IT takes to set in is usually about three months.
So the risk of and this is anecdotally, there's been lots of research published about if posta post asteroid syndrome is real or fake and IT is real, but it's one of those things that a combination of organic and inorganic disease, almost kind of like fibro biog a where it's definitely real. And there's lots of things that you can do to help with IT, but it's very unlikely to occur if you stop taking your supplement or medication after you have side effects. Interesting why I certainly .
feel Better when I am taking five grams of creating monochromes ate per day. I know most people take IT for muscle growth and tissue repair and things that sort mainly I think brings water into the muscle tissue is Better.
But I I take IT for the brain effects and also because i'd like to think that IT gives me a little bit of dht bump um that I can actually see in my my blood charts when i've done them ah I know many people want to avoid the hair loss that can sometimes be associated with dht levels going too high. And so i've been asked many times, does creating mono hydrate cause her loss? IT would make sense that if creating increases, D H T and D H T bind to the enter interceptor on the scalp can induce hair loss.
That that would be the case. Is that true? Or is our people just really concerned about something that's a trivial or non existent each male?
And so yes, I can potentially add IT. I don't like to say IT causes IT, but it's IT can be a little bit more fuel to the fire. So just like everybody has a different sensitivity of their energy ing receptor or they have a different amount of gene transcription that is going to cause death of the that's an arbitrary threshold. So you don't really know until you start losing hair.
And if somebody takes a little bit of creating for the to increase their dht, maybe for the code of enhancing effects or for whatever reason, and they know a little, little bit more hair falling out in the sink and they stop taking, you just said death of the follower, which sounds very dramatic, are those are those little stem cell nisha that reside in the follow, which her grow from? Are those that abolished like there's there's no going back? Or can you one rescue the hair .
IT takes months. If they're still there, the hair will come back. So the loss of the hair itself is a Normal part of a hair cycle. So you have your energy phase, your cat tag en phase, your team and phase and then .
your hair loss and then .
the sharks have tea. So ark the truth and one that comes through or losing your baby tooth. And you have a new one, but your hair just always keeps coming through.
So it's natural for IT to die and lose. That's why. That's why when you start five out reductive and is often you have a big shed. So what happens during that big shed is all of these cells that are unhealthy, they immediately judicious in the air, and they start making a much healthier new follow. so.
All the hairs that are in at the end of their telega phase, then um they have what's called telga a flu vian which also happens after pregNancy, also happens in a thy road pathologies. So you shed IT, a new one comes in place and you think that you're having A A horrible hair loss caused by your financial iter, whatever whatever you're doing. And monoxide le does this too, but you're really just having a new healthy eer follow. If you go a really long time, if you go a year, then those hairs might come back and they might not.
So for simplicity, say, if somebody is concerned about or is experiencing her loss, male or female, what are their options of ways to offset that hair loss that are not going to negatively impact other tissues sensitive to the hd? And i'm basically saying here is I can imagine taking A A D H D inhibit on a pill of some sort of an injection, some sort and offsetting hair loss, maybe even stimulate more hair growth. It's clear that i'm not doing that, but I know people that do, but then experience some of the other negative effects of blunting dht reduced affect reduce lib to reduce drive um disruptions and prostate function or or even sexual function in generally so what could can people do if they want to maintain or grow back hair, but they don't want all those other effects? What should they avoid and what should they perhaps consider talking to their doctor about?
Yeah, there's a whole host of options. I I try to separate alopecia or hair loss into two different categories, male pattern baldness or androgens alis android genetic ala versus other types of aloisa, usually telega flubs. And if it's android genetic alpi hot or male pattern baldness, even if their female props A P S something like that, then you want some sort of strategy to decrease the activity of the androgens sector.
So women forget male pattern for this. absolutely. okay. I have to read my head around that one. But okay.
so there's a lot of different things that you can do that are topical. The most promising is called dusti misal therapy. Essentially, what IT is is IT very localized injections and areas that are prone to male powder baldness, whether there are female or male.
And IT acts locally only. And you repeat these injections from time to time. IT decreases the conversion of testosterone to dht just in the scalp.
so that can avoid protest effects. And what are some of the negative effects of blocking the ht in females in the peripheral anion, not on the scalper in the brain? Where's dht doing its stuff?
Yeah so it's both the dht and then also that five alpha, three ela progesterone, which is called A T H P di hydro protesters on or tetra hydro, tri hydro. So they're active in the central nova system, but it's also just active again. Binding to the energies receptor in a female as well, causing them to have the effort feel good motivation.
A lot of women that are sensitive to D, H, T, because women can be sensitive to D H T as well, feel very different when they start an oral contraceptive, not because IT altered their D H. T to a huge amount. IT does a sum degree, because the negative feedback inhibition in the petite aria and less produced in the hovers.
But IT increases sbg really high. So because their shabu are significantly higher, their free dht is way lower. Say.
how does a woman know if he has pco s policy stic ovarian syndrome? What are the issues with policy stic ovarian syndrome? What can be done about P, C, O, S? I confess I was naive to P C O S.
Um that wasn't supposed to rim but since IT does, I do confess I was completely naive to um and I start getting a lot of questions about IT in various forms. And I think that's actually the reason why initially approached to you, I know you have treated a lot of P C O S. Uh, what age women should be thinking about P C O S? What's pcs teachers about P C O S.
please here. So P C O S is policeman of very in syndrome. And this is one of those conditions which is under diagnosed.
So it's prevalences much higher than we think IT is. There's been a lot of studies in some some studies say prevalence of ten percent, some say twenty percent. It's not completely clinically penetrant. So most people don't know they have pcs until they have infertility or sub fertility.
And this is P O S happening, this frequency in twenty year old women and thirty old women and forty and onward.
most women find out they have P C O S in their thirties, especially it's on a spectrum, a continuing like a lot of things where you can have a weak reversion or a very severe version.
What are the symptoms? There's, uh.
criteria called the rather damp criteria. And in the rather damp criteria, there's a couple different ways that you can diagnose. You're looking for androgen excess insulin resistance. And you can also look for policy scovens. You don't actually have to have policy to covers or get an ultrasound of your overs to be diagnosed if you have androgen access, for example, android ic iconic or hormonal aconites.
If you hair growth like a hair growth on the chain, it's called a hortus m or if you have you know like deeping of the voice, um any symptom of too much and a male pattern baldness, fear female, that's A A symptom of P C O S as well. Then you can also have instant resistance. So this says obesity.
Its prediabetes a high fasting, a home I R over to a faster issue over six. So if you have significant insulin resistance and also androgen dominance, that's a sign of IT. Energon dominance often leads to what's called a legal miner. So if you're having more than thirty five day and travis in between a period or if you have less than nine per year there, there can be a sign that you have a legal which means too little mineria, which means mencius. So that's a very common sign of pcs if you have infertility. So if your under the age of thirty five and you've been trying for more than a year or you're over the age of thirty five and you've been trying for more than six months, then that can also be at a very common presenting complaint when somebody presents with pcs.
And assuming that are a woman is doing the all these other things as a paying attention to the six pillars that we you talk about earlier, diet, exercise, choric restriction in some bases, right not everyone needs to be clerk or start to um stress sleep in sunlight spirit um assuming that they're doing all those things. Uh what other things in the realm of dire supplementation can help them avoid pcs if they have subclinical pcs or they have not developed but don't want to developed IT because IT doesn't sound like a good .
thing yeah so depending on on where they are, if they're very strong on the insulin resistance spectrum, then uh, optimizing their body composition, decreasing their body fat and treating that meta lic syndrome can help. So a lot of people ask, what is everybody that's on? Like, does everybody need to be a mat form? And that has P.
C. S. Not necessarily. But metformin is one of the tools that can help with insulin sensitization.
Other tools I can help or inauspicious. So my anos, ital is an insular, sensitive tizer. It's a cousin.
D Caroline. Hospital is a weak anti androgen. A lot of types of an hospital have both of those in IT. So depending on on if you're a female or a male or the type of an hospital does matter.
Yeah, this is a very important point. I I just today I said trying this new supplement, I asked at all for its role and help perhaps in handing sleep even further my sleeves generally pretty good lately. It's been a little bit off for a number of reasons.
So I took IT for the first time last night and and I said I thought IT helped. And just subjectively, and you said, what kind of an hospital is that? Because an hospital is a very poor androgen inhibit IT. Turns out I was taking mile in hospital, which is not an androgen inhibited the type. The other type that you mention, which is an androgen inhibit, is d .
carron off at all. It's usually in a ratio of one to twenty five or one to forty in a much of lower amount compared to mio and off .
the all in in a supplementary in .
the body in a supplement to help induce ovl tion.
But for women who have pcs who might want to try and to reduce androgen, then they would perhaps want to take a form of an hospital that reduce the energy receptor activity.
They want both. So if you're a woman that you've ever talk to your doctor about on the oral contracts, tive or spiral oc term, which is also an anti androgen, but IT happens to be a patashie span diores tic blood pressure medicine as well d car and hostile might be a Better option. Dim or Diana mEthane e is other another kind of a weak anti estrogen ti that a lot of women should .
consider as well. You mention oral contracts tion. I've done a few posts on these less just call them. They really are perceptual effects, whereby it's been demonstrated in human several times now. And what would appear to me to be very solid studies where women that take uh oral contraceptive there is both a shift in their perception of men because these studies only looked at sexual A A the sort of arrangements here um where women who are on oral contracts tion because IT blunts some of the pixel valleys of of hormonal put no longer a experience the same peaks and valleys in their assessment of other men's attractiveness.
So its sort of flattens the their perception so to speak, they still find certain men attractive and certain men unattractive but the the the the degree of difference is kind of mellowed out um and likewise men pit these data say that men perceiving women's attractiveness, they still see women on our contraceptives ves as attractive. But there a woman taking all contracts tion eliminates this kind of peak in her attractiveness that men would otherwise perceive. In other words, our contractors are changing the way that we perceive each other, at least in terms of these male fee, male experiments.
What is going on with that? Is that because all contraceptives ves blunt the increase in testosterone, one that occurs just before violation, or is IT because of a complex cade? What is going on?
I find this fascinating. There's differences in how your and I wouldn't use the word change necessarily, but alter the severity or alter the a peak, as you said. So it's just like, T, R, T, is not going to change you as a person.
And oral contraceptives will not change you as a person. IT will just change your day today. Pegs and troughs in libido and attractiveness. So one of the main effects of oral contraceptives, almost all of them have a synthetic estrogen and a synthetic projection in them.
One common type of synthetic estrogens Ethanol extra dial there is another new h synthetic esterton is out there as well, but that in dota, that seems to have even more side effects. So this ethnical extradition is one hundred times more potent than indulging ous or and the extradition in the liver. So IT bins to the extra dinner ept or in the liver.
And it's going to increase sex hormones. Ini, global. Lin, which second darling, as you mentioned, decreases your free testosterone and especially your free D.
H. T. So that a little testosterone pump that you get when you're a female is emulating that's really flat line. And it's already is a pretty insignificant difference. It's not negligible, but it's a little bit of a hump and you have significantly less of that when you're on an oral contraceptive.
And is that blaunch associated increasing libido that Normally would occur from that increase in the androgen? Yes, interesting. Um what about other forms of contraception, right? Because there are there's copper R U D, there's um vous implants, there's rings, there's a huge number of different forms of these. So what we're talking about is, as I understand, IT is only the effect of or contracts tion that impacts hormone output that correct. Yeah.
there's a lot of other effects as well. For example, your choice of synthetic progestin will alter how higher platelets and S H B G O IT appears to be. The higher your platelets and higher your S H B G, the higher rest of a blood lot.
So a lot of women know that if they're on a oral contraceptives and they're ready, predisposed to a blood clot or a Venus thrumbing embalms m and there's vain, they have a blood neither they their leg or they're long, then they can increase that chance. So you can choose a synthetic progestin that is not going to have as high of our response. Um but there's there's various present cons.
Some synthetic protestants are a weak anti androgen as well. For example, there's one known as slim, which is made from spratt. So some women are on spring oec tone. And that is well, which is made from spring oic tone, which probably isn't IT particularly unnecessary unless I need IT for a diaeresis .
hypertensive effect. I see I just to intentionally interrupt and I apologized but specifically because I want to ask about, um there is this notion that that oral contract action taken over long periods of time can disrupt futility in ways that are independent of just the a the age related decrease and infertility. Is that true?
IT depends on what you mean by a long time, six to twelve months is possible. Past that IT seems very unlikely. However, the persistently elevated S B G can be present for quite some time.
Wait, so if if a woman takes all contracts tion for six to twelve months and then stops, will SHE essentially be where he would have been anyway in terms of her fertility at that age? Or are you saying that I can cause permanent damage?
Her fertility would be equitable as if he had never taken IT if she's certainly twelve months but probably six months .
would SHE women that I ve taken all contraction for many years are in addition to the age related decline in fertility that occurs that's inevitable. Um of course the slope is going to be different depending on um the individual. But are they quickening the the transition to infertility?
Probably not. Um you could make a case that because they've been an oral, they may have been slightly more predisposed to insulin resistance and or lower the body mass, but it's probably going to be a negligible difference compared to their resistance training and also the chloric restriction or chloric madness.
First, there are also effects of having children yeah yeah I mean on all these parameters because it's a major lifestyle shift, right um that obviously what people contend with and have first since the beginning of a human time anyway.
Um I want to ask some questions about male hormones therapy and male hormones generally but before I do that, I I have a couple of burning questions that I get very often that i'm just going to insert now marijuana, i've heard that I can decrease the in men and women. I've heard that I can increase test astro alcohol. I think there's general consensus that high alcohol intake, high barbiturate intake can does in fact reduce the aston one.
What about modest increase of alcohol? I'm not a drinker, so i'm not asking these questions for me. I don't smoke, but just never really like marijuana.
Alcohol is not my thing, but many people want to know the answers to these. And the data that i've seen are very confused and conflicting. So what about marijuana? Does IT reduce just for strong to significant degree or not?
Can abolish itself, whether it's T H C or C B D, are not going to reduce testosterone by themselves. If it's smokes marijuana, then it's very likely to increase your remedy, which increases your exr gen. And you know that's going it's romantic sing from testosterone one.
So that is going to decrease testosterone when you have an increased estrogen like air dio that's going to work on your patuit ary to make less hormones that caused the release of test stones. You're going to have less L H and less F S H. So most kind of like, uh you know o bets are well known to um opiate agonists.
They are going to decrease L N F S H and subsequently to stop on smoked mary will as well as far as alcohol, high alcohol will decrease to start strong as well. Any very potent gab agonist, whether it's a arbitrate or a benzeor dies of peer or non benzo u or alcohol, they're definitely going to moderate alcohol. I guess that depends on what your .
definition of that is. The some people I know that don't seem to be alcoholics, at least by my you know assessment, will have a glass or two of wine four nights a week, which to me seems like a tremendous amount. Only because I don't like alcohol, I don't have a promote. There are people like in alcohol. But but I think many for many people, that would be considered low or or moderate intake.
Yeah I would consider that low intake. The american hard association for men recommends between one and two drinks a day. On average, they are around one per.
So i'm making my heart less healthy by not drinking alcohol.
Recommend very low amount of alcohol for men, for a women they recommend the zero road to one. So that's going to hard to interpret the z road to one. Um but the protective effect of alcohol, especially if it's a red wine um with pa phones and IT outweight the deleterious effect interesting because i've seen some studies that .
point to the idea that even low intake of alcohol over a prolonged period of time might actually decrease brain volume or at least volume of particular brain areas but of course we don't know the consequence of of decreasing the volume of of a given rainy or either mean one can image decreasing the size of ones a middle and making them less stress.
Although there's no evidence to support the i've been told that I need to drink many, many times, but I always replied that I don't need to drink anything in order to speak my mind. So again, uh, individual differences. Uh, very interesting. So that sounds like smoke marijuana may in fact reduce testosterone or at least increase the conversion to stone k.
And with alcohol and gaba, important to remember that IT shouldn't be daily. So one drink of alcohol day is actually very mildly immunosuppressive. So it's Better to have two drinks of alcohol one day the week, and then two more drinks of alcohol another day of the week, and then no alcohol arrest the time. The same could be said even for supplements that have gaba in them, a lot of sleep supplements have give up you terrie acid.
which casion ally take A, I occasionally take a hundred and two hundred milligrams of gaba in order to enhance sleep. But I do IT maybe every third or four night, no more than three or four nights a week.
Yeah, that's perfect. okay. So there's a lot of sleep supplements that should not be taken daily and gave s one of them.
Another one of them is treason. And in melatonin is kind of arguable and IT depends on the situation. But in general, if you're taking A A sleep supplement, IT should not be taken every night.
The the sleep supplement that I understand okay to take every night or nearly every night of things like magnesium three and eight APP genin. If that's not true, correct me. Are those I certainly take them night unless I forget them in back home and traveling.
Magnesium, one of the exceptions, healthy ini, is also another exception.
great. Well, then at least I haven't put anything into the world that's wrong in that category yet. And hopefully I want. But if I do, i'll correct myself. So let's talk about testosterone in in males.
There you see these um headlines all the time now that tester levels are dropping um sperm cancer dropping um fina types of men are changing over time. And and I can't quite follow the literature on that because obviously those are hard controlled experiments to do because techniques change over time and sensitivity of techniques change over time. But regardless, i'm aware that a lot of people are considering increasing their testosterone by taking test stone A A few years ago that was considered steroid use and was really extreme kind of stance.
Nowadays, IT seems like there's more discussion about IT. First off, i'd like to know, does testosterone supplementation and hear i'm time out prescription from a doctor, does that make one more prone to prostate cancer? That seems always be the first question that comes .
yeah and there is a huge gypt of misinformation about this too. So teston is not going to cause a prostate cancer. However, Normal aging causes prostate cancer and testa drone will grow your prostate.
So if you are a eighty old mae and you have an autopsy and there's at least fifty percent chance that you have a prostate cancer. If you're ninety hundred years old, there's at least a ninety percent chance. So for humans, with a prostate is only a matter of time until you get a prostate cancer. So that begs the question, do you, anna, take something that's going to grow IT for sure once you have IT? So it's an individual assessment and it's important to follow things like PSA as well.
So A P sa of of four or less. I mean, idea you wouldn't be at fork as that kind of the upper threshold is um the simplest read out of whether not there's um excessive prostate growth. There is beni prostate hyperplasia a where the prostate is growing but um it's non cancer is correct.
And then of course there are the symptom logic like people have changed the urination, the sexual difficulties that set a i'm always struck by the correlation that people drawing between testa and prostate health and the fact that or I should say the claim that testore um makes prostate health worse because if you think about IT, Young males have high test stone often, if not always, certainly often. And you don't see a lot of prostate overgrowth in cancer in Young males. So something's going on here. How would should we conceptualize this?
So if you have A P, S, A of three point nine, and you are a twenty five year old mail versus a seven five year old mail, and you have A P sa of five point nine, the three point nine p sa is significantly more concerning. So think of your project is taking cumulative damage from not only to start one, but also estrogen and also growth hormone on.
So that's why obese individuals have higher incidences of prostate cancer as well, is because they don't have those cell checkpoints where your immune system takes a second and says, alright, stop replicas, fast prostate cells. Let's see if there is any eight book of ones. And then IT finds those and IT prevents them from reproducing.
That's why a therapy and cancer is so promising as because they can target these certain things. So the older mail is going to have that cumulative of damage happen already. And arguably, prostate cancer is a Normal you know IT with aging.
You know a fast aging is abNormal, very slow aging is Normal. There's a fine line to walk between those two, but there is a lot of things that can be done to decrease the turnover, decrease the information and decrease the congestion of the prostate over time. There's also a lot more than just psas that can be done, the prostate, mr. Ize and things like that. They can look at the structure and the function of the prostate.
So what should every male do to maintain the health of the prostate? And I realized that Young ger males aren't thinking about IT all although seems like now is I get this kind of what I call um cryptic questions you know um I think women are more comfortable talking about their hormone and sexual health because of cycle, because of mantra cycles.
They are used to fluctuations that it's so give them the experience of what it's like to have different levels of protesters on estrogens assert. I get these kind of cypher questions often in my direct messages where what I think people are asking is um what you know what is there something wrong with my prostate? What should I do for my prostate? These are often indirect questions for other other aspects of their life where they're suffering. But um and I don't say that uh in just I I I think um more direct discussion would be great. So uh what should all males do to to maintain prostate health throughout the life span?
Maintaining prostate health can be looked at similarly, how you can maintain a good natural optimal. So you look for things that can hurt you. You don't necessarily look for one thing that can improve IT or boost IT.
So for Young males, those are prosthetist s so goes hand in hand with epidemics. So different infections of the prostate, the Younger the male is, the more likely IT is related to something that could be sexually transmitted. But another very common cause is we call gram negative and aneroid c bacteria. The is right by the end of the coin. So if you have chronic constipation, or if you have cos, or if you have, you know, even just an equal I overgrowth in the coin is very likely to cause an infection of the prostate as well.
What you'd males do to prevent .
that have a diet that is good healthy pre biotic fiber pro BIOS as well. Um make sure that they're having regular bw movements that they don't have granic constipation, have good sources of dietary fiber, which is often as solid ble fiber and enough in solid fiber, most people get enough in solid or non dietary fiber, so that can help prevent the chance of diverticulum, which is another type of infection. IT can also decrease the chance of colitis and decrease the chance of prostate .
infections as well. Uh are there any foods and or supplements that man should take or avoid? What about you hear about soul, palm metal? Yeah, supplements for or supplements that support or cause issues for the prostate.
If there is a strong genetic predisposition to enlarge prostates or even just really early prostate cancers that grow fast, the nit consider taking sol poetic or even kr human as an antiangiogenic able to tolerate IT. It's an individualized basis and depends on their history as far as um making sure that their prostate is not congested. There's an interesting correlation between having girls and having prostate in gl.
So if if you're offspring are females, then you're slightly more likely to have prostate cancer. There is some um there is hypotheses that link estrogen to prostate cancer rather than to stop one. So if you have hyper estrogens m, your prostate has more a typical cells. In general, the higher your sea reactive protein, which is the general mark of information in your body, we call crp, and the test order is H S C R P or high sensitivity C R P. If your C R P uh raises up very high, if you have an autumn e disease, like if you over ches flair or if you have uh lupis or infection or a sexually transmitted infection or even uh code us even the flu, your C R P is going to raise .
significantly that yeah so you want .
to get a baseline C R P when you haven't had any of those things recently. And if your C R P is higher, you also have more female offspring. If your C R P is higher, then your reactive oxon species, which are causing mutations and a typical sell turn over in the process state, are also likely higher. So you want to keep a very low C R P. interesting.
And what about blood flow and pelvic floor in general? We should try to do a whole episode on pell VC floor. Yeah there's so much interesting um data coming out of the the fields of clinical and research europe logy.
I realize its kind of the netherlands of of biology and medicine. People probably aren't thinking so much about this. But pelvic floor is obviously A A confluence of a ton of a vague latter of nerves and of course the prostate resides there, and of course the genitals and resides there as well.
So I would imagine that the one of the six pillars you exercise being able to maintain adequate blood flow to those regions is key. What about just postal things? People sitting too much um not um hydrating well enough, you mention avoiding constipation, but what are some other things, including medications that can serve to support the prostate over time and maybe even support pavet floor in general, both in males and females over time?
absolutely. And this is something that's ridered link getting more and more attention the way I explain the perfec floor is your abdominal cavity, which includes your pet onion, or where most of your organs are, your retrolental im, your pelvic space. Think of IT as a box, and your ABS are the front of the box.
Your back muscles are of the back, your diet frame is the top of the box, and your pelvic floor. That's where your port is to the outside world. Especially important that has muscles as well, and you can do exercises.
Health c floor physical therapy are becoming more and more utilized, especially after childbirth. But another situations as well, including by men getting care from biologists. So you want to be strengthened the pelvic floor and make sure that the tubes sitter dog to the outside world are working well enough, but they're not too loose.
They're not working too well. So there's a lot of medications that can be positives or negatives for your pelvic floor. We kind of talk about your gut and colon health in general, as far as your prostate health and as far as your blood neary system health.
You think about a couple different classes. So you have your fast food, dio stresses, you have your teda fill. Basically, this is going to help decrease congestion in the prostate. A lot of people take IT for E, D, but IT can actually help you decrease you.
You to find that, uh, a lot of min take to deliver l generic is c Alice has a much longer half life than viagra or the future as half life is almost today. So you can take a very low dose of IT. Instead of taking twenty milligrams, you take two or two a half milgram.
So they're taking you're saying that a lot of take IT for erect function, yeah but that IT at lower doses that may have serve purposes for prostate health independent of of erection. correct?
The most common scenario is if a male is waking up twice at night to p on average, it'll cut that down to once. So if they are waking up at four times at night, and IT can cut that down to twice at night, just because you have easier blood flow. We used to use other medications like flow max, which is temper losing.
That's an alpha antagonist. So IT basically binds to a receptor in smooth muscle, and IT helps relax that there are several other alpha tag onions. And then you also have your medications at a hormonal like fanatic y that a lot of people take for process health to decrease the enlargement of the prostate, the perrier retherton area, or perier retherton lobe. There, several lobes of the prostate ate that tends to be especially enlarged in cases of B P H, N B, B P H, prostate hyperplasia, or in large prostate. And if you are able to shrink that area at that point is just a liming problem and the year and is able to get by easier.
Yeah, my understanding is that now there is A A growing I don't say a movement um, but the idea of taking very low dose like two point five milligram or five milligram to dollar fill even daily, is becoming pretty common for many men who do not have rect all this function simply to either maintain or enhances prostate health. Is that that correct? Yeah, that's correct. And are there do you see any negative effects of doing that?
There can be negative effects. IT can lower blood pressure so theoretically can increase your chance of visual veyle sync a py. A lot of people take IT as an alternative to pump because I kind of work similarly to siri um or different pump products and and IT can certainly help with that. But if you're about to go to a dead lift where you might pass that anyway, I can certainly increase the chance that happens because you don't have that captain sory exercise hypertension response.
Could someone just take that away from exercise?
They could, uh, if you took to delafield, then it's that's gonna be has a long half life. Whether vagrant of feature is just a few hours to allahu is almost today, some interesting studies on vago have been done as well. I can potentially alter your race and coins in your eye.
So the usual recommendation for pilots that need to have red Green discrimination from very long distances with very small indicator lights is to not take um viagra. So I usually say if you fear pilot, that your profession. Perhaps hold off from that for a while.
There is also studies with viagra that significantly, which is also a silt dentification, as the generic now IT can increase eyebrow hair growth. So potentially what he does is that helps vice so diary and relax the vein in especially in older men and windows veins are relaxed to have Better blood flow. That's one of the proposals or theories behind why older men get the andy genetic alpha more you're having less blood flow on the scale. So theoretically, IT can also help prevent that.
So what the theory increasing blood, oh, because increases blood flow systemically throughout the body, not just in in specific tissues. Well, I find IT incredibly interesting that yeah there these online forms building up now around loads to dollar fill, daily use of loads to dollar fill. Again, not for sexual erect tile is function, but for sake of of long term prostate health. Is there any reason why women might want to take loads to dolphin? To .
dolphin is also a weak androgen receptor sensitizer, kind of like l karani, where the density of the available Anderson recept tors to bind increases slightly. So there could potentially be A A benefit from that. But are most the time is used in men?
Very interesting. We haven't really talked about testosterone in optimizing test astro in mails, assuming someone is paying attention to the six pillars, there is a kind of a gap as I see IT between doing all those things and T R T hormonal replacement therapy um and again they are the replacement in T R T is a little bit of a um in quote snowes because a lot of people who have testosterone one in that three hundred to nine hundred nine agram pedestal arranged, opt to take loads testoon. Anyway, my understanding is that there been no out of movements in this area toward, for instance, not doing big, a large doses in, injected infrequently, but rather low doses quite frequently, obviously prescribed by a doctor, monitor by a doctor at sea. Is that generally what you like to see in your patients if they're going to take this route?
If there are a hypocrite, al, patient, whose benefits our way, risks of T, R, T, then you wanted have a nice, even steady state. It's not gonna exactly the same as producing power tile to stop strone release dorg ously from your own body. When you have a steady state, you don't have a pear, a trauth and when you have a peak, that's when the energies recept gene is overactive.
That's when you get more errors, roo polton or epo release. And that leads to a lot of the side effects of thick blood. So hire him of romans and MAdeline rates and then uh, when you have a crash, you don't feel good.
So it's definitely not optimal. There's a lot of ways to get around this. So when you're doing to stop m replacement, if you're someone that needs to, you can have different types of esters or you can do topical to stop, run.
So the ester is basically something that attached to increase the biological life. life. The most common ones are cip, na and na.
There's also ever short acting appropriate a which has almost no clinical relevance. And there's also very long acting ones to can wait and undecorated and different mixtures of all those. So if you're someone who has a very, very low S H P G, you're gonna have trouble of regulating your serum test aste rone.
In the long run, if you do IT topically, then the testosterone one is absorbed, hopefully bound to S B G. And then a lot of times you reapply to twice daily or once daily. But you have lots of variations. So for most people, especially for people who can absorb IT, well, that's not going to be a great option.
So injections would be preferred.
Most people end up injecting because they have either side effects from too high to low or just too much of a very dose when they do topic. Al, there's also a capsule with a special emphatic absorption. So it's not being absorbed through the liver, not partially metabolize, but it's absorbed through the lymph and it's essentially testosterone undecaying then put into a capsule.
So not taken twice daily. I has fairly steady half lives, but you have to take IT at specific times the day. So um that being said, and it's new enough to whether isn't a huge amount of data on IT, but IT is F T A approved. So IT is IT is brand name now Scotty tensor. But um the injecting ables in general, the lower your g the longer of an extra you want.
Because when you inject IT, uh whether its intra muscular or subcutaneous, just talk to your doctor about the risks in the benefits of those subcutaneous has slightly larger active half life because the air aces take a longer to reach that similate or an and the estate cleve in. So most men, a lot of people asking me about like what are usual doses for most people, IT would be a total of about one hundred to one twenty for a week for an actual replacement. Those little grams, milligrams, one twenty to the one hundred milligrams per week administer two to three times per week.
And you're not. So you seeing dividing that into two or three, right? Because i'm sure the lunch we love are thinking one hundred three times a week, which is actually quite, quite high dose. Yeah there really does seem to be a shift in uh tod um spreading these uh dosages out into you know dividing them in two or three a smaller doses and then um along those lines five ten years ago IT was common to hear about inhibitors estrogen through a roman inhibitors. Now's you hear and I think it's uh true at least by my read of the literature that that inhibit ting estrogen can disrupt brain function, can cause active tissue issues and even can cause um reductions in libido so a lot of um people think that estrogen if if you crash a gen that basically video goes up but actually the opposite is often to you don't want estrogen too high or too low is that drugs in for that reason um do you shy away from people taking your romantic inhibitors?
Yeah um very few people truly need a robot and emit or there's almost always lifestyle mentions IT can just depend on which gene how act of your robot tes gene is some people's romita gene is a very active a lot of times these individuals have a pupil going to come asia, which is breast issue growth and males even despite no other risk factor.
even if they're 0。
Some people get that if they are lean. I remember growing else.
There were a few kids that got mild cases of gna commas you that were transient, like they sort like they develop going to class year. And then I went away .
often its unattended on one side to, so growth hormone, a hot times. Is the fuel to that fire interesting? Yeah.
there were a couple of kids. I mean, they took some teasing because back then there was an online discussions about one hundred and things like that. But then I would seem transient.
And they were the people i'm thinking of were actually leaning individuals. And so they they weren't overwork, which of course can cause gona mass here, because I add, post faced issue can convert to stand into stroganoff. So IT sounds like, except in special cases, that avoiding a romantic inhibitors is probably gonna a good idea.
There are several other ways that you can control your estrogen and keep IT at a healthy level, which you do have to check. There's a lot of patients who share me that their extra genes is going to be sky high and it's actually very low. And vice verso. But calcium d glue rate is a supplement that can help with estrogen control.
What's a typical dosage of calcium d glue rate?
Five hundred to one thousand milligrams.
But is there the risk that if someone's estrogen is a Normal range and they take the supplement that their emerging will go too low? Is that that post .
it's not that and it's not near as potens in a omitted inhabit. So that helps with excretion and also the sensitivity of the astro general sector itself. H I helps out compete IT.
Um some people also take dim or um different criss vegetable begin from crucifiers vegetables like kale, but or broccoli. And that is both an anti estrogen and an anti androgen. So if you're on T, R T and you're on that, then you're probably just on too much T R T.
And I remember a few years ago, I A friend, and I truly not like I have a friend thing because i'm very cautious about which supplements I think I think people might get the impression that i'm very careful about this, but i'm not. I always alter one thing at a time. I talked to physicians.
I know what I suggest other people do. I actually do, and i've done for a long period of time. And I recall wanting to take dim I back then you here, okay, reduce estrogen. My estrogen levels weren't out of range, so they were fine. But at that, what would the experience be of bringing those down? But someone I know quite informed in this area said, yeah, exactly what you said, which is that dim can reduce exigent, but also test also, I just never opted to try and take IT. I do want serve airing in this direction, but we went straight from the six pillars to T, R, T, or to what some people now call sports T R T, which is basically code language for saying taking exogenous testosterone even though one doesn't need IT to get into a semi super physiological range or a um high end um like nine hundred to a thousand gram predecessors or range and people always point out I should mention that oh well in certain countries the high end range is twelve hundred and grounds for this leader in the us is nine hundred and so if you're twelve hundred are you really have superphysical logical all that aside, um I neglected to ask about that gap in between where individuals could think about supplementation, non prescription approaches to increasing testosterone and here we should probably also talk about things like, is IT true that ice bath increased as ostrom or not lifestyle factors that go beyond the six pillars for increasing test astre one. If you could comment on those that would be terrific supplements that are useful and be wonderful if you can mention where some of these same practices and supplements might be useful for women as well as men to increase testosterone for all the reasons we talked about earlier.
Yeah so this is where a true individualized approach comes in when you're talking about what dose of T R T you should beyond one thing to keep in mind as the law diminishing returns. Um quality of life is a subjective thing and it's different for each person. So some people are more willing to give up, uh, a little bit of athleticism or body composition.
Some people are more willing to give up or not willing to give up lab to or sexual health. And as we mentioned earlier, everybody's android receptor is less or more sensitive. So you can make a case that if somebody's and general ept or is half as sensitive as somebody else, the one the person with the less sensitive receptor does need a level of one thousand or two, one hundred. There's no great way to know that. And you can alter the sensitivity for energy reception with things like l carnet and to allah.
L has mentioned, definitely come back to our current because I really intrigued the data. L current team, both for women and men in terms of egg quality, firm quality, fertility and a bunch of other interesting effects.
So we will come back to but a lot of how you feel the bio feedback or subjective, I feel like this comes from the ratio of your android to your estrogen. And a lot of that is lifestyle. So if someone's also in A H C G that can Operatically aromas.
well, in H G, human korean ic ata open found, used to be found in red, is still found in pregnant women, but used to be believer that there was a black market for pregnant women's urn before IT, this stuff was developed synthetically. So in other is, what we're saying is men typically would buy pregnant women's run, yes, through a black market in order to get the hcg, in order to get the testosterone on enhancing effects of H C G.
So in other words, men, we're using pregnant women. You're in for H G. I do not want to know how they they got into their body. Let's just skip to what you are going to saying. X instead.
Yeah uh, so that's H C G. Um there's a lot of other things that are regularly estrogen. Alcohol significantly increases a so if you're very sensitive to air gen, then you probably shouldn't even consume the two glasses three times a week. High fat meals also a break than me. So if you're on a chioggia diet, but you have hyper estrogens m, then you should take care without as well.
All kinds of fat are just saturated.
I'm not sure if it's just treated fats, but fat definitely increases both fat in your body and consumption of a high amount of calories in places of robotic.
So it's the racial test after I don't want to break your flow, but that but since we're talking about fat, I have to ask x rogen stores and are both synthesized from the collection o molecule. I've heard that ingesting some amount of saturated fact can be useful because of the way that cholesterol can uh, service a precursor to these molecules.
Now I want said, uh, on a podcast that I like butter so much, I occasionally eat pats of butter somehow that misinterpreted to mean that I eat entire many pats of butter like one or two pets butter here there. And I have no guilt to a shame about my blood. Lip is are in great shape also, so I feel good. But is IT possible that people who are ingesting too little of saturated fat could um IT directly or indirectly reduce or somehow disrupt the proper ratio of testoon to estrogen in men and women?
It's theoretically possible. But IT probably doesn't happen in developed countries, just like it's theoretically possible to have not enough omega six fatty assets, but that probably does not happen in developed countries.
So I don't need the butter pets. I'm going to do IT anyway. I'm just curious um okay.
grasped butter has good omega three content as well. So uh, grasped foods in general, you know it's not the end dubon. Everybody doesn't need grasped foods, but they are one of the only sources of healthy transfer. So a naturally a korean transfer comes from ruminants. So ruminants, I think of like cows and uh the the rumination and the different stomachs can change your omega three and omega six to trans lindlay ic and trans lyin laic fati assets which are healthy for so it's actually omega and omega sixes that just happened to have a train instead of a sasa.
So uh in these healthy h transfer s would be found in um ruminant cheese and milk and butter from ruminants and or the meat and the meat yes so and for people were following a purely plant based diet or or mostly planned based diet, are they at risk of not getting enough of certain types of fats, other nutrients to maintain that healthy ratio to stop estrogen or not?
If they're vegetarian, they're probably not at risk. If they are a vegan, they very well could be at risk. Most of begins are aware of this, uh, very acutely and theyll supplement with, you know, L G, or those supplement with other sources of healthy fats, I say.
so they take away that I am drawing from this. Is that less so than getting saturated of fat? It's key to get these healthy transfer s from ruminants, yes, or the food products of those ruminants as well as um to get proper amount of mega trees. And to be clear.
you don't need any transacts IT just happens that those will make a three and make a success or in a trance I M I see OK.
So that's nutrition. What other supplements can support healthy to dosa and estrogen ratios?
Anything that alters aroma tace can support healthy taste. Tron to estrogen and um your testosterone to estrogen ratio. Think about IT as how much estrogen activity do you have the beta astro dia receptor and your alpha astro dial up.
So it's hard to tell. But depending on what you're eating, if you have a lot of plant based diets or public fanes, many of these are our beta extradition factors. People know about turkestan one and also beta actin oone, which are two active steroid that are beta extradition cept or agonists. So they activate the beta tra dios cept or so. If you have a very low amt of emergent, naturally you're probably .
a Better candidate for a for taking turkestan. I've never tried them, but I know my understanding is they worked tremendously well for some people and not at all for others. And so one is simply has to try. But in um in promoting the activity of this exogenous receptor, is there a risk that the castro active their own could cause some of the coding problems associated with increasing astruc activity like reduced libido? Water attention um water water attention.
Yes, reduce me to probably not uh closing growth plate and the bone no because that's the alpha asteroid or sector.
I've talked before on a couple of podcast about tonga ali in um which is this indonesian urb. I guess it's also um made and found in malaysia, but IT seems to be the indonesian variety of toner ali.
That's most effective for potentially for reducing sex forward morning binding global and thereby freeing up test astre one um whether not the effects are through that pathway or another pathway, a lot of people report improvements and things like libido and maybe androgen like a few types right feeling more vital IT set. And of course some of that could be placed al correct um but what are your thoughts on tongue ali and please chAllenge my statements about tongue ally if they are incorrect. I'm not looking for validation here. I just really want to know what your thoughts are on IT. You ever recommended to patients when men, women, one of the other.
yeah so tune cat ali or long jack, is that has multiple mechanisms of action. And there have been several play bal controlled studies on IT. Some of them show decreased in h pg. At least one of them did not show when he change in asp. G however, IT is IT does act on a roman very weekly, probably not so strongly that you would have to be concerned of .
hypo exogenous. M, so reduces ros and thereby can reduce astro. correct.
Okay, it's also a week. It's not a term. So it's not a selective extra generic tor model five, but it's probably a way it's probably an an ARM as well or a non selective extra genoese a motl fire. And that should help with decreasing negative feedback inhibition of air dial in various locations and also increasing to tosti.
O yeah the dosage that i've been using for years now, its four hundred milligrams taken once a day, typically early in the day, because I can going to have a mild stimulant fact, very mild. And I you know that some of the products out there recommend dosages that are much higher any time I ve taken more than four hundred. I don't feel very good how to describe rather, this is a little overly stimulating in terms of makes me kind of it's like drinking too much coffee um so that's that's interesting. And so would women ever want to take toner, ali for any reason?
Yeah, absolutely. So there's a lot of women that have hyper stRoger ism, and unlike a geno fatigue, Andrew, posers, actually. I C D ten coats for hyper X A genius.
I C D ten codes to .
c des, to where your doctor can actually diagnose you with something. So if you go to your doctor and you say I have a dream fatigue, they can't diagnose you with that. Or if you say I have Andrew polls, they also looking diagnosed with that.
Um but if you say you have hyper estrogens m the most common complaint that comes with that is indeede IOS is which is overgrowth of the lining of the U. S. And uh those people could potentially I think that's one a area where we might see tong cat supplementation more and more because not only is a decrease, a romeo likely mentioned to stop string in females as higher than ever gen in females. So a lot of females get estrogen from a robotization as well. Peripheral etr rogen is sometimes so we call IT because it's not directly produced in the voices, but they could be good candidates for tancred, if that's the case.
Really interesting in IT, in my understanding, that people should be looking for sources, indonesian tongue in particular.
correct. Another interesting in application is essentially a alcoa P, C, T. But essentially what that means. P, C, T means how the finance post cycle therapy acronym scientists .
love acronis military love acronyms. yeah. C, T, post ycl there. This is people coming off form on therapy or series.
This would actually be for a women that are coming off of their birth control pill, because perhaps you can help lower that S H B G back to Normal, which is sometimes persistently elected. And then I can help prevent the subsequent hyper estrogens m that happens.
This toner ali need to be cycled. When I first start taking that, I would cycle IT. I would do a few three, four months, and I would take some time off. Now I just been taking IT continuously for years and and I should say I do blood work to check my liver in zone and everything else and I don't see any reason to for me to see staking IT.
Yeah, probably not. There is been human studies on both tongue and photo sia and full disclosure. I did help design erick's new testers, an optimization supplement which has both photoshop arresters and also Tonya ali in IT. Yeah.
let's talk about for dosia separately in a moment. but. If IT, let's say someone is only taking tony ali for a whatever reason, but do they need to cycle law?
Likely not. But I would just to be safe because that does both affect your remain at an extra gene recept modifier and .
what what would be a reasonable cycle off. So how long to take can how long to to stop before taking again?
Yeah um there's a couple different protocols that you can do, but eleven month on, one month off for tone cat is pretty reasonable. Now this I guess this is, we'll talk about this later too. But if it's combined with photos a, the protocol that I would do is three weeks on, one week off.
So that's tony ali.
But i'm curious what your thoughts are on photo gia aggress s this nigerian rub or this extract from nigerian troops that, least in my experience and my read of the literature, has the potential to increase testosterone and probably other hormones as well, by way of increasing luti zing hormone, something that we haven't really talked about much up until now. What are your thoughts about dogie gratis? What are your ideas about the proposed mechanism or mechanisms? And where might this be useful for deep on war off or more replacement therapy?
Yeah, photos, a justice has just reached a point. What we have enough evidence to, we know IT probably helps both with luna izy hormone released which stimulates later cells in the tests to produce more testosterone and probably with A L H receptor sensitivity as well, which is a good combination of the two um IT does come from the nigerian rub but um there is not quite enough evidence for me to be able to say that is safe for somebody to take this all the time. Which again fall to stroke disclosure.
That's why I recommended that we uh recommended for people to cycle this supplement. So three weeks on, one week off, that's likely safe. The only toxic studies uh in general are in rats and in humans .
that looks quite safe monitoring is that the studies in rats showed uh toxic to the testicular cells that certain ly concerning, but that the dosages that were used um or translating the dosages used to humans um would lead to a situation where the dosage is that humans would have to take would be very, very large. So the amount of I no longer take for dog a but I I took IT at six hundred milligrams per day for a long time and I cease taking IT because um I was experimenting with other things and I didn't want to come found those things not because I had any negative side effects in fact, I was monitoring blood work in another by logical parameters that would have told me if there is a cute toxify and there wasn't what's put that way.
Yeah I think it's extremely safe and i'm i'm just not convinced that there's enough overwhelming evidence for a long term, consistent a administration.
So do you recommend this to people who are not taking T. R. T? And do you recommend to men and women?
yeah. So if you have a really high L H and there's probably a gonads t issue, whether is he damaged the tests of eric cio um a history of testicular cancer or your L H is a going to be higher. So if your L H S R T very high, increasing in even more is probably not can help. However, if lh is a low and obviously try to find out if is IT low, is IT deficient or is this just a little bit low if it's low and you don't have an issue with product and you don't have an issue with uh O P O cept antagonism and now track zone can actually potentially help and tagging ize that to increase l age as well, especially in people recovering from um opiate are likely and alcohol. So you're looking for a sub clinical secondary hypoglycemia essentially just think of that is lower h so in people with that lower lh and their extra genis fine and their product and is fine, then photo sia is a particularly good option.
interesting. So three weeks on, one week off for uh for six hundred milgram for dog a uh four hundred milligrams tongue ali indonesian tonga could potentially be be good. Of course, everyone should always check with their physician, clear this, do blood work at sea.
I would say we don't just say that to protect us, we say that to protect you um meaning the consumer um is very, very important. You don't want to get you don't want to fly blind with any other stuff. You want to do blood work.
right? That's the cash. Twenty two supplements is most of them are safer than medications, but the only difference between them and a medication is once prescribed and one's .
not and sometimes with supplements it's unclear whether or not what's list on the bottles so in the bottles but yeah um but I think there are a number of repeatable brands now. Um the the other supplement I want to talk about in terms of testosterone augmentation is born. Ah what is born thought to do, does IT actually do that? And do you ever recommend born?
yeah. So born on is actually an element, and you can find IT on the period table. It's a more plentiful in orris soils, so frequent farming can deplete the soil of boron. It's very plenty of in the medicine, an area like greece and .
turkey. So a lot of people will just eat dates or reasons that are grown. There are right um in a and that's not a good thing.
Sign in deficiency, okay, but there they're .
eating grapes and dates that were grown in soil that has high amount of born on a yes.
So born can help regulate sbg, but it's effect is mostly acute. So it's unlikely to have a bad effect. So a lot of people take born because it's probably not going to hurt and IT will lower S H B G, even if IT is for a short period of time. So I guess you make a case that maybe cycling boron can .
help to what source of dosages are are useful for boron supplementation.
On three to six, mellow grams wants to twice a day.
interesting. So that's higher than the amount that I taking. I belong in doing this cocktail of toner ali. Again, I stopped taking for dog a, but for a long time with father gia and born. I think I was two to four milligrams per day, but maybe I could forward to go hier, although my blood work is where I want IT, thankfully. So circling back to photo, gia podolia um was attractive to me as a supplement because I saw increases in lh test stone and free test stone.
My estrogen stayed in check but I also did not see a dog regulation of lh when I would cycle off um wherewith H C G um human court on can Robin which does now arrive in um in forms not from pregnant women. You're only but the system forms that people inject that as I understand, that can actually suppress hormonal indulgence, horr mono output if one takes IT for a long period of time. So why would a man or woman want to take hcg? And what are the potential risks and benefits of taking hcg?
yes. So H C G, or human cardio a gena ropin is actually very similar .
to T S H sim, correct?
So um when a woman is pregnant, SHE produces more H C G, especially in the first trimester. When you take a pregNancy test, whether it's a quality of equanimity, you see the hcg rise and IT actually doubles every forty eight hours. So um if you're five weeks pregnant t you can eat A H D G level.
And then two days later, five weeks in two days, you can see your H G G and maybe went from five hundred to a thousand. So IT precipitately increases IT does a few things. One thing is that prevents hyper thread sm or hypothermic ima of pregNancy, which is one of the most common causes of miscarriage.
It's also why if you are uh if you have hyper partisan and you get pregnant in the first trimester, you, anna, increase your dose from twenty five to forty percent to keep your free t four high as much as possible. And the reason why you have to do that as opposed to somebody who does not have hypo hr ism, is if you have hypothetically m then likely your thyroid will not respond to either T S H or H C G. So the increase H C G does not compensate for that. So if you take H G, then I can potentially improve your fireside function, so that, along with solenius, are likely the two best things that you can do for fire road health.
H C G and selenium. I definitely um make sure I get enough slender by eating three to five brazil nuts per day. Try very much. Enjoy the taste of also, uh who should take A H C G and can H C G suppress one's Normal loni zing hormonal output ah.
it's suppresses L H in a dose dependent manner. So then hire the dose of H C G you take the more suppresses L H A common dose for fertility. Fertility is usually why H C G S prescribe in men or women in both is a ten thousand I use all at one time.
which is quite a bit. That's a tremendous.
In fact, some formulation, some brand names of H C G come in auto n ject, or pins to where you cannot even do slower than five thousand units at a time. Wow, yes.
But I know a number of people who take H C G to maintain, to stimulate unction while on to stores one therapy or augmentation of some sort. Does IT does that work to do that?
Yeah, some people are on hdg mono therapy. IT can be slightly Better on your lipids than being on T R T.
Also, people are using hdg alone as a kind of a neither a sort of a hormonal argument.
indirect hormonal augmentation. Some clinics advert as a non suppressive alternative to T R T. But IT is impressive of L H. But IT could .
also increase asteroid pretty potently. yeah. And is IT true that increasing lh and or H C G can improve sensitivity of the genitals? And is that true for men and women? You've heard this aniuta people say H C G makes sexual activity more pleasurable for people because of some. Is that a direct effect on on some of the nerve cells in the in the generals?
Yeah so L H is also uh an agonist in the prostate and engineer tissue in general. So it's a very common uh, treatment for post fan asteroids in drome or post five alpha dog takes when you ve blocked the conversion of dht for a long time. IT helps reu regulate dht.
So someone who's been taking fantasy d to prevent her loss comes off IT feels maybe because they felt lousy but then feel feel even lows here for reasons you talk about a earlier. And then they might use hg as a transition treatment to um transition back to Normal a hormonal health that .
right it's extremely helpful in many cases. Now, when you come off the H G, then you need to have a strategy of how to return to your Normal as fast as possible as well. But IT will up regulate those five alpha ducket enzymes you have in your geritol skin, both scatter skin and penile skin and paranoia and general.
You have, uh, I believe it's called stratum elusive m. It's a skin layer that is very, very thin. But IT has the highest concentration of five alpha duct. So you have a lot of activity and and after you've been on something that inhibits the enzyme, the five they are in that in those tissues, then you do something else to up regulate those ensigns. Whether it's waiting and taking time, whether it's trying to telephone, whether it's trying creating even or whether it's trying H C G A, A lot of times those of the go toes .
for postman acs and row any risks for women taking H C G um on their ability to get pregnant or um or risk generally yeah obi.
it'll make any pregNancy test positive so that's a risk that some women don't know.
So one could, in theory, fake of pregNancy task by injecting H. C. G. Absolutely interested. I have no motivation to do that. I was so curious, what about a proactive, you know, the simple version of this that I was taught? Because I was taught mainly from the neural undergoing perspective, was depine is a kind of close cousin of testosterone and also echogen for that matter drives competitive behaviors including pursuit of sexual partner sex itself motivated behaviors generally then um post copulate ory post orgasmic states are accompanying by a proactive increase sets of reference ory period for meeting in males, maybe even in females as well.
Involved in milk let down and said a what are sort of the the general controls of of syndromes or things that people could be on the look out for of having too much proactive or too little proactive and I am aware of a number of people who take, uh, dopamine e agronian tyre, see, keep golan things that that to really boost third dopamine levels. And that isn't always a good thing, as IT turns out of, as people become kind of hyper dopa energia. And so they have the drive to do all these competitive things, you know filling the blanks um but they don't always um have the ability because IT seems just as testosterone and ergen need to be in the proper ratios, dopamine and production need to be in the appropriate ratio. So how should we think about um and perhaps act on our project in systems .
absolutely the way I describe IT as the dopamine wave pool. So if you're increasing your dopamine too much, you're onna overflow and then you're going to have that wave crash too much. So you want to have nice even waves that are not going too far about of the pool of dopamine and produced will follow.
So production and exogenous or quite close cousins eta gen up regulator gene called the P R L gene or pro act and gene that directly increases protein synthesis. So proactive is going to uh also inhibit the release of testosterone from the battery. So if you're using a dopamine agonist, then you are going to help decrease the process and producing cells, including if you have a profound and producing micro noa in the petite ory.
How common are those because that I mean, I hear a lot about these you know um hypoglycemia or and of course I can be due to an issue at the testicles les or I um I pregny m uh can also be of course in like ovarian syndrome. And then there's of course, the brain side of IT, where the signals aren't coming from the brain, you're not enough going out to drop and not enough luizi hormones and their ways of teasing this apart through with an anchor ologies that are quite elegant, in fact, right? Using stimulator too much to dive into here.
How often does one actually have one of these pituitary tumors? Um I have heard ah that people that play a lot of high contact ports, so boxing, football, people that had headed the socket ball quite a lot um sadly um people whose jobs force them to take head blows um for you know could be military and so they were firing fifty culver guns and the kind of woodpecker's of the brain inside of the skull. Um and construction workers, or just a concussion, can cause the paternity to go about functional.
Is that really common? Or is this something that you know is is a rare like one percent? Yeah.
it's extremely common. It's another one of those conditions where a lot of people never know. They have IT.
They just feel a little bit more fatigue. They have that high product and feeling all the time. But to eti micro, noma can be none producing as well.
So you're proactive, can be totally Normal of your growth. Normal. And G, F, one can be totally Normal. That's the second common producing micro add. Nm is growth for moon, causing either acromegaly is growth of carlier giant ism.
This is the the big Brown ah .
so those are fairly common a causes about numerous, but a lot of people that have a very small uh anoma you know much less than once in cheese. It's hard to see on imaging even if you have a contrast that specifically looks at the battery and many people aren't symptomatic. So um it's one of those things, along with pcs and prediabetes that are much more frequent when IT comes to prevalence, which is the amount the percentage of people that habit in the general population.
I'm glad you mention the dopamine and wave. I know nowaday um there's a lot of interest in augmenting doping. I know a number of people to do this through prescription drugs out of all lin mada el. And those drugs, of course hit many transmitter systems but doable is certainly involved people taking into depression, like, well by train, tap into that system. And of course, people are trying to inhibit protein and promote serotonin and reduce serotonin.
To me, that all seems like a very delicate dance, right? I mean, to just imagine the arousal arc of for mating behavior for sexual reproduction is searching in elaborate dance between sympathetic drive and parasympathetic drive, even with across the span of minutes, right? I mean, I ve talked about this before. The podcast said the arousal is kind of more per sympathetic um orgasm and um itself is is a sympathetic, responsible, completely different set of neurons.
And so where do you see people getting into trouble just trying to hit the gas pedal on doping? And where do you think there is a place for people to perhaps are experiencing low drive and motivation, not just sexual but in general um to increase the amount of dopamine circulating in the brain and body? Do you think about that giving this wave pool analogy?
Yeah so it's important to pass IT out and start with the least powerful interventions. So if someone's concerned about doping or maybe they have a slightly higher, then they eliminate things that could be increasing that production. So uh, casing or gluten, which are new O P A recept agonists or any new O P O A recept agonists .
in the gut. So milk to correct and increase.
proactive, correct, interesting. In addition to that, they should, uh, if they need a tutti M R I, and they should get up a tutti M R I if they don't have an ma or if they don't have a high enough level to, they need A M R I. Uh, if there have been visual symptoms or they're having uh all factory symptoms with the nose than it's more likely that they do that they do.
But um if they don't, a lot of times a product and undergo forty is not too big of a deal. They can take a dopamine e agonies that agonized that d to receptor like p5 p which is essentially vitamin b six。 It's period xian five pyro ops hy and period xian environment be six. So that can help fifty milligrams wants to twice today. And vitamin e can also help, especially if it's mixed to co for us a lot of people have the a high levels of a vitamin, but low levels of the gamma form of vitamin.
So I can also help. fascinating. And so god you mention via be six and p5 p um I have heard that one can short in the refractory period after um after orgasm to essentially to be able to uh how sex again to be quite direct about IT by a by way of bidin b six blunting of the product in response which turns out to be quite potent um but i've also heard that vitamin b six can be neurotic toxic, especially in the in the prefer that IT can cause preferable the oates if it's taken IOS. But that p5 p is the safer form。
Is that true? It's pre activated so IT does not build up. Think of IT as a allegory to how fully can build up. It's not method for late, but IT builds up a and I can increase levels of homocide n or if you have too much vitamin, be twelve of another water, soil will be vitamin. You can have too much metal mechanics or MMA. So depending on what your insects tic conversion is to the act of form of the eni, often it's just safer to take the act of form of the .
very interesting, okay, well, at risk of going down every hormonal pathway and talking about supplementation, lifestyle factors, I think touching on as we have to stores one and stroke. And i'd love to chat a little bit about l carneta. We talked about this earlier.
And but I want to raise this discussion about l. carneta. Not in the context of our carneta itself, but in the context of fertility. Because my read of the literature is that alternative can be very beneficial for enhancing sperm quality and egg quality and even rates of conception. Um what forms does our community come in that people can reasonably um consider again, talk to your doctor folks um what is he doing and do we know how it's doing IT and do you often use this senior patients?
Yeah so the way I think about l carney and i'll try to tidy with creative and other things as well, is if your sell is an energy factory or a car, then l carneta is the shuttles that helps you get the fuel into the motor to use the motor. The motor is mostly due to lifestyle factors. So like you know, you're diet, your exercise and the type of fuel itself is N A D plus.
We don't need begin N A, N A D precursors or in a and or anything. And then the accessories fuel tank is your creative for fee. So creative is your accessory fuel tank.
Your N A D status, which is largely determined by your rim sleep and quality sleep and exercise along with implementation is the fuel. The carney shuttle is a carney palette coin zine. A, and that takes medium chain fatty acids.
That takes different molecules of fat, two main energy sources other than q tones of. Glue, cose or cards if your fat or fatty assets. And that takes IT across the layer of the modern reo so that I can be utilized so up regulate. That is why things that have flagella, in general, the flagella, are gona work Better, like the legal.
anything out of the way, little generous on cell types, which were there everywhere, right in the got.
yeah. So those are going to work significantly Better. And in general, your money and I are going to work Better. So the worst, your money and I are off the bat, the Better they are going to be. Helped by the shuttle that shuttle them across the IT also slightly increases the density of the energy recept tor as well.
Is that a local effect? So if counties injected into a particular muscle, will that increase the density of android and receptors in that muscle?
likely.
So so how are people taking your currently their capsule forms and their injectable forms? Most people are gonna be taking the caps of forms because that's all they're going to have access to. And then we also ask, can get our our team from food.
yeah. So l carney is just a combination of is actually a very small peptide. So glut I own is just, uh, three mini assets.
L Carol is the smallest peptide. two. So peptide is just a protein, has a mina's between two and about two hundred and l count is just to mini house. amazing.
So just like a micro peptide.
yeah. So your body synthesizes enough. IT likes to absorbed the amino assets by themselves and ended IT puts them together there, makes all carine.
It's not very by available. If you take IT, a lot of people will take l carnet, l tar or A O L carnet. And that's about ten percent bioavailable. So if you want one gram or a thousand milligrams of carney, you can take ten grams of oral alcaraz.
Is that is the one gram, the typical those you recommend one gram per day .
for fertility and androgen recept tor up regulation.
that means taking ten grams of the capsule form.
Yeah, that's about fifteen to twenty capsules.
which is a lot.
That is a lot. You can also potentially .
increase ta. Yeah, I won't ask about that because ta on your blood charges when that elevated, that's gona some concern. You taught me a trick, however, that one can take six hundred milligrams of garlic t capsule for the Allison as Alice go alson。 It's like the name alison but were two else yeah okay.
Um and that had a remarkable effect in reducing T M L. Um so that's quite poor. And also really was IT just coincidence that IT really brought my L D L down as well.
Uh I am not sure if the L I O is a coincidence, but depending on your gut microbiome or your micro biota, some microbial uh beneficial bacteria will convert a calling and also calling. So any calling proposal like alpha gpc, forest ital, syrian, they will convert them more or less the t mao. So t mao is something that you can get measured in a blood test and see if entire low. Some people might not not even need alison. Some people do benefit from.
Interesting, although I think I think he was you that also told me that that alison and garlic can have positive effects on a cardiovascular tone and blood flow generally right? Yeah okay. So maybe so is six hundred milligrams garlic and excess excessive amount? Can I just eat garlic? you? I yeah yeah.
So okay. So one could also just eat garlic. Um if one were going to take part in injectable form, how much of that is by available?
Uh one hundred percent if you injected IT is in an acquired solution. So it's uh bacterial static water essentially. So it's not in a Carrier oil. So it's really it's gna burn a lot if you inject IT subtask eusden, so it's going to be absorbed faster and more evenly and also just hurt all A S if you inject them into a muscle.
But one could then just take one one gram per day injected or divided up into a couple days, yeah.
or five hundred. And minimally effective dose for inject tables, probably around two hundred when IT comes to spur mortality and android and reception of regulation. So IT really depends on why you're taking IT .
in terms of fertility and in terms of blood test generally. Um I always say that um if possible, um either by way of insurance or by way of um some some other way, affording IT IT would be great for people to have blood tests to know what their hormone levels and other levels of other things like meta lic markers in that its were in their is also in their thirties, also in their forties.
I think there's this idea that you only take a blood test when you have a problem but then of course, you one can actually do the comparison that you mentioned earlier or state the comparison to one's physician um that things are changing over time and IT seems to me that basic everyone should get at least a one to year blood test. Is there the hope that insurance will someday just cover IT for everybody? This will be standard care. I would think that everybody should know what sorts of things are floating round in the bloodstream and what they need more of in, less of in life.
I doubt IT will ever be covered by insurance. In many cases you can make an argument that is indicated as insurance begins to cover more of the population for pathologies. The um things like F S.
Says or H S says or care credit will likely cover this advanced testing, which become IT, continues to come down and down in Price. So it'll be affordable. But i'll be free.
I'd like to shift gear slightly and talk about social interactions and relational effects on hormones, something that I just find fascinating. We touch on this little bit earlier with terms of contraction tion, but now that we have the backdrop of what these various harmons do, some involved and neurotransmitter systems like doping and um production associated pathways, production of course being formed ed on a transmit.
But you know there's a phenomenon um in human beings where people get very excited about a new partner um and that excitement no doubt is related to the dopamine e system, among other systems and that excitement can be maintained or can wane over time. And here I am talking about attraction, but i'm also talking about just general excitement in the sense of novelty because that's what associated with given that um you know europe you work with human beings and they have lives, lives and relationships and lifestyles and they have hormones and and all these things interact. What are some of the ways that we could think about adJusting our relationships in order to optimize hormones, as opposed to just thinking about how to optimize hormones for sake of our relationship? Because that is by directional, of course.
And this assumes, I should say, that one is already paying attention to the six pillars talk about earlier is doing that people are doing most things right. How should we think about relationships and hormones? Friendships, romantic relationships, new partners, long term partners? Um yeah, how do you think about this kind of stuff?
yeah. So if you have a new partner, then IT is largely regulated by the diplomatic gic system, which changes over time. So people may have heard the same, that you have to go through A A full calendar with someone that are in a relationship .
so that you really .
good is so you you really know what to do and what not to do. But uh because you know you experience both of your families and the holidays and all the different situations. But I would argue until you have a moved in together, had a baby and then erased that baby, um preferably breast feeding because that's when you get the process and Spikes. You don't you don't really gone through every stage in life yet. Now you can really do that with every person .
that you are considering. Well, some people do. But IT IT can be quite uh costly in terms of time and finances and emotionally costly in the here I am difficultly not referring to any personal experience of having done all that many times over. But what would you suggest people uh do or think about as they enter relationship or for people later in long term relationships where they feel like something has shifted? And indeed, those shifts may reflect the output of different hormonal systems and neural transport systems and almost certainly has to be the case, right?
So just like, uh, women who spend a lot of time together, whether there their co workers or whatever, a lot of times they are mental cycles will there is a lot of fairmont and hormonal cross talk, including prox and between minute women. So spending a hundred percent of the time together, this is why people think it's so hard to work together and live together there around each other.
Twenty four, seven, you don't have the reprieve where you let that they have mean settle down and then you're excited when you see them again. A lot of guys know that they have gone on A A hunting trip. If they gone a trip for a long time, they come back and they see their partner.
It's like a new not quite like a new relationship, but almost like a new relationship. They have that excitement again. And purposely building that into every relationship can help significantly, especially if you choose to have a child, they're pregnant or be breast feed.
Because you just plan ahead for both of your protectors to be high and both of your deep a means to be low and both of your test stones to be low. So um there's a there's a lot of planning that you can do. Essentially every relationship goes through, uh, a crisis and that crisis is personal between, uh, the two of you. And you can plan ahead and figure out a way maybe it's not supplementation, maybe it's not even a the amount of time you spend away from each other, but plan ahead to have good times if you know you're ready to go to a crisis.
And so IT sounds like time apart and time together, which is actually built into a number of cultures where men and women will will purposely ly avoid each other for some period of time, avoid physical touch and may be in proximity and then will reconvene and yet those are very stable relationships over often.
Um is the inverse also true um for instance, for people that are in long distance relationships um where they're only seeing each other or three or four days a week or two days a week, um does this explain the fact that uh some of those relationships can go on for a very long period of time without ever actually entering the um let's called the hyper tract in phase of actually moving in together and at a like in other words, is that A A way in which people are spiking and trafficking to open mine that keeps them attached? This kind of elusive, this sort of a what is that called I think it's called like a cat string like if you play with a cat, you move the string away, they're keep reaching. But if you throw the string on the ground, then they're totally ally uninterested in IT.
Is that that what's going on? Because that's a dope energy c phenomenon, the cat string example. We know this experimentally.
In those cases, the relationship hasn't really progressed. In many of those cases passed the dopamine Spike, the fun initial stage, honeywood stage, what everyone to call IT. So it's almost kind of like a roommate if you're looking for a romance, if IT was for college, after college or ever, you know you can fill out forms and look for common interest. But until you're actually together, a significant proportion of the time, you're not really going to know if you're going to be compatible or not.
And is um a evidence that the appearance of of an infant changes? Obviously there gonna harmonic shifts uh we know actually is that for uh in both women and in men there's a proactive increase of when when when couples are expecting a child. Uh, this is the it's almost like a brooding phenomenon.
You see this in birds where it's called actually cause called brooding and it's caused by proactive crease. But turns out this also occurs in humans and some people argue this causes the the dad bot phenomenon, because IT actually productions bolin laying down a body fat, preparing for sleepiness. And personally, that IT Spike in proactive is there also to suppress sexual activity, because there are periods of time immediately near childbirth where sexual activity is not advantages.
Yeah, you see a pro act and Spike right after breast feeding. So if you think about IT, often when you have an infant, um your breast feed put the infant to bed and then immediately go to bed with your partner, which is not particularly conducive and almost like trying to have inner course back to back and it's very differ because .
of in in the production sense.
Yeah yeah low developing high oxytocin is also increased significantly to help with milk light down as well. So um yes, as far as brooding, there is definitely uh a human equivalent of brooding um some humans call IT nesting instinct, which is both helpful. But it's it's not necessarily a bad change in in relationship.
It's just a change. And as long as you know that it's coming, you're going to do Better with IT just like any medication uh, if you are aware of the side effect and that IT might happen. And when that happens, it's not only, uh, less severe but also happens less often. Interesting television.
As a neuroscientist, I come from the framework that, of course, hormones impact perception and behavior, but perception and behavior also impact hormone. es. I found this faster also really like the example you gave of um people taking time apart but also these are filling ative bonds that are um nonromantic bonds can show as kind of a reserve war to replenish doping um that is then released upon experience going back to the one's partner or some sort of regular feature of home. Um very interesting and of course should exist on both sides. I'm guessing that um from both the male side and female side, there's an interest in kind of separation in reunion as as the theme and I guess the frequency will vary for different, different couples in different situations.
Yeah and I don't want to make IT seem like production is all bad. So production does help with the nesting instinct. IT helps with breast meeting as well. A lot of women are diagnosed with ludie phase effects, which is basically the phase after violation, but before a period or giving birth, the pregnant is kind of a prolonged glue al phase, and a lot of them will go on progesterone. For this, progesterone can also decrease protectant, and prolats is also helpful for the maturity of longs and infant, so IT helps the swinger violin to lechester ratio, so you can decree if you, if you're productions too low through pregNancy, Spikes are very high during pregNancy, then IT can lead to increased risk of respiratory or distress of the newborn.
Really interesting, yes. So we certainly don't want to paint a picture where proactive is the bad bad hormone to avoid. Its its without proof and none of us would be here um of course um so vital. I realized that earlier, I raised the question about whether or not cold exposure could modify hormone output, in particularly whether not ice baths or I supplied to specific tissues of the body, as people are doing one where the other can change to ostern levels, estrogen levels. Other words, to taking ice basin cold showers, increased testosterone end or estrogen.
yeah. So taking an ice bath or a cold shower or a cold exposure in general, it's not going to correct of ian deed efficiency remedios x endroit. So there's a lot of things that I will not correct that are causes of hypo gandia m or or low tedster one. But IT will help acutely, specifically the application of cold to tests that are too warm.
So, uh, if you have a very cascio or if you have a little bit of a primary hypo gonad ism, which is where to tell stone is not released by the testes, but your lh and fs h signals are sufficiently high, then uh, you'll likely respond to cold exposure Better. And there's actually under garments that are designed specifically to help with fertility. And there's probably going to be more more than in the future. You just need to be careful not to get frost by because it's a particularly bad spot to get frost. Ed, by .
noted, could you define very cascio you mention a few times. Is that a very surveyin?
yeah. So it's essentially a very covey IT brings warm blood and the Venus flow or the flow back to the heart is not as good, just like in the legs. IT can happen in this grow.
M, usually about twenty to twenty five percent of people have one great of veracious those grades one through four or one through five. And most people just have a very mild one, usually on the left side, because the blood has to go through further to get back to the heart. And IT raises the temperature of the testy. Temperature is the enemy of testy, so they like to be five to ten degrees cooler than the rest of body.
So our song is particularly bad for sperm production.
They can be.
when you say, can be, how long could one safely be in the sauna? Or would you want to go back and forth between the cold and sona? Is any are there any data?
If someone is having infertility, then I tell them to avoid all sonus empirically if someone has um if they're not in further but they have a low sperm count, I also tell them to avoid. However, it's mostly a warmed water that can raise the to nature of the testes faster than the sona. T yeah so hot, have energy. Kuzan, those are enemies. Number one and number two of sperm.
What about ice breaths in cold showers for women? Any evidence that I can shift hormonal output in women?
Yeah, IT can IT increases the the activity of the beta ago, epic receptors, even in the center nura system and the astra sites as well. So I can do a few things that can slightly decrease uh the drive for food, which exercise and beta eero gic receptors have uh some medications that away loss medications also do similar things. But IT IT can be beneficial and the women do. But no, ever.
Instead, IT changes estrogen output in women, correct?
Now that I know me.
the peptides, lot of discussion these days about peptides pepps course just being strings of a minae. Ts, as you mention, very small ones, like two, two minus, like all the way up to polypeptides, which has been many, many, many menu acids. There are so many peptides that there's which pride to do an entire episode about peptides.
But I think one of the reasons i'm hearing so much about peptides these days is that they are not called steroids. You know that the name steroids um um I think has been uh has come to be associated with animal exteriorly in the context of you acme testosterone, rage, sea. But of course, to stop, excuse me, s rogen as a stereo ID hormone, right? There are other story, hormones, as we both know, but peptides are gaining increasing popularity.
I am willing to go on record saying that you can be sure that many of the incredible transformations that you see in hollywood are the consequence of peptide use. And i'd put my my name behind that because i'm well aware of people that uses to prepare for rules but athletes use them and then everyday people are using them to, for instance, um sir morin test moil in IPO morin to stimulate uh the release of growth hormone rather than taking growth hormone on a bpc one five seven, which is a essentially a sthetic gastro juice that Normally that repairs the gut. They being used to treat injuries, and there are other ones as well.
What can we say generally about peptides? Are they safe? Are they not safe? What about sourcing? And are there any peptides that you think could be a particular use for people? And we should probably also touch on peptides that people shouldn't go anywhere near with .
a ten foot pole. Yeah, definitely. So peptides are very heterogenous there, very dangerous ones and a very safe ones.
My favorite peptide is the original peptide, which is in sin. So insuing is a appetite. And you, less than one hundred years ago, there is a scientist studying in insulin.
And at some point they saw that an animal had its diabetes, cared by insulin, inc. Cared by insulin injection. Less than a year later, they were injected in insuing into every type one diabetic because IT was .
saving their lives. And yet insuing can kill you if you take IT at the incorrect those yeah.
So just like issue should be prescribed by a doctor. There is over the encounter insulin. Uh, rely on our N P H, but ideally your insulin is prescribed by your doctor for a your diabetes as as life saving peptides should be prescribed by doctors as well.
And there are several that fda approved. So you mention a lot of different ones. Uh, let's start with test moral. So test moral with recently F, D, A approved for something called lippo destroy IT happens where body fat is displaced into abNormal areas, often as part of aides or severe burns, things like that.
And IT helps to redistribute this body fat and give people that are quality of life back test moran is A G H R H, which I kind of looked into the category of G H R P. So growth hormones, releasing peptides. So it's only a couple of mino acids different from indorser ously produced growth hormone, releasing hormone.
So growth ormon itself is also a peptide. It's a peptide hormone on not a stereo ID hormones. So you have um uh different semantic troops which are a very similar to growth.
Another fun fact is that H P L which is human plus antal lactamase. We love acronyms, right? Human placental active gen is nearly identical to growth hormone ah. The growth formal in pregNancy is not what causes the sugar Spike and gestational diabetes. It's the human placental acg en.
So if you look at twin pregnancies, if they have two placentation or more placental tissue making more human placental actin, the risk of gestation diabetes is exponentially higher. So this H P L is only a couple molecules different from growth hormones. Is interesting that these different G H R H es in G H R PS actually have pretty different mechanisms of action.
Grin is also uh hormone on that's released when you're hungry. This is probably one of the reasons why you have more growth home man released overnight. And there's a lot of peptides that are very similar to grow in.
So these peptides are not bioidentical peptides, but they just have a couple different amino acids change. So they're almost identical, and they're probably going to be used in the future for growth. And until I encies, including in kids, they've been studied.
So if somebody wants to increase in the growth for more now, but in addition to not eating within two hours of sleep, getting good deep sleep, um doing all the other things of in the six pillars that you mentioned earlier, especially resistance exercise at some point earlier in the day, what are the risks and benefits of taking a growth hormone releasing horn peptide like Simon prescribed by a doctor, of course ah what should one be concerned about um how long could one take these i've been heard that they can modify gene expression so that they really are changing your hypothetic illness are in very .
long lasting ways yeah um there's definitely lot of risk, tumor growth and cancer. So you look at a type one diabetic, they have very high incidences, es of various types of cancer. They have very high growth or known but low I G F one, paradoxically.
So they would likely give you a similar cancer risk to a type one diabetic that has very high growth hormone. However, there are the benefits of IT. You think of Apollo is a decreased body fat, increased only in body mass.
A lot of those can you can use other things to get those benefits. So then you know you don't need growth hormones for those benefits. That just leaves cosmetic benefit to which you you can usually use topics to get, you know your hair and your skin and your nails.
There's a lot of other things that you can do other than growth hormone. So a lot of people just don't need these G H R P S. If they, if they don't have libo destroy y or if they don't have growth.
Formal fiction ency. There is other uses of them, specifically in injuries. So I know that theyve been studied, uh, much of its in the military we mention the woodpecker or the cow control injury so they can have been sitting .
back and for the brain, busy slammed up against the side of the school, the football heading the ball in soccer, definitely people who use the fifty calva and military or that that's a fairly small population. And I think anyone that hit their head hard more than what yeah.
we can talk about. B, P, C, one five seven for a bit. G, H, K, copper peptide for a bit. Uh T, V, five hundred or a Thomasine beta for analogue. And then we can also talk about uh bram milanovic which is milanovic they have milanovic into and then they also have one at ten.
three and four. Let's have P C one, five, seven and millennia ten because I think those are the ones that most people are um eying, so to speak.
So B, P, C one, five, seven is body protective compound one, five, seven, eight, uh identical or bioidentical to gastro protective compound one, five, seven that produced in the stomach. So as you age, you get a tropic gas ride us very often. That's why you have less intrinsic factor, which is kind of another peptide that bins divide them and be twelve.
That's why you can get age related b twelve deficiencies. So that's one reason why you have more colitis, more diverticulitis says you age, you don't have that gastro protective compound. It's uh IT increases veg f vaio lar indo theoria growth factor, which basically makes your blood vessels grow more.
So that's what causes your body to form a blood vessel. So another medication on as a vasty is on the W A chose list of a central medications for cancer. So many different types of cancer, including colon cancer you treat IT with of asking which is a vegetable inhibited. So if you have cancer or a high cancer risk, you probably don't want to be taking the medication. That's the exact opposite mechanism of action as your essential anti cancer men.
In other words, if you have cancer, your risk of cancer avoid. Bpc one five seven. correct?
A lot of people prescribed IT for six weeks and bpc one five seven. So grim melanotan de, that is after approved for a hypo active uh sexual disorder test. Moran, that's also approved for a lipo destroy y interestingly, another one of the millenia tanz is also approved for lipo destroy y and also deficiency in the milano cora receptor.
So the receptor that receives um the alpha milano sites stimulating hormone is a very rare condition. It's also approved for that because if you don't take IT, then you get obesity. But um B P C one five seven is not after approved, but IT is essentially standard of care this point. And I would say that you know if you're not counting insula or growth hormones, peptides, it's one of the most commonly used peptides. And anecdotally and in some clinical literature, it's fairly well tolerated for short periods of time. I'm not in the camp that everybody needs to do IT two to three times a week or even daily for six weeks no matter what the major benefit is when you're onna take IT early on because it's gonna allow you body to increase blood flow to the injured area and the less blood flow has, for example, cartilage, ligament have horrible blood flow, especially as people age, it's going to make a significant difference. So I would wait you that that russian jimnez that actually healed in one month and completely from A A full ruptures was likely taking bp in one five seven or something very similar.
I'm willing to wager on that as well. Remarkable recovery. And so because this is prescription, there are non prescription forms.
My understanding of the non prescription forms and the danger of going after non prescription forms is that often times they will contain what they claim they contain bpc one five seven in this case. But they are not adequately cleaning out the lp s the epipolae right, which can cause information. In fact, in the laboratory, we use lps to deliberately induce fever and inflation tion to study systemic information.
So this is a warning to people, if you're interested in petites, you absolutely need to work with a physician, in my opinion, get IT from a really good compounding pharmacy who will clean out, put that, cleans out the lp s because if you're buying IT through a source that um a lot of people, I don't want to name sources, but there are these common sources on the internet that everyone knows about, they're buying these sources theyll ship IT to anyone essentially. But then the lps is really causing information, and many people experiences a kind of mild fever tingle internet when they inject IT. And like I can feel IT working.
That's probably L P S. Action, which yeah is not good for the brain. I don't know about on other preferable tissues um haven't heard of people dropping dead from the stuff yet, but I certainly wouldn't to be interesting any L, P, S, unnecessarily. So would you agree that you should work with the doctor? After all.
you are A D R. Definitely talk to your doctor about this and talk to them about the dozen regime as well. So if they have you doing IT for six weeks, asking, why am I doing IT for six weeks? Why not two weeks? Or why not as soon as I feel Better, can I just stop? IT? Yeah, there's a lot of good questions like that that you should ask doctor.
And if somebody y's trying to prescribe you a bunch of different things, then see, is this what they proscribed? Everybody is as individualized for me. There are peptides like G H K oper peptide, which is produced in augen ously in the liver more at Younger ages.
That's why the liver can regenerate for the is this A G H K copper peptide helps. And if you're copper deficient, which not a whole lot of people or but a lot of people that have had Better atrix surgery, A G H K copper petite can help significantly with your nervous system and is also synergistic CS. So any growth agonists like Simon bet made in kids in the familist, which shrinks.
That's another reason why kids heal really well that G H K is somewhat synergic with bpc. But if you don't need all three, you don't want them. And if you don't need IT for more than a week, you don't want IT for more than week.
I I really appreciate you saying that I often say that sometimes the best do so something to take a zero. It's often that the case that the best dosage is zero, you mention mulatta. There are several kinds of multa a um I find IT a little bit of a funny conversation because that I first learned about milanese from reading about discovering that people were taking injecting melanin attend to get ten because it's in in the melanin synthesis pathway.
They also discovered um this is an individual, this is reading about this in various manuscripts and peer reviewed papers that um IT could cause things like pipi m like like a sustained direction that might be the last one that anyone would ever have um because of damage to to the vascular or also women taking milena ton as a as a way to get ten and lose body fat. So this sounds all very recreational. Are there any clinical usage of mulata? So separate from the kind of extreme biohacking cosmetic world, which is really not the main focus on this podcast, more in terms of you know health pursuing health optimization?
Yeah there's actually three fd approved indications believe that are not not many people know about but this three well accepted indications one of them is the hypo active sexual disorder and more and women that's for eno tide.
Those are women that have essentially no lebed's whatsoever but other hormones are not seem are in check yeah classical.
It's um before mini pause. So those hormonal issues are not contributing. And um when you give them this peptide is also as P T one four one that help significantly. A lot of times you use IT in nasal spray. IT goes straight to the central of system and actual you can also inject IT, and you can also take IT for a rokey.
Men and women take IT, correct?
It's approved for a women, but I can also help men, and it's relatively safe. The only relative contra indication that I tell people, and a lot of people say that there is no side effects that I know of. But if you have a family history of melanoma or potentially have a million oma and don't know about IT, that's why a big advocated mosque y as well.
And regular check the theoretical cally, it's gna increase the alpha milano sites stimulating hormone and I can grow that. So that's definitely not a good thing. So be very careful about a long term ministration of IT.
It's also approved for a lip hoodies ropy which is the same exact thing as test, which I believe is also something as uh uh a vista or a grifter. And then it's also approved for the rear genetic condition where you're recept tors or your milano sites don't proferred as well, so usually have hypo pigmentation. It's not true albinism um but it's associated with morbid morbid obesity and very bad poor outcomes from that in childhood. So it's used in kids actually.
interesting. Well, peptides are a fascinating landscape, but thank you for that deep dive into several of them. And we will probably return to you, uh, to talk about appetizers again in the in the near future because I know there's a lot more there and a lot of interest. I wanted talk about the sixth pillars, right? So just remind people you said diet, exercise where appropriate, chloric restriction, managing stress, sleep and sunlight are critical for everyone at all ages to manage and optimize formal health.
Then you have the six category, which is a really intriguing one, which is spirit, which is a kind of unusual thing to hear coming from a medical doctor, except that I have many colleagues and and indeed our uh former director, the national institutes of health, Frances Collins has talked about this notion spirit we talked to about belief effects on this podcast before with alterum how one's understanding of the things that they do and their world in general really creates an important effect on everything at the level of physiology, not your psychology. So as a physician, how do you conceptualize the spiritual aspect? And how do you talk to patients about this, given that people walking in the your clinic are presumable have a bunch of different religious and not a religious background? I'm sure summer atheism are probably strong believer. S how do you deal with that? And how should people think about this?
Yeah, I believe IT IT is surprisingly well received. You wouldn't think at first gLance that a patient really wants to talk about their spiritual health with their doctor. But the way I think about IT and the way that IT really is is is like a vin diagram.
And you have a body and a mind and a soul. And you can't have one healthy without the other healthy even if you're mental health is a phenomenal. And even if you're physical health is phenomenal, the mental aspect of spirituality, if that piece is not there, then that's going to affect your body physiologically as well. And I rumbles done some excEllent work.
There's also been a lot of other studies regarding prayer and i'm a Christian, I believe in god and that gives me a lot of that resilience, ts and motivation that gives me the the cornerstone or the groundwork how I can interact with life and regardless of someone's an atheist, to regardless of regardless of what someone believes as far as religion or the origin of the species, they can know that their spirituality is going to have a profound effect on their mental and physical health as well. People like to compart mini ze IT, so they would like to talk to their doctor only about the physical health because it's comfortable to do that. They only talk to their pastor or a mom wiki here for their spiritual health, and they just talk to their therapist, psychiatrist about their mental health.
But you need to bring all three those things together. It's well known that into disciplinary clinics lead to improved patient outcomes, and that's just disappointed with medicine. So that's just doctors that are specializing in this or this.
So this takes a step back and upper uh in upper part of that tree before you reach those eec omy or the spliff s you have your you have your body and your mind and your soul. So your spiritual health and your mental health and your physical health. So if you're in line in all three, those things that builds the corner stone for the rest of your health and the rest of your life.
So if someone comes into your clinic and they say they're feeling one way in their body, they're feeling one way in their emotional life, you run their charge, you get their blood work and they are atheist or their ignostic um what are some of the six pillar practices that they can consider that are in keeping with their um atheism or notices m um because I have to assume that people who are um in participate or feel that they belong to you particular religious sex will have particular prescription ves from those religious sex that will direction towards ds pattillo lar types of prayer.
But how would somebody who doesn't have a prescriptive coming to them from some other source? What would they? What could they do or would they do?
Yeah so I certainly don't force prayer on anybody or anything like that, but it's my belief that especially been an agonist c it's almost the hardest thing because if you're an atheist, then you have some groundwork and you have some spirituality. Even if he has to do with a the human spirits interaction with the environment, IT can be physically explained well phenomenon like the work that ali chrome us.
But if you're agnostic, you're still trying to find that so I hope that everybody does find what they truly believe in as far as their own spirituality but uh yeah that that's A A personal journey uh from a physician standpoint and even if my friends with him as well, from my friend's standpoint, I don't like to push anybody in any specific direction. So I don't think that everybody should believe what I believe, and I don't feel like there should be any pressure for them to believe something different. So I think that there can be excEllent physician patient reports regardless of what of what we believe and what our backgrounds are.
Yeah that's wonderful to here I can say without revealing in the names that I have close colleagues, that um in every bin of this spectrum like hard core aias, hard core religious in different domains, a different religions um I don't know I don't know find how many agnostic as to whether not I know any notice S I should say I um it's not something that people commonly discuss but um in the context of science and medicine, but it's starting to happen more and more.
And certainly this issue of spirituality is is one of the areas in which neurosciences is asking a lot of questions like what spiritual experiences really are in terms of how they're grounded in the brain or not grounded in the brain. I think it's a really interesting area for discovery. And I appreciate that you that you bring that up and you bring IT up.
And in the non pressured way that you do, I think that a lot IT stimulate a lot of thinking, which is ultimately the goal of of this podcast. Well, I have one final question that I, A listener, insisted I ask, and it's a very straight forward one. It's not at all occurred ball and not at all related to what we were just talking about.
But IT was the most common question when I told people that I was going to talking to you, which is, is caffeine problematic for hormones is amazing. I received hundreds of the same question about caffeine. And since it's probably the most commonly used drug on the planet, I know it's taking us back into the very practical but in enclosing when not criteria. But in closing, is caffeine having a in effect one where or the other on to stone etra genre? Other hormones that uh is positive, negative or neutral only if .
if if exit sleep. So he works on a dinoseb and I can actually slightly improve allergies as well, but negligible effects otherwise.
great. Well, sorry to end on such a practical brass tax type of type of question. But I did promise the listeners that I would, I would ask that question.
Listen, I want to sincerely thank you. We covered a basically at an enchant ology textbook and neuroendocrine logy textbook worth of information, a ton of practical tips. And um where can people find out more about you? We will certainly provide links.
And um I guess the other question is, are you taking patients? I'm sure you'll hear that in the various venues where people can contact you. But but where are you active um in terms of public facing work?
I'm active on the instagram kyle gette, md. I'm also active on the social media of my brand new clinic, which is geeta health. It's an act geeta health on instagram or geeta health dot com. great.
We'll provide links to those. And I should say that you the continent you've putting out on inserm is terrific because you actually point to specific studies and you put things into action context, which is a very meaningful for me. Kyle doctor, just I should say thanks so much for your time. I really appreciate that. I know the listeners well.
too. Thank you, my pledge.
Thank you for joining me for my discussion about horton healthy and optimization with doctor called geeta. As you just heard, he is a treasure trove of actionable, clear information. And again, you can find him teaching more about hormones and other aspects of health on instagram, at kyle galette, that galette two ties and two else but no eat, kyle glottal, md.
On instagram and sheetz health on all other platforms. And if you would like more information about his practice, you can find that at a let health dot com. If you're learning from and door enjoying this podcast, please subscribe to us on youtube. That's a horrific, zero cost way to support the podcast. In addition, please subscribed to the podcast on spotify and apple.
And on apple, you have the opportunity to leave us up to a five star review if you have questions or comments about this or any episode of the huberman la podcast or if you'd like to suggest topics that you'd like us to cover or guess that you would like me to talk to, please put that in the comment section on youtube. In addition, please check out the sponsors mention at the beginning of today's episode that is the best way to support the podcast and has mentioned the beginning of today's we are now partnered with momentous supplements because they make single ingredient formulations, that absolute highest quality and their ship international. If you go to live moment to take com slash huberman, you will find many of the supplements that have been discussed on very episodes of the human and lab podcast, and you will find various protocols related to those supplements if you are not already following us on instagram and twitter.
Please do so. It's huberman lab on both insured and twitter. And there I cover science and science space tools, some of which overlap with the content of the huberman lab podcast, but much of which is distinct from the contents of the huberman lab podcast. Thank you once again for joining me for your today's discussion with after college ete. And as always, thank you for your interest in science.