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cover of episode #291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2

#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2

2024/2/26
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The Peter Attia Drive
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Derek: 本期节目讨论了外源性分子对男性和女性健康的影响，包括睾酮、DHT、DHEA、孕酮、克罗米芬（Clomid）、HCG和各种肽。还讨论了FDA关于肽类药物使用的最新更新，以及通过抑制肌生成素来增加肌肉质量的策略，包括利用卵泡抑素基因疗法和补充剂。此外，还探讨了健美运动员用于减脂保肌的各种策略，包括对减肥药物的见解。 Derek详细解释了睾酮和DHT的作用机制、对肌肉生长的调节以及对男性和女性特征的影响。他还探讨了女性使用TRT的复杂性和潜在风险，以及DHEA补充剂对男性和女性的不同影响。此外，他还讨论了孕酮在男性和女性中的作用、补充剂的优缺点以及剂量的重要性。 Derek还讨论了测量游离睾酮水平的方法，以及早期对TRT感兴趣的趋势以及使用地下来源睾酮的风险。他还探讨了在TRT中使用克罗米芬、E-克罗米芬和HCG的复杂性和注意事项，以及低睾酮的诊断、潜在原因、治疗方案和其他考虑因素。 此外，他还讨论了生长激素释放肽，以及FDA最近将其归类为高风险物质的原因。他还探讨了利用卵泡抑素基因疗法和抑制肌生成素来增加肌肉质量的最新网络炒作、人类和动物数据以及更多研究的必要性。 最后，Derek还讨论了降低卡路里摄入和减脂的简单技巧，以及在保持肌肉的同时进行可持续减脂的方法。他还探讨了延长禁食对睾酮水平的影响、高蛋白冰淇淋以及探索减脂补充剂和药物，例如左旋肉碱和依降醇等。 Peter: Peter与Derek讨论了激素替代疗法（HRT）的方方面面，包括睾酮、DHEA和孕酮在男性和女性中的作用，以及这些激素补充剂的潜在风险和益处。他们还探讨了克罗米芬（Clomid）、HCG和各种肽在TRT中的作用，以及FDA最近对肽类药物使用做出的更新。此外，他们还讨论了健美运动员减脂保肌的策略，以及一些减肥药物。 Peter对女性使用睾酮的剂量过高表示担忧，并指出目前没有FDA批准的女性睾酮制剂。他还强调了测量游离睾酮的不同方法，以及准确测量的重要性。此外，他还讨论了DHEA补充剂的疗效，以及孕酮在男性和女性中的作用。 Peter还对年轻人寻求睾酮替代疗法的趋势表示担忧，并探讨了地下来源睾酮的风险。他还讨论了Clomid、E-Clomid和HCG在TRT中的作用，以及低睾酮的诊断、潜在原因和治疗方案。 此外，Peter还讨论了生长激素释放肽、卵泡抑素基因疗法以及其他一些减脂补充剂和药物。他还强调了营养和运动在改善身体成分方面的重要性，即使是在使用外源性睾酮的情况下。最后，他还强调了批判性思维在评估在线健康建议方面的重要性。

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Testosterone, a primary androgen, plays a crucial role in muscle growth and anabolic activity in both men and women. While men produce significantly more testosterone than women, its mechanisms of action are the same in both sexes. DHT, a metabolite of testosterone, has a higher affinity for androgen receptors and contributes to the development of masculine characteristics.
  • Testosterone is the primary androgen responsible for muscle growth and anabolic activity.
  • DHT has a higher affinity for the androgen receptor than testosterone.
  • Both men and women produce testosterone, estradiol, and DHT, but in differing proportions.

Shownotes Transcript

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Derek is a fitness educator, the entrepreneur behind More Plates More Dates, and an expert in exogenous molecules commonly used and misused by bodybuilders and athletes. In this episode, Derek returns to the podcast to explore the impact of exogenous molecules on male and female health. He covers testosterone, DHT, DHEA, progesterone, clomiphene (Clomid), hCG, and various peptides, alongside updates from the FDA affecting peptide use. Additionally, he addresses the recent hype around increasing muscle mass through myostatin inhibition via follistatin gene therapy and supplementation. Additionally, Derek discusses the various strategies that bodybuilders use for losing fat while preserving muscle, including insights on weight loss drugs.

We discuss:

  • Testosterone and DHT: mechanisms of action, regulation of muscle growth, and influence on male and female characteristics [2:15];
  • TRT in women: the complexities and potential risks associated with testosterone use in women [9:00];
  • DHEA supplementation: exploring the benefits and risks for women, and the differing effects on men vs. women [22:00];
  • The role of progesterone in both men and women, pros and cons of supplementation, the importance of tailored doses, and more [28:00];
  • Measuring levels of free testosterone [37:15];
  • The trend towards earlier interest in TRT, and the risks of underground sources of testosterone [42:00];
  • The complexities and considerations surrounding the use of Clomid, E-Clomid, and hCG in TRT [46:00];
  • Low testosterone: diagnosis, potential causes, treatment options, and other considerations [53:45];
  • Growth hormone-releasing peptides: rationale and implications of the recent FDA categorization as high-risk substances [1:03:45];
  • Follistatin gene therapy and myostatin inhibition for increasing muscle mass: the recent hype online, human and animal data, and the need for more research [1:14:45];
  • Simple tips for lowering calorie intake and losing fat [1:32:30];
  • Methods of sustainable fat loss with muscle preservation: insights gleaned from bodybuilders [1:40:00];
  • Could prolonged fasting impact testosterone levels? [1:55:30];
  • High-protein ice cream [1:57:00];
  • Exploring fat loss supplements and drugs: L-carnitine, yohimbine, and more [2:02:15];
  • Potential remedies for individuals experiencing metabolic dysfunction due to hypercortisolemia [2:12:30];
  • The cornerstones of body composition improvement remain nutrition and exercise, even in the presence of exogenous testosterone [2:19:15];
  • The importance of approaching health advice found online with a critical eye and a healthy dose of skepticism [2:23:30]; and
  • More.

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