cover of episode The future of robotic surgery

The future of robotic surgery

2025/1/10
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Renee Zhao
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Renee Zhao: 我专注于软材料和软机器人的力学特性研究。我的研究始于探索不同的软机器人系统,后来我开始思考如何将这些系统应用于生物医学领域,特别是针对人体软组织的医疗应用。这主要是因为软机器人系统与人体软组织具有更好的生物相容性。我们开发的毫米级机器人系统可以通过磁场控制,能够在脑血管等复杂环境中进行导航和操作。该系统具有多功能性,可以携带药物并将其输送到特定部位,例如溶解血栓。此外,该机器人还可以通过旋转运动产生的剪切力来物理性地减少血栓体积,这是一种纯物理的治疗方法,无需药物或化学反应。 目前,我们正在与介入放射科医生合作,开发用于治疗中风的微型机器人。这项技术可以帮助解决目前介入放射学中面临的挑战,例如导管在脑血管中的导航和可追踪性问题。我们的目标是开发出能够自主进行手术的微型机器人,最终减少对高技能医生的依赖。 在机器人的微型化方面,我们正在探索不同的刺激方式,例如磁场、热激活和电场,以实现更小的尺寸和更高的功能性。选择哪种刺激方式取决于具体的应用场景和所需的功能。对于需要较大力量的应用,例如骨科手术,我们需要考虑使用能够提供足够能量的刺激方式。 人工智能和机器学习技术在我们的研究中也扮演着越来越重要的角色。我们可以利用这些技术来优化微型机器人的结构设计,从而提高其性能。未来,我们甚至可以根据患者的具体情况,设计出个性化的机器人,以更好地解决患者的个体化需求。 毫米级机器人尺寸对于血管内操作来说已经足够小,进一步缩小尺寸并不一定能提高性能。因为更小的尺寸可能会带来一些挑战,例如在粘性流体中的运动能力和与目标物体的相互作用。因此,我们目前的研究重点是优化毫米级机器人的性能和功能。 Russ Altman: 在与Renee Zhao的对话中,我了解到目前机器人手术主要依赖于人类使用刚性工具和机器人手臂进行操作,远程手术是一个发展方向,但仍然需要高技能的医生操作。未来,软材料和人工智能技术将推动机器人手术的变革,微型机器人将能够自主进行手术,并实现个性化医疗。这将极大地提高医疗效率和治疗效果,并为更多患者提供先进的医疗服务。 在讨论中,我们还探讨了微型机器人的尺寸、控制方式、动力来源以及人工智能在机器人设计中的作用。Renee Zhao 提到的毫米级机器人,其尺寸和功能性已经达到了一个很好的平衡点。通过磁场控制,无需电池和电机,可以有效地进行导航和操作。此外,人工智能和机器学习技术可以帮助优化机器人设计,并实现个性化医疗。 总的来说,这次对话让我对微型机器人辅助手术的未来充满了期待。我相信,随着技术的不断发展,微型机器人将在医疗领域发挥越来越重要的作用,为人类健康做出更大的贡献。

Deep Dive

Key Insights

What are millirobots, and how do they function in medical applications?

Millirobots are millimeter-scale soft robots designed to navigate the human body, particularly blood vessels, to treat conditions like blood clots and brain aneurysms. They are controlled by external magnetic fields, allowing them to swim through blood vessels at speeds of up to 30 cm per second. These robots are multifunctional, capable of delivering drugs directly to targeted sites and physically interacting with clots to reduce their size by over 90% through mechanical forces.

Why are soft robots particularly suited for medical applications?

Soft robots are ideal for medical applications because they are compatible with the human body's soft tissues and organs. Inspired by natural systems like octopus arms, they can deform and move flexibly without rigid components. This flexibility allows them to navigate complex, tortuous environments like blood vessels without causing damage, making them safer and more effective for delicate procedures.

How do millirobots navigate through the body, and what technologies are used to control them?

Millirobots are controlled using external magnetic fields, which allow them to swim through blood vessels. Imaging technologies like X-rays and CT scans provide 3D maps of the vasculature, enabling precise navigation. The robots are guided in real-time using these imaging systems, ensuring they can move through complex pathways without colliding with vessel walls or tissues.

What role does AI play in the design and optimization of millirobots?

AI and machine learning are used to optimize the design of millirobots by analyzing vast design spaces. These tools help determine the best structural parameters for specific tasks, such as swimming in different fluid viscosities or navigating varying vessel sizes. AI also enables personalized robot designs tailored to individual patients' anatomies, improving treatment efficacy and precision.

What challenges do current robotic surgery systems face, and how do millirobots address them?

Current robotic surgery systems rely on rigid tools and catheters, which struggle to navigate highly tortuous blood vessels, especially in the brain. Millirobots eliminate the need for tethered systems by using magnetic fields for control, allowing them to swim freely and reach difficult areas. This reduces the reliance on highly skilled surgeons and enables faster, more effective treatments for conditions like strokes.

Why is the millimeter scale optimal for medical robots?

The millimeter scale strikes a balance between size and functionality. Robots at this scale are small enough to navigate blood vessels but large enough to interact effectively with tissues and clots. Smaller scales, like micro or nano, face challenges in generating sufficient force for tasks like clot removal, making millimeter-scale robots more practical for current medical applications.

How do millirobots treat blood clots without medication?

Millirobots treat blood clots mechanically by generating shear forces as they spin. These forces densify the fibrin network within the clot, reducing its volume to less than 10% of its original size. This physical interaction eliminates the need for clot-dissolving chemicals, offering a purely mechanical solution to clot removal.

Chapters
Renee Zhao's journey into soft robotics, initially focused on soft materials and mechanics, transitioned into biomedical applications due to the compatibility of soft systems with the human body. This shift was driven by the potential of soft robotics to address problems within soft tissues and organs.
  • Initial research focused on soft materials and mechanics.
  • Transition to biomedical applications due to compatibility with human body.
  • Inspiration to use soft systems to address problems in a soft body.

Shownotes Transcript

Guest Renee Zhao) works at the cutting-edge of robotic surgery – literally. Emboldened by advances in 3D-printing and miniaturization, she builds “millibots,” magnet-controlled, millimeter-scale soft robots that navigate the bloodstream to remove blood clots and treat brain aneurysms. While the millibot’s promise is clear, much work remains before the devices are commonplace. Revolutionizing health care with surgical robots will require a delicate balance of design, buildability, and functionality, Zhao tells host Russ Altman) on this episode of Stanford Engineering’s The Future of Everything podcast.

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Chapters:

(00:00:00) Introduction

Russ Altman introduces guest Renee Zhao, a professor of mechanical engineering at Stanford University.

(00:03:34) Robotic Surgery and Healthcare

Renee’s inspiration for soft robotics and its potential in healthcare applications.

(00:05:49) Current Status of Robotic Surgery

Current robotic surgery technologies and the push for more advanced solutions.

(00:09:32) Nature-Inspired Soft Robotics

How soft robotic systems are ideal for working within delicate human tissues.

(00:11:41) Millirobotic Systems

Recently developed millimeter-sized robots that swim and navigate blood vessels.

(00:14:46)** Millirobot Control**

The role of magnetic fields and imaging technology for robot navigation.

(00:17:18) Treating Blood Clots and Aneurysms

The multifunctional abilities of robots to deliver drugs and treat blood clots.

(00:19:46) Doctor’s Reaction to New Technology

Excitement for the new robotic advancements amongst the need for better tools.

(00:21:04) Trends in Robot Size and Functionality

The design challenges for creating small yet functional robots.

(00:25:52) AI and Machine Learning in Robotic Design

AI’s role in optimizing robot design for specific patients.

(00:28:59)  Why Millimeter-Scale Robots

Why millirobots strike the right balance for performance and functionality.

(00:32:34) Conclusion

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