Millirobots are millimeter-scale soft robots designed to navigate the human body, particularly blood vessels, to treat conditions like blood clots and brain aneurysms. They are controlled by external magnetic fields, allowing them to swim through blood vessels at speeds of up to 30 cm per second. These robots are multifunctional, capable of delivering drugs directly to targeted sites and physically interacting with clots to reduce their size by over 90% through mechanical forces.
Soft robots are ideal for medical applications because they are compatible with the human body's soft tissues and organs. Inspired by natural systems like octopus arms, they can deform and move flexibly without rigid components. This flexibility allows them to navigate complex, tortuous environments like blood vessels without causing damage, making them safer and more effective for delicate procedures.
Millirobots are controlled using external magnetic fields, which allow them to swim through blood vessels. Imaging technologies like X-rays and CT scans provide 3D maps of the vasculature, enabling precise navigation. The robots are guided in real-time using these imaging systems, ensuring they can move through complex pathways without colliding with vessel walls or tissues.
AI and machine learning are used to optimize the design of millirobots by analyzing vast design spaces. These tools help determine the best structural parameters for specific tasks, such as swimming in different fluid viscosities or navigating varying vessel sizes. AI also enables personalized robot designs tailored to individual patients' anatomies, improving treatment efficacy and precision.
Current robotic surgery systems rely on rigid tools and catheters, which struggle to navigate highly tortuous blood vessels, especially in the brain. Millirobots eliminate the need for tethered systems by using magnetic fields for control, allowing them to swim freely and reach difficult areas. This reduces the reliance on highly skilled surgeons and enables faster, more effective treatments for conditions like strokes.
The millimeter scale strikes a balance between size and functionality. Robots at this scale are small enough to navigate blood vessels but large enough to interact effectively with tissues and clots. Smaller scales, like micro or nano, face challenges in generating sufficient force for tasks like clot removal, making millimeter-scale robots more practical for current medical applications.
Millirobots treat blood clots mechanically by generating shear forces as they spin. These forces densify the fibrin network within the clot, reducing its volume to less than 10% of its original size. This physical interaction eliminates the need for clot-dissolving chemicals, offering a purely mechanical solution to clot removal.
Guest Renee Zhao) works at the cutting-edge of robotic surgery – literally. Emboldened by advances in 3D-printing and miniaturization, she builds “millibots,” magnet-controlled, millimeter-scale soft robots that navigate the bloodstream to remove blood clots and treat brain aneurysms. While the millibot’s promise is clear, much work remains before the devices are commonplace. Revolutionizing health care with surgical robots will require a delicate balance of design, buildability, and functionality, Zhao tells host Russ Altman) on this episode of Stanford Engineering’s The Future of Everything podcast.
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Chapters:
(00:00:00) Introduction
Russ Altman introduces guest Renee Zhao, a professor of mechanical engineering at Stanford University.
(00:03:34) Robotic Surgery and Healthcare
Renee’s inspiration for soft robotics and its potential in healthcare applications.
(00:05:49) Current Status of Robotic Surgery
Current robotic surgery technologies and the push for more advanced solutions.
(00:09:32) Nature-Inspired Soft Robotics
How soft robotic systems are ideal for working within delicate human tissues.
(00:11:41) Millirobotic Systems
Recently developed millimeter-sized robots that swim and navigate blood vessels.
(00:14:46)** Millirobot Control**
The role of magnetic fields and imaging technology for robot navigation.
(00:17:18) Treating Blood Clots and Aneurysms
The multifunctional abilities of robots to deliver drugs and treat blood clots.
(00:19:46) Doctor’s Reaction to New Technology
Excitement for the new robotic advancements amongst the need for better tools.
(00:21:04) Trends in Robot Size and Functionality
The design challenges for creating small yet functional robots.
(00:25:52) AI and Machine Learning in Robotic Design
AI’s role in optimizing robot design for specific patients.
(00:28:59) Why Millimeter-Scale Robots
Why millirobots strike the right balance for performance and functionality.
(00:32:34) Conclusion
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