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cover of episode 🧬Resurrection Biology in the Digital Age: AI's Transformative Role in Reviving Extinct Species - Reviving extinct species with AI

🧬Resurrection Biology in the Digital Age: AI's Transformative Role in Reviving Extinct Species - Reviving extinct species with AI

2025/5/9
logo of podcast AI Unraveled: Latest AI News & Trends, GPT, ChatGPT, Gemini, Generative AI, LLMs, Prompting

AI Unraveled: Latest AI News & Trends, GPT, ChatGPT, Gemini, Generative AI, LLMs, Prompting

AI Deep Dive Transcript
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Etienne Newman
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Marc Thiessen
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Etienne Newman: 我认为人工智能是使灭绝物种的复活从一个很酷的想法转变为实验室实际开展并获得严重资金支持的研究的关键催化剂。人工智能对于理解基因组中的海量数据至关重要,尤其是在处理古代受损的DNA方面。它贯穿了整个复活灭绝物种的过程,包括分析、工程和预测。与旧方法相比,人工智能重写了灭绝的规则,因为它能够处理真正消失的基因。人工智能能够处理大型、混乱的数据集,这对于处理古代DNA至关重要。人工智能算法可以筛选基因噪声,识别真正的古代片段,并将它们拼凑起来,并预测缺失的部分。人工智能驱动的技术吸引了大量的资金,并取得了一些成果,例如用猛犸基因改造的小鼠。功能性复活的重点是创造一个在生态系统中发挥与灭绝物种相同作用的生物体,即使其基因组并不完全相同。通过使用CRISPR技术,并以人工智能为指导,比较古代和现代基因组,可以创造出具有灭绝物种特征的杂交动物,以填补生态位。人工智能对于处理大型数据集、识别最佳基因靶点以及预测编辑结果至关重要。“工程抗压性”的目标是创造能够在现代世界生存和繁荣的动物,而不是仅仅创造外观相似的动物。工程抗压性包括三个主要部分:复活核心基因、工程增强和工程抗压性。人工智能对于预测多基因性状(由许多相互作用的基因控制)的结果至关重要。 Danielle Pletka: 人工智能擅长模式识别,可以从古代DNA中筛选出真正的古代DNA片段,并将其组装起来。人工智能可以纠正古代DNA中的错误,并组装剩余的片段。生成式人工智能模型可以根据已知的基因组规则,预测古代基因组中缺失的部分。 Marc Thiessen: 人工智能可以预测古代基因的功能。人工智能可以进行比较基因组学分析,以识别赋予灭绝物种独特特征的基因。可解释的人工智能技术可以帮助科学家验证人工智能的预测。人工智能可以用来寻找灭绝动物蛋白质中具有有用特性的分子,例如药物。人工智能可以提高CRISPR编辑的精确性和效率。人工智能工具可以预测CRISPR编辑的脱靶位点,并设计更好的引导RNA。人工智能可以预测多重编辑的综合效应。人工智能可以帮助从编辑后的细胞创建实际的动物。人工智能可以帮助评估胚胎的活力,并选择最有可能成功着床和发育的胚胎。人工智能对于构建复杂的生态系统模拟和预测重新引入物种的影响至关重要。

Deep Dive

Shownotes Transcript

This podcast discuss the rapidly advancing field of de-extinction, highlighting the crucial role of artificial intelligence (AI) in making this a tangible scientific pursuit. AI is presented not merely as a tool but as an architect across all stages, from reconstructing degraded ancient DNA and predicting gene function to optimising gene editing and modelling ecological impacts. While companies like Colossal Biosciences pursue ambitious projects for species like the woolly mammoth and dire wolf, often driving technological innovation with commercial spin-offs, organisations like Revive & Restore focus on genetic rescue for endangered species, illustrating differing approaches within this landscape. The podcast underscore the **significant technical, ecological, and ethical challenges **inherent in de-extinction, particularly concerning animal welfare, resource allocation, and potential ecological disruption, while also pointing to valuable spillover innovations benefiting broader conservation and human health.

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