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How Far Are We from Animal Organs Saving Lives?
2025/6/24
Chasing Life
S
Sanjay Gupta
Sanjay Gupta: 我对异种移植非常感兴趣，并为此拍摄了一部纪录片。异种移植是指将一个物种的器官移植到另一个物种，特别是将猪的器官移植到人体。目前已经进行了四例活体患者的猪肾脏移植，以及两例猪心脏移植。这些患者都是异种移植领域的先驱，他们的努力推动了科学的进步。异种移植使用的免疫抑制药物与人际移植类似，但剂量通常更高，并添加了一些其他药物。异种移植成功的关键在于对猪的DNA进行基因工程改造，使其更接近人类。异种移植有望在五年内成为解决器官短缺危机的重要手段，肾脏将率先实现规模化应用，心脏、肝脏和肺脏也有望跟进。异种移植结合了体外受精、克隆、CRISPR基因编辑、移植免疫学和移植外科等多种科学发展，有望拯救和延长许多人的生命。仅在美国，就有10万人等待器官移植，每天有17人因等待器官而死亡，因此需要大量的器官来解决器官短缺问题。异种移植甚至可以为那些目前不符合移植条件的人提供器官。
Deep Dive
This chapter explores the concept of personalized organs grown from a patient's own cells using pig organ scaffolding. It discusses the potential benefits, including reduced rejection and the creation of organs tailored to individual needs. The technology is still under development but holds immense promise for the future of transplantation.
- Personalized organs using pig organ scaffolding and human cells are under development.
- This approach aims to reduce or eliminate organ rejection.
- The technology is still further off than current xenotransplantation methods.
Shownotes Transcript