117: Tertiary Lymphoid Structures in Colorectal Cancer Prognosis | Dr. Aleks + AI
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Leveraging AI for Deep Insights into Tertiary Lymphoid Structures in Colorectal CancerIn this episode of the Digital Pathology Podcast, I introduce 'Aleks + AI,' a new experimental series leveraging Google's Notebook LM to delve deeper into scientific literature. Today's focus is on tertiary lymphoid structures (TLS) and their potential to predict colorectal cancer prognosis. We discuss a study published in the October 2024 issue of Precision Clinical Medicine, exploring different methods of quantifying TLS using digital pathology and AI.  The paper title is: "Comparative analysis of tertiary lymphoid structures for predicting survival of colorectal cancer: a whole-slide images-based study")The findings highlight TLS density as a reliable predictor of survival and its correlation with immune responses and microsatellite instability. We also touch upon the potential for AI to streamline TLS analysis in clinical settings and the broader implications for personalized medicine. Join us as we dive into the intersection of digital pathology and computer science, featuring insights and commentary from my AI co-hosts, Hema and Toxy.00:00 Welcome and Introduction00:45 Introducing the New AI Tool: Notebook LM by Google01:11 Experimental Series: "Aleks + AI"02:06 Deep Dive into Tertiary Lymphoid Structures (TLS)03:18 Understanding TLS and Their Role in Colorectal Cancer04:20 Quantification Methods and Key Findings05:02 Implications for Personalized Medicine09:02 AI in TLS Analysis and Future Prospects11:00 CMS Classification and TLS Density12:08 Study Limitations and Future Directions15:40 Final Thoughts and Wrap-Up16:28 Feedback and Future PlansTHIS EPISODE'S RESOURCES

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PUBLICATION DISCUSSED TODAY**📝 Comparative analysis of tertiary lymphoid structures for predicting survival of colorectal cancer: a whole-slide images-based study🔗**https://academic.oup.com/pcm/article/7/4/pbae030/7826772

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