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cover of episode How to Succeed at Failing, Part 4: Extreme Resiliency (Update)

How to Succeed at Failing, Part 4: Extreme Resiliency (Update)

2025/5/21
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Freakonomics Radio

AI Deep Dive AI Chapters Transcript
People
A
Amy Edmondson
B
Babak Javid
G
Gary Klein
R
Roy Shalem
S
Samuel West
S
Stephen Dubner
以《怪诞经济学》系列著名的美国作家、记者和广播电视人物。
T
Theresa McPhail
W
Will Coleman
Topics
Stephen Dubner: 结核病是全球头号传染病杀手,但却被忽视。结核病在过去二三十年来一直是全球头号传染病杀手,尽管人们可能认为COVID-19或疟疾等疾病更为致命。结核病之所以被忽视,部分原因是缺乏公众关注和资金投入。 Babak Javid: 我认为结核病是一种不公正的疾病,需要解决。结核病是一种与贫困相关的疾病,在发展中国家是一个主要问题。结核病研究面临许多失败,但通过实验发现,细菌的适应性错误翻译实际上可以促进创新,使其更具韧性。我从自身经历出发,强调了科研的艰难,以及面对失败时坚持的重要性。链霉素通过抑制新蛋白质的合成以及导致细菌在制造这些蛋白质时出错来起作用,但令人震惊和惊讶的是,细菌似乎并不介意这些错误,它们仍然继续繁殖,直到我真正大幅提高错误率时,它们才死亡。这些细菌非常有韧性,这让我退一步思考,也许这些错误实际上并非有害,至少在适量的情况下是这样。经过大量的实验、盲目的尝试和错误的转弯后,我们发现这种错误翻译使细菌能够创新。我创造了“适应性错误翻译”这个术语,即有时这些错误发生在正确的背景和正确的程度上,实际上对细菌有好处。

Deep Dive

Chapters
Tuberculosis (TB) has been the leading infectious disease killer globally for decades, claiming over a million lives annually. Despite its severity, TB receives less attention and funding compared to other diseases. Research into TB, including Babak Javid's work on adaptive mistranslation, reveals that errors in protein synthesis, in the right context, can strengthen the bacteria, highlighting the resilience of this disease.
  • TB is the world's deadliest infectious disease
  • TB is a disease of poverty, prevalent in developing countries
  • Research on TB reveals that errors in protein synthesis can increase bacterial resilience

Shownotes Transcript

Everyone makes mistakes. How do we learn from them? Lessons from the classroom, the Air Force, and the world’s deadliest infectious disease.