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cover of episode Exploring Xenotransplantation with Dr. Sanjay Gupta: Inside the Future of Organ Transplants

Exploring Xenotransplantation with Dr. Sanjay Gupta: Inside the Future of Organ Transplants

2025/6/12
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Health Discovered
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Dr. Neha Bhattak
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Dr. Sanjay Gupta
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Dr. Neha Bhattak: 目前器官移植面临巨大需求缺口，即使普遍捐献也无法满足。异种移植作为一种解决方案，利用基因改造猪进行研究，具有巨大潜力。然而，这项技术也引发了伦理争议，需要深入探讨其科学原理、潜在影响以及伦理考量。 Dr. Sanjay Gupta: 我对基因编辑技术在异种移植中的应用非常感兴趣。器官移植等待名单上的病人面临着生命威胁，异种移植为他们带来了希望。然而，即使每个人都愿意捐献器官，仍然无法满足需求，因为只有一小部分人死于适合器官移植的方式。因此，我们需要使猪的基因组与人类基因组相容，从而减少排异反应。此外，宗教信仰对猪的看法以及感染疾病的风险也是重要的伦理考量。

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The podcast starts by highlighting the critical shortage of organs for transplant, with over 100,000 Americans on the waiting list and 17 dying daily. Even universal organ donation wouldn't suffice. The discussion then pivots to xenotransplantation as a potential solution and explores the complexities of organ matching and the limitations of current human organ donation.
  • Over 100,000 Americans await life-saving organ transplants.
  • 17 people on the waitlist die each day.
  • Even universal organ donation is insufficient to meet the demand.
  • The complexities of human organ matching and the limitations of current human organ donation are discussed.

Shownotes Transcript

Over 100,000 Americans are waiting for life-saving kidney transplants), with 17 dying each day. Why isn’t universal donation enough? Could xenotransplantation – transplanting gene-edited organs from other species into humans – be the answer? We sat down with Sanjay Gupta, MD), CNN’s chief medical correspondent, to unpack his documentary Animal Pharm and explore the promise and perils of this scientific frontier. We dive into his visits to biosecure pig facilities, ethical questions across faiths, and concerns around infection, cost, and organ rejection. Dr. Gupta also looks ahead to the potential use of pig hearts, lungs, and livers. Tune in for a rare blend of hope, controversy, and cutting-edge science.

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