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cover of episode Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

2025/5/26
logo of podcast Huberman Lab

Huberman Lab

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A
Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
M
Melissa Ilardo
Topics
Andrew Huberman: 今天我们主要探讨人类遗传学、表观遗传学以及行为如何塑造跨代基因表达。我们将深入研究哺乳动物潜水反射,这是一种对冷水中屏气的生理反应,可以显著改变脾脏的生理机能,从而显著增加红细胞计数和大脑及身体的氧气供应。此外,我们还会探讨伴侣选择与免疫系统之间的关系,以及外部特征如何反映器官功能和大脑生理机能的变化。 Melissa Ilardo: 我们对环境如何改变基因表达的理解正在不断加深,许多过去被认为是完全预先决定的事情,现在发现是可以改变的。基因会根据环境刺激不断改变表达方式,有些变化在几分钟或几小时内发生,有些变化则会跨代传递。创伤和饥饿等经历可以通过表观遗传变化遗传给后代,这些变化可能在当时有助于生存,但在环境改变后可能不再有益。此外,基因的实际变化,如突变或变异频率的增加,可能发生在短至1000-2000年的时间内。

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Shownotes Transcript

My guest is Dr. Melissa Ilardo, Ph.D.), professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection events happening in humans today.

We also discuss the immune system–related reasons people find the smells of potential mates attractive—or not.

We explore how physical and psychological traits are passed from one generation to the next, and the specific behaviors that can influence gene expression to improve health and performance.

Melissa explains her lab’s pioneering research on breath-hold training and how activation of the dive reflex through breath holding can significantly improve oxygen availability by changing spleen size and function.

We also delve into the medical uses and ethics of gene editing to cure disease in both babies and adults.

For those interested in genes and inheritance, human performance, immune system function, and natural selection, this episode illustrates the remarkable interplay between human nature and nurture.

Read the episode show notes at hubermanlab.com).

Thank you to our sponsors

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Timestamps

00:00:00 Melissa Ilardo

00:02:35 Nature vs Nurture, Gene Expression, Eye Color

00:07:06 Sponsors: Joovv & Eight Sleep

00:10:24 Epigenetics, Trauma, Mutations; Hybrid Vigor, Mate Attraction

00:15:47 Globalization; Homo Sapiens, Mating & Evolution; Mutations

00:25:28 Sea Nomads, Bajau & Moken Groups; Free Diving, Dangers & Gasp Reflex

00:32:52 Cultural Traditions, Free Diving & Families; Fishing

00:35:36 Mammalian Dive Reflex, Oxygen, Spleen, Cold Water & Face; Exercise

00:42:43 Sponsors: AG1 & LMNT

00:46:00 Free Diving, Spleen, Thyroid Hormone, Performance Enhancement

00:52:00 Dive Reflex, Immune System; Swimming & Health; Coastal Regions & Genetics

00:55:17 Female Free Divers, Haenyeo, Cold Water, Age, Protein

01:03:20 Human Evolution & Diet, Lactase, Fat

01:05:07 Korean Female Free Divers & Adaptations, Cardiovascular, Pregnancy

01:10:13 Miscarriages & Genetic Selection; Bajau, External Appearance, Mate Selection

01:17:15 Sponsor: Function

01:19:03 Free Diving, Underwater Vision; Super-Performers & Genetics

01:25:01 Cognitive Performance, Autism, Creativity; Genetic Determinism & Mindset

01:36:30 Genetics & Ethics, CRISPR, Embryo Genetic Screening

01:44:36 Admixture, Genetics; Are Humans a Single Species?

01:49:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

Disclaimer & Disclosures)

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