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cover of episode Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

2024/4/1
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Huberman Lab

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Andrew Huberman
是一位专注于神经科学、学习和健康的斯坦福大学教授和播客主持人。
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本期播客讨论了肽疗法对身心健康的益处和风险,涵盖了组织修复、新陈代谢和生长、长寿和活力提升四个方面。首先介绍了肽的概念,以及获取肽的三种途径:处方药、灰色市场和黑市。然后详细介绍了几种常用的肽类,包括BPC-157、胸腺素β4、生长激素促分泌剂(如Sermorelin、Tesamorelin、CJC-1295)、表皮素和Kisspeptin等,并分析了它们的机制、作用和潜在风险,例如肿瘤生长风险、内分泌紊乱等。最后,播客强调了在使用肽类疗法时,需要谨慎选择来源,并咨询专业医生的建议,以最大限度地降低风险,并获得最佳疗效。 播客中还讨论了不同肽类在剂量、周期、给药途径以及联合应用方面的注意事项。例如,BPC-157通常采用皮下或肌内注射的方式,剂量为300-500微克,每周2-3次,疗程约为8周,之后需要进行停药周期。生长激素促分泌剂通常在睡前服用,以增强夜间生长激素的自然分泌高峰。此外,播客还强调了不同肽类之间的相互作用,以及联合应用时需要考虑的因素,例如避免不必要的促乳素和皮质醇升高。

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In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination. 

This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals.

For show notes, including referenced articles and additional resources, please visit hubermanlab.com).

Use Ask Huberman Lab), our new AI-powered platform, for a summary, clips, and insights from this episode.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman)

Mateína: https://drinkmateina.com/huberman)

Levels: https://levels.link/huberman)

Joovv: https://joovv.com/huberman)

LMNT: https://drinklmnt.com/huberman)

Momentous: https://livemomentous.com/huberman)

Timestamps

(00:00:00) Peptides

(00:03:20) Sponsors: Mateina, Levels & Joovv

(00:07:44) What is a Peptide?

(00:12:06) Peptide Sourcing, Lipopolysaccharide (LPS)

(00:14:48) Rejuvenation & Tissue Repair: BPC-157, Angiogenesis

(00:21:50) BPC-157 & Tissue Injury; Mode of Delivery

(00:27:53) BPC-157: Safety, Doses, Cycling, Tumor Risk

(00:35:16) Sponsor: AG1

(00:36:43) Tissue Repair: Thymosin Beta-4, TB-500

(00:40:49) Growth & Metabolism: Growth Hormone, IGF-1, Risks

(00:45:25) Secretagogues, Sermorelin, Tesamorelin, CJC-1295

(00:52:21) Sponsor: LMNT

(00:53:44) Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing

(00:58:69) Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing

(01:06:12) Longevity: Thymosin Beta-4, Epitalon (Epithalon)

(01:12:09) Vitality: Melanotan, PT-141 (Vyleesi), Risks

(01:17:21) Vitality: Kisspeptin

(01:21:46) Peptides, Potential Benefits, Side-Effects & Risks

(01:24:19) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter

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