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Essentials: Understanding & Healing the Mind | Dr. Karl Deisseroth

2025/5/15

Huberman Lab

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Karl Deisseroth

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Karl Deisseroth: 精神病学与神经病学不同，前者处理的是无法通过物理手段直接观察到的疾病，缺乏明确的生物标记物或血液测试来支持诊断，这使得精神病学的诊断过程更加依赖于患者的自我报告和临床观察。作为一名精神科医生，我深刻体会到我们所面临的挑战，因为我们主要的工具是语言，通过与患者的交流来理解他们的感受和经历。然而，语言本身是主观的，不同的人对同一词语的理解可能存在差异，这增加了诊断的难度。尽管我们使用各种评定量表来评估症状，但这些量表仍然依赖于患者的自我报告，无法提供客观的生物学证据。面对大脑这个宇宙中最复杂的结构，我们却只能依靠语言来探索其内部的运作机制，这无疑是一个巨大的挑战。我坚信，随着科学技术的不断发展，未来我们一定能够找到更精确的诊断方法，例如通过脑电图或其他生物标记物来客观地评估精神疾病，从而更有效地帮助患者。

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Dr. Deisseroth explains the key difference between neurology and psychiatry, highlighting the challenges of diagnosing and treating mental illnesses due to the lack of measurable physical markers. Psychiatrists rely heavily on words and rating scales, making diagnosis more subjective compared to neurology.

Neurology deals with measurable physical problems in the nervous system.
Psychiatry deals with disorders lacking clear physical markers, relying on words and symptoms.
Diagnosis in psychiatry is more challenging due to the subjective nature of symptoms.

Shownotes Transcript

In this episode of Huberman Lab Essentials, my guest is Dr. Karl Deisseroth, M.D., Ph.D.), a clinical psychiatrist and professor of bioengineering and of psychiatry and behavioral sciences at Stanford University.

We discuss his experiences as a clinician treating complex psychiatric conditions and his lab’s pioneering work in developing transformative therapies for mental illness. He explains the complexities of mental illness and how emerging technologies—such as optogenetics and brain-machine interfaces—could revolutionize care. We also explore promising new therapies, including psychedelics and MDMA, for conditions like depression and PTSD.

Read the episode show notes at hubermanlab.com).

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at ⁠hubermanlab.com)⁠.

Thank you to our sponsors

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Timestamps

00:00:00 Karl Deisseroth; Neurology vs Psychiatry

00:01:36 Speech; Blood Test?; Seeking Help

00:04:20 Feelings, Jargon; Psychiatric Treatment

00:09:40 Sponsor: David

00:10:55 Future Treatment; Vagus Nerve Stimulation, Depression, Optogenetics

00:19:40 Brain-Machine Interfaces

00:20:53 Sponsor: Eight Sleep