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cover of episode Precision Medicine in Pharma: Sanofi’s Frank Nestle

Precision Medicine in Pharma: Sanofi’s Frank Nestle

2022/8/2
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Frank Nestle: 赛诺菲正在进行从初级保健向专科保健的转型，专注于免疫学、肿瘤学和罕见病药物的研发。我的工作是发现和转化下一代突破性药物，为等待治疗的患者提供帮助。我最初的训练是皮肤病学和临床免疫学，我一直致力于理解疾病机制并将这些机制转化为治疗方法，最终实现精准医疗。免疫系统是一个相互关联的复杂系统，其细胞在不同组织间移动，可以通过血液样本进行研究。免疫系统在癌症防护和自身免疫疾病中发挥着关键作用，其基本原理也应用于疫苗研发。单细胞免疫学技术结合AI算法，能够更深入地了解免疫系统，并用于新药研发。利用单细胞免疫学技术和AI算法，可以对免疫系统进行深入分析，甚至可以研究疾病发生部位的细胞，从而实现对疾病机制的更深入理解，并辅助新药研发。AI在药物研发中的应用分为两步：首先是探索和绘制生理和病理图谱，然后在此基础上建立理论模型并研发药物。AI算法可以帮助分析大量细胞基因数据，从而识别和注释不同类型的免疫细胞。AI在药物研发中的应用并非简单的流程优化，而是创造了全新的可能性，解决了过去无法解决的问题。AI可以用于药物分子设计，通过虚拟筛选大量的分子结构，找到具有功能性影响的分子，从而加快药物研发进程。AI可以辅助药物分子设计，通过生成算法筛选大量的分子结构，并与化学家的经验相结合，从而提高药物研发的效率。AI模型可以预测分子结构，减少需要合成的分子数量，从而降低研发成本并缩短研发周期。AI模型的学习过程是基于对多种分子属性的测试和优化，并非简单的二元分类。他最引以为傲的AI应用是利用内部开发的AI算法对单细胞免疫学细胞进行注释。他对AI的担忧在于人们对AI的误解，认为AI会取代人类，而实际上AI更擅长解决特定问题。他对AI未来的最大愿望是提高AI的可解释性，消除人们对AI的误解。阅读阿尔贝·加缪的小说《鼠疫》激发了他投身医疗事业的热情，希望通过自己的努力帮助他人。

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Frank Nestle discusses how AI is enabling Sanofi to scale drug discovery by analyzing thousands of cells and genes, and how this technology is revolutionizing the pharmaceutical industry.

Shownotes Transcript

Frank Nestle, Sanofi’s global head of research and chief scientific officer, was inspired to enter the health sciences field after reading an Albert Camus novel and realizing his calling was to help others. In his current role, Frank oversees the pharmaceutical company’s transition from primary care to specialty care, which includes developing medicines for immunology, oncology, and rare diseases. In this episode, Frank explains how artificial intelligence enables Sanofi to work toward drug discovery in more agile ways. Read the episode transcript here).

*Me, Myself, and AI *is a collaborative podcast from MIT Sloan Management Review and Boston Consulting Group and is hosted by Sam Ransbotham and Shervin Khodabandeh. Our engineer is David Lishansky, and the coordinating producers are Allison Ryder and Sophie Rüdinger.

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Guest bio:

Dr. Frank O. Nestle is global head of research and chief scientific officer at Sanofi, with responsibility for its main therapeutic research areas of immunology and inflammation, oncology, neurology, rare diseases, hematology, and genomic medicine. Before joining Sanofi in 2016, Nestle was a professor and chair of cutaneous medicine and immunotherapy at King’s College London and practiced medicine at Guy’s and St. Thomas’ Hospital. At King’s College, he led research, translational clinical trials, and teams in dermatology, allergology, and immunology. He also held several executive roles, in particular at the Guy’s and St Thomas’ Biomedical Research Center.

Nestle is a fellow of the Academy of Medical Sciences, a senior investigator emeritus at the National Institute for Health Research, and past president of the Federation of Clinical Immunology Societies. He has published over 220 scientific articles and has received several awards and honors, including the Alfred Marchionini Research Award at the 20th World Congress of Dermatology.

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