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cover of episode New lasso-shaped antibiotic kills drug-resistant bacteria

New lasso-shaped antibiotic kills drug-resistant bacteria

2025/3/26
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Nature Podcast

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Benjamin Thompson
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Dan Fox
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Jerry Wright
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Sharmini Bandel
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Jerry Wright: 我和团队发现了新型抗生素lariocidin,这是一种套索肽,它以独特的方式作用于细菌核糖体,从而抑制细菌蛋白质合成,最终杀死细菌。lariocidin具有广谱抗菌活性,对多种革兰氏阳性和革兰氏阴性致病菌有效,并且不易产生耐药性。目前,我们正在对其进行化学修饰,以改善其药物特性,并最终将其用于临床试验。虽然抗生素耐药性是不可避免的,但lariocidin展现出良好的抗耐药性潜力。 Sharmini Bandel: 智利绿色能源项目与大型天文望远镜选址的冲突,体现了可持续发展中不同领域利益的平衡问题。绿色能源发展固然重要,但也要兼顾对科研和环境的潜在影响,避免不可逆的损失。 Benjamin Thompson: 南极洲冰山崩解事件为研究人员提供了前所未有的机会,揭示了冰层下隐藏的丰富海洋生物多样性。这不仅扩展了我们对极地生态系统的认知,也凸显了保护这些脆弱生态系统的重要性,因为气候变化正在对它们构成威胁。

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00:46 Newly discovered molecule shows potent antibiotic activity

Researchers have identified a new molecule with antibiotic activity against a range of disease-causing bacteria, including those resistant to existing drugs. The new molecule — isolated from soil samples taken from a laboratory technician’s garden — is called lariocidin due to its lasso-shaped structure. The team say that in addition to its potent antibiotic activity, the molecule also shows low toxicity towards human cells, making it a promising molecule in the fight against drug-resistant infections.

*Research Article: *Jangra et al.)

09:36 Research Highlights

A reduction in ships' sulfur emissions linked to a steep drop in thunderclouds, and the epic sea-voyage that let iguanas reach Fiji.

*Research Highlight: *Ship-pollution cuts have an electrifying effect: less lightning at sea)

Research Highlight: Iguanas reached Fiji by floating 8,000 kilometres across the sea)

13:54 Assessing the nuances of humans’ biodiversity impacts

A huge study analysing data from thousands of research articles has shown that the human impacts on biodiversity are large but are in some cases context dependent. The new study reveals that at larger scales, communities of living things are becoming more similar due to human influence, but at the smaller scale they are becoming more different. "These are generally unwanted effects on biodiversity," says study author Florian Altermatt, "this is one more very strong argument that stopping and reducing these pressures to halt and reverse biodiversity declines is needed."

*Research article: *Keck et al.)

21:45 Briefing Chat

How a proposed green-energy facility in Chile could increase light pollution at one of the world’s most powerful telescopes, and how a calving Antarctic iceberg revealed an unseen aquatic ecosystem.

*Nature: *Light pollution threatens fleet of world-class telescopes in Atacama Desert)

*Scientific American: *Stunning Antarctic Sea Creatures Discovered after Iceberg Breaks Away)

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